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5-aminolevulinic acid guided resection of paediatric central nervous system tumours: the largest single centre series in the UK
Charlotte Burford*1, Nida Kalyal2, Anand Pandit2, Jose Pedro Lavrador2, Cristina Bleil2, Ahilan Kailaya-Vasan2, Bassel Zebian2
1King's College London, UK, 2King's College Hospital, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
5-Year event-free survival (EFS) and neurocognitive outcome in children with medulloblastoma (MB) between 3 and 5 years of age: results of Children's Oncology Group Study ACNS0331
Roger Packer*1, Yimei Li6,2, Kristina Hardy1, Anna Janss4, Catherine Billups6,2, Leanne Embry3, Yuanyuan Han6,2, Patricia Cullen5, Thomas Merchant6, Nancy Tarbell11, Ian Pollack7, Amar Gajjar6, Sarah Leary8, Maryam Fouladi9, Jeff Michalski10
1Children's National Health System, USA, 2Children's Oncology Group, USA, 3UT Health Science Center, USA, 4Emory Children's Hospital, USA, 5University of Denver, USA, 6St. Jude's Children's Hospital, USA, 7Pittsburgh Children's Hospital, USA, 8Seattle Children's Hospital, USA, 9Cincinnati Children's Hospital, USA, 10Washington University, USA, 11Massachussets General Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A 3D hydrogel culture system facilitates study of primary pediatric low-grade glioma cells in vitro
Karen D. Wright*1,2, Emily Chadwick1, Christopher Rota1, Alexander Brown3, Linda Stockdale3, Mark W. Kieran1,2, Keith Ligon1,2, Liliana Goumnerova1,2, Douglas Lauffenburger3, Linda Griffith3, Rosalind Segal1
1Dana-Farber Cancer Institute, USA, 2Boston Children's Hospital, USA, 3Massachusetts Institute of Technology, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A biobank of patient-derived molecularly characterized orthotopic pediatric brain tumor models for preclinical research
Sebastian Brabetz1,2, Susanne N. Groebner1,2, Natalie Jaeger1,2, Till Milde1,2, Jonas Ecker1,2, Florian Selt1,2, Olaf Witt1,2, Jessica M. Rusert6, Jan Koster3, Sarah E. Leary4, Xiao-Nan Li5, Robert J. Wechsler-Reya6, James M. Olson4, Stefan M. Pfister1,2, Marcel Kool*1,2
1Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2German Cancer Research Center (DKFZ), Germany, 3Academic Medical Center, The Netherlands, 4Fred Hutchinson Cancer Research Center and Seattle Children's Hospital, USA, 5Baylor College of Medicine, USA, 6Sanford Burnham Prebys Medical Discovery Institute, USA
Monday, July 2:  Preclinical Models/Drug Discovery  -  8:30am - 9:30am
A case for early dabrafenib use in patients with low-grade gliomas
Krupesh Patel*1,2, Derek Hanson1
1Hackensack University Medical Center, USA, 2Rutgers New Jersey Medical School, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A case of molecularly profiled extraneural medulloblastoma metastases in a child
Nahla Ali Mobark1, Musa Al-Harbi*1, Sandro Santagata2, Malak Abedalthagafi3
1Paediatric Haematology Oncology Department, Comprehensive Cancer Centre, King Fahad Medical City, Saudi Arabia, 2Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., USA, 3Research Centre and Pathology Department, Saudi Human Genome Lab, King Fahad Medical City and King Abdulaziz city for science and technology., Saudi Arabia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A centralized molecular diagnostic service for pediatric brain tumors in Japan
Koichi Ichimura*1,7, Yoshiko Nakano1,7, Takako Yoshioka2,7, Junko Hirato3,7, Mai Kitahara1, Tomoko Shofuda4,8, Sumihito Nobusawa3,7, Kai Yamasaki5,7, Yonehiro Kanemura4,8, Hiroaki Sakamoto5,8, Ryo Nishikawa6,7, Junichi Hara5,7
1National Cancer Center Research Institute, Japan, 2National Center for Child Health and Development, Japan, 3Gunma University Hospital, Japan, 4Osaka National Hospital, Japan, 5Osaka City General Hospital, Japan, 6Saitama Medical University International Medical Center, Japan, 7Japan Children's Cancer Group, Japan, 8Japan Pediatric Molecular Neuro-Oncology Group, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A comprehensive gene/protein investigation of the tumour microenvironment in diffuse midline glioma in children
Katie Loveson*, Helen Fillmore
University of Portsmouth, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A failure to resolve inflammation: Role of resolvins in the treatment of pediatric CNS tumors
Jessica Clymer*4, Chantal Barksdale1,2, Jaimie Chang1,2, Nicholas Kieran1,2, Megan Sulciner1,2, Romain Colas3, Pratiti Bandopadhayay4, Sui Huang5, Charles Serhan3, Dipak Panigrahy1,2, Mark Kieran4
1Center for Vascular Biology Research Beth Isreal Deaconess Medical Center, Harvard Medical School, USA, 2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA, 3Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, USA, 4Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, USA, 5Institute for Systems Biology, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A four-year follow-up study of neurocognition in children treated for a brain tumor
Jurgen Lemiere*, Josefien Vandereydt, Linde Van den Wyngaert, Trui Vercruysse, Charlotte Sleurs, Sandra Jacobs
UZLeuven, Belgium
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A human neural stem cell DIPG model identifies the relative contribution of different oncogenic elements to invasive malignant transformation
Youngran Park*, Ping An, Dacheng Ding, Charles G. Eberhart, Eric H. Raabe
Division of Pediatric Oncology and Neuropathology, Johns Hopkins University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A kinome-wide shRNA screen uncovers VRK3 as an essential gene for DIPG survival
Cláudia CS Evangelista1, Emilie Barret1, Jane Merlevede1, Ambre Saccasyn1, Stéphanie Puget2, Jacques Grill1,3, David Castel1,3, Marie-Anne Debily*1,4
1UMR8203 Vectorologie and Thérapeutiques Anticancéreuses, CNRS, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay,, France, 2Département de Neurochirurgie Pédiatrique, Hôpital Necker-Enfants Malades, Université Paris V Descartes, France, 3Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, France, 4Département de Biologie, Université Evry Val-d'Essonne, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A multi-centre clinical trial of CNS germ cell tumours in Hong Kong
Matthew MK Shing*1, Godfrey CF Chan2, CW LUK3, Dennis TL Ku4, Anthony Liu2, SC Ling5
1Lady Pao Children's Cancer Centre, Dept. of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, 2Dept. of Paediatrics, Queen Mary Hospital, The University of Hong Kong, Hong Kong, 3Dept. of Paediatrics, Queen Elizabeth Hospital, Hong Kong, 4Dept. of Paediatrics, Tuen Mun Hospital, Hong Kong, 5Dept. of Paediatrics, Princess Margaret Hospital, Hong Kong
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A national UK guideline for managing pituitary adenomas in children and young people under 19 years developed according to the AGREE II framework
Jo Blair*2, Márta Korbonits1, Amy Ronaldson1, Mary Dang1, Helen Spoudeas3
1Barts and the London School of Medicine, Queen Mary University of London, UK, 2Alder Hey Children's NHS Foundation Trust, UK, 3Great Ormond Street Hospital for Children NHS Foundation Trust, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A novel HDAC inhibitor in new patient-derived diffuse intrinsic pontine glioma (DIPG) models
Matthew Biery*1, Carrie Myers1, Emily Girard1, Shelli Morris1, Savanna Carmack1, Alyssa Noll1,2, Jay Sarthy1,3, Eric Ferguson1, Andrew Mhyre1, Andrew Strand1, James Olson1,3, Nicholas Vitanza1,3
1Fred Hutchinson Cancer Research Center, USA, 2University of Washington School of Medicine, USA, 3Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A novel pediatric IDH1 mutant glioblastoma cell line and xenograft model
Dennis Metselaar*1, Michaël Meel1, Piotr Waranecki1, Kenn Zwaan1, Pino Poddighe1, Dannis van Vuurden1, Gertjan Kaspers1,2, Esther Hulleman1
1VU Medical Center / Cancer Center Amsterdam, The Netherlands, 2Princess Máxima Center of Pediatric Oncology, The Netherlands
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A p53 independent mouse model of Group 3 medulloblastoma
Ran Tao1, Najiba Murad1, Konstantin Okonechnikov2, Peng Zhang1, Samuel Rivero-Hinojosa1, Marcel Kool2, Brian Rood1, Yanxin Pei*1
1Children's National Medical Center, USA, 2German Cancer Research Center, Germany
Tuesday, July 3:  Medulloblastoma - Basic/Translational Research  -  9:00am - 10:20am
A phase 1 trial of the histone deacetylase inhibitor panobinostat in pediatric patients with recurrent or refractory diffuse intrinsic pontine glioma: a Pediatric Brain Tumor Consortium (PBTC) study
Tabitha Cooney*1,8, Arzu Onar-Thomas2, Jie Huang2, Rishi Lulla3, Jason Fangusaro3, Kim Kramer4, Patricia Baxter5, Maryam Fouladi6, Ira J. Dunkel4, Katherine E. Warren7, Michelle Monje1
1Stanford University, USA, 2St Jude Children's Research Hospital, USA, 3Lurie Children's Hospital, USA, 4Memorial Sloan Kettering Cancer Center, USA, 5Texas Children's Hospital, USA, 6Cincinnati Children's Medical Center, USA, 7National Cancer Institute, USA, 8UCSF Benioff Children's Hospital, USA
Monday, July 2:  Early Phase Trials  -  9:30am - 10:30am
A phase 2 trial of response-based radiation therapy for patients with localized central nervous system germ cell tumors (CNS GCT): a children's oncology group (COG) study
Jason Fangusaro*1, Shengjie Wu2, Shannon MacDonald3, Erin Murphy4, Dennis Shaw5, Ute Bartels6, Soumen Khatua7, James Boyett2, Chris Williams-Hughes13, Mark Souweidane12, Hsiao-Ming Lu3, David Morris8, Ashok Panigrahy9, Arzu Onar-Thomas2, Maryam Fouladi10, Amar Gajjar2, Girish Dhall11
1Ann and Robert H. Lurie Children's Hospital of Chicago, USA, 2St. Jude Children's Research Hospital, USA, 3Massachusettes General Hospital Cancer Center, USA, 4Cleveland Clinic Foundation, USA, 5Children's Hospital and Regional Medical Center, USA, 6Hospital for Sick Children, Canada, 7MD Anderson Cancer Center, USA, 8Univeristy of North Carolina at Chapel Hill, USA, 9Children's Hospital of Pittsburgh, USA, 10Cincinnati Children's Hospital, USA, 11Children's Hospital Los Angeles, USA, 12Memorial Sloan Kettering Cancer Center, USA, 13Children's Oncology Group, Operations Center, USA
Sunday, July 1:  Germ Cell Tumors  -  1:30pm - 2:30pm
A phase I dose escalation trial of the MEK1/2 inhibitor MEK162 (binimetinib) in children with low-grade gliomas and other Ras/Raf pathway-activated tumors
Nathan Robison*1,2, Jasmine Pauly1, Jemily Malvar1, Mariella Gruber-Filbin11,3, Rebecca Loret de Mola4, Kathleen Dorris5, Anne Bendel6, Daniel Bowers7, Miriam Bornhorst8, Karen Gauvain9, Sarah Leary10, Patricia Diaz1, Yi Juin Tan1, Ashley Margol1,2, Girish Dhall1,2, Tena Rosser1,2, Pratiti Bandopadhayay11,3, Tom Davidson13, Nicole Ullrich12,11, Mark Borchert1,2, Marvin Nelson1,2, Claire Sinai11, Keith Ligon11,3, Richard Sposto1,2, Mark Kieran11,12
1Children's Hospital Los Angeles, USA, 2University of Southern California Keck School of Medicine, USA, 3The Broad Institute, USA, 4Oregon Health and Science University, USA, 5Children's Hospital Colorado, USA, 6Children's Hospitals and Clinics of Minnesota, USA, 7University of Texas Southwestern Medical Center at Dallas, USA, 8Children's National Health System, USA, 9Washington University, USA, 10Fred Hutchinson Cancer Research Center, USA, 11Dana-Farber Cancer Institute, USA, 12Boston Children's Hospital, USA, 13University of California Los Angeles, USA
Sunday, July 1:  Low Grade Gliomas  -  8:45am - 11:00am
A phase I trial of TTFields with and without concomitant temozolomide and bevacizumab in pediatric patients with high-grade glioma
Derek Hanson
Hackensack University Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A phase II study of panobinostat in paediatric patients with solid tumors including malignant rhabdoid tumor/atypical teratoid rhabdoid tumours
Paul Wood*1,2, Jayesh Desai3,4, Nick Gottardo5,6, Jason Cain7, David Ashley8
1Monash University, Australia, 2Monash Health, Australia, 3Peter MacCallum Cancer Centre, Australia, 4Royal Melbourne Hospital, Australia, 5Telethon Kids Institute, Australia, 6Princess Margaret Hospital, Australia, 7Hudson Institute of Medical Research, Australia, 8Duke University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A phase II trial of Poly-ICLC in the management of recurrent or progressive pediatric low grade gliomas (NCT01188096): preliminary analysis
Dolly Aguilera*1, Tobey MacDonald1, John Crawford2, Nadja Kadom1, Anna Janss1, Claire Mazewski1, Robert Craig Castellino1, Rachael Gray3, Minya Pu4, Erin Connelly3, Andres Salazar5, Donald L. Durden2
1Children's Health Care of Atlanta, Emory University School of Medicine, USA, 2Rady Children’s Hospital-San Diego University of California, San Diego, USA, 3Children's Health Care of Atlanta, USA, 4Moores Cancer Center, USA, 5Oncovir, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A precision medicine strategy to avoid the harm of brain injury in survivors of childhood brain tumours
David Walker*1, Jo-Fen Liu1, Ruman Rahman1, Emma Campbell1, Sophie Wilne2, Donald MacArthur3, Thomas Chu1, Richard Grundy1
1Children’s Brain Tumour Research Centre, University of Nottingham, UK, 2Department of Paediatric Oncology, Nottingham University Hospitals NHS Trust, UK, 3Department of Neurosurgery, Nottingham University Hospitals NHS Trust, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
A single center experience of managing a series of childhood macroprolactinomas
Antonia Dastamani*1, Chloe Bulwer2, Marta Korbonits3, Helen Spoudeas1
1Great Ormond Street Hospital, UK, 2Royal Devon and Exeter Hospital, UK, 3Department of Molecular Endocrinology Queen Mary University of London Tavistock and Portman NHS Foundation Trust, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A spatial and prognostic analysis of immune cell infiltrate in paediatric ependymoma
Timothy A Ritzmann*1, Francesca Francis1, Sarah-Louise Brudenell1, Hazel A Rogers1, Alex Virasami4, Thomas S Jacques4, Simon ML Paine1,2, Richard G Grundy1,2
1The University of Nottingham, UK, 2Nottingham University Hospitals NHS Trust, UK, 3UCL GOS Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital for Children NHS Trust, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A standardized algorithm and educational approach to nutrition support in patients undergoing treatment for cancer: A QI project.
Meghan Belongia*1, Craig Erker3, Jennifer Hoag1, Kerri Houser1, Sarah Everett2, Jeffrey Knipstein1
1Department of Pediatrics, Medical College of Wisconsin, USA, 2Children's Hospital of Wisconsin, USA, 3Cincinnati Children's Hospital Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
A whole chromosome aberration phenotype in non-WNT/non-SHH tumors predicts outcome within standard-risk medulloblastomas from the HIT-SIOP-PNET4 clinical trial
Tobias Goschzik1, Edward C Schwalbe2,3, Debbie Hicks*2, Dominique Figarella-Branger4, Francois Doz5, Stefan Rutkowski6, Göran Gustafsson7, Birgitta Lannering8, Torsten Pietsch1, Steven C Clifford2
1Dept. of Neuropathology, University of Bonn Medical Center, Germany, 2Northern Institute for Cancer Research, Newcastle University, UK, 3Dept. of Applied Sciences, Northumbria University, UK, 4Dept. of Pathology and Neuropathology, Aix Marseille University, France, 5Institut Curie and University Paris Descartes, France, 6University Medical Center Hamburg-Eppendorf, Germany, 7Karolinska Institute, Sweden, 8Department of Pediatrics, University of Gothenburg and the Queen Silvia Children's Hospital, Sweden
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Academic achievement prediction and outcomes in children with brain tumors
Hannah McAtee*, Sheila Barron, Natalie Denburg, Amanda Grafft, Timothy Ginader, Charles Lynch, Mariko Sato
University of Iowa, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Active chromatin in H3K27M DIPG reveals distinct epigenetic subtypes and subtype-specific mechanisms of pathogenesis
Surya Nagaraja*1, Michael Quezada1, Shawn Gillespie1, Anna Geraghty1, Volker Hovestadt2,5, Mariella Filbin2,5, Mario Suva2,5, Javad Nazarian3,4, Michelle Monje1
1Stanford University, USA, 2Massachusetts General Hospital and Harvard Medical School, USA, 3Children's National Medical Center, USA, 4George Washington University School of Medicine and Health Sciences, USA, 5Broad Institute of Harvard and MIT, USA
Monday, July 2:  DIPG/Diffuse Midline Glioma  -  1:30pm - 3:00pm
Adding a parent to the brain tumor team: evaluating a peer support intervention for parents of children with brain tumors
Mary Nelson1, Kathy Riley*2
1Children's Hospital Los Angeles, USA, 2Pediatric Brain Tumor Foundation, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Advanced MR imaging of germinoma
Fumiyuki Yamasaki*, Yasuyuki Kinoshita, Takeshi Takayasu, Satoshi Usui, Manish Kolakshyapati, Motoki Takano, Naoto Yamada, Kazuhiko Sugiyama, Kaoru Kurisu
Hiroshima University Hospital, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
ALK expression at the protein level is a marker for the differentiation diagnosis of  the WNT-activated type of pediatric medulloblastoma
Maria Lastowska1,5, Joanna Trubicka*1, Magdalena Niemira2, Magdalena Paczkowska-Abdulsalam2, Agnieszka Karkucinska-Wieckowska1, Magdalena Kaleta1, Monika Drogosiewicz3, Magdalena Tarasinska3, Marta Perek-Polnik3, Adam Kretowski2,4, Bozenna Dembowska-Baginska3, Wieslawa Grajkowska1, Maciej Pronicki1, Ewa Matyja5
1Department of Pathology,The Children’s Memorial Health Institute, Poland, 2Clinical Research Centre,Medical University of Bialystok, Poland, 3Clinic of Oncology, The Children’s Memorial Health Institute, Poland, 4Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Poland, 5Department of Experimental and Clinical Pathology, Mossakowski Medical Research Centre Polish Academy of Sciences, Poland
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
An analysis of putative cells of origin for Malignant Rhabdoid Tumours (MRT): a frontier for development of MRT cancer modelling and identification of potential therapeutic targets
Ras Ramli*1, Martina Finetti1, Matthew Selby1, Yura Grabovska1, Stepehn Crosier1, Simon Bailey1, Steven Clifford1, Daniel Williamson1
1Northern Institute for Cancer Research, Newcastle university, UK, 2Universiti Sultan Zainal Abidin (UniSZA), Malaysia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
An international workshop to develop a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome (CMS) in children and young people
_ The Cerebellar Mutism Syndrome (CMS) Workshop
The Cerebellar Mutism Syndrome (CMS) Workshop Nottingham 2017, UK
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
Analysis of expression of YAP1, RELA, MAMLD1 and FAM118B genes in pediatric ependymoma
Bruna Mascaro-Cordeiro1,2, Indhira Oliveira1, Maria Teresa Alves1,3, Frederico Adolfo Silva1, Nasjla Saba-Silva1, Andrea Capellano*1, Sergio Cavalheiro1,4, Patricia Dastoli1, Silvia Toledo1,2
1Pediatric Oncology Institute/GRAACC, Department of Pediatrics, Federal University of São Paulo, Brazil, 2Department of Morphology and Genetics, Division of Genetics, Federal University of São Paulo, Brazil, 3Department of Pathology, Federal University of São Paulo, Brazil, 4Department of Neurology, Federal University of São Paulo, Brazil
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Analysis of paired BRAFV600E mutant glioma patient samples identifies novel resistance mechanisms to targeted BRAF inhibition
Jean Mulcahy Levy*1,2, Bridget Sanford1, Andrew Morin1,2, Adam Green1,2, Patrick Flannery1,2, Kenneth Jones1, Anurhada Banerjee3, Kellie Nazemi4, David Samuel5, Lindsay Kilburn6, David Solomon3, Theodore Nicolaides3
1University of Colorado Denver, USA, 2Morgan Adams Pediatric Brain Tumor Reserach Program, USA, 3University of San Francisco, USA, 4Oregon Health Sciences University, USA, 5Valley Chidren's Healthcare, USA, 6Children's National Health System, USA
Sunday, July 1:  Low Grade Gliomas  -  8:45am - 11:00am
Angiocentric glioma - exploring a novel therapeutic option
Sayani Tewari*, Rene McNall-Knapp
University of Oklahoma Health Sciences Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Antiangiogenic metronomic therapy for children with recurrent ependymoma
Daniel Alderete*, Lorena Baroni, Claudia Sampor, Candela Freytes, Carla Pennella
Hospital Prof. Dr. Juan P. Garrahan, Argentina
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Anti-GD2 chimeric antigen receptor T cells as a potent immunotherapy regimen in xenograft models of histone 3 K27M mutant diffuse midline glioma
Christopher Mount*, Robbie Majzner, Shree Sundaresh, Evan Arnold, Meena Kadapakkam, Samuel Haile, Louai Labanieh, Pamelyn Woo, Skyler Rietberg, Hannes Vogel, Michelle Monje, Crystal Mackall
Stanford University, USA
Monday, July 2:  DIPG/Diffuse Midline Glioma  -  1:30pm - 3:00pm
ApoE4 as a genetic predictor for neurocognitive outcomes in pediatric brain tumor survivors
Cassie Kline*1, Erin Felton1, Lennox Byer1, Schuyler Stoller1, Joseph Torkildson2, Karen Gauvain3, David Samuel4, Elizabeth Tong1, John Liu1, Heather Fullerton1, Dena Dubal1, Sabine Mueller1
1University of California, San Francisco, USA, 2UCSF Benioff Children's Hospital Oakland, USA, 3Washington University, Saint Louis, USA, 4Valley Children's Healthcare, USA
Sunday, July 1:  Quality of Life/Survival/Rehabilitation  -  1:30pm - 3:00pm
Arg-auxotrophic patient-derived glioblastoma multiforme cell lines show increased sensitivity towards Doxycycline-induced growth inhibition
Fatemeh Shokraie1,2, Christin Riess3, Tomas Fiedler3, Björn Schneider4, Carl Friedrich Classen*1, Claudia Maletzki5
1University Childrens Hospital, Germany, 2Department of General Surgery, Germany, 3Institute for Medical Microbiology, Germany, 4Institute for Pathology, Germany, 55Department of Medicine, Clinic III, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
ASL perfusion imaging of the frontal lobes predicts the occurrence and resolution of posterior fossa syndrome
Derek Yecies*1, Katie Shpanskaya2, Gerald Grant1, Samuel Cheshier1, David Hong1, Michael Edwards1, Kristen Yeom3
1Division of Pediatric Neurosurgery, Lucile Packard Children's Hospital at Stanford, USA, 2Stanford University School of Medicine, USA, 3Division of Pediatric Radiology, Lucile Packard Children's Hospital at Stanford, USA
Sunday, July 1:  Imaging  -  4:00pm - 5:00pm
Assessing the utility of DNA methylation profiling in brain tumor diagnostics—the prospective MNP2.0 study
Dominik Sturm*1,2, Felix Sahm3,4, Felipe Andreiuolo5, David Capper3,6, Agata Rode1,2, Kerstin Grund1,7, Stefan Rutkowski8, Brigitte Bison9, Marco Gessi5, Andreas von Deimling3,4, Monika Warmuth-Metz9, Torsten Pietsch5, Stefan M. Pfister1,2, David T.W. Jones1
1Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Germany, 2Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Germany, 3Department of Neuropathology, University Hospital Heidelberg, Germany, 4Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Germany, 5Brain Tumor Reference Center, Department of Neuropathology, Bonn University Hospital, Germany, 6Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology and German Cancer Consort, Germany, 7Institute for Human Genetics, University Hospital Heidelberg, Germany, 8Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany, 9Neuroradiology Reference Center, Department of Neuroradiology, Würzburg University Hospital, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Assessment of early stage autophagy inhibition in BRAFV600E brain tumor cell response to chemotherapy
Shadi Zahedi*1,2, Brent E. Fitzwalter1, Daniel L. Gustafson3, Andrew Morin1,2, Michele Desmarais1,2, Lindsey M. Hoffman1,2, Jean M. Mulcahy Levy1,2
1University of Colorado Denver, USA, 2Children's Hospital Colorado, USA, 3Colorado State University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Assisted reproductive technologies and the development of malignant rhabdoid tumours
Karolina Nemes1, Martin Hasselblatt2, Susanne Bens3, Anat Erdreich-Epstein4, Jaclyn Biegel5, Ziad Khatib8, Olga Liaugaudiene7, Alireza Sadeghipour8, Georg Ebetsberger-Dachs9, Andreas Lemmer10, Claudia Khurana11, Nicolas von der Weid12, Irene Schmid13, Jaume Mora14, Carmen Hernandez Marques15, Jane Pears16, Beate Timmermann17, Uwe Kodes18, Joachim Gerss19, Rhoikos Furtwängler20, Reiner Siebert3, Michael Christoph Frühwald*1,21
1Swabian Children's Cancer Center, Children's Hospital, Klinikum Augsburg, Germany, 2Institute of Neuropathology, University Hospital Muenster, Germany, 3Institute of Human Genetics, University of Ulm, University Hospital of Ulm, Germany, 4Children’s Center for Cancer and Blood Diseases, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, USA, 5Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, USA, 6Department of Pediatric Hematology and Oncology, Miami Children's Hospital, USA, 7Department of Genetics and Molecular Medicine, Hospital of Lithuanian, University of Health Sciences, Kauno Klinikos, Lithuania, 8Department of Pathology, Rasoul Akram Medical Complex, Iran University of Medical Sciences, Iran, 9Division of Pediatric Hematology and Oncology, Kepler University Hospital Linz, Austria, 10Children's Hospital, HELIOS Klinikum Erfurt, Germany, 11Children's Center, Evangelisches Krankenhaus Bielefeld, Germany, 12Department of Pediatric Hematology and Oncology, University Children’s Hospital Basel (UKBB), Switzerland, 13Department of Pediatric Hematology and Oncology, Dr. von Haunerschen Kinderspital, Germany, 14Department of Pediatric Hemato-Oncology, Hospital Sant Joan de Déu, Spain, 15Department of Pediatric Oncology, Hospital Infantil Universitario Niño Jesús, Spain, 16Department of Pediatric Oncology, Our Lady's Children's Hospital, Ireland, 17Clinic for Particle Therapy, University Hospital Essen, West German Cancer Center (WTZ), Germany, 18Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany, 19Institute of Biostatistics and Clinical Research, University of Münster, Germany, 20Department of Pediatric Oncology and Hematology, Saarland University of Hospital Saarland, Germany, 21Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Associations between sensory, perceptual, and cognitive impairment in the visual domain in children treated for optic pathway glioma
Chiara Papini*1, Nicola Pitchford1, Rob Dineen2, David Walker3
1School of Psychology, University of Nottingham, UK, 2Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK, 3Children's Brain Tumour Research Centre, University of Nottingham, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Astroblastoma – a report from 3 cases
Monika Drogosiewicz*1, Iwona Filipek1, Marta Perek-Polnik1, Ewa Swieszkowska1, Iwona Kosciesza2, Wieslawa Grajkowska3, Bozenna Dembowska-Baginska1
1Department of Oncology, The Children's Memorial Health Institute, Poland, 2Department of Radiology, The Children's Memorial Health Institute, Poland, 3Department of Patology, The Children's Memorial Health Institute, Poland
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
At home neurocognitive testing is possible in pediatric brain tumor patients
Amy Rosenfeld*1, Michael Etzl2, Annie Gieseking2, Amanda Goodman2, Dianne Peterson2, Thomas Daniels3, Adrian Schmebri4, Brian Harel5
1AstraZeneca, USA, 2Phoenix Children's Hospital, USA, 3Mayo Clinic, USA, 4Cogstate, Australia, 5Takeda, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Automated cell enrichment and digital cell sorting using dielectrophoretic arrays for isolation of circulating tumor cells in pediatric brain tumor patients
Katherine Barnett*, Kaicen Zhu, Guomiao Shen, Jonathan Serrano, David Harter, Jeffrey Wisoff, Amanda Yaun, Shiyang Wang, Sharon Gardner, Matija Snuderl
NYU Langone Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
B7-H3 expression as a potential biomarker of prognosis and target in pediatric glial and non-glial CNS tumors
Uday Bhanu Maachani*1, Zhiping Zhou2, Daniel Martinez3, Mariarita Santi3, Nadia Dahmane1, Mark Souweidane1
1Department of Neurological Surgery, Weill Cornell Medical College, USA, 2Department of Pediatrics, Memorial Sloan Kettering Cancer Center, USA, 3Department of Pathology, Children's Hospital of Philadelphia, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Bariatric surgery for treatment of hypothalamic obesity
Thomas Inge*, Megan Kelsey
Childrens Hospital of Colorado, USA
Sunday, July 1:  Quality of Life/Survival/Rehabilitation  -  1:30pm - 3:00pm
Barriers to enrollment on CNS late effects studies, a single-center experience
Emily Owens Pickle, Amie Deak*, Michelle Pelletier, Ana Aguilar-Bonilla, Amy Smith
Arnold Palmer Medical Center, USA
Saturday, June 30:  Social Work Session  - 
Bcor loss impacts SHH medulloblastoma formation via transcriptional up-regulation of Igf2
Daisuke Kawauchi*1,2, Jessica Clark1,2, Konstantin Okonechnikov1,2, Nadja Batora1,2, Mikaella Vouri1,2, Sjoerd van Rijn1,2, Micah Gearhart3, Brent Orr4, Andrey Korshunov2,5, Marcel Kool1,2, Vivian Bardwell3, Stefan Pfister1,2, Paul Northcott4
1Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2German Cancer Research Center (DKFZ), Germany, 3University of Minnesota, USA, 4St. Jude Children's Research Hospital, USA, 5Heidelberg University Hospital, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Better social, cognitive, and academic outcomes among pediatric brain tumor survivors treated with proton versus photon radiation therapy
Emily Warren*1,2, Amanda Child1,2, Paul Cirino1, David Grosshans4, Anita Mahajan5, Arnold Paulino4, Murali Chintagumpala2,3, Fatih Okcu2,3, M. Douglas Ris2,3, Charles Minard2, Andres Viana1, Johanna Bick1, Steven Woods1, Jessica Orobio2,3, Judy Xue2,3, Lisa Kahalley2,3
1University of Houston, USA, 2Baylor College of Medicine, USA, 3Texas Children's Hospital, USA, 4The University of Texas M.D. Anderson Cancer Center, USA, 5Mayo Clinic, USA
Sunday, July 1:  Quality of Life/Survival/Rehabilitation  -  1:30pm - 3:00pm
Bevacizumab for pediatric low grade glioma
Keita Terashima*1, Chikako Kiyotani1, Yui Kimura1, Tomoo Osumi1, Yoko Shioda1, Motohiro Kato1, Daisuke Tomizawa1, Kenichi Usami2, Hideki Ogiwara2, Hidekazu Aoki3, Yoshiyuki Tsutsumi3, Rie Irie4, Takako Yoshioka4, Kimikazu Matsumoto1
1Children's Cancer Center, National Center for Child Health and Development, Japan, 2Division of Neurosurgery, National Center for Child Health and Development, Japan, 3Department of Radiology, National Center for Child Health and Development, Japan, 4Department of Pathology, National Center for Child Health and Development, Japan
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Blackfynn: A secure, cloud-based platform for sharing and analyzing research ready data for pediatric CNS cancers
Courtney Johnson*1, Amanda Christini3, Alex Felmeister2, Chris Baglieri3, Madhuri Kambhampati1, Angela Waanders2,4, Jennifer Mason2,4, Roger Packer1, Adam Resnick2,4, Javad Nazarian1,4
1Children’s National Health System, Center for Genetic Medicine Research, USA, 2Children’s Hospital of Philadelphia, USA, 3Blackfynn, Inc., USA, 4On behalf of the Children’s Brain Tumor Tissue Consortium (www.cbttc.org), USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Bone metastases in pediatric high grade glioma: a case series and review of the literature
Megan Paul*, John Crawford, Jennifer Elster
University of California San Diego, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Bone morphogenetic protein 4 differentiates glioma stem cells to increases chemosensitivity via decreasing H3K4me3 in pediatric high grade gliomas
Sonali Nayak1, Benamin Best1, Emily Hayes1, Barbara Mania-Farnell2, Tadanori Tomita1, Guifa Xi*1
1Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 2Purdue University Northwest, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Brain metastasis in Wilms' tumor: a case report
Mehdi Borni*, Anis Abdelhedi, Fatma Kolsi, Brahim Kammoun, Mohammed Zaher Boudawara
Neurosurgery Department UHC Habib Bourguiba, Tunisia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Brain tumor patient derived orthotopic xenografts induce tumors of mouse origin
Andrew Strand*1, Bonnie Cole2,3, Sarah Leary2,3, James Olson1,2
1Fred Hutchinson Cancer Research Center, USA, 2Seattle Children's Hospital, USA, 3University of Washington, USA
Monday, July 2:  Preclinical Models/Drug Discovery  -  8:30am - 9:30am
Brain tumors of the first years of life: ten years of IOP/GRAACC/Universidade Federal de Sao Paulo experience
Patricia Dastoli1,2, Jardel Nicácio1,2, Marcos Costa1,2, Andrea Cappellano*1, Frederico Silva3, Nasjla Silva1, Sergio Cavalheiro1,2
1Instittuto de Oncologia Pediátrica/GRAAC/UNIFESP; Division of Neuroncology, Brazil, 2Universidade Federal De Sao Paulo, Discipline of Neurosurgery, Division of Pediatric Neurosurgery, Brazil, 3Instituto De Oncologia Pediátrica GRAACC/UNIFESP, Division of Neuroradiology, Brazil
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
BrainChild pipeline: locoregional immunotherapy with chimeric antigen receptor (CAR) T-cells for recurrent/refractory central nervous system tumors
Nicholas Vitanza*1,2, Juliane Gust2,3, Sarah Leary1,2, Navin Pinto2,4, Amy Lee5, Jason Hauptman5, Jeff Ojemann5, Leslie Elliott6, Olivia Finney6, Catherine Lindgren7, Zahid Hossain6, Robert Pierce8,9, Nicole Lieberman6, Courtney Crane6, Adam Johnson6, Rebecca Gardner2,4, Laura Finn9, Julie Park2,4, Michael Jensen1,6
1Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, USA, 2Center for Clinical and Translational Research, Seattle Children's Research Institute, USA, 3Division of Pediatric Neurology, Department of Neurology, University of Washington, USA, 4Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle Children's Hospital, USA, 5Division of Neurosurgery, Department of Neurological Surgery, University of Washington, Seattle Children's Hospital, USA, 6Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, USA, 7Therapeutic Cell Production Core, Seattle Children's Research Institute, USA, 8Fred Hutchinson Cancer Research Center, USA, 9Division of Pathology, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Brainstem radiation exposure confers substantial risk of diffuse intrinsic pontine glioma (DIPG) in medulloblastoma survivors: a report from the International DIPG Registry
Hunter Gits1, Maia Anderson1, Becky Zon1, Christopher Howell2, Katayoon Kasaian1, Tingting Qin1, Stefanie Stallard1, Daniel Polan1, Martha Matuszak1, Marcia Leonard1, Drew Pratt1, Daniel Spratt1, Siriam Venneti1, Rajen Mody1, James Leach3, Blaise Jones3, Christine Fuller3, Sarah Leary4, Ute Bartels5, Eric Bouffet5, Torunn Yock6, Patricia Robertson1, Maryam Fouladi3, Nicholas Gottardo2,7, Carl Koschmann*1
1Michigan Medicine, USA, 2Princess Margaret Hospital for Children, Australia, 3Cincinnati Children's Hospital, USA, 4Seattle Children's Hospital, USA, 5Hospital for Sick Children, Canada, 6Massachusetts General Hospital, USA, 7Telethon Kids Institute, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Building a neurofibromatosis therapeutics program
Molly Hemenway*, Nicholas Foreman, Melissa Waters
Children's Hospital Colorado, Univ of Colorado, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Burden of diffuse intrinsic pontine glioma diagnosis in a developing country
Zebin Al Zebin*, Maisa Sawidan, Ahmed Ibrahimi, Hadeel Halalsheh, Kawther Khalifeh, Raed Ramlawi, Nisreen Amayiri
King Hussein Cancer Center, Jordan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Can we change the landscape of pediatric diffuse intrinsic pontine glioma (DIPG)? First demonstration of clinical and radiographic response in a pediatric H3-K27M mutated DIPG to the DRD2-antagonist ONC201
Matthew Hall*1,2, Yazmin Odia1, Joshua Allen3, Rohinton Tarapore3, Ziad Khatib2, Ossama Maher2, Toba Niazi2, Doured Daghistani1, Lee Schalop3, Andrew Chi4, Wolfgang Oster3, Minesh Mehta1
1Miami Cancer Institute, USA, 2Nicklaus Children's Hospital, USA, 3Oncoceutics, USA, 4NYU Langone Medical Center and School of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Cancer predisposition among children with rhabdoid tumors: a single-centre retrospective review
Hallie Coltin*1,2, Anna Pan3,4, David Malkin3,4, Annie Huang3,4, Catherine Goudie3,4
1Children's Hospital of Eastern Ontario, Canada, 2University of Ottawa, Canada, 3Hospital for Sick Children, Canada, 4University of Toronto, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Cancer stem cells promote relapse in neurofibromatosis type 1 associated malignant peripheral nerve sheath tumors
Daochun Sun1, Sameer Farouk Sait*1,2, Zilai Wang1, Luis Parada1
1Sloan-Kettering Institute, USA, 2Memorial Sloan-Kettering Cancer Institute, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Carboplatin and vinblastine therapy for pediaric low-grade glioma
Anandani Nellan*1,3, Erin Wright2, Molly Hemenway1,3, Jennifer Raybin1,3, Nicholas Foreman1,3, Sarah Rush2, Kathleen Dorris1,3
1Children's Hospital Colorado, Center for Cancer and Blood Disorders, USA, 2Akron Children's Hospital, USA, 3Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Carboplatin synergizes with BCL-2 inhibitor to potentiate killing of DIPG cells
Smit Shah*1,2, Jeffrey Rubens1, Charles Eberhart1, Eric Raabe1
1Johns Hopkins University School of Medicine, USA, 2Rutgers Robert Wood Johnson Medical School, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
CAR-T Cell Therapy in Pediatric Brain Tumors- Early Supportive Care Lessons.
Corrine Hoeppner*, Susan Holtzclaw
Seattle Childrens Hospital, USA
Saturday, June 30:  Nursing Symposium  - 
Case based learning: Three centuries of lessons from two craniopharyngeoma patients
John R. Apps1,2, J Ciaran Hutchinson1,2, Susan Shelmerdine1,2, Alex Virasami2, Eduard Winter3, Thomas S Jacques1,2, Juan-Pedro Martinez-Barbera1, Owen Arthurs1,2, Thomas Czech*4
1UCL Great Ormond Street Institute of Child Health, UK, 2Great Ormond Street Hospital for Children NHS Foundation Trust, UK, 3Natural History Museum, Austria, 4Department of Neurosurgery, Medical University Vienna, Austria
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Case series of intracranial non-germinomatous germ cell tumor: A single institution experience
Nidhi Shah*, Andrew Walter
Nemours/AI Dupont Hospital For Children, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
CCR2+ hematopoietic stem cells overcome treatment resistance to PD-1 in medulloblastoma
Catherine Flores*, Tyler Wildes, Jeffrey Drake, Rebecca Abraham, Duane Mitchell
University of Florida, USA
Tuesday, July 3:  Medulloblastoma - Basic/Translational Research  -  9:00am - 10:20am
Celastrol induced degradation of FANCD2 sensitizes pediatric high-grade glioma to the DNA-crosslinking agent carboplatin
Dennis Metselaar*1, Michaël Meel1, Piotr Waranecki1, Kenn Zwaan1, Dannis van Vuurden1, Gertjan Kaspers1,2, Esther Hulleman1
1VU Medical Center / Cancer Center Amsterdam, The Netherlands, 2Princess Máxima Center of Pediatric Oncology, The Netherlands
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Celebrate life, honor courage: Brain tumor specific bereavement programing
Melissa Mark*, Bridget Kikta, Aimee Thompson, Wanda Meriwether, Mandy Bley, Sue Jelinek, Maryam Fouladi, Lionel Chow
Cincinnati Children's Hospital Medical Center, USA
Saturday, June 30:  Social Work Session  - 
Cerebellar mutism, neurocognitive and academic outcome in a consecutive sample of pediatric cerebellar tumor patients 
Thomas Pletschko1, Ulrike Leiss*1, Tina Feichtenberger2, Martin Kalser1, Doris Lamplmair1, Ulrike Kastner-Koller2, Ursula Deimann2, Thomas Czech1, Irene Slavc1, Andreas Peyrl1
1Medical University of Vienna, Department of Pediatrics, Austria, 2University of Vienna, Faculty of Psychology, Austria
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Cerebrospinal fluid penetration of pexidartinib (PLX3397), a CSF1R inhibitor, in a nonhuman primate model
Arman Odabas*1, Cynthia M. Lester McCully1, Rafael Cruz1, William D. Figg1, John Glod1, Andrey Rymar2, Cody Peer1, Katherine E. Warren1
1National Institutes of Health, USA, 2Plexxikon Inc., USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Changes in structural brain connectivity within the frontal lobes during cranial radiotherapy in children treated for medulloblastoma
Wilburn Reddick*, John Glass, Qing Ji, Heather Conklin, Julie Harreld, Giles Robinson, Amar Gajjar
St. Jude Children's Research Hospital, USA
Sunday, July 1:  Imaging  -  4:00pm - 5:00pm
Characteristics of patients ≥ 10 years of age with diffuse intrinsic pontine glioma: A report from the International DIPG Registry
Craig Erker*1, Adam Lane1, Brooklyn Chaney1, Nancy Yanez Escorza1, Christine Fuller1, Raya Saab2, Mark Kieran3, Roger Packer4, Javad Nazarian4, Jane Minturn5, Andrew Dodgshun6, Sarah Parkin6, Nicholas Foreman7, Emmett Broxson8, Mercedes Garcia Lombardi9, Stewart Goldman10, Eric Sandler11, Kathy Warren12, Robert Greiner13, Nickolas Gottardo14, Hetal Dholaria14, Chie-Schin Shih15, Tim Hassall16, Jordan R Hansford17, Shiqi Stacie Wang17, Yvan Samson18, Sarah Leary19, Jie Ma20, Ute Bartels21, Alberto Broniscer22, Michelle Monje23, Paul Fisher23, David Ziegler24, Lars Wagner25, Carl Koschmann26, Renee Doughman1, Rachid Drissi1, Blaise Jones1, James Leach1, Peter White1, Phillip Dexheimer, MS1, Jacob Hendershot1, Cynthia Hawkins21, Pratiti Bandopadhayay3, Maryam Fouladi1
1Cincinnati Children's Hospital Medical Center, USA, 2American University of Beirut, Lebanon, 3Boston Children's Hospital/Dana-Farber Cancer Institute, USA, 4Children's National Medical Center, USA, 5Children's Hospital of Philadelphia, USA, 6Christchurch Hospital, New Zealand, 7Children's Hospital Colorado, USA, 8Dayton Children's Hospital, USA, 9Hospital de Ninos Ricardo Gutierrez, Argentina, 10Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 11Nemours Childrens Specialty Care, USA, 12National Cancer Institute/National Institutes of Health, USA, 13Penn State Milton S. Hershey Medical Center, USA, 14Princess Margaret Hospital for Children, Australia, 15Riley Children's Hospital, USA, 16Royal Children's Hospital, Australia, 17Royal Children's Hospital, Australia, 18CHU Sainte-Justine, Canada, 19Seattle Children's Hospital, USA, 20Xinhua Hospital, China, 21Hospital for Sick Kids, Canada, 22Children's Hospital of Pittsburgh, USA, 23Lucile Packard Children's Hospital Stanford, USA, 24Sydney Children's Hospital, Australia, 25UK Kentucky Children's Hospital, USA, 26University of Michigan Mott Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Characteristics of successfully salvaged patients with relapsed central nervous system (CNS) non-germinomatous germ cell tumors (NGGCTs)
Mohammad H. Abu Arja*, Mohamed S. AbdelBaki, Jonathan L. Finlay
The Division of Hematology, Oncology and BMT, Department of Pediatrics, Nationwide Children’s Hospital, The Ohio State University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Characterizing tumor-immune interactions in Diffuse Intrinsic Pontine Glioma
Nicole Lieberman*1, Heather Kovar1, Kole DeGolier1, Amira Davis1, Virginia Hoglund1, Jeffrey Stevens2, Conrad Winter2, Gail Deutsch3, Nicholas Vitanza1,4, Sarah Leary4, Courtney Crane1
1Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, USA, 2Seattle Children's Hospital, USA, 3Division of Pathology, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle Children's Hospital, USA, 4Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Washington, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Checkpoint molecule B7-H3 is highly expressed on Atypical Rhabdoid Teratoid Tumor (ATRT) and is a promising candidate for CAR T cell therapy
Johanna Theruvath*, Claus-Moritz Graef, Sabine Heitzeneder, Robbie Majzner, Siddhartha Mitra, Samuel H Cheshier, Crystal Mackall
Stanford University, USA
Monday, July 2:  ATRT  -  11:00am - 12:30pm
CHEK2 mutation in high-risk medulloblastoma
Nidhi Shah*, Andrew Walter
Nemours/AI duPont Hospital for Children, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Chemi-genomic analysis of patient-derived xenografts to identify personalized therapies for medulloblastoma
Jessica M. Rusert1, James Jensen2, Sebastian Brabetz3, Alexandra Garancher1, Yoko T Udaka2, Lourdes A. Esparza1, Till Milde3, Yoon-Jae Cho6, Xiao-Nan Li5, James M. Olson7, John R. Crawford4,2, Michael L. Levy4,2, Marcel Kool3, Stefan Pfister3, Pablo Tamayo2, Jill Mesirov2, Robert Wechsler-Reya*1,2
1Sanford Burnham Prebys Medical Discovery Institute, USA, 2University of California San Diego, USA, 3German Cancer Research Center (DKFZ), Germany, 4Rady Children's Hospital, USA, 5Texas Children's Cancer Center, USA, 6Oregon Health Sciences University, USA, 7Fred Hutchinson Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Childhood brain tumors in Morocco an 11-year retrospective study
Amal Haimer*1, Faouzi Habib2, Abdelmajid Soulaymani1, Abdelrhani Mokhtari1, Hinde Hami1
1Laboratory of Genetics and Biometry, Faculty of Science, Ibn Tofail University, Morocco, 2Al Azhar Oncology Center, Morocco
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Childhood Cystic Craniopharyngioma: 15 years of intra-tumoral chemotherapy with interferon-alpha at IOP/GRAACC/UNIFESP 
Patricia Dastoli1,2, Jardel Nicácio1,2, Marcos Costa1,2, Andrea Cappellano*1, Nasjla Silva1, Sergio Calvalheiro1,2
1Instituto de Oncologia Pediátrica GRAACC/UNIFESP, Division of Neuroncology, Brazil, 2Universidade Feceral de São Paulo- Discipline of Neurosurgery, Division Neurosurgery Pediatric, Brazil
Sunday, July 1:  Craniopharyngioma/Rare Tumors  -  2:30pm - 3:30pm
Children with pineoblastoma. A single-institution series
Iwona Filipek*1, Monika Drogosiewicz1, Marta Perek-Polnik1, Ewa Swieszkowska1, Wieslawa Grajkowska2, Elzbieta Jurkiewicz3, Pawel Kowalczyk4, Bozenna Dembowska-Baginska1
1The Children’s Memorial Health Institute, Pediatric Oncology Department, Poland, 2The Children’s Memorial Health Institute, Pathology Department, Poland, 3The Children’s Memorial Health Institute, Radiology Department, Poland, 4The Children’s Memorial Health Institute, Neurosurgery Department, Poland
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Children's Brain Tumour Drug Delivery Consortium
Ruman Rahman1, Richard Grundy1, Emma Campbell1, Henry Brem2, Monica Pearl2, Jordan Green2, Miroslav Janowski2, Kenneth Cohen2, Piotr Walczak2, Katherine Warren3, Stephen Lowis4, Alexander Mullen5, Marie Boyd5, Gareth Veal6, Darren Hargrave7, Dannis van Vuurden8, Steven Powell9, David Walker*1
1Children's Brain Tumour Research Centre, The University of Nottingham, UK, 2Johns Hopkins University, USA, 3National Cancer Institute, USA, 4Bristol Royal Hospital for Children, UK, 5University of Strathclyde, UK, 6Newcastle University, UK, 7University College London, Institute of Child Health, UK, 8VU University Medical Center, The Netherlands, 9Fast Track Pharma Limited, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Choroid Plexus Carcinoma in infancy: Favorable outcome in three patients treated with chemotherapy
Reuben Antony*1, James Boggan1, Arzu Ozturk1, Theo Nicolaides2, Lee-Way Jin1, Marike Zwienenberg-Lee1
1University of California at Davis Comprehensive Cancer Center, USA, 2University of California, San Francisco, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Choroid plexus papillomas in families with DICER1 mutation associated disease
Barbara Rivera*1, Anne-Sophie Chong1, Christian Thomas2, Sommayeh Fahiminiya3, Doug Strother4, John Priest5, Martin Hasselblatt2, William Foulkes1,3
1Department of Human Genetics, McGill university, Canada, 2Institute of Neuropathology, University Hospital Münster, Germany, 3Cancer Research program, Research Institute of McGill university health care centre,, Canada, 4Department of Oncology, Cumming School of Medicine, University of Calgary, Canada, 5Minneapolis, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Choroid plexus tumors in 2018: the CPT-SIOP experience and long-term outcome
Uwe R Kordes*1, Stefan Hartung1, Ulrike Löbel1, Ann-Kathrin Ozga1, Heidi Traunecker2, Jenny Adamski3, Iwona Filipek5, Miklos Garami4, Guirish Solanki3, Martin Hasselblatt6, Torsten Pietsch10, Rolf-Dieter Kortmann7, Ricken Christoph8, Beate Timmermann8, Johannes Wolff9
1University Medical Center Hamburg Eppendor, Germany, 2Department of Paediatric Oncology, Children's Hospital for Wales, UK, 3Department of Pediatric Oncology, Birmingham Children's Hospital, UK, 42nd Department of Pediatrics, Semmelweis University, Hungary, 5Department of Oncology, The Children's Memorial Health Institute, Poland, 6Institute of Neuropathology, University Hospital Münster, Germany, 7Department of Radiation Therapy, University of Leipzig, Germany, 8West German Proton Therapy Centre Essen (WPE), Germany, 9AbbVie, USA, 10Department of Neuropathology, University of Bonn, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Chromatin immunoprecipitation of diffuse intrinsic pontine glioma tumor tissue is feasible and show different enrichment compared to primary cell line
Yong Yean Kim*1, Jaclyn Andricovich2, Sridevi Yadavilli1, Madhuri Kambhampati1, Alexandros Tzatsos2, Javad Nazarian0
1Children's National Medical Center, USA, 2George Washington University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Chromatin segmentation in ATRT reveals an important role for residual SWI/SNF members
Pascal Johann*1,2, Serap Erkek1,2, Martina Finetti3, Martin Hasselblatt4, Daniel Williamson3, Stefan Pfister1,2, Marcel Kool1,2
1German Cancer Research Center, Germany, 2Hopp Tumor center, Germany, 3Northern Institute for Cancer Research, UK, 4Insititute for Neuropathology, Germany, 5Department of Pediatric Oncology, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Classic radiologic findings associated with blastic hyperleukocytic crisis
Nidhi Shah*, Vinay Kandula
Nemours/AI Dupont Hospital for Children, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
CLEE011XUS17T (NCT 02607124):  A phase I/II study of ribociclib (LEE011) following radiation therapy (RT) in children and young adults with newly diagnosed non-biopsied diffuse pontine gliomas (DIPG) and RB+ biopsied DIPG and high grade gliomas (HGG)
Mariko DeWire*, Christine Fuller, Trent Hummel, Lionel Chow, Ralph Salloum, Luke Pater, Rachid Drissi, Qing Lu, Charles Stevenson, Adam Lane, John Breneman, David Witte, James Leach, Maryam Fouladi
Cincinnati Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Clinical and molecular risk factors in children with atypical teratoid/rhabdoid tumour (AT/RT) - evidence from the EU-RHAB Registry
Michael Fruehwald*1, Martin Hasselblatt2, Reinhard Schneppenheim3, Karolina Nemes1, Susanne Bens4, Pascal Johan5, Peter Hauser6, Eduardo Quiroga7, Palma Solano-Paez7, Veronica Biassoni8, Maria Joao Gil-da-Costa9, Martha Perek-Polnik10, Marianne van de Wetering11, Martin Ebinger12, Gudrun Fleischhack13, Rhoikos Furtwaengler14, Pablo Hernaiz-Driever15, Harald Reinhard16, Stefan Rukowski3, Paul-Gerhardt Schlegel17, Irene Schmid18, Beate Timmermann19, Uwe Kordes3, Joachim Gerss20, Kornelius Kerl21, Karsten Nysom22, Reiner Siebert4, Marcel Kool5, Norbert Graf14
1Children's Hospital Ausgburg, Germany, 2Institute of Neuropathology, Germany, 3University Medical Center Hamburg-Eppendorf, Germany, 4Institute of Human Genetics, Germany, 5Hopp Children’s Cancer Center at NCT Heidelberg (KiTZ), Germany, 6Semmelweis University, Hungary, 7Hospital Infantil Virgen del Rocio, Spain, 8Fondazione IRCCS Istituto Nazionale dei Tumori, Italy, 9University Hospital S. João Alameda Hernani Monteiro, Portugal, 10The Children's Memorial Health Institute, Poland, 11Emma Children's Hospital/Academic Medical Center, The Netherlands, 12Children's University Hospital Tübingen, Germany, 13University Hospital of Essen, Germany, 14University of Saarland, Germany, 15Charité – Universitätsmedizin Berlin, Germany, 16Asklepios Kinderklinik Sankt Augustin, Germany, 17University Wuerzburg, Germany, 18Ludwig-Maximilian-University Munich, Germany, 19Particle Therapy Clinic at West German Proton Therapy, Germany, 20Institute of Biostatistics and Clinical Research, Germany, 21University´Children's Hospital Muenster, Germany, 22Rigshospitalet, Copenhagen University, Denmark
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Clinical experience of BRAF and MEK inhibitor therapy in paediatric glioma
Patricia O'Hare*1, Thalia Loka1, Felice D'Arco2, Sarita Depani1, Anthony Michalski1, Olga Slater1, Mette Jorgensen1, Thomas Jacques3, Darren Hargrave1,3
1Department of Paediatric Oncology, Great Ormond Street Hospital NHS Trust, UK, 2Department of Pediatric Neuroradiology, Department of Radiology, Great Ormond Street Hospital NHS Trust,, UK, 3Developmental Biology and Cancer Programme, University College London Great Ormond Street Institute of Child Health,, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Clinical features of 1027 tumors of central nervous system in children: single institutional report from Shanghai Xinhua Hospital, the founding member of CNOG
Yipeng Han, Yang Zhao, Feng Jiang, Qifeng Li, Baocheng Wang, Chenran Zhang, Jie Ma*
Department of Pediatric Neurosurgery, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, China
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Clinical outcome of pediatric ependymomas: a single institution experience
Naoyuki Ohe*, Takayuki Nishiwaki, Noriyuki Nakayama, Hirohito Yano, Toru Iwama
Gifu University, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Clinical tumor whole exome sequencing for pediatric neuro-oncology patients – results from the Baylor Advancing Sequencing in Childhood Cancer Care (BASIC3) clinical sequencing study
Frank Lin*1,2, Samara Potter1,2, Michelle Ting1,2, Raghu Chandramohan1, Nipun Kakkar1, Tao Wang1, Robin Raesz-Martinez2, Sarah Scollon1,2, Katie Bergstrom1,2, Dolores Lopez-Terrada1,2, Adekunle Adesina1,2, Carrie Mohila1,2, William Whitehead1,2, Uma Ramamurthy1, Susan Hilsenbeck1, David Wheeler1, Stacey Berg1,2, Murali Chintagumpala1,2, Christine Eng1, Richard Gibbs1, Angshumoy Roy1,2, Sharon Plon1,2, D. Williams Parsons1,2
1Baylor College of Medicine, USA, 2Texas Children's Cancer Center, USA
Sunday, July 1:  Embryonal Tumors  -  11:30am - 12:30pm
Clinical, radiological, pathological and molecular characteristics of children <3 years with diffuse intrinsic pontine glioma (DIPG): a report from the International DIPG Registry
Allison Bartlett*1, Anne Cochrane1, Adam Lane1, Nancy Yanez-Escorza1, Brooklyn Chaney1, Renee Doughman1, Mariko DeWire-Schottmiller1, Stewart Goldman2, Kathy Warren3, Pratiti Bandopadhayay4, Nicholas Foreman5, Chie-Schin Shih6, Jane Minturn7, Ute Bartels8, Roger Packer9, Javad Nazarian9, Tim Hassall10, Yvan Samson11, Michelle Monje-Deisseroth12, Paul Fisher12, Lars Wagner13, Carl Koschmann14, David Ziegler15, Mark Kieran4, Cynthia Hawkins8, Peter White1, Phillip Dexheimer1, Jacob Hendershot1, Rachid Drissi1, Christine Fuller1, James Leach1, Blaise Jones1, Maryam Fouladi1
1Cincinnati Children's Hospital Medical Center, USA, 2Lurie Children's Hospital, USA, 3National Institutes of Health National Cancer Institute, USA, 4Dana-Farber Cancer Institute, USA, 5Children's Hospital Colorado, USA, 6Riley Hospital for Children at IU Health, USA, 7Children's Hospital of Philadelphia, USA, 8The Hospital for Sick Children, USA, 9Children's National Medical Center, USA, 10Children's Health Queensland Hospital and Health Service, Australia, 11Centre Hospitalier Universitaire Sainte-Justine, Canada, 12Stanford University, USA, 13Kentucky Children's Hospital, USA, 14C.S. Mott Children's Hospital, USA, 15Sydney Children's Hospital, Australia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Clinically relevant and minimally invasive tumor surveillance in pediatric gliomas using liquid biome
Eshini Panditharatna*1,2, Lindsay Kilburn1, Mariam Aboian3, Madhuri Kambhampati1, Heather Gordish-Dressman1, Suresh Magge1, Nalin Gupta3, John Myseros1, Eugene Hwang1, John Crawford4, Kathy Warren5, Adam Resnick6, Roger J. Packer1, Michael Prados3, Sabine Mueller3, Javad Nazarian1,2
1Children's National Health System, USA, 2George Washington University, USA, 3University of California San Francisco, USA, 4University of California, USA, 5National Cancer Institute, USA, 6Children's Hospital of Philadelphia, USA
Monday, July 2:  DIPG/Diffuse Midline Glioma  -  1:30pm - 3:00pm
Clinicopathologic features of suprasellar and lateral cerebral desmoplastic infantile astrocytoma and ganglioglioma
Cody Nesvick*, Ryan Naylor, Anton Wohl, Aditya Raghunathan, Laurence Eckel, Gesina Keating, David Daniels
Mayo Clinic, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
CMMRD (constitutional mismatch repair deficiency) associated-brain tumors: report from the European C4CMMRD consortium.
Léa Guerrini-Rousseau*1, Chrystelle Colas2, Katharina Wimmer3, Christine Devalck4, Enrico Opocher5, Franck Bourdeaut2, Felipe Andreiuolo6, Karin Dahan7, Maurizio Genuardi8, Yael Goldberg9, Michaela Kuhlen‬10, Vanesa Pérez Alonso11, Astrid-Marie Sehested12, Irene Slavc13, Sheila Unger14, Pascale Varlet6, Jacques Grill1, Laurence Brugières1
1Gustave Roussy, Université Paris-Saclay, France, 2Curie Institute, France, 3Medical University Innsbruck, Austria, 4Hôpital Universitaire Reine Fabiola, ULB Université Libre de Bruxelles, Belgium, 5Azienda Ospedaliera di Padova, Italy, 6Centre Hospitalier Sainte-Anne, Université Paris Descartes, France, 7Centre de Génétique Humaine, Institut de Pathologie et de Génétique, Belgium, 8Fondazione Policlinico Universitario A. Gemelli, Italy, 9Rabin Medical center, Israel, 10University Children´s Hospital, Germany, 11Doce de Octubre Hospital, Spain, 12Copenhagen University Hospital, Denmark, 13Medical University of Vienna, Austria, 14University of Lausanne, Switzerland
Monday, July 2:  Epidemiology  -  11:30am - 12:00pm
CMV pp65 RNA-pulsed dendritic cell vaccines for pediatric glioblastoma and medulloblastoma: a phase I trial
Daniel Landi*1, Eric Thompson2, James Herndon2, John Sampson2, David Ashley2
1Preston Robert Tisch Brain Tumor Center, Department of Pediatrics, Duke University, USA, 2Preston Robert Tisch Brain Tumor Center, Duke University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
CNS toxicity after proton radiotherapy in pediatric patients treated in PTC Prague
Barbora Ondrová*1, Jiří Kubeš1, David Sumerauer2, Vladimír Vondráček1, Martin Kynčl2, Stepan Vinakurau1
1Proton Therapy Center Czech, Czech Republic, 2Motol University Hospital, Czech Republic
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Cognition, health-related quality of life and mood in children and young adults diagnosed with a glioneuronal tumor in childhood
Christoffer Ehrstedt*1, Ann-Margret Rydell2, Marina Gabert Hallsten1, Bo Strömberg1, Gunnar Ahlsten1
1Department of Women´s and Children´s Health, Section for Pediatrics, Uppsala University, Sweden, 2Department of Psychology, Uppsala University, Sweden
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Combination therapy with vincristine, irinotecan, and temozolomide in central nervous system malignancies
Amber Gibson*, Abhishek Bavle, Naina Gross, Theresa Gavula, Rene McNall
Oklahoma University Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Combinations of quantitative and qualitative MRI features identify prognostic and molecular subgroups of supratentorial pediatric high-grade glioma
John Lucas*1, Chih-Yang Hsu1, Zhaohua Lu1, Jared Becksfort1, Christopher Tinkle1, Alberto Broniscer2, Thomas Merchant1, Brent Orr1, Suzanne Baker1, Zoltan Patay1, Scott Hwang1
1St. Jude Children's Research Hospital, USA, 2Children's Hospital of Pittsburgh of UPMC, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Combined multiple chemotherapy and posterior fossa radiotherapy in infants with nonmetastatic medulloblastoma
Daniel Alderete*, Lorena Baroni, Fabiana Lubieniecki, Roberto Jaimovich
Hospital Prof. Dr. Juan P. Garrahan, Argentina
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Combined radiological, pathological and molecular outcome evaluation in newly diagnosed non-brainstem pediatric high-grade glioma from the randomized, multicenter HERBY phase II trial
Tim Jaspan*1, Paul Morgan1, Daniel Rodriguez1, Daniel Warren2, Monika Warmuth-Metz3, Esther Sanchez Aliaga4, Raphael Calmon5, Chris Jones6, Alan Mackay6, Pascale Varlet7, Darren Hargrave8, Adela Canete9, Maura Massimino10, Amedeo Azizi11, Marie-Cecil Le Deley12, Frank Saran13, Raphael Rousseau14, Gudrun Zahlmann15, Josep Garcia15, Gilles Vassal12, Jacques Grill12
1Nottingham University Hospitals NHS Trust, UK, 2Leeds Teaching Hospitals NHS Trust, UK, 3Wurzburg University, Germany, 4Univeristy Medical Center, The Netherlands, 5Assistance Publique-Hopitaux de Paris, France, 6Institute of Cancer Research, UK, 7Sainte-Anne Hospital, France, 8Great Ormond Street Hospital, UK, 9Hospital La Fe, Spain, 10Fondazione IRCCS Instituto Nazionale dei Tumori, Italy, 11Medical University of Vienna, Austria, 12Institute Gustave Roussy, France, 13Royal Marsden Hospital, UK, 14Gritstone Oncology Inc, USA, 15F Hoffmann-La Roche, Switzerland
Sunday, July 1:  Imaging  -  4:00pm - 5:00pm
Combining Chk1/2 inhibition with radiation enhances in vitro and in vivo cytotoxicity in medulloblastoma
Raelene Endersby*1,2, Hilary Hii1, Brooke Strowger1, Patrick Dyer1,2, Meegan Howlett1, Mani Kuchibhotla1, Nicholas Gottardo1,3
1Telethon Kids Institute, Australia, 2University of Western Australia, Australia, 3Princess Margaret Hospital, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Comparative integrative analysis of primary and relapsed atypical teratoid/rhabdoid tumors (AT/RTs)
Till Holsten*1,2, Malik Alawi4,5, Michael Spohn4, Martin Hasselblatt6, Christine Haberler7, Manila Antonelli8, Arend Koch9, Marcel Kool10, Michael Frühwald11, Ulrich Schüller3,1
1Research Institute, Children's Cancer Center Hamburg, Germany, 2Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany, 3Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Germany, 4Heinrich-Pette Institute, Leibniz Institute for Experimental Virology, Germany, 5Bioinformatics Core, University Medical Center Hamburg-Eppendorf, Germany, 6Institute of Neuropathology, University Hospital Münster, Germany, 7Institute of Neurology, Medical University of Vienna, Austria, 8Department of Radiological, Oncological and Anatomo-Pathological Sciences, University of Rome, Italy, 9Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, and Berlin Institute of Health, department of Neuropathology, Germany, 10Hopp Children's Cancer Center at the NCT amd German Cancer Research Center Heidelberg, Germany, 11Children's Hospital Augsburg, Swabian Children's Cancer Center, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Comparative survival analysis of pediatric central nervous system tumors between Boston and Egypt
Emily Auwarter*1,2, Derek Shyr2, Clement Ma2, Amal Abdel Aziz3, Islam Maher3, Alaa El Haddad3, Ahmed Ibrahim3, Mohamed El Beltagy3, Karen Marcus2, Mohamed Zaghloul3, Peter Manley2
1Boston University School of Public Health, USA, 2Dana Farber Cancer Institute, USA, 3Children's Cancer Hospital Egypt, Egypt
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Comparing surgery alone or surgery plus radiation therapy in craniopharyngioma management
Godfrey Chi-Fung Chan*1, Dennis Tak-Noi Ku2, Chun Wing Luk3, Alvin Siu-Cheung Ling4, Matthew Ming-Kong Shing5, Anthony Pak-Yin Liu1
1The University of Hong Kong, Hong Kong, 2Tuen Mun Hospital, Hong Kong, 3Queen Elizabeth Hospital, Hong Kong, 4Princess Margaret Hospital, Hong Kong, 5Prince of Wales Hospital, Hong Kong, 6Chinese University of Hong Kong, Hong Kong, 7On behalf of the Hong Kong Paediatric Haematology Oncology Study Group (HKPHOSG), Hong Kong
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Comparison of 3D printed headrest for pediatric patients and BRAINLAB® SRS standard headrest in radiotherapy
Longhui Luo1, Wei Wu1, Ping Zhang1, Peng Dai1, Qing Huang1, Guanghua Deng1, Xin Zhang1, Weiping Hong1, Xiao Xiao1, MingYao Lai1, Xingan Wang2, Daqing Wang3, Changguo Shan1, Linbo cai*1
1Guangdong 999 Brain Hospital, China, 2Dongguan Kanghua Hospital, China, 3Guangdong Puneng Biotechnology Co Ltd, China
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Comparison of pharmacokinetic parameters between non-human primates and human patients
Ethan Baratz*, Cynthia McCully, Joanna Shih, Katherine Warren
National Institute of Health (NIH/NCI), USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Compound heterozygous mutation of the PMS2 gene in an infant with constitutional mismatch repair deficiency and medulloblastoma
Claudia Lukas*, Melissa Crenshaw, Ignacio Gonzalez-Gomez, Joseph Potthast, Nir Shimony, George Jallo, Stacie Stapleton
Johns Hopkins All Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Comprehensive clinical and molecular analysis of pediatric thalamic glioma
Courtney Johnson*1, Heloisa Moser1, Madhuri Kambhampati1, Krutica Gaonkar2,3, Roger Packer1, Adam Resnick2,3, Javad Nazarian1,3
1Children’s National Health System, Center for Genetic Medicine Research, USA, 2Children’s Hospital of Philadelphia, USA, 3On behalf of the Children’s Brain Tumor Tissue Consortium (www.cbttc.org), USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: germline DNA repair defects as a potential etiology
John DeSisto*1, John Lucas3, Andrew Donson1, Bridget Sanford1, Gang Wu3, Gregory Armstrong4, Michael Arnold4, Smita Bhatia4, Patrick Flannery1, Rakeb Lemma1, Lakotah Hardie1, Lindsey Hoffman1,2, Kathleen Dorris1,2, Arthur Liu1,2, Nicholas Foreman1,2, Rajeev Vibhakar1,2, Kenneth Jones1, Sariah Allen3, Suzanne Baker3, Thomas Merchant3, Brent Orr3, Adam Green1,2
1Morgan Adams Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, USA, 2Children's Hospital Colorado, USA, 3St. Jude Children's Research Hospital, USA, 4Childhood Cancer Survivor Study, USA
Monday, July 2:  High Grade Glioma  -  3:30pm - 5:00pm
Concurrent IDH1 and SMARCB1 mutations in a pediatric medulloblastoma: a case report
Moatasem El-Ayadi*1,7, Doron Merkler3,4, Kristof Egervari3,4, Thomas Alexander Mckee3,4, Fabienne Gumy- Pause1,2, David Capper5, Torsten Pietsch6, Marc Ansari1,2, André O. von Bueren1,2
1Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Hospital of Geneva, Switzerland, 2Department of Pediatrics, CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Switzerland, 3Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland, 4Division of Clinical Pathology, University Hospital of Geneva, Switzerland, 5Berlin Institute of Health, Department of Neuropathology, Germany, 6Institute of Neuropathology, University of Bonn Medical Center, Germany, 7Department of Pediatric Oncology, Children Cancer Hospital of Egypt (CCHE-57357), Egypt
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Congenital rhabdoid tumors as a major clinical challenge - A collaborative European effort
Karolina Nemes*1, Nathalie Clément2, Denis Kachanov3, Susanne Bens4, Tatyana Shamanskaya3, Svetlana Varfolomeeva3, Kornelius Kerl10, Floor Abbink11, Martin Ebinger12, Stephan Tippelt13, Norbert Graf9, Martin Hasselblatt5, Pablo Hernáiz-Driever14, Maria João Gil-Da-Costa15, Thomas Klingebiel16, Rolf-Dieter Kortmann17, Jane Pears18, Paul-Gerhardt Schlegel19, Nicolas Andre20, Anne-Isabelle Bertozzi21, Nadège Corradini22, Christelle Dufour23, Fanny Fouyssac24, Pierre Leblond25, Olivier Delattre26, Julien Masliah-Planchon27, Thorsten Simon28, Beate Timmermann6, Olaf Witt29, Reinhard Schneppenheim7, Joachim Gerss8, Reiner Siebert4, Rhoikos Furtwängler9, Franck Bourdeaut2, Michael Christoph Frühwald1,10
1Swabian Children's Cancer Center, Children's Hospital, Klinikum Augsburg, Germany, 2PSL Research University, Institute Curie, Pediatric care and research Center, France, 3National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Russia, 4Institute of Human Genetics, University of Ulm & University Hospital of Ulm, Germany, 5Institute of Neuropathology, University Hospital Muenster, Germany, 6Clinic for Particle Therapy, University Hospital Essen, West German Cancer Center (WTZ), Germany, 7Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany, 8Institute of Biostatistics and Clinical Research, University of Münster, Germany, 9Department of Pediatric Oncology and Hematology, Saarland University of Hospital Saarland, Germany, 10Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Germany, 11Department of Pediatric Oncology and Hematology, Vu Medical Center, The Netherlands, 12Department of Pediatric Hematology and Oncology, Children's University Hospital, University Hospital (UH) of Tuebingen, Germany, 13Department of Pediatric Oncology and Hematology, Pediatrics III, University Hospital of Essen, Germany, 14Department of Pediatric Oncology, Hematology and BMT, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany, 15Department Padiatric Hematology and Oncology, Pediatric Hospital, Hospital São João, Portugal, 16Department of Pediatric Oncology and Hematology, University Hospital Frankfurt, Germany, 17University Clinic of Radiooncology and Radiotherapy, Germany, 18Department of Pediatric Oncology, Our Lady's Children's Hospital, Ireland, 19Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital Clinical Cancer Center Mainfranken, University of Würzburg, Germany, 20Department of Pediatric Hematology and Oncology, La Timone Hospital, University of Marseille, Germany, 21Department of Pediatric Hematology and Oncology, University Hospital of Toulouse, France, 22Institute of Pediatric Hematology and Oncology, Leon Berard Center, France, 23Department of Childhood and Adolescent Oncology, Gustave Roussy - Grand Paris Cancer Campus, France, 24Department of Pediatric Hematology and Oncology, University Hospital of Nancy, France, 25Department of Pediatric Oncology, Oscar Lambret Center, France, 26PSL Research University, INSERM U830, Institut Curie, France, 27PSL Research University, Institut Curie, Unite de génétique somatique, France, 28Department of Pediatric Oncology and Hematology, University of Cologne, Germany, 29Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Germany
Monday, July 2:  ATRT  -  11:00am - 12:30pm
Conservative surgery followed by proton therapy for craniopharyngioma in children: a phase II study to examine the feasibility of dose escalation
Claire Alapetite*1, Stephanie Puget2, Catherine Nauraye1, Kevin Beccaria2, Stephanie Bolle3, Paul Lesueur1, Hervé Brisse1, Nathalie Boddaert2, Remi Dendale1, François Doz1, Christian Sainte Rose2, Eric Bouffet5, Jean-Louis Habrand4
1Institut Curie, France, 2Hopital Necker Enfants Malades, France, 3Institut Gustave Roussy, France, 4CLCC François Baclesse, France, 5Hospital for Sick Children, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Constitutional mosaicism of clinically important genetic markers in pediatric brain tumors detected by next-generation sequencing
Joanna Trubicka*1, Malgorzata Rydzanicz2, Iwona Filipek3, Piotr Iwanowski4, Wieslawa Grajkowska1,5, Maciej Pronicki1, Rafal Ploski2, Bozenna Dembowska-Baginska3, Maria Lastowska1,5
1The Children’s Memorial Health Institute, Department of Pathology, Poland, 2Warsaw Medical University, Department of Medical Genetics, Poland, 3The Children’s Memorial Health Institute, Department of Oncology, Poland, 4The Children's Memorial Health Institute, Department of Medical Genetics, Poland, 5Mossakowski Medical Research Centre Polish Academy of Sciences, Department of Experimental and Clinical Pathology, Poland
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Construction and preliminary clinical application of a high-sensitivity and multisite immunomagnetic liposome-fluorescence CTC system for CTC capturing in pediatric brain tumor
Yang Zhao1, Changbin Zhu1, Yipeng Han1, Qifeng Li1, Feng Jiang1, Qianhua Wang1, Xiaofei Liang2, Jie Ma*1
1Department of Pediatric Neurosurgery, Shanghai Xinhua Hospital affiliated to Shanghai Jiaotong University, School of medicine, China, 2State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, China
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Correlation between APT-CEST and 18F-Choline PET in glioma at 3T
Marilena Rega1, Francisco Torrealdea2, Joe Hearle3, Moritz Zaiss4, Ana Cavalho1, Asim Afaq1, Shonit Punwani2, Xavier Golay5, John Dickson1, Ananth Shankar6, Harpreet Hyare*5
1Institute of Nuclear Medicine, UK, 2Centre for Medical Imaging, UK, 3UCLH Medical School, UK, 4Max Planck Institute, Germany, 5UCL Institute of Neurology, UK, 6Teenage Cancer Unit, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Correlation between F-Dopa PET and MRI in brain tumours
Francesco Fraioli1, Ananth Shankar1, Harpreet Hyare1, Marilena Rega1, Kshitij Mankad*2, Vincenzo Militano1, Stefan Voo1, Valentina Ferrazzoli2, Anna Barnes1
1University College London Hospitals, UK, 2Great Ormond Street Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Critical brain contingency: a tool to improve patient safety and outcomes
Caroline Fitzgerald, Kathryn Matson*, Deborah Shiers
Dana-Farber Boston Children’s Cancer and Blood Disorders Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
CSF disturbances after transcallosal resection: Are there predicting factors?
Christian Dorfer*1, Julia Vendl1, Gregor Kasprian2, Andreas Peyrl4, Christine Haberler3, Irene Slavc4, Thomas Czech1
1Medical University of Vienna, Department of Neurosurgery, Austria, 2Medical University of Vienna, Department of Radiology and Nuclear Medicine, Austria, 3Medical University of Vienna; Institute of Neurology, Austria, 4Medical University of Vienna, Department of Pediatrics and Adolescence Medicine, Austria
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Current issues in the management of desmoplastic nodular medulloblastoma in young children
Mohamed AbdelBaki*1, Daniel Boué3, Jonathan Finlay1, Mark Kieran2
11 Division of Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, USA, 2Dana-Farber Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, USA, 3Department of Pathology, Nationwide Children’s Hospital and The Ohio State University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Current prognostic factors and treatment results in young children medulloblastomas
Ekaterina Salnikova1, Sergey Ozerov1, Anastasiya Ektova1, Marina Ryzhova2, Andrey Korshunov3, Aleksey Nechesnyuk1, Artur Merishavyan1, Svetlana Gorbatykh4, Elena Erega6, Aleksander Shapochnik5, Aleksander Karelin1, Ella Kumirova*1, Aleksander Rumyantsev1
1Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Russia, 2The Federal State Autonomous Institution "National Medical Research Center for Neurosurgery named after Academician N. N. Burdenko" of the Ministry of Health of the Russian Federation, Russia, 3German Cancer Research Center (DKFZ), Germany, 4Morozov Children's City Clinical Hospital of the Department of Health of Moscow, Russia, 5Orenburg Regional Clinical Oncology Center, Russia, 6Regional State Budgetary Healthcare Institution "Children's Regional Clinical Hospital, Russia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Cutaneous reactions to targeted therapies in children with CNS tumors: A cross-sectional study
Connie Zhong1, Hannah Song1,2, Mark Kieran3, Susan Chi*3, Karen Wright3, Jennifer Huang2
1Harvard Medical School, USA, 2Boston Children's Hospital, USA, 3Dana-Farber/Boston Children's Cancer Center and Blood Disorder Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
CXorf67 expression is a putative driver of PFA ependymoma
Jens-Martin Hübner*1,2, Konstantin Okonechnikov1,2, Ji Wen4, Wilda Orisme4, Bo Tang4, Sujuan Jia4, Ruth Tatevossian4, Jinghui Zhang5, Stefan M. Pfister1,3, Kristian W. Pajtler1,3, David W. Ellison4, Marcel Kool1,2
1Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 3Department of Hematology and Oncology, University Hospital, Germany, 4Department of Pathology, St. Jude Children’s Research Hospital, USA, 5Department of Computational Biology, St. Jude Children’s Research Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Cystic dynamic evaluation and early late toxicity in two pediatric low grade gliomas treated with  active scanning proton beam radiotherapy
Barbara Rombi*1, Mino Zucchelli2, Sabina Vennarini1, Mirko Lipparini1, Soraia Micò3, Ilario Ammendolia4, Daniele Zama5, Arcangelo Prete5, Silvia Cammelli4, Francesco Toni6, Letizia Ronchi4, Alessio G. Morganti4, Andrea Pession5, Maurizio Amichetti1, Fraia Melchionda5
1Proton Therapy Center, Santa Chiara Hospital, Italy, 2Pediatric Neurosurgery, Bellaria Hospital, Italy, 3Radiation Oncology Department, Vall D’ Hebron, Spain, 4Radiation Oncology Department, Bologna University, S. Orsola Hospital, Italy, 5Onco-Hematology Department, Bologna University, S. Orsola Hospital, Italy, 6Neuro Radiology Department, Bellaria Hospital, Italy
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Deciphering and targeting EZH2 overexpression in medulloblastoma
Etienne Danis*, Angela Pierce, Ilango Balakrishnan, Dong Wang, Sujatha Venkataraman, Rajeev Vibhakar
University of Colorado Denver - Anschutz Medical Campus, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Deciphering the AT/RT ligandome
Ana Marcu1, Nico Trautwein1, Stefan Stevanovic1, Pascal Johann2, Antje Technau3, Johanna Lager3, Camelia-Maria Monoranu4, Lisa Henkel3, Jürgen Krauß5, Martin Ebinger6, Martin Schuhmann7, Ulrich Thomale8, Torsten Pietsch9, Matthias Wölfl3, Paul Gerhardt Schlegel3, Michael Frühwald10, Florian Oyen11, Yair Reisner12, Hans-Georg Rammensee1, Matthias Eyrich*3
1Department of Immunology, University of Tübingen, Germany, 2DKFZ, Germany, 3Children's Hospital, University Medical Center, Germany, 4Institute of Pathology, Department of Neuropathology, Germany, 5Department of Neurosurgery, University Medical Center, Germany, 6Children's Hospital, University Medical Center, Germany, 7Department of Neurosurgery, University Medical Center, Germany, 8Department of Neurosurgery, Charite, Germany, 9Institute of Neuropathology, DGNN Brain Tumor Reference Center, Germany, 10Children's Hospital, Augsburg Medical Center, Germany, 11Children's Hospital, University Medical Center, Germany, 12Weizmann Institute of Science, Israel
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Decision making in the face of incurable high grade gliomas: a qualitative analysis
Ashley F. Lanzel1,2, Katharine E. Brock*1,2, Abby R. Rosenberg3, Justin N. Baker4, Amy E. Caruso Brown5, Ann Mertens1,2, Rebecca Pentz1, Karen Wasilewski-Masker1,2
1Emory University, USA, 2Children's Healthcare of Atlanta, USA, 3Seattle Children’s Hospital, USA, 4St. Jude Children's Research Hospital, USA, 5SUNY Upstate Medical University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Decision-making management guideline for children and young people up to 19 years (CYP) presenting with idiopathic pituitary stalk thickening (iTPS) and/or idiopathic central diabetes insipidus (iCDI)
Manuela Cerbone*1, Johannes Visser2, Chloe Bulwer3, Ashraf Ederies1, Kirtana Vallabhaneni4, Stephen Ball5, Ian Kamaly6, Ashley Grossman7, Helena Gleeson8, Marta Korbonits9, Vasanta Nanduri10, Vaya Tziaferi11, Tom Jacques1, Helen A Spoudeas1
1Great Ormond Street Hospital, UK, 2Cambridge University Hospitals, UK, 3Royal Devon and Exeter Hospital, UK, 4University College London, UK, 5University of Manchester, UK, 6Royal Manchester Children’s Hospital, UK, 7Oxford University, UK, 8University Hospitals Birmingham, UK, 9Queen Mary University of London, UK, 10Watford General Hospital, UK, 11University Hospitals of Leicester, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Delayed RT in select patients with DIPG
Kevin De Braganca*, Viviana Benitez, Stephen Gilheeney, Matthias Karajannis, Yasmin Khakoo, Kim Kramer, Suzanne Wolden
Memorial Sloan Kettering Cancer Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Delivery of chemotherapeutics to pediatric brain tumors using citrate-capped gold nanoparticles
Krishna Madhavan*1,2, Ilango Balakrishnan1, Angela Pierce1, Sujatha Venkataraman1,2, Rajeev Vibhakar1,2
1Department of Pediatrics and Section of Pediatric Hematology/Oncology/BMT, Children’s Hospital Colorado and University of Colorado Denver, Anschutz Medical Campus, USA, 2The Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Monday, July 2:  Drug Delivery
Detection of IDH1 R132H mosaicism in anaplastic astrocytoma patients
Sulgi Lee*1,2, Miriam Bornhorst1, Eshini Panditharatna1,2, Madhuri Kambhamptai1, Joyce Turner1, Roger J Packer1, Lindsay Kilburn1, Javad Nazarian1
1Children's National Health System, USA, 2The George Washington University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Development and characterization of diffuse intrinsic pontine glioma mouse models generated by brainstem in utero electroporation
Smruti Patel1, Rachel Hartley1, Heather Bear2, Timothy Phoenix*1,2
1University of Cincinnati, USA, 2Cincinnati Children's Hospital Medical Center, USA
Monday, July 2:  DIPG/Diffuse Midline Glioma  -  1:30pm - 3:00pm
Development and comprehensive characterization and utilization of preclinical models of pediatric high grade gliomas
Sridevi Yadavilli*1, Kathleen Knudson2, Madhuri Kambhampati1, Eshini Panditharatna1,2, Michael Prados3, Sabine Mueller3, Suresh Magge1, Lindsay Kilburn1, Eugene Hwang1, Roger Packer1, Javad Nazarian1,2
1Children's National Health System, USA, 2George Washington University School of Medicine and Health Sciences, USA, 3University of California, San Francisco School of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Development of a care pathway for the child with a brain tumor : from multidisciplinary to interdisciplinary collaboration
Elsie Willems*, Annelies Mannaerts, Geneviève Laureys, Leen Willems
University Hospital, Belgium
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Development of a multidisciplinary care service for adolescent and young adult oncology patients at an urban pediatric academic center  
Kasey Rangan*, Laura Bava, Chelsea Bailan, Sherry Carcich, Sarah Green, Mary Beth Vingelen, Jacqueline O'Connell, Stefanie Thomas
Children's Hospital Los Angeles, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Development of a neuro-oncology long term follow up nurse clinician at a tertiary health care center
Naomi Evans*, Dana Anderson
BC Children's Hospital, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Development of an interactive app for dynamic screening of basic sensory, cognitive, and motor abilities of paediatric patients with brain tumours
Nicola J. Pitchford1, David Walker*1, Jair Barbosa2, Eduard Moresi2, Michel Lopes2, Julio Santos2, Marcos Morais2, Mauricio Júnior2, Andre Rodrigues2, Luiz Albernaz2, Mario Braga2
1University of Nottingham, UK, 2Catholic University of Brasilia, Brazil
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Diagnostic accuracy and added value of qualitative radiological review of 1H-MRS in evaluation of childhood brain tumors
Karen Manias*1,2, Simrandeep Gill1,2, Lesley MacPherson2, Adam Oates2, Benjamin Pinkey2, Paul Davies2, Niloufar Zarinabad1,2, Nigel Davies1,3, Ben Babourina-Brooks1,2, Martin Wilson1,3, Andrew Peet1,2
1Institute of Cancer and Genomic Sciences, University of Birmingham, UK, 2Birmingham Children’s Hospital NHS Foundation Trust, UK, 3Department of Imaging and Medical Physics, University Hospitals Birmingham NHS Foundation Trust, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Diagnostic accuracy of neuroimaging in pediatric optic pathway/sellar/suprasellar tumors
Gregory Norris*, Jacquelyn Garcia, Todd Hankinson, Michael Handler, Nicholas Foreman, David Mirsky, Nicholas Stence, Kathleen Dorris, Adam Green
Children's Hospital Colorado, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Diagnostic exposure to low-dose radiation and spontaneous regression in intracranial germ cell tumors
Naoki Kagawa*1, Ryuichi Hirayama1, Shogo Fukuya2, Takamune Achiha1, Chisato Yokota1, Yasuyoshi Chiba3, Daisuke Eino1, Toru Umehara1, Takanori Fukunaga1, Manabu Kinoshita4, Yasunori Fujimoto1, Haruhiko Kishima1
1Department of Neurosurgery, Osaka University Graduate School of Medicine, Japan, 2Department of Neurosurgery, Takatsuki General Hospital, Japan, 3Department of Neurosurgery, Osaka Women’s and Children’s Hospital, Japan, 4Department of Neurosurgery, Osaka International Cancer Institute, Japan
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Diagnostic re-evaluation and pooled clinical data analysis of patients with previous diagnosis of CNS-PNET
Katja von Hoff*1,2, Christine Haberler3, Giles Robinson4, David Sumerauer5, Jaeho Cho6, Martin Mynarek2, Eugene Hwang7, Sandra Jacobs8, Theresa de Rojas9, Martha Perek10, Christelle Dufour11, Matija Snuderl12, Richard Grundy13, Maria Joao Gil da Costa14, Dannis van Vuurden15, Irene Slavc16, Nicolas U. Gerber17, Jessica Pickles18, Amar Gajjar4, Barry Pizer19, Stefan Rutkowski2, David Capper20, Dominik Sturm21,22, Brent Orr23, Pieter Wesseling24, Peter Hauser25, Maria Lastowska26, Andrey Korshunov27, Tom Jacques18, Felice Giangaspero28,29, Cynthia Hawkins30, Dominique Figarella31, Charles Eberhart32, Peter Burger32, Marco Gessi33, Stefan M. Pfister21,22, Torsten Pietsch34, Marcel Kool21
1Department of Pediatric Hematology and Oncology, University Medicin Berlin, Germany, 2Department of Pediatric Hematology and Oncology,University Medical Center Hamburg-Eppendorf, Germany, 3Institute of Neurology, Medical University of Vienna, Austria, 4Department of Oncology, St Jude Children's Research Hospital, USA, 5Department of Pediatric Hematology and Oncology, University Hospital Motol, Czech Republic, 6Dept. of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Republic of Korea, 7Children's National Medical Center, USA, 8Department of Pediatrics, KU Leuven and University Hospitals Leuven, Belgium, 9Pediatric Oncology Department, Hospital Niño Jesús, Av. Menéndez Pelayo, Spain, 10Children's Memorial Health Institute, Poland, 11Institute Gustave Roussy, France, 12Department of Pathology NYU Langone Health, USA, 13The Children's Brain Tumour Research Centre, University of Nottingham, UK, 14University Hospital S.João, Porto, Portugal, 15Princess Máxima Center for Pediatric Oncology, The Netherlands, 16Department of Pediatrics and Adolescent Medicine , Medical University of Vienna, USA, 17Department of Oncology, University Children's Hospital, Switzerland, 18UCL GOS Institute of Child Health, UK, 19Alder Hey Children’s Hospital, UK, 20Department of Neuropathology, Charité Universitätsmedizin Berlin, Germany, 21Hopp Children´s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 22Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 23Department of Pathology, St Jude Children's Research Hospital, USA, 24Department of Pathology, Princess Máxima Centre for Pediatric Oncology, The Netherlands, 252nd Department of Pediatrics, Semmelweis University, Hungary, 26Department of Pathology, Children's Memorial Health Institute, Poland, 27Division of Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ),, Germany, 28Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Italy, 29Neuromed Institute, IRCCS, Italy, 30Division of Pathology, The Hospital for Sick Children, Canada, 31Department of Pathology and Neuropathology, La Timone Hospital, Aix Marseille University, France, 32Department of Pathology, Johns Hopkins University, USA, 33Division of Histopathology, Fondazione Policlinico Universitario "A.Gemelli," Università Cattolica S.Cuore, Italy, 34Department of Neuropathology, University of Bonn, Bonn, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Diagnostic value of early postoperative MR imaging and diffusion-weighted imaging following transsphenoidal resection of non-functioning pituitary macroadenomas
Mohamed M. Arnaout*1, Hanan A. Hassan2, Manar A. Bessar2, Islam R. Herzallah3, Adrienne M. Laury4, Mohamed A. Basha2
1Department of Neurosurgery, Zagazig University, Egypt, 2Department of Radiodiagnosis, Zagazig University, Egypt, 3Department of Otorhinolaryngology, Zagazig University, Egypt, 4Department of Otolaryngology-Head and Neck Surgery, San Antonio Uniformed Services Health Education Consortium, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Diagnostic yield and morbidity after neuronavigation guided frameless stereotactic biopsy for deep seated brain tumours in children
Amit Kanwar, Ian Kamaly*
Royal Manchester Childrens Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Differences in RNA and miRNA expression between PTCH and SUFU mutated medulloblastoma in two patients with Gorlin's syndrome
Sivan Gershanov1,5, Helen Toledano*2,3, Nitza Goldenberg-Cohen4,6, Mali Salmon-Divon1
1Department of Molecular Biology, Ariel University, Israel, 2Department of Pediatric Oncology,Schneider Children’s Medical Center of Israel, Israel, 3Sackler Faculty of Medicine, Tel Aviv University, Israel, 4Department of Ophthalmology, Bnai Zion Medical Center, Israel, 5The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Beilinson Hospital, Israel, 6The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Differential microRNA expression in the molecular subgroups of medulloblastomas: role in tumor biology and clinical characteristics
Satishkumar Singh1, Harish Bharambe1, Raikamal Paul1, Kedar Yogi1, Pooja Panwalkar1, Rakesh Jalali2, Epari Sridhar2, Aliasgar Moiyadi2, Tejpal Gupta2, Girish Chinnaswamy2, Neelam Shirsat*1
1Advanced Centre for Treatment, Research & Education in Cancer, Tata Memorial Centre, India, 2Tata Hospital, Tata Memorial Centre, India
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Diffuse intrinsic pontine glioma cells are interconnected by ‘tumor microtubes’  
Shawn Gillespie*, Surya Nagaraja, Michelle Monje-Deisseroth
Stanford University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Diffuse midline glioma with osseous metastases at diagnosis: A case report
Meghan Belongia*1, Neel Bhatt1, Kerri Houser1, Andrew Foy3, Jason Jarzembowski4, Mariko Suchi4, Teresa Kelly4, Mohit Maheshwari2, Jeffrey Knipstein1
1Department of Pediatrics, Medical College of Wisconsin, USA, 2Department of Radiology, Medical College of Wisconsin, USA, 3Department of Neurosurgery, Medical College of Wisconsin, USA, 4Department of Pathology, Medical College of Wisconsin, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Diffusion kurtosis imaging can help differentiate low- and high-grade gliomas in pediatric patients with specific location-related patterns: a prospective single centre study
Ioan Paul Voicu, Antonio Napolitano, Chiara Carducci, Lorenzo Lattavo, Andrea Carai, Maria Camilla Rossi Espagnet, Maria Vinci*, Antonella Cacchione, Angela Mastronuzzi, Paolo Tomà, Giovanna Stefania Colafati
Bambino Gesù Children's Hospital, Italy
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Diffusion kurtosis imaging can help differentiate low- and high-grade gliomas in pediatric patients: a prospective single centre study
Ioan Paul Voicu, Antonio Napolitano, Chiara Carducci, Lorenzo Lattavo, Maria Camilla Rossi Espagnet, Andrea Carai, Antonella Cacchione, Mara Vinci*, Angela Mastronuzzi, Paolo Tomà, Giovanna Stefania Colafati
Bambino Gesù Children's Hospital, Italy
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Discovery of CT-179: a small molecule inhibitor of the OLIG2 transcription factor with potent anti-tumor in pediatric brain cancer
Terrance Johns*1,2, Sameer Greenall2, Charlotte Chen2, Bryan Day3
1Telethon Kids Institute, Australia, 2Hudson Institute of Medical Research, Australia, 3QIMR Berghofer Medical Research Institute, Australia
Monday, July 2:  Early Phase Trials  -  9:30am - 10:30am
DiseaseXpress, a cancer data analytics and visualization tool for identifying immunotherapeutic targets in pediatric brain tumors and other cancers
Pichai Raman1, Komal Rathi1, Karthik Kalletla1, Yuankun Zhu1, Bo Zhang1, Anthony Cros1, Javad Nazarian3, Angela J Waanders1, Sabine Mueller2, Phillip B Storm1, Adam C Resnick*1
1Children's Hospital of Philadelphia, USA, 2UCSF Benioff Children's Hospital, USA, 3Children’s National Health System, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Diversion of CSF with programmable ventriculoperitoneal shunts: role with intraventricular radioimmunotherapy
Kim Kramer*, Maria Donzelli, Milan Grkovski, Jeffrey Greenfield, Mark Souweidane, Neeta Pandit Taskar
Memorial Sloan Kettering Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
DNA methylation analysis of high-grade glioma in patients with mismatch repair deficiencies
Andrew Dodgshun*1,2, Kohei Fukuoka3, Brittany Campbell3,4, Melissa Edwards3,4, Alexandra Sexton-Oates5, Valérie Larouche6, Vanan Magimairajan7, Scott Lindhorst8, Michal Oren9, Gary Mason10, Bruce Crooks11, Shlomi Constantini9, Maura Massimino12, Stefano Chiaravalli13, Jagadeesh Ramdas14, Warren Mason15, Ashraf Shamvil16, Roula Farah17, An van Damme18, Enrico Opocher12, Syed Ahmer Hamid19, David Ziegler20, David Samuel21, Kristina A Cole22, Patrick Tomboc23, Duncan Stearns24, Gregory Thomas25, Alexander Lossos26, Richard Saffery5, Michael Sullivan27,28, Jordan R Hansford27,28, David Jones29, Uri Tabori3,4
1Christchurch Hospital, New Zealand, 2University of Otago, New Zealand, 3The Hospital for Sick Children, Canada, 4University of Toronto, Canada, 5Murdoch Children's Research Institute, Australia, 6Université Laval, Canada, 7University of Manitoba, Canada, 8Medical University of South Carolina, USA, 9Tel Aviv Sourasky Medical Center, Israel, 10Children’s Hospital of Pittsburgh, USA, 11IWK Health Centre, Canada, 12University of Padova, Italy, 13Fondazione IRCCS Istituto Nazionale dei Tumori, Italy, 14Janet Weis Children's Hospital, USA, 15Princess Margaret Cancer Centre, Canada, 16Indus Children Cancer Hospital, Pakistan, 17Saint George Hospital University Medical Center, Lebanon, 18Université Catholique de Louvain, Belgium, 19Liaquat National Hospital, Pakistan, 20Sydney Children's Hospital, Australia, 21Valley Children's Hospital, USA, 22Children's Hospital of Philadelphia, USA, 23West Virginia University, USA, 24UH Rainbow Babies and Children's Hospital, USA, 25Oregon Health & Science University, USA, 26Hadassah Medical Centre, Israel, 27Royal Children's Hospital, Australia, 28University of Melbourne, Australia, 29Deutsches Krebsforschungszentrum, Germany
Monday, July 2:  High Grade Glioma  -  3:30pm - 5:00pm
DNA methylation stochasticity in DIPG
Michael Koldobskiy*, Garrett Jenkinson, Elisabet Pujadas, Allison Martin, Charles Eberhart, John Goutsias, Eric Raabe, Andrew Feinberg
Johns Hopkins University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Does the efficacy of salvage re-irradiation in recurrent medulloblastoma depend upon risk-stratification, site of relapse, and molecular subgroup?
Tejpal Gupta*, Madan Maitre, GodaJayant Sastri, Rahul Krishnatry, Neelam Shirsat, Sridhar Epari, Girish Chinnaswamy, Vijay Patil, Aliasgar Moiyadi, Rakesh Jalali
Tata Memorial Centre, India
Tuesday, July 3:  Radiation Oncology  -  8:00am - 9:00am
Dramatic response in a child treated for glioblastoma with immune check point inhibitor Nivolumab
Christine Dahl*, Gorm Von Ottingen, Britt Elmedal Laursen, Yasmin Lassen
Aarhus University Hospital, Denmark
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Drug screening linked to molecular profiling identifies novel dependencies in patient-derived primary cultures of paediatric high grade glioma and DIPG 
Alan Mackay*1, Valeria Molinari1, Diana Carvalho1, Helen Pemberton1, Sara Temelso1, Anna Burford1, Matthew Clarke1, Mariama Fofana1, Jessica Boult1, Elisa Izquierdo1, Kathryn Taylor2, Lynn Bjerke1, Janat Fazal Salom1, Ketty Kessler1, Rebecca Rogers1, Christopher Chandler3, Bassel Zebian3, Andrew Martin4, Simon Stapleton4, Samatha Hettige4, Lynley Marshall5, Fernando Carceller5, Henry Mandeville5, Sucheta Vaidya5, Leslie Bridges5, Safa Al-Sarraj5, Jane Pears6, Angela Mastronuzzi7, Andrea Carai7, Francesca del Bufalo7, Carmen de Torres7, Mariona Sunol8, Ofelia Cruz8, Jaume Mora8, Andrew Moore9, Simon Robinson1, Christopher Lord1, Angel Montero Carcaboso8, Maria Vinci7, Chris Jones1
1Institute of Cancer Research, UK, 2Stanford University, USA, 3Kings College Hospital, UK, 4St George's Hospital, UK, 5Royal Marsden Hospital, UK, 6Our Lady Children's Hospital, Ireland, 7Ospedale Pediatrico Cambio Gesu, Italy, 8Hospital San Joan de Deu, Spain, 9Queensland Children's Tumour Bank, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Dual inhibition of mTORC1/C2 and MEK pathway is synergistic in multiple human models of pediatric low-grade glioma including a novel patient-derived NF1 pilocytic astrocytoma cell line
Antje Arnold*1, Ming Yuan1, Fausto Rodriguez1, Charles Eberhart1, Eric Raabe1,2
1Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, USA, 2Division of Pediatric Oncology, Johns Hopkins University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Durable response to Nivolumab in a pediatric patient with refractory glioblastoma and constitutional biallelic mismatch repair deficiency
Musa Al-Harbi*1, Nahla Ali Mobark1, Latifa Al-Mubarak2, Rasha Alaljelaify2,3, Mariam AlSaeed2, Amal Almutairi2, Fatmah Alqubaishi2, Emarat Hussain3, Lamia Alsubaie4, Saeed AlShiebans5, Nada alTassan6, Shakti H. Ramkissoon7,8, Malak Abedalthagafi2,9
1Oncology Department, Comprehensive Cancer Centre, King Fahad Medical City, Saudi Arabia, 2Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Saudi Arabia, 3Radiology Department, King Fahad Medical City, Saudi Arabia, 4Division of Genetics, Department of Pediatrics, King Abdulaziz Medical City, Saudi Arabia, 5Department of Pathology, King Abdulaziz Medical City, National Guard Health Affair, Saudi Arabia, 6Genetics Department, King Faisal Specialists Hospital and Research Center, Saudi Arabia, 7Wake Forest Comprehensive Cancer Center and Department of Pathology, USA, 8Foundation Medicine, Inc., USA, 9Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Earlier recognition of symptoms and diagnosis may reduce treatment and late effect burden in children, teenagers and young adults with intracranial germ cell tumours
James Hayden*1, Ute Bartels2, Anthony Penn3, Matthew Murray4, Gabriele Calaminus5, James Nicholson4
1Alder Hey Children’s NHS Trust, UK, 2The Hospital for Sick Children, Canada, 3Royal Manchester Children’s Hospital, UK, 4Cambridge University Hospitals NHS Trust, UK, 5University Hospital, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Early childhood medulloblastoma: Subgroup-specific survival in patients treated with systemic chemotherapy and intraventricular MTX to avoid craniospinal radiotherapy
Martin Mynarek*1, Marcel Kool2,3, Ulrich Schueller1, Katja von Hoff1,4, Tanvi Sharma2,3, Vasilisa Rudneva5, Torsten Pietsch6, Paul Northcott5, B.-Ole Juhnke1, Barbara Meissner1, Monica Warmuth-Metz7, Rolf D. Kortmann8, Giles Robinson5, Andreas von Deimling3,9, Stefan Pfister2,3, Stefan Rutkowski1
1University Medical Center Hamburg Eppendorf, Germany, 2Hopp Children´s Cancer Center at the NCT Heidelberg (KiTZ) and German Cancer Research Center (DKFZ), Germany, 3University Hospital Heidelberg, Germany, 4Charite – University Medical Center Berlin, Germany, 5St. Jude Childrens Research Hospital, USA, 6University of Bonn, Germany, 7University of Würzburg, Germany, 8University of Leipzig, Germany, 9German Cancer Research Center (DKFZ), Germany
Tuesday, July 3:  Medulloblastoma - Clinical  -  10:40am - 12:10pm
Early detection of CNS germinoma in pituitary stalk thickening using non-invasive microRNA testing
Matthew Murray*1,2, Lorena Verduci1, Victoria Kyle1, Dawn Ward1, James Nicholson2, Cinzia Scarpini1, Nicholas Coleman1,2
1University of Cambridge, UK, 2Cambridge University Hospitals NHS Foundation Trust, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Early diagnosis of childhood brain tumours: helping family clinicians to be more ‘HeadSmart'
Shaarna Shanmugavadivel1, Rebecca Chellaswamy2, Jo-Fen Liu1, David Walker*1
1Children's Brain Tumour Research Centre, University of Nottingham, UK, 2Royal College of General Practitioners, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Early preclinical outcomes of Intratumoral Modulation Therapy for diffuse intrinsic pontine glioma and glioblastoma
Andrew Deweyert*, Hu Xu, Eugene Wong, Sussane Schmid, Matthew Hebb
University of Western Ontario, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Eating behavior and oxytocin in childhood-onset craniopharyngioma patients 

Anna Daubenbüchel1, Anika Hoffmann1, Monika Warmuth-Metz2, Maria Eveslage3, Jale Özyurt4, Hermann L. Müller*1
1Dep.of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg, Medical Campus University Oldenburg, Germany, 2Dep. of Neuroradiology, University Hospital Würzburg, Germany, 3Institute of of Biostatistics and Clinical Research, University Münster, Germany, 4Biological Psychology Lab, Department of Psychology, Faculty of Medicine and Health Sciences, 14 Carl von Ossietzky University, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Effect of intensive nutrition intervention on pediatric patients with central nervous system tumors with concurrent radiochemotherapy
Yangqiong Zhang, Xiulan Wu, Minting Ye, Mingyao Lai, Linbo Cai, Li Juan*
Guangdong 999 Brain Hospital, China
Saturday, June 30:  Nursing Symposium  - 
Effect of knockdown of KDM6A by CRISPR/CAS9 editing in medulloblastoma
Susan Fosmire, Molishree Joshi, Tim Smith, Sujatha Venkataraman, Rajeev Vibhakar*
University of Colorado, Anschutz Medical Campus, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Effect of neurofibromatosis type 1 on long-term health outcomes in adult survivors of childhood astrocytoma: a report from the Childhood Cancer Survivor Study
Peter de Blank*1,2, Nan Li3, Nicole Ullrich4, Michael J. Fisher5, Smita Bhatia6, Yutaka Yasui3, Charles Sklar7, Wendy Leisenring8, Rebecca Howell9, Kevin Oeffinger10, Kristina Hardy11, M. Fatih Okcu12, Todd Gibson3, Les Robison3, Gregory T. Armstrong3, Kevin Krull3
1University of Cincinnati, USA, 2Cincinnati Children's Hospital Medical Center, USA, 3St. Jude Children's Research Hospital, USA, 4Harvard Medical School, USA, 5Children's Hospital of Philadelphia, USA, 6University of Alabama at Birmingham, USA, 7Memorial Sloan Kettering Cancer Center, USA, 8Fred Hutchinson Cancer Research Center, USA, 9MD Anderson Cancer Center, USA, 10Duke Cancer Institute, USA, 11Children’s National Medical Center, USA, 12Texas Children’s Hospital, USA
Tuesday, July 3:  Neurofibromatosis  -  8:00am - 9:00am
Embryonal tumor with multilayered rosettes: the MD Anderson Cancer Center experience
Nelda Itzep*, Wafik Zaky, Citla Sridhar, Bhanu Gogia, Heather Meador, Sheetal Phadnis, David Sandberg, Greg Fuller, Leena Ketonen, Soumen Khatua
MD Anderson Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Emotion recognition in pediatric brain tumor patients: viewing patterns and white matter structure
Iska Moxon-Emre*1,2, Eric Bouffet1, Suzanne Laughlin1, Jovanka Skocic1, Cynthia de Medeiros1, Donald J Mabbott1,2
1The Hospital for Sick Children, Canada, 2University of Toronto, Canada, 3Pediatric Oncology Group of Ontario, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Enabling access to support; what can we learn from those that do and do not attend parent support groups?
Sophie Thomas*1,2, Emily Bennett1, Emily Talbot1, Abigail Lee2, Shirley Thomas2
1Nottingham Children's Hospital, UK, 2University of Nottingham, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
End-of-life experiences of children with brain tumors: perspectives from a panel discussion
Katharine Brock*1,2, Erin Connelly2, Brian Jackson3,4, David Wrubel1,2, Claire Mazewski1,2
1Emory University, USA, 2Children's Healthcare of Atlanta, USA, 3University of Colorado, USA, 4Children's Hospital Colorado, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Endonasal endoscopic approach to pituitary adenomas: single center early experience
Mohamed M. Arnaout*1, Mohamed G. Ammar1, Mansour A. Mekia1, Magdy O. Elshiekh1, Ismail Elnashar2
1Neurosurgery department, Zagazig University, Egypt, 2ENT Department, Zagazig University, Egypt
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Endoscopic approach to pineal region lesions with splitting of the choroid fissure and massa intermedia
Charlotte Burford*1, Cristina Bleil2, Jose Lavrador2, Ahilan Kailaya-Vasan2, Bassel Zebian2
1King's College London, UK, 2King's College Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Endoscopic challenge for sellar and parasellar tumors: from above or below
Mohamed M. Arnaout*1, Diego Mazzatenta2, Khaled Aziz3
1Department of Neurosurgery, Zagazig University, Egypt, 2Department of Neurosurgery, Bellaria Hospital, Bologna University, Italy, 3Deparment of Neurosurgery, Allegheny General Hospital, Drexel University College of Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Endoscopic resection of intraventricular lesions using an endoscopic ultrasonic aspirator
Charlotte Burford*1, Nida Kalyal2, John Hanrahan1, Ali Ansaripour1, Wisam Al-Faiadh2, Anna Oviedova2, Prajwal Ghimire2, Cristina Bleil2, Bassel Zebian2
1King's College London, UK, 2King's College Hospital, UK
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
Enhanced efficacy of nano-formulated vismodegib shows the potential for polyoxazoline micelles to improve drug delivery to brain tumors
Duhyeong Hwang, Yuling Zhao, Hedi Liu, Alexander Kabanov, Timothy Gershon, Marina Sokolsky*
University of North Carolina at Chapel Hill, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Enhancing brain lesions in children with Neurofibromatosis type 1
Mariana Fernandes, João Passos, Daniela Garcez, Manuela Mafra, Sofia Nunes, Duarte Salgado*
Instituto Português de Oncologia de Lisboa, Portugal
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
EphA3 a novel tumour specific therapeutic target for medulloblastoma
Carolin Offenhauser1, Benjamin Carrington1, Kris Thurecht2, Kathleen Ensbey1, Zara Bruce1, Paul Jamieson1, Yi Chieh Lim1, Seckin Akgul1, Michelle Li1, Brett Stringer1, Simon Puttick2, Adrian Fuchs2, Daniel Picard3, Wendy Ingram2, Andrew Hallahan2, Andrew Moore2, Terrance Johns4, Nicholas Gottardo4, Marc Remke3, Andrew Boyd1,2, Bryan Day*1
1QIMR Berghofer MRI, Australia, 2The University of Queensland, Australia, 3University of Düsseldorf, Germany, 4Telethon Kids Institute, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Epidemiology, management and outcome of paediatric low grade glioma in Hong Kong
Dennis TL Ku*1, Matthew MK Shing2, Anthony Liu3, CW Luk4, SC Ling5, Godfrey CF Chan3
1Dept. of Paediatrics, Tuen Mun Hospital, Hong Kong, 2Lady Pao Children's Cancer Centre, Dept. of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, 3Dept. of Paediatrics, Queen Mary Hospital, The University of Hong Kong, Hong Kong, 4Dept. of Paediatrics, Queen Elizabeth Hospital, Hong Kong, 5Dept. of Paediatrics, Princess Margaret Hospital, Hong Kong
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Epidemiology, treatment and outcomes of infant medulloblastoma: a single centre study in Singapore
Enrica Tan*, Aubrey Pagaduan, Lee Ping Ng, Sharon Low
KK Women's and Children's Hospital, Singapore
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Epigenetic/genetic/morphologic analyses reveal clinical/prognostic insight of pediatric low grade gliomas
Kohei Fukuoka*1,9, Yasin Mamatjan2, Ruth Tatevossian5, Michal Zapotocky1,9, Scott Ryall3,9, Ana Guerreiro Stucklin1,9, Julie Benett1,9, Betty Luu4, Ji Wen5, Lili-Naz Hazrati6, Norm Laperriere7, James Drake8, James Rutka8, Peter Dirks8, Abhaya Kulkarni8, Michael Taylor8, Ute Bartels1, Annie Huang1, Kenneth Aldape2, Eric Bouffet1, Vijay Ramaswamy1, David Ellison5, Cynthia Hawkins6,9, Uri Tabori1,9
1Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Canada, 2Princess Margaret Cancer Centre and MacFeeters-Hamilton Centre for Neuro-Oncology Research, Canada, 3Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada, 4Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Canada, 5Division of Pathology, St Jude Children's Research Hospital, USA, 6Division of Pathology, The Hospital for Sick Children, Canada, 7Department of Radiation Oncology, Princess Margaret Hospital, Canada, 8Division of Neurosurgery, The Hospital for Sick Children, Canada, 9The pLGG taskforce, The Hospital for Sick Children, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Errors on bedside testing of anti-saccades may predict cognitive dysfunction
Raja Khan*, Thomas Merchant, Kathryn Russell, Zsila Sadighi, Jason Ashford, Heather Conklin
St. Jude Children's Research Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Establishing a baseline time-frame for symptom onset to definitive diagnosis of children with newly-diagnosed central nervous system (CNS) tumors: a multi-institutional collaborative study
Scott Coven*1,2, Vanisha Patel3, Joseph Stanek1, David Walker4, Sarah Rush3, Jonathan Finlay1,2
1Nationwide Children's Hospital, USA, 2The Ohio State University, USA, 3Akron Children's Hospital, USA, 4University of Nottingham, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Establishment of a 3D spheroid-based model of medulloblastoma that recapitulates tumour growth, drug response and migration
Sophie J. Roper*1, Paul J. Scotting2, Beth Coyle1
1Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, UK, 2Division of Genetics, Ecology and Evolution, School of Life Sciences, University of Nottingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Establishment of a rehabilitation clinical specialist in oncology significantly improved rehabilitation access for pediatric neurooncology patients: a single institution experience
Lynn Tanner*, Anne Bendel
Children's Minnesota, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
E-survey of current international physiotherapy practice for children with ataxia following surgical resection of posterior fossa tumour
Helen Hartley*1, Bernie Carter2, Lisa Bunn3, Ram Kumar1, Elizabeth Cassidy4, Steven Lane5, Barry Pizer1
1Alder Hey Children's NHS Foundation Trust, UK, 2Edge Hill University, UK, 3Plymouth, UK, 4Freelance academic, Austria, 5Liverpool University, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Evaluate the anti-cancer of novel chelator DPC on glioblastoma multiforme cells
Godfrey Chi-Fung Chan
The University of Hong Kong, Hong Kong
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Evaluating pediatric spinal low-grade gliomas-a 30-year retrospective analysis
Steven Carey*1, Zsila Sadighi1, Shengjie Wu1, Jason Chiang1, Yahya Ghazwani1, Sahaja Acharya1, Fredrick Boop1,2, Amar Gajjar1, Ibrahim Qaddoumi1
1St. Jude Children's Research Hospital, USA, 2Le Bonheur Neuroscience Institute, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Evaluating the power of patient tumor-derived orthotopic xenograft (PDOX) models of pediatric brain tumors to predict drug responses in humans
Sarah Injac*, Yuchen Du, Mari Kogiso, Frank Braun, Huiyuan Zhang, Lin Qi, Holly Lindsay, Sibo Zhao, Xiao-nan Li
Texas Childrens's Cancer and Hemaology Center, USA
Monday, July 2:  Preclinical Models/Drug Discovery  -  8:30am - 9:30am
Evaluating therapeutic vulnerabilities in DIPG using aurora kinase inhibitor as a novel therapy  
Liang Zhang*1, Andrew Bender2, David Daniels1
1Mayo Clinic, USA, 2Vanderbilt University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Evaluation of a novel 18F-labeled tryptophan tracer for PET imaging of brain tumors in a medulloblastoma mouse model 
Nagma Dalvi*1, Shaohui Zhang2, Alisa Litan3, Yangchun Xin2, Xuyi Yue2, Zhiqin Li3, Hua Li2, Hancheng Cai4, Harry Chugani1, Diane Chugani2, Sigrid Langhans3
1Department of Neurology, Nemours/Alfred I. duPont Hospital for Children, USA, 2Katzin Diagnostic & Research PET/MR Center, Nemours/Alfred I. duPont Hospital for Children, USA, 3Nemours Center for Childhood Cancer Research, Nemours/Alfred I. duPont Hospital for Children, USA, 4Mayo Clinic, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Evaluation of cobimetinib, a MEK inhibitor, in low-grade pediatric brain tumors
Martin Roskoski, Danuta Gasinski, Henry Friedman, Darell Bigner, Stephen Keir*
The Preston Robert Tisch Brain Tumor Center, Duke University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Evaluation of different radiotherapy techniques on incidental radiation doses to the whole ventricular system during focal irradiation for non germinomatous germ cell tumours after chemotherapy
Yasmin Lassen-Ramshad*1, Klaus Seiersen1, Ian Gleeson2, Anita Mahajan3, Arnold Paulino4, Thankamma Ajithkumar2
1Danish Centre for Particle Therapy, Aarhus University Hospital, Denmark, 2Department of Oncology, Cambridge University Hospitals NHS Trust, UK, 3Department of Radiation Oncology, Mayo Clinic, USA, 4Department of Radiation Oncology, MD Anderson Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Evaluation of molecular characteristics of diffuse leptomeningeal glioneuronal tumor
Erin Wright*, Alexis Judd, Jennifer Stanke, Dimitri Agamanolis, Sarah Rush
Akron Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Evaluation of pediatric glioma outcome using intraoperative MRI: A cohort study using I-MiND (IMRIS multicenter iMRI neurosurgery database)
Michael Karsy1, Samuel Cheshier*1, S. Hassan Akbari2, David Limbrick2, Eric C. Leuthardt2, John Evans2, Matthew D. Smyth2, Jennifer Strahle2, Jeffrey Leonard3, Douglas L. Brockmeyer1, Robert J. Bollo1, John R. Kestle1, John Honeycutt4, David J. Donahue4, Richard A. Roberts4, Daniel R. Hansen4, Garnette Sutherland5, Clair Gallagher5, Walter Hader5, Yves Starreveld5, Mark Hamilton5, Ann-Christine Duhaime6, Randy L. Jensen1, Michael R. Chicoine2
1Department of Neurosurgery, University of Utah, USA, 2Department of Neurosurgery, Washington University School of Medicine, USA, 3Department of Neurosurgery; Nationwide Children’s Hospital, USA, 4Department of Neurosurgery, Cook Children’s Neurosciences, USA, 5Department of Neurosurgery, University of Calgary, Canada, 6Department of Neurosurgery, MassGeneral Hospital for Children, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Evaluation of the implementation of the RANO criteria in the HERBY trial of pediatric patients with newly diagnosed high-grade gliomas
Daniel Rodriguez*1, Paul Morgan1, Daniel Warren15, Monika Warmuth-Metz12, Esther Aliaga-Sanchez13, Raphael Calmon14, Chris Jones11, Pascale Varlet10, Darren Hargrave8, Adela Cañete6, Maura Massimino4, Amedeo Azizi5, Marie-Cecil Le Deley3, Frank Saran7, Raphael Rousseau2, Gudrun Zahlmann9, Josep Garcia9, Gilles Vassal3, Jacques Grill3, Tim Jaspan1
1Nottingham University Hospitals Trust, UK, 2Gritstone Oncology Inc, USA, 3Gustave Roussy, France, 4Fondazione IRCCS - Istituto Nazionale dei Tumori, Italy, 5Medical University of Vienna, Austria, 6Hospital La Fe, Spain, 7Royal Marsden Hospital, UK, 8Great Ormond Street Hospital, UK, 9F. Hoffmann-La Roche Ltd, Switzerland, 10Sainte-Anne Hospital, France, 11Institute of Cancer Research, UK, 12Universität Würzburg, Germany, 13VU University Medical Center, The Netherlands, 14Hôpitaux de Paris, France, 15Leeds Teaching Hospital Trust, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Evolution of pituitary EndoSurgery
Mohamed M. Arnaout
Neurosurgery department, Zagazig University, Egypt
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Evolving survival trends in infants with brain tumors: a longitudinal population based study
Claire Faltermeier1, Timothy Chai2, Lior Elkaim3, George Ibrahim4, Anthony Wang1, Alexander Weil3, Anne Bendel*5, Aria Fallah1, Albert Tu5
1UCLA, USA, 2Stanford University, USA, 3Universite de Montreal, Canada, 4University of Toronto, Canada, 5Children's Minnesota, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Ex vivo tissue metabolite profiles predict progression-free survival in paediatric cerebellar pilocytic astrocytomas
Christopher Bennett*1,2, Sarah Kohe1,2, Simrandip Gill1,2, Neelakshi Ghosh1,2, Karen Manias1,2, Adam Oates2, Martin English2, Jenny Adamski2, Daniel Tennant3, Andrew Peet1,2
1Institute of Cancer and Genomic Sciences, University of Birmingham, UK, 2Birmingham Children's Hospital, UK, 3Institute of Metabolism and Systems Research, University of Birmingham, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Excitatory synapses between presynaptic neurons and postsynaptic glioma cells promote DIPG progression 
Humsa Venkatesh1, Anna Geraghty1, Wade Morishita1, Lydia Tam1, Itay Tirosh2, Aviv Regev2, Hannes Vogel1, Mario Suva2, Robert Malenka1, Michelle Monje*1
1Stanford University, USA, 2Broad Institute, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Experience with 18F-FET PET/MRI for CNS-tumors in children and adolescents
Lisbeth Marner1, Karsten Nysom*2, Astrid Sehested2, Lise Borgwardt1, René Mathiasen2, Peder Skov Wehner6, Otto Mølby Henriksen1, Michael Lundemann1, Carsten Thomsen3, Lars Bøgeskov4, Jane Skjøth-Rasmussen4, Helle Broholm5, David Scheie5, Marianne Juhler4, Liselotte Højgaard1, Ian Law1
1Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet, Denmark, 2Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Denmark, 3Department of Diagnostic Radiology, Copenhagen University Hospital Rigshospitalet, Denmark, 4Department of Neurosurgery, Copenhagen University Hospital Rigshospitalet, Denmark, 5Department of Pathology, Copenhagen University Hospital Rigshospitalet, Denmark, 6Hans Christian Andersen Children’s Hospital, Odense University Hospital, Denmark
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Experience with the intraoperative magnetic resonance in pediatric brain tumor surgery
Sonia Tejada*1, Shivaram Avula2, Benedetta Pettorini2, Conor Mallucci2
1Clínica Universidad de Navarra, Spain, 2Alder Hey Children´s Hospital, UK
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
Expression and functional analysis of the CD166/activated leukocyte cell adhesion molecule (ALCAM) in medulloblastoma
Takamune Achiha*1, Noriyuki Kijima2, Naoki Kagawa1, Chisato Yokota1, Yasunori Fujimoto1, Haruhiko Kishima1
1Department of Neurosurgery, Osaka University Graduate School of Medicine, Japan, 2Department of Neurosurgery, National Hospital Organization Osaka National Hospital, Japan
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Expressive writing for adolescents with brain tumor: a case study
Sofia Anzeneder1, Domitilla Elena Secco1,2, Angela Mastronuzzi*2, Anna Rita Colasanti3, Simonetta Gentile1
1Neurosciences and Neurorehabilitation Department, Clinical Psychology Unit, Pediatric Hospital Bambino Gesù of Rome, Italy, 2Pediatric Onco-Hematology and Transfusion Medicine Department, Neuro-Oncology Unit, Pediatric Hospital Bambino Gesù of Rome, Italy, 3Salesian Pontifical University, Faculty of Educational Science, Italy
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Extracellular vesicles from metastatic medulloblastoma cell lines carry mRNAs known to correlate with metastatic disease
Hannah K Jackson*1, Franziska Linke1, Ian D Kerr2, Beth Coyle1
1Children’s Brain Tumour Research Centre, School of Medicine, University of Nottingham, UK, 2Division of Cell Signalling & Pharmacology, School of Life Sciences, University of Nottingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Extracranial metastasis of glioblastoma- - a report of three pediatric patients
Chelsee Greer*1,2, Virginia Harrod1,2, Chandra Krishnan1,2, Timothy George1,2
1Dell Children's Medical Center, USA, 2Dell Medical School, University of Texas at Austin, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
EZH2 overexpression increases the oncogenic character of cerebellar progenitors and isografts in mice result in tumors resembling group 3 medulloblastoma
Ismail Sola*, Sujatha Venkataraman, Angela Pierce, Ilango Balakrishnan, Diane Birks, Nicholas K. Foreman, Rajeev Vibhakar
University of Colorado Denver, Anschutz Medical Campus, USA
Tuesday, July 3:  Medulloblastoma - Basic/Translational Research  -  9:00am - 10:20am
Familial pediatric clear cell meningioma with germline SMARCE1 mutation
Pournima Navalkele*1,2, Miguel Guzman1,2, Hailey Pintz2, Amelia Kirby1,2, Thomas Geller1,2, Saleem Abdulrauf1
1Saint Louis University, USA, 2SSM Cardinal Glennon Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Family huddle – one family’s personal experience
Kate Fernandez*, Kate Cameron
Women's and Children's Hospital, Australia
Saturday, June 30:  Social Work Session  - 
Fatigue and quality of life in childhood brain tumor after the end of treatment
Sonia Di Profio*1, Marco Crocco2,5, Antonio Verrico2, Claudia Milanaccio2, Natascia Di Iorgi4,5, Flavia Napoli4, Mattia Pacetti3, Maria Luisa Garrè2
1UOSD Psicologia Clinica Gaslini Children's Hospital, Italy, 2UOSD Neuro-oncologia Gaslini Children's Hospital, Italy, 3UOC Neurochirurgia Gaslini Children's Hospital, Italy, 4UOC Endocrinologia Gaslini Children's Hospital, Italy, 5DINOGMI University of Genova, Italy
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Favorable outcomes in children with pineoblastoma treated with risk-adapted craniospinal irradiation and chemotherapy: results and molecular analysis from the SJYC07 and SJMB03 trials
Anthony Liu*1, Brent Orr2, Tong Lin3, Eric Bouffet4, Sridharan Gururangan5, John Crawford6, Stewart J. Kellie7, Murali Chintagumpala8, Michael Fisher9, Daniel C. Bowers10, Tim Hassall11, David Ellison2, Giles Robinson1, Amar Gajjar1
1Department of Oncology, St Jude Children's Research Hospital, USA, 2Department of Pathology, St Jude Children's Research Hospital, USA, 3Department of Biostatistics, St Jude Children's Research Hospital, USA, 4Paediatric Brain Tumour Program, The Hospital for Sick Children, Canada, 5Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, USA, 6University of California San Diego and Rady Children's Hospital, USA, 7Children's Cancer Centre, The Children's Hospital at Westmead & University of Sydney, Australia, 8Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, USA, 9Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, USA, 10Division of Pediatric Hematology and Oncology, University of Texas Southwestern Medical Center, USA, 11Lady Cilento Children's Hospital, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Feasibility and toxicity of daily carboplatin during craniospinal irradiation for high risk pediatric embryonal brain tumors: first report from a middle income country
Carlos Leal-Cavazos*, Michelle Gutierrez-Herrera, David Hernández-Barajas, Manuel De la O-Cavazos
Hospital Universitario Dr. José Eleuterio González, Mexico
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Feasibility of screening and reasons for screening failures in the SIOPE PNET 5 MB trial
François Doz*1,2, Steven Clifford3, Torsten Pietsch4, Shivaram Avula5, Martin Mynarek6, Regine Riechers6, Martin Benesch7, Nicolas U. Gerber8, Maura Massimino9, Magnus Sabel10, Sandra Jacobs11, Miguel Garcia Ariza12, Antony Michalski13, Jaroslav Sterba14, Virve Pentikäinen15, Stefan Rutkowski6
1Institute Curie, 26 rue d'Ulm, 75231 Paris Cedex 05, France, 2University Paris Descartes, 12 rue de l’Ecole de Médecine, France, 3Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, UK, 4Department of Neuropathology, University Bonn, Sigmund-Freud-Str. 25, Germany, 5Alder Hey Children's NHS Foundation Trust, Eaton Road, UK, 6Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany, 7Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 38, Austria, 8Department of Oncology, University Children's Hospital, Steinwiesstrasse 75, Switzerland, 9Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, Italy, 10Barncancercentrum, Drottning Silvias Barn-och ungdomssjukhus, Sweden, 1110. Department of Pediatrics, University Hospitals Leuven, Herestraat 49, Belgium, 12Unit of Paediatric Haematology, Oncology Hospital Cruces Bilbao, Plaza de Cruces s/n, Spain, 13Department of Paediatric Oncology, Great Ormond Street Hospital for Children, Great Ormond Street, UK, 14Department of Paediatric Oncology, University Hospital Brno, Masaryk University, Cernopolni 9, Czech Republic, 15Department of Pediatric Oncology, Haematology and Stem Cell Transplantations, Helsinki University Central Hospital, PO Box 281, Finland
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Fertility preservation in girls with brain tumors: a single center experience
Rina Dvir*1,3, Foad Azem2,3, Michal Manistersky1, Ilana Berkley3, Ronit Elhasid1,3
1Tel-Aviv Medical Center Department of Pediatric Hemato-Oncology, Israel, 2Tel-Aviv Medical Center,Institute of IVF and reproduction, Israel, 3Sackler Medical School, Tel-Aviv University, Israel
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Final results of the Phase II, single arm trial of Irinotecan and Cisplatin in children with high-risk glial tumors
Ofelia Cruz*1, Victoria Caloretti1, Mariona Suñol2, Carmen de Torres3, Andres Morales1, Antonio Guillen4, Jordi Muchart5, Eva Rodriguez4, Veronica Celis1, Hector Salvador1, Joan Vinent6, Sara Perez-Jaume3, Jaume Mora1,3
1Hospital Sant Joan de Deu. Pediatric Oncology, Spain, 2Hospital Sant Joan de Deu. Pathology, Spain, 3Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Spain, 4Hospital Sant Joan de Deu. Pediatric Neurosurgery, Spain, 5Hospital Sant Joan de Deu. Pediatric Neuro-radiology, Spain, 6Hospital Sant Joan de Deu. Pediatric Pharmacology, Spain
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
First in human use of Canvas imaging system for visualization of tozuleristide-induced tumor fluorescence
Amy Lee*1,4, Jason Hauptman1,4, Bonnie Cole1,4, Kimberly Starr1, Sandra Poliachik1, Jeffrey Ojemann1,4, Sam Browd1,4, Richard Ellenbogen1, Dennis Miller2, Laura Ishak2, Carolyn Gombotz2, Stacey Hansen2, Jeff Perry2, David Kittle3, Julie Novak2, Adam Mamelak3, James Olson5,1, Sarah Leary1,5
1Seattle Children's Hospital, USA, 2Blaze Bioscience, USA, 3Teal Light Surgical, USA, 4University of Washington, USA, 5Fred Hutch, USA
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
Functional characterization and effective targeting of NRF1-BRAF and ATG7-RAF1 fusions identified in anaplastic pleomorphic xanthoastrocytoma patients without BRAF p.V600E mutation
Poonam Sonawane1, Patrick Diviney1, Joanna Phillips2, Payal Jain*1, Phillip Storm1, Adam Resnick1, Angela Waanders1
1Children’s Hospital of Philadelphia, USA, 2University of California, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Gabriella Miller Kids First Data Resource Center advancing genetic research in childhood cancer and structural birth defects through large scale integrated data-driven discovery and cloud-based platforms for collaborative analysis
Allison P Heath1, Pichai Raman1, Yuankun Zhu1, Jena V Lilly1, Deanne Taylor1, Phillip B Storm1, Angela J Waanders1, Sam Volchenboum2, Lincoln Stein3, Kyle Ellrott4, Adam Margolin4, Brandi Davis-Dusenbery7, Robert Grossman2, Vincent Ferretti3, Sabine Mueller6, Javad Nazarian5, Adam C Resnick*1
1Children's Hospital of Philadelphia, USA, 2University of Chicago, USA, 3Ontario Institute for Cancer Research, Canada, 4Oregon Health & Science University, USA, 5Children’s National Health System, USA, 6UCSF Benioff Children's Hospital, USA, 7Seven Bridges, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Gamma knife radiosurgery for the treatment of grade I and II astrocytomas in the pediatric population
Ashley S. Plant1, Jody Pathare1, Darcy Engelhart*2, Venita Williams1, Ivan Kirov1, William G. Loudon1
1Children's Hospital Orange County, USA, 2University of California, San Diego, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Gangliogliomas in children- MD Anderson Cancer Center experience
Muhammad Baig*1, David McCall1, Sana Mohiuddin1, Shekhar Patil1, Minjeong Park2, Wafik Zaky1, Soumen Khatua1
1Division of Pediatrics, University of Texas M.D Anderson Cancer Center, USA, 2Division of Statistics, University of Texas M.D Anderson Cancer Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Generation, characterization and treatment of novel murine models for human pediatric glioma
Britta Ismer*2,1, Itai Moshe3, Dinorah Friedmann-Morvinski3, David T. W. Jones2,1
1German Cancer Research Center (DKFZ), Germany, 2Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 3Tel Aviv University, Israel
Monday, July 2:  Preclinical Models/Drug Discovery  -  8:30am - 9:30am
Genomic analyses revealed radiation-induced glioblastoma in a Subset of recurrent medulloblastomas
Ji Hoon Phi*1, Ae Kyung Park2, Semin Lee3, In-Pyo Baek4, Eun-Hye Kim5, Hee-Chul Park8, Byung Chul Kim8, Jong Bhak8, Sung-Hye Park1, Ji Yeoun Lee1, Kyu-Chang Wang1, Dong-Seok Kim7, Kyun Won Shim7, Se Hoon Kim7, Chae-Yong Kim8, Seung-Ki Kim1
1Seoul National University Children's Hospital, Republic of Korea, 2Sunchon National University, Republic of Korea, 3Ulsan National Institute of Science and Technology, Republic of Korea, 4TheragenEtex Bio Institute, Republic of Korea, 5Gerotech Inc., Republic of Korea, 6Clinomics Inc., Republic of Korea, 7Yonsei University, Republic of Korea, 8Seoul National University Bundang Hospital, Republic of Korea
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Genomic analysis methods for identification of cancer driver pathways in childhood brain tumors
Lauren Sanders*1, Brittany Rose-Dey2, Holly Beale1, Jacob Pfeil1, Ellen Kephart1, Katrina Learned1, Ann Durbin1, Isabel Bjork1, Rob Currie1, Olena Morozova1, Sameer Agnihotri2, Sofie Salama1, David Haussler1
1UC Santa Cruz, USA, 2University of Pittsburgh, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Genomic complexity and evolution of Embryonal Tumors with Multilayered Rosettes (ETMR)
Sander Lambo1,2, Sebastian M. Waszak3, Tobias Rausch3, Susanne Groebner1,2, Christin Schmidt1,2, Sebastian Brabetz1,2, Stefan M. Pfister1,2, Andrey Korshunov2, Marcel Kool*1,2
1Hopp Children's Cancer center at the NCT Heidelberg (KiTZ), Germany, 2German Cancer Research Center (DKFZ), Germany, 3European Molecular Biology Laboratory, Genome Biology Unit, Germany
Sunday, July 1:  Embryonal Tumors  -  11:30am - 12:30pm
Germline microsatellite signature reliably differentiates children with medulloblastoma
Samuel Rivero-Hinojosa*1, Nicholas Kinney2, Harold Garner2, Brian Rood1
1Children's National Health System, USA, 2Edward Via College of Osteopathic Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Glial tumours in children and young adults: Isolated ATRX alterations, do they represent distinct subgroup?
Sridhar Epari*, Mamta Gurav, Vickky Pandit, Omshree Shetty, Vinayak Kadam, Ayushi Sahay, Girish Chinaswamy, JayantSastri Goda, Prakash Shetty, Aliasgar Moiyadi, Tejpal Gupta, Rakesh Jalali
Tata Memorial Centre, India
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Glioma oncogenesis in constitutionnal mismatch repair deficiency (CMMRD) syndrome: a clinico-pathological and molecular study in 15 patients
Jane Merlevede1,5, Felipe Andreiuolo2, Marie-Anne Debily4,5, Lea Guerrini-Rousseau1,5, Stephanie Picot5, Emilie Barret5, Noémie Lavoine1, David Castel1,5, Stephanie Puget3, Laurence Brugieres1,5, Pascale Varlet2, Jacques Grill*1,5
1Gustave Roussy, France, 2Sainte-Anne Hospital, France, 3Necker Hospital, France, 4Evry University, France, 5UMR 8203 CNRS, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
GMYC: A novel inducible transgenic model of Group 3 medulloblastoma
Holger Weishaupt*, Oliver Mainwaring, Sonja Hutter, Antonia Kalushkova, Helena Jernberg-Wiklund, Gabriela Rosén, Fredrik J. Swartling
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Sweden
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
H3 K27M-mutant gliomas in adults vs. children share similar histological features and adverse prognosis
Jean Mulcahy Levy*1,2, B.K. Kleinschmidt-DeMasters1
1University of Colorado Denver, USA, 2Morgan Adams Pediatric Brain Tumor Reserach Program, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
HDAC and NFκB antagonists synergistically inhibit growth of MYC-driven medulloblastoma
Viktoria Marquardt*1,2, Johanna Theruvath5, David Pauck1,3, Daniel Picard1,3, Nan Qin1,3, Lena Blümel1,3, Finn Hansen2,6, Jörg Felsberg4, Samuel Cheshier5, Guido Reifenberger1,4, Arndt Borkhardt1,3, Thomas Kurz2, Siddhartha Mitra5, Marc Remke1,3
1Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site University Hospital Düsseldorf, Germany, 2Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Germany, 3Departement of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany, 4Institute of Neuropathology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany, 5Departement of Neurosurgery, Institute for StemCell Biology and Regenerative Medicine and Division of Pediatric Neurosurgery, Lucile Packard Children's Hospital, Stanford University, USA, 6Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Leipzig University, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
HDAC inhibition in thalamic and spinal cord H3K27M+ diffuse midline glioma
Sara Kreimer*, Grant Lin, Pamelyn Woo, Michelle Monje-Deisseroth
Stanford University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Hearing chemoprotection with sodium thiosulfate (STS) in children, adolescents and young adults with standard risk medulloblastoma
Edward Neuwelt*1,2, Susan Lindemulder4, Kristin Knight5, Rochelle Fu6, Archie Bleyer7, Penelope Brock8
1Department of Neurology, Oregon Health & Science University, USA, 2Department of Neurosurgery, Oregon Health & Science University, USA, 3Portland Veterans Affairs Medical Center, USA, 4Doernbecher Children’s Hospital, Oregon Health & Science University, USA, 5Department of Pediatric Audiology, Oregon Health & Science University, USA, 6Oregon Health & Science University-Portland State School of Public Health, USA, 7Department of Radiation Medicine, Oregon Health & Science University, USA, 8Department of Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Hematopoietic stem cell-derived dendritic cells reprogram the brain tumor microenvironment
Tyler Wildes*, Catherine Flores, Bayli DiVita, Kyle Dyson, Adam Grippin, Duane Mitchell
University of Florida, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Hematopoietic stem cells potentiate efficacy of adoptive cell therapy against brain stem glioma
Catherine Flores*, Tyler Wildes, Ginger Moore, Brandon Wummer, Duane Mitchell
University of Florida, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Hepatotoxicity during Induction chemotherapy, with or without high-dose methotrexate (HD-MTX), on the Head Start II trial for primary central nervous system (CNS) tumors
Mohammad H. Abu Arja*1, Lubna S. Mehyar1, Diana S. Osorio1, Scott Coven1, Sharon Gardner2, Jonathan L. Finlay1
1The Division of Hematology, Oncology and BMT, Department of Pediatrics, Nationwide Children’s Hospital, The Ohio State University, USA, 2The Stephen D. Hassenfeld Children’s Center for Cancer & Blood Disorders, New York University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Heterogeneity within the PFB Ependymoma Subgroup
Florence Cavalli1, Jens-Martin Hübner2, Tanvi Sharma2, Martin Sill2, Betty Luu1, Michal Zapotocky1, Andrey Korshunov2, Stefan Pfister2, Kristian Pajtler2, Michael Taylor1, Kenneth Aldape3, Marcel Kool2, Vijay Ramaswamy*1
1Hospital for Sick Children, Canada, 2German Cancer Research Center, Germany, 3Princess Margaret Cancer Centre, Canada
Sunday, July 1:  Ependymoma  -  3:30pm - 5:00pm
High grade glioma cell line cohort as an example of children’s brain tumor tissue consortium tumor specimen processing pipeline
Mateusz Koptyra, Valerie Baubet, Lamiya Tauhid*, Namrata Choudhari, Tiffany Smith, Kristina Cole, Heba Ijaz, Angela Waanders, Adam Resnick
Children's Hospital of Philadelphia, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
High precision stereotactic conformal radiotherapy (SCRT) improves the long term functional outcome in children and adolescent patients of craniopharyngioma: data from a prospective randomized trial
Jayant Goda*1, Uday Krishna1, Debnarayan Dutta1, Sadhna Kannan1, Savita Goswami1, Nazia Bano1, Tejpal Gupta1, Nalini Shah2, Rajiv Sarin1, Rakesh Jalali1
1Tata Memorial Centre, India, 2King Edwards Medical college, India
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
High-dose thiotepa, carboplatin and etoposide with autologous hematopoietic stem-cell transplantation for patients with recurrent medulloblastoma  
Asmik Gevorgian*1, Polina Tolkunova1, Tatiana Iukhta1, Ilya Kazantsev1, Elena Morozova1, Tatiana Andreeva1, Andrew Kozlov1, Svetlana Safonova1, Yury Punanov1, Ludmila Zubarovskaya1, Olga Zheludkova2, Boris Afanasyev1
1Raisa Gorbacheva Memorial Institute of Pediatric Oncology, Hematology and Transplantation, Russia, 2Russian Scientific Center of Roentgenoradiology, Russia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Higher pseudoprogression rates after proton versus photon radiotherapy in pediatric patients with low-grade glioma
Ethan Ludmir*1, Anita Mahajan2,1, Arnold Paulino1,3, Jeremy Jones4,3, Leena Ketonen1, Joann Ater1,3, Jack Su3, David Grosshans1, Adekunle Adesina3, Robert Dauser3, Jeffrey Weinberg1, Murali Chintagumpala3
1The University of Texas MD Anderson Cancer Center, USA, 2Mayo Clinic, USA, 3Texas Children's Hospital, USA, 4Nationwide Children's Hospital, USA
Tuesday, July 3:  Radiation Oncology  -  8:00am - 9:00am
High-resolution analysis of the T-cell receptor repertoire after adoptive cellular therapy in pediatric patients with central PNETs (Re-MATCH trial)
Oleg Yegorov, Yanina Yegorova, Anjelika Dechkovskaia, Sridharan Gururangan, Duane Mitchell*
University of Florida Brain Tumor Immunotherapy Program, Preston A. Wells, Jr. Center for Brain Tumor Therapy & McKnight Brain Institute, Lillian S. Wells Department of Neurosurgery, University of Flo, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
High-throughput drug screening of primary cultures reveals irreversible ERBB2 inhibition as novel therapeutic vulnerability of ependymomas
David Pauck*1,2, Sevgi Sarikaya-Seiwert4,5, Viktoria Marquardt1,6, Daniel Picard1,2, Jasmin Bartl1,2, Lena Blümel1,2, Mara Maue1,2, Christian Dimitriadis1,2, Michaela Kuhlen2, Ute Fischer2, Hans-Jakob Steiger5, Guido Reifenberger3, Arndt Borkhardt2, Thomas Beez5, Marc Remke1,2
1Division of Pediatric Neuro-Oncogenomics, German Cancer Consortium and German Cancer Research Center, partner site Essen/Düsseldorf, Germany, 2Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany, 3Institute of Neuropathology, Heinrich Heine University Düsseldorf, Germany, 4Department of Neurosurgery, University of Bonn Medical Center, Germany, 5Department of Neurosurgery, Heinrich Heine University Düsseldorf, Germany, 6Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Germany
Sunday, July 1:  Ependymoma  -  3:30pm - 5:00pm
Histological diagnoses of bifocal, DI-negative, and tumor marker-negative tumors; and outcome after non-CSI strategy for cytology-positive germinomas in Japan.  Homework after Delphi consensus.
Ryo Nishikawa*1, Masayuki Kanamori2
1Saitama Medical University International Medical Center, Japan, 2Tohoku University, Japan
Sunday, July 1:  Germ Cell Tumors  -  1:30pm - 2:30pm
Histone Deacetylase Inhibitor Panobinostat synergizes with dual mTOR inhibitor TAK228 to potentiate killing of DIPG cells
Smit Shah*1,2, Jeffrey Rubens1, Charles Eberhart1, Eric Raabe1
1Johns Hopkins University School of Medicine, USA, 2Rutgers Robert Wood Johnson Medical School, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Histone H3 lysine 4 trimethylation is a potential target to improve chemotherapeutic efficacy for pediatric primary ependymomas
Guifa XI*1,2, Yuping Li1, Lindsey Hoffman3, Rintaro Hashizume2, Rebecca Lewis1, Gordan Gravohac4, Nitin Wadhwani1, Gavin Rice1, Chunfa Jie5, Benjamin Best1, Amanda Saratisis1,2, Tord Alden1, Robin Bowman1,2, Arthur DiPatri1,2, Barbara Mania-Farnell7, Marcelo Soares6, Charles James2, Nick Foreman3, Tadanori Tomita1,2
1Ann & Robert H. Lurie Children’s Hospital of Chicago, USA, 2Northwestern University Feinberg School of Medicine, USA, 3University of Colorado Denver, USA, 4King’s College Hospital, UK, 5Des Moines University, USA, 6University of Illinois College of Medicine at Peoria, USA, 7Purdue University Northwest, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
HMGA2 is a prognostic factor to induce malignant phenotype in medulloblastoma
Yoshiki Arakawa*, Bin Liu, Yukinori Terada, Yasuzumi Matsui, Etsuko Hattori, Sosuke Sumiyoshi, Nobuyuki Fukui, Masahiro Tanji, Yohei Mineharu, Susumu Miyamoto
Kyoto University, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Home physical activity intervention to improve cognitive late effects in children treated with radiation for brain tumors: descriptive feasibility data from a pilot randomized controlled trial (RCT)
Pamela Wolters*1, Cristina Abel1, Staci Martin1, Kevin Smith2, Mary Anne Toledo-Tamula3, Marie Claire Roderick1, Bart Drinkard2, Kong Chen4, Arthur Kramer5, Adrian Schembri6, Joan Han7, John Glod1, Katherine Warren1
1Pediatric Oncology Branch, National Cancer Institute, USA, 2Clinical Center, National Institutes of Health, USA, 3Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research Inc., NCI Campus at Frederick, USA, 4National Institute of Diabetes and Digestive and Kidney Diseases, USA, 5Northeastern University, USA, 6Cogstate Inc., Australia, 7Department of Pediatrics, University of Tennessee Health Science Center and Children's Foundation Research Institute, Le Bonheur Children's Hospital, USA
Sunday, July 1:  Quality of Life/Survival/Rehabilitation  -  1:30pm - 3:00pm
Hypermutant pediatric high grade gliomas are driven by RAS/MAPK mutations and respond to MEK inhibition
Brittany B Campbell*1, Daniel A Morgenstern1, Tatiana Lipman1, David Fabrizio2, Adam Shlien1, Eric Bouffet1, Cynthia Hawkins1, Uri Tabori1
1The Hospital for Sick Children, Canada, 2Foundation Medicine, USA
Monday, July 2:  Early Phase Trials  -  9:30am - 10:30am
Hypoxia-inducible factors regulate diffuse intrinsic pontine glioma growth in normoxic culture
Christopher Waker*1,2, Chanel Keoni1,2, Brianna Schurko1,2, Thomas Brown1, Robert Lober1,2
1Wright State University, USA, 2Dayton Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
ID1 expression correlates with H3F3A K27M mutation and extra-pontine invasion in DIPG
Stefanie Stallard1, Robert Siddaway4, Zachary Miklja1, Brendan Mullan1, Taylor Garcia1, Daniel Zamler2, Katayoon Kasaian1, Xuhong Cao1, Bailey Anderson1, Shawn Hervey-Jumper3, Maria G. Castro1, Pedro R. Lowenstein1, Rajen Mody1, Arul Chinnaiyan1, Sriram Venneti1, Cynthia Hawkins4, Carl Koschmann*1
1Michigan Medicine, USA, 2MD Anderson Cancer Center, USA, 3UCSF, USA, 4Hospital for Sick Children, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Identification and investigation of a novel epigenetic modulator in posterior fossa ependymoma, SIRT2
Davis Witt*1,2, Andrea Griesinger1,2, Jessica Hansen1, Sujatha Venkataraman1,2, Ilango Balakrishnan1,2, Angela Pierce1,2, Irina Alimova1,2, Andrew Donson1,2, Vladimir Amani1,2, Rajeev Vibhakar1,2, Nicholas Foreman1,2
1Children's Hospital Colorado, USA, 2University of Colorado Anschutz Medical Campus, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Identification of a therapeutic time window that improves vision in an NF1-deficient optic pathway glioma mouse model
Miriam Bornhorst*1, Emma Jecrois1, Daphine Kwesiga Mugayo2, Wang Zheng1, Steven Stasheff1, Patrick Mateas1, Austin Friend1, Yuan Zhu1
1Children's National Medical Center, USA, 2University of Maryland Medical School, USA
Tuesday, July 3:  Neurofibromatosis  -  8:00am - 9:00am
Identification of BIRC5 as a novel therapeutic target for Diffuse Intrinsic Pontine Glioma
Meng Li1, Jiajia Wang1, Yi Sui1, Tiantian Li1, Fang Liu1, Lei Zhang1, Wenyan Jiang1, Jie Ma1, Michelle Monje2, Yujie Tang*1
1Shanghai Jiao Tong University School of Medicine, China, 2Stanford University School of Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Identification of circulating miRNAs in DIPG patients as predictors of response to targeted therapy and as classifiers of clinical outcome
Loris De Cecco1, Federica Maria Ianno’1, Silvana Canevari1, Elisabetta Schiavello2, Andrea Anichini3, Veronica Biassoni2, Lorenza Gandola4, Maura Massimino*2
1Department of Applied Research and Technology Development , Fondazione IRCCS Istituto Nazionale Tumori, Italy, 2Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Italy, 3Human Tumors Immunobiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy, 4Radiology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Identification of genes functionally involved in the detrimental effects of mutant histone K27M-H3.3 using Drosophila melanogaster
Johannes Berlandi1, Amel Chaouch2, Isabel Tegeder1, Katharina Thiel1, Claudia L. Kleinman3,4, Margret Shirinian5, Nicolas De Jay3,4, Astrid Jeibmann1, Paul Lasko2, Nada Jabado6, Martin Hasselblatt*1
1Institute of Neuropathology, University Hospital Münster, Germany, 2Dept. of Biology, McGill University, Canada, 3Dept. of Human Genetics, McGill University, Canada, 4The Lady Davis Institute, Jewish General Hospital, Canada, 5Dept. of Experimental Pathology, Immunology, and Microbiology Faculty of Medicine, American University of Beirut,, Lebanon, 6Dept. of Paediatrics, McGill University and the McGill University Health Center Research Institute, Canada
Monday, July 2:  DIPG/Diffuse Midline Glioma  -  1:30pm - 3:00pm
Identification of SETD2 mutation in an aggressive pilocytic astrocytoma presenting as an inflammatory optic nerve lesion
Robyn Gartrell*1, Lenore Omesi1, Andrew Silverman1, Ashley Campbell2, Neil Feldstein1, Yvonne Saenger1, Mahesh Mansukhani1, George Zanazzi1, Peter Canoll1, Michael Kazim1, James Garvin1
1Columbia University, USA, 2Johns Hopkins Wilmer Eye Institute, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Identification of two protein-signaling states delineating transcriptionally heterogeneous human medulloblastoma
Walderik Zomerman1, Sabine Plasschaert*2, Siobhan Conroy1, Frank Scherpen1, Tiny Meeuwsen-de Boer1, Harm-Jan Lourens1, Sergi Guerrero Llobet1, Marlinde Smit1, Lorian Slagter-Menkema1, Annika Seitz1, Corrie Gidding3, Esther Hulleman4, Pieter Wesseling4,2, Lisethe Meijer1, Leon van Kempen1,5, Anke van den Berg1, Daniel Warmerdam1, Frank Kruyt1, Floris Foijer1, Marcel van Vugt1, Wilfred den Dunnen1, Eelco Hoving2, Victor Guryev1, Eveline de Bont1, Sophia Bruggeman1
1University Medical Center Groningen, The Netherlands, 2Princess Maxima Center for Pediatric Oncology, The Netherlands, 3Radboud University Medical Center, The Netherlands, 4VU University Medical Center, The Netherlands, 5McGill University, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Identifying and accelerating potential new drug therapies for pediatric atypical teratoid rhabdoid tumors (ATRTs) through drug repurposing
Nicole Wood*1, Kevin Ginn1, Anuradha Roy2, Coral Huntley2, Scott Weir2, Prabhu Ramamoorthy3, Shrikant Anant3
1Children's Mercy Kansas City, USA, 2University of Kansas Cancer Center, USA, 3University of Kansas Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Identifying the most frequent variants in pediatric medulloblastoma driver genes: A single institution study
Bruna Mascaro-Cordeiro1,2, Indhira Oliveira1, Leonardo Santos2, Renan Martin3, Rafael Silva3, Maria Teresa Alves1,4, Nasjla Saba-Silva1, Patricia Dastoli1, Sergio Cavalheiro*1,4, Silvia Toledo1,2
1Pediatric Oncology Institute/GRAACC, Department of Pediatrics, Federal University of São Paulo, Brazil, 2Department of Morphology and Genetics, Division of Genetics, Federal University of São Paulo, Brazil, 3Department of Biophysics, Federal University of Sao Paulo, Brazil, 4Department of Pathology, Federal University of Sao Paulo, Brazil, 5Departament of Neurology, Federal University of Sao Paulo., Brazil
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Imaging and immunohistochemical characteristics of H3 G34R-mutant gliomas -a report of two cases
Shumpei Onishi*1,2, Vega Karlowee1, Yoshiko Nakano3, Manish Kolakshyapati1, Takeshi Takayasu1, Motoki Takano1, Vishwa Jeet Amatya4, Yukio Takeshima4, Koichi Ichimura3, Kazuhiko Sugiyama5, Kaoru Kurisu1, Fumiyuki Yamasaki1
1Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan, 2Department of Neurosurgery, Higashihiroshima Medical Center, Japan, 3Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Japan, 4Department of Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan, 5Department of Clinical Oncology and Neuro-oncology Program, Hiroshima University Hospital, Japan
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Imaging characteristics of BRAF V600E mutated pediatric brain tumors
Nicholas Stence*1,2, Jean Mulcahy-Levy1,2, Lindsey Hoffman1,2, Adam Green1,2, David Mirsky1,2, Ilana Neuberger1,2, Laura Fenton1,2, John Maloney1,2, Bette Kleinschmidt-DeMasters1,2, Rajeev Vibhakar1,2, Nicholas Foreman1,2, Kathleen Dorris1,2
1University of Colorado School of Medicine, USA, 2Children's Hospital Colorado, USA
Sunday, July 1:  Imaging  -  4:00pm - 5:00pm
Immune checkpoint inhibition for pediatric hypermutant glioblastoma multiforme resulting from Lynch Syndrome
Sarah Supples, Daniel Couture, Christopher Whitlow, Katharine Pearsall, Michael Chan, David Kram*
Wake Forest Baptist Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Immune response generated with the use of autologous dendritic cells pulsed with an allogenic tumoral cell lines lysate in patients with newly diagnosed DIPG
Andres Morales La Madrid*1, Daniel Benitez-Ribas2, Raquel Cabezón2, Georgina Flórez2, Mari Carmen Molero1, Patricia Puerta1, Antonio Guillen1, Sonia Paco1, Angel M. Carcaboso1, Vicente Santa-Maria Lopez1, Ofelia Cruz1, Carmen De Torres1, Noelia Salvador1, Manel Juan1,2, Jaume Mora1
1Hospital Sant Joan de Deu, Spain, 2Hospital Clinic, IDIBAPS, Spain
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Immunogenic cell death during maintenance chemotherapy and subsequent multimodal immunotherapy for GBM
Stefaan Van Gool*, Jennifer Makalowski, Volker Schirrmacher, Wilfried Stuecker
IOZK, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Immunotherapeutic nanotechnology targeting IDO1 for pediatric diffuse intrinsic pontine glioma
Alicia Lenzen*1,2, Lisa Cole2, Kristen L. Lauing2, Lijie Zhai2, Erik Ladomersky2, Rishi R. Lulla1, Rintaro Hashizume2, Alexander Stegh2, Derek A. Wainwright2
1Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 2Northwestern University Feinberg School of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Impact of a central nervous system (CNS) tumor patient and family event.
Meghan Belongia*1, Suzanne Novak2, Jeffrey Knipstein1
1Department of Pediatrics, Medical College of Wisconsin, USA, 2Children's Hospital of Wisconsin, USA
Saturday, June 30:  Nursing Symposium  - 
Impact of a Latin America-Wide teleconferenced brain tumor board
Diana S. Osorio*1, Alvaro Lassaletta2, Andres E. Morales la Madrid3, Joseph Stanek1, Ute Bartels4, Ibrahim Qaddoumi5, Jonathan L. Finlay1
1Nationwide Children's Hospital and The Ohio State University, USA, 2Hospital Infantil Universitario Niño Jesús, Spain, 3Hospital Sant Joan de Déu, Spain, 4Hospital for Sick Children, Canada, 5St. Jude Children's Research Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Impact of BRAFv600e mutation 7q34 duplication and CDKN2A deletion in a monocentric cohort of 86 pediatric low grade gliomas (PLGG)
Benoit Lhermitte, Eric Guerin, Michelle Legrain, Marc Arca, Marie Coutant, Consuelo Sebastia, Valérie Douzal, Flaviu Gabor, Natacha Entz-Werlé*
University Hospital of Strasbourg, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Impact of integrating palliative care into a Neuro-Oncology Clinic
Lauren Hancock, Deborah Lafond*
Children's National Health System, USA
Saturday, June 30:  Nursing Symposium  - 
Impact of molecular subgroup on surgical management of medulloblastoma
Andrea Carai*1, Alessandra Marongiu2, Andrea Trezza1, Alessandro De Benedictis1, Silvia Cossu1, Franco Randi1, Evelina Miele5, Antonella Cacchione5, Giovanna Stefania Colafati3, Francesca Diomedi Camassei4, Angela Mastronuzzi5, Carlo Efisio Marras1
1Neurosurgery Unit, Neurosciences and Neurorehabilitation Department, Bambino Gesù Children's Hospital, Italy, 2Neurosurgery Unit, NESMOS Department, Sant'Andrea Hospital, Sapienza University of Rome, Italy, 3Neuroradiology Unit, Imaging Department, Bambino Gesù Children's Hospital, Italy, 4Pathology Department, Bambino Gesù Children's Hospital, Italy, 5Neuro-oncology Unit, Onco-Hemathology and Cell Therapy Department, Bambino Gesù Children's Hospital, Italy
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
Impact of molecular subtypes on treatment outcomes in rhabdoid tumors - A report from the Rare Tumor Consortium
Ben Ho1, Adriana Fonseca*1, Salma Al-Karmi1, Ashley Margol2, Fupan Yao1, Sylvia Cheng8, Ronald Grant1, Jordan Handsford7, Abha Gupta1, Alexandre Vasiljevic4, Bruce Pawel3, Nada Jabado5, Cynthia Hawkins1, Lucie Lafay-Cousin6, Alexander Judkins2, Eric Bouffet1, Annie Huang1
1The Hospital for Sick Children, Canada, 2Children's Hospital of Los Angeles, USA, 3Childrens Hospital of Philadelphia, USA, 4Groupement Hospitalier Est, CHU de Lyon, France, 5McGill University, Canada, 6Alberta Children's Hospital, Canada, 7Royal Children's Hospital, Australia, 8BC Children's Hospital, Canada
Monday, July 2:  ATRT  -  11:00am - 12:30pm
Impact of radiation dose on physical and emotional outcomes in pediatric brain tumor
John Bobo*1, Kaitlin Oswald1, Betty Herrington1, Maru Barrera2, Andrea Patenaude3, Mary Kupst4, Cynthia Gerhardt5, Kathryn Vannatta5, Cynthia Karlson1
1Department of Pediatrics, University of Mississippi Medical Center, USA, 2Psychology, The Hospital for Sick Children, Canada, 3Psychiatry, Dana-Farber Cancer Institute – Harvard Medical School, USA, 4Psychology, Medical College of Wisconsin, USA, 5Psychology/Neuropsychology, The Research Institute at Nationwide Children’s Hospital and The Ohio State University College of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Impact of radiotherapy modality on neuropsychological outcomes of pediatric brain tumor patients
Jeffrey Gross*1, Stephanie Powell1,2, Frank Zelko1,2, William Hartsell1,2, Stewart Goldman1,2, Jason Fangusaro1,2, Rishi Lulla1,2, Natasha Pillay-Smiley1,2, John Chang1,2, Vinai Gondi1,3
1Northwestern University Feinberg School of Medicine, USA, 2Ann and Robert H. Lurie Children's Hospital, USA, 3Northwestern Medicine Chicago Proton Center, USA
Tuesday, July 3:  Radiation Oncology  -  8:00am - 9:00am
Implementation of methylation profiling for CNS tumor diagnosis in the Princess Máxima Center for Pediatric Oncology, The Netherlands
Pieter Wesseling*1,2, Loudy Priesterbach-Ackley3, Sabine Plasschaert4, Eelco Hoving5, Benno Küsters6, Mirthe Schoots7, Eleonora Aronica8, Bas Tops1, Wendy de Leng3
1Dept. of Pathology, Princess Máxima Center for Pediatric Oncology, The Netherlands, 2Dept. of Pathology, VU Univ. Med. Ctr., The Netherlands, 3Dept. of Pathology, Univ. Med. Ctr. Utrecht, The Netherlands, 4Dept. of Pediatric Oncology, Princess Máxima Center, The Netherlands, 5Dept. of Neurosurgery, Univ. Med. Ctr. Utrecht, The Netherlands, 6Dept. of Pathology, Radboud Univ. Med. Ctr., The Netherlands, 7Dept. of Pathology, Univ. Med. Ctr. Groningen, The Netherlands, 8Dept. of (Neuro)Pathology, Academic Medical Center, The Netherlands
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Importance of surgical intervention in recovery of visual function in a teenager with an acidophilic stem cell adenoma
Courtney Johnson*1, John Jane, JR3, Priya Vaidyanathan1, Young Kwok2, Steven Stasheff1, Roger Packer1, Eugene Hwang1
1Children's National Medical Center, USA, 2University of Maryland School of Medicine, USA, 3University of Virginia Health System, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Improved diagnostic algorithm for differential diagnostics of CNS embryonal tumors (former CNS-PNET) by neuropathological re-evaluation of 256 cases and crossvalidation by methylation classification
Torsten Pietsch*1, Dominique Figarella-Branger2, Felice Giangaspero3, Marco Gessi4, Cynthia Hawkins5, Thomas Jacques6, Andrey Korshunov7, Charles Eberhart8, Peter Burger8, Katja von Hoff9, Marcel Kool10, Christine Haberler11, for the International CNS-PNET Working Group1
1University of Bonn, Germany, 2Aix Marseille Université, France, 3Sapienza University of Rome, Italy, 4Catholic University of Rome, Italy, 5The Hospital for Sick Children, Canada, 6University of London, UK, 7University of Heidelberg, Germany, 8Johns Hopkins University, USA, 9University Clinics Berlin Charite, Germany, 10DKFZ, Germany, 11University of Vienna, Austria
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Improved endocrine outcome with conservative surgery and early adjuvant radiation strategy in childhood craniopharyngioma: a review by treatment decade in a single centre
Chiara Guzzetti*1, Laura Losa1, Richard Hayward2, Kristian Aquilina3, Yen-Ching Chang4, Helen A. Spoudeas1
1Department of Paediatric Neuro Endocrinology, Great Ormond Street Hospital, UK, 2Neurosurgery Department, Great Ormond Street Hospital, UK, 3Neuroradiology Department, Great Ormond Street Hospital, UK, 4Oncology Department, Great Ormond Street Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Improvement in visual acuity of pediatric patients with brain tumors with bevacizumab
Matthew McEvoy1, Molly Hemenway1,2, Jennifer Raybin1,2, Adam Green1,2, Anandani Nellan1,2, Jean Mulcahy Levy1,2, Rajeev Vibhakar1,2, Nicholas Foreman1,2, Emily McCourt1, Kathleen Dorris*1,2
1Children's Hospital Colorado, USA, 2Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
In vitro evaluation of the potential of glucose restriction as an adjuvant therapy for paediatric brain tumours
George Lockwood, Janhavi Apte, Delyan Ivanov, Rebecca Parr, David A Walker, Lisa CD Storer*, Richard G Grundy
University of Nottingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
In vitro modeling of tumor dissemination from hypoxic primary derived cell lines (PDCL) spheroids recapitulated tumor development and progression in patients
Anne Florence Blandin1, Aurelie Durand1, Eric Guerin2, Isabelle Lelong-Rebel1, Monique Dontenwill1, Natacha Entz-Werle*1,2
1UMR CNRS 7021, France, 2University Hospital of Strasbourg, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
In vitro modelling of tumour evolution and radiotherapy resistance in medulloblastoma
Stacey Richardson*, Rebecca Hill, Matthew Selby, Janet Lindsey, Gholamreza Rafiee, Simon Bailey, Daniel Williamson, Steve Clifford
Northern Institute for Cancer Research, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
In vivo metabolomics reveals a potent combination therapy for MYC-driven medulloblastoma
Allison Hanaford*, Brad Poore, Jesse Alt, Barbara Slusher, Charles Eberhart, Eric Raabe
Johns Hopkins School of Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Incidence and risk factors of posterior fossa syndrome in children with posterior fossa tumors
Mariko Sato*, Demi Eble, Tomoaki Sasaki, Bridget Zimmerman, Arnold Menezes, Jeremy Greenlee, Saul Wilson, Brian Dlouhy, Satsuki Matsumoto, Aaron Boes, Sue O'Dorisio
University of Iowa, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Incidence of cavernomatous lesions on brain MR of pediatric patients treated with intraventricular radioimmunotherapy
Kim Kramer*, Suzanne Wolden, Maria Donzelli, Sofia Haque
Memorial Sloan Kettering Cancer Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Increased toxicity of conventional dose chemotherapy utilizing body surface area for dosing in infants and young children enrolled on the "Head Start" 4 clinical trial
Girish Dhall*1, Ziad Khatib3, Ossama Maher3, Megan Jaeger2, Myeshia Harmon2, Kelley Haley2, Teresa Rushing1, Jonathan Finlay2
1Children's Hospital Los Angeles, USA, 2Nationwide Children's Hospital, USA, 3Nicklaus Children's Hospital, USA
Monday, July 2:  Drug Delivery
Individualized therapy of an anaplastic ependymoma pediatric patient with a Notch1 germline mutation
Alexandra Russo*1, Claudia Paret1, Nadine Lehmann1, Hannah Bender1, Arthur Wingerter1, Marie Astrid Neu1, Francesca Alt1, Nora Backes1, Lea Roth1, Larissa Seidmann2, Jörg Faber1
1Children's Hospital, Germany, 2Pathology, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Infant gliomas comprise multiple biological and clinicopathological subgroups
Matthew T Clarke*1, David TW Jones2, Alan Mackay1, Diana Carvalho1, Elisa Izquierdo1, Lotte Hiddingh2, Sara Temelso1, Anna Burford1, Valeria Molinari1, Jessica KR Boult1, Alex Virasami3, Fernando Carceller4,1, Lynley V Marshall4,1, Bassel Zebian5, Chris Chandler5, Safa Al-Sarraj5, Stephen Lowis6, Jeffrey Knipstein7, Simon Bailey8, Stephen Crosier8, Angela Mastronuzzi9, Andrea Carai9, David W Ellison10, Suzanne J Baker10, David Capper13, Mellissa Maybury11, Andrew S Moore11, Maria Vinci9, Darren Hargrave3, Sergey Popov12, Thomas S Jacques3, Chris Jones1
1The Institute of Cancer Research, UK, 2German Cancer Research Center (DKFZ), Germany, 3UCL Great Ormond Street Institute of Child Health, UK, 4The Royal Marsden NHS Foundation Trust, UK, 5King's College Hospital NHS Foundation Trust, UK, 6University Hospitals Bristol NHS Foundation Trust, UK, 7Children's Hospital of Wisconsin, USA, 8Newcastle upon Tyne Hospitals NHS Foundation Trust, UK, 9Ospedale Pediatrico Bambino Gesù, Italy, 10St. Jude Children's Research Hospital, USA, 11University of Queensland, Australia, 12University Hospital of Wales, UK, 13Charité Berlin, Germany
Monday, July 2:  High Grade Glioma  -  3:30pm - 5:00pm
Inhibition of AXL sensitizes diffuse intrinsic pontine glioma to cytotoxic therapies
Michaël Meel*1, Mark de Gooijer2, Kenn Zwaan1, Piotr Waranecki1, Marjolein Breur1, Levi Buil2, Tonny Lagerweij1, Laurine Wedekind1, Jos Twisk1, Jan Koster3, Rintaro Hashizume4, Eric Raabe5, Ángel Montero Carcaboso6, Marianna Bugiani1, Olaf van Tellingen2, Dannis van Vuurden1,7, Gertjan Kaspers1,7, Esther Hulleman1,7
1VU University Medical Center, The Netherlands, 2The Netherlands Cancer Institute, The Netherlands, 3University of Amsterdam Academic Medical Center, The Netherlands, 4Northwestern University Feinberg School of Medicine, USA, 5Johns Hopkins University School of Medicine, USA, 6Hospital Sant Joan de Déu, Spain, 7Princess Máxima Center for Pediatric Oncology, The Netherlands
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Inhibition of mTORC1 through amino acid transporter CD98/LAT1 maintains the stemness of glioma stem cell
Yipeng Han1,2, Atsushi Enomoto2, Masahide Takahashi2, Jie Ma*1
1Department of Pediatric Neurosurgery, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, China, 2Department of Pathology, Nagoya University Graduate School of Medicine, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Initial management strategy as a discriminator of visual outcome in children presenting with neurofibromatosis type 1 and optic pathway glioma - results from a Société Internationale d'Oncologie Pédiatrique Europe (SIOPE) clinical trials workshop
Amedeo A. Azizi*1, David A. Walker2, Jo-Fen Liu2, Astrid Sehested3, Timothy Jaspan4, Ian Simmons5, Rosalie Ferner6, Jacques Grill7, Darren Hargrave8, Pablo Hernaiz-Driever9, D. Gareth Evans10, Enrico Opocher11
1Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna, Austria, 2Children’s Brain Tumour Research Centre, University of Nottingham, UK, 3Department of Pediatrics, Copenhagen University Hospital, Denmark, 4Department of Radiology, Nottingham University Hospitals NHS Trust, UK, 5Departments of Ophthalmology and Paediatric Oncology, Leeds Teaching Hospitals NHS Trust, UK, 6Department of Neurology Guy's and St. Thomas' NHS Foundation Trust and IoPPN, King’s College London, UK, 7Institut de Cancérologie Gustave Roussy, France, 8Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, UK, 9Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany, 10Centre for Genomic Medicine, Division of Evolution and Genomic Sciences, University of Manchester, St Mary's Hospital, UK, 11Department of Pediatrics, University of Padua, UK, 12on behalf of the SIOPE NF1 OPG Nottingham, UK, Workshop 2014, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Institutional experience of pediatric patients with atypical teratoid rhabdoid tumors treated at Phoenix Children's Hospital from 2000-2017
Elizabeth Eden*, Nicole Mis, Lisa Keller, Cynthia Wetmore
Phoenix Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Integrated Diffuse Intrinsic Pontine Glioma (DIPG) next-generation sequencing reveals epigenetic dysregulation of gene expression and bromodomain inhibition as a novel therapeutic target
Amanda Saratsis*1,2, Andrea Piunti3, Tina Huang2, Elizaeth Bartom3, Patrick Ozark3, Stacy Marshall3, Jin Qi2, Rintaro Hashizume2,3, Rishi Lulla4,5, C. David James2, Ali Shilatifard3
1Division of Pediatric Neurosurgery, Ann & Roert H. Lurie Children's Hospital of Chicago, USA, 2Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, USA, 3Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, USA, 4Department of Hematology, Oncology, Neuro-Oncology & Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 5Department of Pediatrics, Northwestern University Feinberg School of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Integrated reporting for pediatric neuro-oncology: the CHLA experience
Jennifer A. Cotter, Joanna C. Green, Matthew C. Hiemenz, Jianling Ji, Jaclyn A. Biegel, Alexander R. Judkins*
Children's Hospital Los Angeles, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Integration of genetic counseling into multidisciplinary brain tumor clinic improves identification and counseling for cancer predisposition syndromes
Shannon M Stasi*1, Bonnie Lynn Cole1,2, Christina M Lockwood2, Sarah ES Leary1
1Seattle Children's Hospital, USA, 2University of Washington, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Integration of genomic data from the OncoKidsSM next generation sequencing panel and chromosomal microarray analysis for diagnosis and prognosis of pediatric CNS tumors
Kristiyana Kaneva*, Matthew Hiemenz, Jianling Ji, Nathan Robison, Ashley Margol, Girish Dhall, Jennifer Cotter, Debra Hawes, Alexander Judkins, Jaclyn A. Biegel
Children's Hospital Los Angeles, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Integrative analyses of MRI parameters, metabolomics and hypoxic biomarkers are showing predictive correlation with patient characteristics and outcome
Natacha Entz-Werle*, Agathe Chammas, Elisa Ruhland, Consuelo Sebastia, Flaviu Gabor, Aurelie Durand, Eric Guerin, Stephane Kremer, Izzie Jacques Namer, Monique Dontenwill
University Hospital of Strasbourg, France
Monday, July 2:  High Grade Glioma  -  3:30pm - 5:00pm
Interference with the function of MYC in Group 3 Medulloblastoma
Jonas Ecker*1,2, Venu Thatikonda3, Ina Oehme1, Gintvile Valinciute1, Florian Selt1,2, Juliane L. Buhl1, Diren Usta1, Cornelis M. van Tilburg2, Christel Herold-Mende4, Martina Schnölzer5, Uwe Warnken5, Marcel Kool3, Natalie Jäger3, Stefan M. Pfister2,3, Olaf Witt1,2, Till Milde1,2
1Clinical Cooperation Unit Pediatric Oncology, Pre-Clinical Program, Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Germany, 2KiTZ Clinical Trial Unit (ZIPO), Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 3Division of Pediatric Neurooncology, Pre-Clinical Program, Hopp Children’s Cancer Center at the NCT (KiTZ), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Germany, 4Department of Neurosurgery, Heidelberg University Hospital, Germany, 5Functional Proteome Analysis (B100), German Cancer Research Center (DKFZ), Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Interfering with medulloblastoma metabolism to improve current therapeutic avenues
Haydn S Munford*1,2, Daniel A Tennant2, Andrew C Peet1,3
1Cancer and Genomic Sciences, University of Birmingham, UK, 2Metabolism and Systems Research, University of Birmingham, UK, 3Birmingham Children's Hospital NHS Foundations Trust, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Inter-rater reliability of a method for determining the pre-operative hypothalamic involvement of pediatric craniopharyngioma
Ros Whelan*1, Eric Prince1,2, David Mirsky2, Robert Naftel3, Aashim Bhatia3, Benedetta Pettorini4, Shivram Avula4, Susan Staulcup2, Matthew Cox-Martin5, Todd Hankinson1,2
1University of Colorado Hospital, USA, 2Children's Hospital Colorado, USA, 3Vanderbilt University Medical Center, USA, 4Alder Hey Children's Hospital, UK, 5Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS) University of Colorado School of Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Intersection of epigenetics and immunity in DIPG
Allison Martin*1, Robert Bell2, Charles Eberhart1, Eric Raabe1, Michael Koldobskiy1
1Johns Hopkins University School of Medicine, USA, 2University of Minnesota Medical School, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Intra- and extra-cranial malignant rhabdoid tumours share common location-independent clinical and molecular disease characteristics
Yura Grabovska*1, Martina Finetti1, Matthew P Selby1, Edward C Schwalbe2, Amanda Smith1, Stephen Crosier1, Jessica C Pickles3,4, Amy R Fairchild3,4, Aimee Avery4, Patricia O'Hare5, Barry Pizer6, Bernadette Brennan7, Darren Hargrave3,5, John Anderson3, Thomas S Jacques3,4, Simon Bailey1, Steven C Clifford1, Daniel Williamson1
1Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, UK, 2Department of Applied Sciences, Northumbria University, UK, 3Developmental Biology and Cancer Programme, University College London Great Ormond Street Institute of Child Health, UK, 4Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, UK, 5Department of Paediatric Oncology, Great Ormond Street Hospital NHS Trust, UK, 6Institute of Translational Medicine, University of Liverpool, UK, 7Royal Manchester Children’s Hospital and University of Manchester, UK, 8Royal Hospital for Children and Bristol Medical School, University of Bristol, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Intracranial extra-skeletal mesenchymal chondrosarcoma:   Case report and meta-analysis of reported cases in adults and children
Saman Shabani*1,2, Ha Son Nguyen1,2, Jeffrey Knipstein1,2, Sean Lew1,2, Bruce Kaufman1,2, Michael Lawlor1,2, Andrew Foy1,2
1Medical College of Wisconsin, USA, 2Children Hospital of Wisconsin, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Intracranial growing teratoma syndrome (IGTS): An international retrospective study
George Michaiel*1, Douglas Strother1, Nicholas Gottardo2, Ute Bartels3, Hallie Coltin4, David D. Eisenstat5, Juliette Hukin6, Donna L. Johnston4, Beverly Wilson5, Shayna Zelcer7, Jordan R. Hansford8, Olivia Wells9, Mohamed S. AbdelBaki10, Mohammad H. Abu-Arja10, Kristina A. Cole11, Girish Dhall12, Paul G. Fisher13, Lindsey Hoffman14, Sarah E.S. Leary15, Emily E. Owens Pickle16, Natasha P. Smiley17, Amy Smith16, Anna Vinitsky18, Nicholas A. Vitanza15, Avery Wright13, Kee K. Yeo12, Lionel M.L. Chow19, Maria Kirby20, Santosh Valvi2, Magimairajan I. Vanan21, Grace Wong22, David Ziegler22, Eric Bouffet3, Lucie Lafay-Cousin1
1Alberta Children's Hospital, Canada, 2Princess Margaret Hospital for Children, Australia, 3The Hospital for Sick Children, Canada, 4Children's Hospital of Eastern Ontario, Canada, 5Stollery Children's Hospital, Canada, 6British Columbia Children's Hospital, Canada, 7London Health Sciences Centre, Canada, 8Royal Children’s Hospital, Murdoch Children's Research Institute, Australia, 9Royal Children’s Hospital, Australia, 10Nationwide Children's Hospital, USA, 11Children's Hospital of Philadelphia, USA, 12Children's Hospital Los Angeles, USA, 13Lucile Packard Children's Hospital Stanford, USA, 14Children's Hospital Colorado, USA, 15Seattle Children’s Hospital, USA, 16Arnold Palmer Hospital for Children, USA, 17Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 18St. Jude Children's Research Hospital, USA, 19Cincinnati Children's Hospital Medical Center, USA, 20Adelaide Women's and Children's Hospital, Australia, 21The Children's Hospital of Winnipeg, Canada, 22Sydney Children's Hospital, Australia
Sunday, July 1:  Germ Cell Tumors  -  1:30pm - 2:30pm
Intratumoral pharmacokinetics of chemotherapy in DIPG: xenograft and initial phase 0 clinical trial results
Adam Green*1,2, Patrick Flannery1, Todd Hankinson1,2, Brent O'Neill1,2, John DeSisto1, Rakeb Lemma1, Lindsey Hoffman1,2, Jean Mulcahy Levy1,2, Jennifer Raybin1,2, Molly Hemenway1,2, Carl Koschmann4, Michael Handler1,2, Nicholas Foreman1,2, Rajeev Vibhakar1,2, Michael Wempe3, Kathleen Dorris1,2
1Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, USA, 2Children's Hospital Colorado, USA, 3University of Colorado School of Pharmacy and Pharmaceutical Sciences, USA, 4University of Michigan, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Intraventricular therapy alternating etoposide, aqueous cytarabine and topotecan is feasible and safe: Experience in 26 pediatric patients with malignant brain tumors
Andreas Peyrl*1, Amedeo Azizi1, Johannes Gojo1, Dominik Reisinger1, Lisa Mayr1, Chryssa Grylli1, Thomas Czech2, Christian Dorfer2, Christine Haberler3, Ulrike Leiss1, Irene Slavc1
1Medical University of Vienna, Department of Pediatrics, Austria, 2Medical University of Vienna, Department of Neurosurgery, Austria, 3Medical University of Vienna, Institute of Neurology, Austria
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Introduction of skin care guidelines for children and teens taking molecularly targeted agents
Kaaren Waters*, Kasey Rangan, Ashley Margol, Nathan Robison, Girish Dhall, Anna Evans
Children's Hospital Los Angeles, USA
Saturday, June 30:  Nursing Symposium  - 
Investigating the role of the RNA binding protein, Musashi 1 in pediatric group 3 medulloblastoma
Michelle Kameda-Smith*1,2, Chitra Venugopal1, David Bakhshinyan1, Branavan Manoranjan1, Ashley Adile1, Minomi Subapanditha1, Adam Fleming1,3, Kristen Hope1, Sheila Singh1,2
1McMaster University Stem Cell and Cancer Research Institute, Canada, 2McMaster University Division of Neurosurgery, Canada, 3McMaster University Department of Pediatrics, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Investment in training teachers of paediatric oncology patients influences support provided in the school environment
Sarah Jane Watts1,2, Katherine Cox1, Simon Bailey*1
1Newcastle Upon Tyne Hospitals NHS Foundation Trust, UK, 2Newcastle University, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
In-vivo metabolite profiles for the non-invasive and rapid identification of molecular subgroup in medulloblastoma
Sarah E. Kohe*1,2, Ben Babourina-Brooks1,2, Fatma Scerif3, Debbie Hicks3, Ed. C. Schwalbe3, Stephen Crosier3, Janet Lindsey3, Magretta Adiamah3, Lisa C.D. Storer4, Anbarasu Lourdusamy4, Simrandip K. Gill1,2, Christopher D. Bennett1,2, Martin Wilson1,2, Shivaram Avula5, Dipayan Mitra6, Rob Dineen4, Simon Bailey3,7, Daniel Williamson3, Richard G. Grundy4, Steven C. Clifford3, Andrew C. Peet1,2
1Institute of Cancer and Genomic SciencesUniversity of Birmingham, UK, 2Birmingham Womens and Childrens NHS Foundation Trust, UK, 3Northern Institute for Cancer Research, Newcastle University, UK, 4Children's Brain Tumour Research Centre, University of Nottingham, UK, 5Alder Hey Children's Hospital, UK, 6Newcastle Hospitals NHS Foundation Trust, UK, 7Great North Children's Hospital, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Irradiation of pediatric glioblastoma cells induces downregulation of tumor suppressor microRNA genes and upregulation of vascular endothelial growth factor (VEGF)
Hisham Alhajala, Ninh Doan, Mona Al-Gizawiy, Jeffrey Knipstein*, Kathleen Schmainda, Cristopher Chitambar
Medical College of Wisconsin, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Isolated pituitary stalk thickening (IPST) in children: natural history and predictors of neoplastic disease
Maggie Skrypek*, Anastasia Brown, Julie Pape-Blabolil, Charles Bendelsmith, Sachin Patel, Richard Patterson, M. Jennifer Abuzzahab, Katherine Ingram, Amy Linabery, Anne Bendel
Children's Minnesota, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Jerantinine: a novel tumour-specific alkaloid for the treatment of paediatric medulloblastoma
Sophie J. Roper*1, Amy F. Lloyd1, Paul J. Scotting2, Tracey D. Bradshaw3, Beth Coyle1
1Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, UK, 2Division of Genetics, Ecology and Evolution, School of Life Sciences, University of Nottingham, UK, 3Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, University of Nottingham, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
KANSL1 gain and fusion - a novel alteration in childhood ependymoma.
Yulia Margolin-Miller2,3, Helen Toledano*1,2, Lital Sela-Tzuriano2,3, Michal Hameiri-Grossman1, Shalom Michowiz4,2, Suzanna Fichman-Horn5,2, Meora Feinmesser5,2, Stefan Pfister6,7, Hendrik Witt6,7, Isaac Yaniv1,2, Smadar Avigad2,3
1Dept. of Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Israel, 2Sackler Faculty of Medicine, Tel Aviv University, Israel, 3Molecular Oncology Laboratory, Felsenstein Medical Research Center, Rabin Medical Center, Israel, 4Department of Neurosurgery, Schneider Children's Medical Center of Israel, Israel, 5Pathology Department, Rabin Medical Center, Israel, 6Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 7Department of Pediatric Oncology Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Ketolytic and glycolytic enzymatic expression in paediatric medulloblastomas: implication for ketogenic diet therapy
Lisa C D Storer*, Zacharias de Beer, George Lockwood, Simon Paine, Richard G Grundy
University of Nottingham, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Kickstarting the cancer immunity cycle by innate checkpoint inhibition to target pediatric brain tumors
Siddhartha Mitra*1,3, Samuel Cheshier1
1Stanford University School of Medicine, USA, 2University of Utah School of Medicine, USA, 3Children's Hospital Colorado, USA
Tuesday, July 3:  Immunotherapy  -  10:40am - 11:40am
Langerhans cell histiocytosis of the orbit and skull base in a 2 year old: case report
William Gump
Norton Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Late development of metachronous atypical teratoid/rhabdoid tumors (AT/RTs) or malignant rhabdoid tumor (MRT) in three patients with germline SMARCB1 mutations
Anne Bendel*1, Helen Toledano2,3, Ian Cohen2,3, Susan Chi4, Jaclyn Biegel5
1Children’s Minnesota, USA, 2Schneider Children’s Medical Center of Israel, Israel, 3Sackler faculty of medicine, Tel Aviv University, Israel, 4Dana-Farber Cancer Institute/Boston Children’s Hospital, USA, 5Children’s Hospital Los Angeles, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Late neuropsychological outcomes with proton radiation in children with brain tumor
Domitilla Elena Secco1, Antonella Cacchione1, Francesca Del Bufalo1, Sabina Vennarini2, Giovanna Stefania Colafati1, Ioan Paul Pietro Voicu1, Simonetta Gentile1, Francesca Santato1, Sofia Anzeneder1, Andrea Carai1, Angela Mastronuzzi*1
1Pediatric Hospital Bambino Gesù, Italy, 2Santa Chiara Hospital, Proton Therapy Unit, Italy
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Late onset or atypical adrenal insufficiency due to ACTH deficiency in survivors of non-pituitary brain tumors
Malinda Wu1, Claire Mazewski*2,1, Dolly Aguilera2,1, Natia Esiashvili3, Briana Patterson1,2
1Emory University, Pediatrics, USA, 2Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, USA, 3Emory University, Radiation Oncology, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Lesion localization in posterior fossa syndrome
Fatimah Albazron*1, Joel Bruss1, Robin Jones2, Torunn Yock3, Margaret Pulsifer4, Annah Abrams5, Mariko Sato6, Aaron Boes1,2
1Neuroimaging & Noninvasive Brain Stimulation Laboratory, Departments of Pediatrics, Neurology & Psychiatry, University of Iowa Hospitals and Clinics, USA, 2Department of Pediatric Neurology, Massachusetts General Hospital, USA, 3Department of Radiation Oncology, Massachusetts General Hospital, USA, 4Department of Psychiatry, Massachusetts General Hospital, USA, 5Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology, Massachusetts General Hospital, USA, 6Department of Pediatric Hematology Oncology, Stead Family Children’s Hospital, USA
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
Leveraging convolutional neural networks to predict adamantinomatous craniopharyngioma diagnosis from preoperative parameters
Eric Prince*1,2, Ros Whelan1,2, Susan Staulcup1,2, Kenneth Jones1, Michael Yang1, Lindsey Hoffman1,2, Michael Handler1,2, Nicholas Stence1,2, Todd Hankinson1,2
1University of Colorado Denver, USA, 2Children's Hospital Colorado, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell free DNA in peripheral blood, CSF, and urine
Melanie Pages*1, Denisse Rotem2, Gregory Gydush2, Sarah Reed2, Justin Rhoades2, Gavin Ha2, Chris Lo2, Adam Tracy2, Robert Jones1, Sarah Becker1, Michaela Haller1, Susan Chi1,3, Mark Kieran1,3, Liliana Goumnerova1,3, J Christopher Love4, Keith L Ligon1,3, Pratiti Bandopadhayay1,3, Karen Wright1,3, Viktor A Adalsteinsson2,4, Rameen Beroukhim1,2
1Dana-Farber Cancer Institute/Boston Children’s Cancer and Blood Disorders Center, USA, 2Broad Institute, USA, 3Boston Children's Hospital, USA, 4Massachusetts Institute of Technology, USA
Sunday, July 1:  Embryonal Tumors  -  11:30am - 12:30pm
Long term follow-up of optic pathway gliomas in children with neurofibromatosis type 1 – an oncology hospital experience
Mariana Fernandes1, João Passos1, Daniela Garcez1, Manuela Mafra1, Maria Fátima Campos2, Sofia Nunes1, Duarte Salgado*1
1Instituto Português de Oncologia de Lisboa, Portugal, 2Hospital de Santa Maria, Portugal
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Longitudinal assessment of ataxia in children following surgical resection of posterior fossa tumours
Helen Hartley*1, Barry Pizer1, Steven Lane2, Lisa Bunn3, Bernie Carter5, Elizabeth Cassidy4, Ram Kumar1
1Alder Hey Childrens NHS Foundation Trust, UK, 2Liverpool University, UK, 3Plymouth University, UK, 4Freelance academic, Austria, 5Edge Hill University, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Long-term cognitive functioning and treatment-related risk factors in childhood posterior fossa tumor survivors
Charlotte Sleurs*1,4, Ellen Turelinckx2, Lissa Maes2, Sabine Deprez3, Anne Uyttebroeck1,4, Sandra Jacobs4, Jurgen Lemiere4
1Development & Regeneration, KU Leuven, Belgium, 2Clinical Psychology, KU Leuven, Belgium, 3Radiology, UZ Leuven, Belgium, 4Pediatric Hemato-Oncology, UZ Leuven, Belgium
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Longterm effect of first line chemotherapy with vincristine and carboplatin to optic pathway gliomas
Andge Valiakhmetova*1,2, Sergey Gorelishev1,2, Boris Kholodov1,2, Olga Medvedeva1, Ekaterina Tarasova1, Svetlana Chulkova2,3, Angelina Egorova2,3
1N.N. Burdenko National Medical Research Center of Neurosurgery, Russia, 2Russian States Research Medical University, Pediatric Oncology Department, Russia, 3N. N. Blokhin National Medical Research Center of oncology, Russia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Long-term health-related quality of life in adult survivors of pediatric intracranial germ cell tumor
Andrea Lo*1,2, Normand Laperriere3,4, David Hodgson3,4, Karen Goddard1,2
1BC Cancer, Vancouver Centre, Canada, 2University of British Columbia, Canada, 3Princess Margaret Cancer Centre, Canada, 4University of Toronto, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Long-term outcome of patients with pediatric tectal glioma
Anthony Liu*1, Julie Harreld2, Lisa Jacola3, Madelyn Gero3, Sahaja Acharya4, Jason Chiang5, Yahya Ghazwani1, Shengjie Wu6, Paul Klimo Jr7,8, Amar Gajjar1, Ibrahim Qaddoumi1
1Department of Oncology, St. Jude Children's Research Hospital, USA, 2Department of Diagnostic Imaging, St. Jude Children's Research Hospital, USA, 3Department of Psychology, St. Jude Children's Research Hospital, USA, 4Department of Radiation Oncology, St. Jude Children's Research Hospital, USA, 5Department of Pathology, St. Jude Children's Research Hospital, USA, 6Department of Biostatistics, St. Jude Children's Research Hospital, USA, 7Department of Surgery, St. Jude Children's Research Hospital, USA, 8Department of Neurosurgery, University of Tennessee Health Science Center, USA, 9Le Bonheur Neuroscience Institute, Le Bonheur Children's Hospital, USA, 10Semmes Murphey Clinic, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Long-term outcomes of symptomatic optic pathway glioma: 32 years of experience at a single tertiary center
Mumtaz Khan1, Robert Lethridge1, Revathi Rajagopal*2, Sharon Lee1, Gabriel Lee1, Mandy Taylor1, Alycea McGrath1, Nicholas G. Gottardo1
1Princess Margaret Hospital for Children, Australia, 2University Malaya Medical Centre, Malaysia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Long-term supratentorial white matter changes and cognitive function following cerebellar tumour resections in childhood
Christian Dorfer*1, Monika Chocholous2, Thomas Pletschko2, Gregor Kasprian3, Christian Widmann3, Irene Slavc2, Thomas Czech1
1Medical University of Vienna, Department of Neurosurgery, Austria, 2Medical University of Vienna; Department of Pediatrics And Adolescence Medicine, Austria, 3Medical University of Vienna; Department of Radiology and Nuclear Medicine, Austria
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Long-term vision impairment is highly prevalent in pediatric Craniopharyngioma patients
M. Fatih Okcu*1,4, Murtaza Saifee3, William Whitehead1, Jane Edmond2
1Baylor College of Medicine, USA, 2University of Texas Dell Medical School, USA, 3University of California, San Francisco, USA, 4Texas Childrens Cancer Center, Texas Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Low concordance between surgical and radiological assessment of degree of resection and treatment-related hypothalamic damage – Results of KRANIOPHARYNGEOM 2007
Hermann L. Müller*1, Julia Reichel1, Svenja Boekhoff1, Monika Warmuth-Metz2, Maria Eveslage3, Junxiang Peng4, Jörg Flitsch5
1Dep.of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg, Medical Campus University Oldenburg, Germany, 2Dep. of Neuroradiology, University Hospital Würzburg, Germany, 3Institute of of Biostatistics and Clinical Research, University Münster, Germany, 4Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, 5Department of Neurosurgery, University Hospital Hamburg-Eppendorf (UKE), Germany
Sunday, July 1:  Craniopharyngioma/Rare Tumors  -  2:30pm - 3:30pm
Low grade diffuse intrinsic pontine glioma? A single institution experience
Margaret Shatara*1,2, Sandeep Sood1,2, Janet M. Poulik1,2, Deniz Altinok1,2, Steven Miller1,2, Xuehui Liu1,2, Zhihong Wang1,2
1Children's Hospital of Michigan, USA, 2Detroit Medical Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Low grade glioma, 16 years single center experience
Stanislava Hederová*1, Andrea Mocná1, Kristína Husáková1, Emília Kaiserova1, Miroslava Makohusová1, Salome Jakešová2, Boris Rýchly3, Alexandra Kolenová1
1Department of Pediatric Hematology and Oncology, Comenius University Children´s Hospital, Slovakia, 2Department of Radiology, Comenius University Children´s Hospital, Slovakia, 3Cytopathos spol. s r.o., Slovakia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
LSD1 modulates NK cell immunotherapy through an onco-immunogenic gene signature in DIPG
Cavan Bailey*1,7, Megan Romero2, Ruolan Han3, Jeffrey Larson3, Oren Becher2, Dean Lee4, Michelle Monje5, Vidya Gopalakrishnan1,7, Wafik Zaky6, Joya Chandra1,7
1Department of Pediatrics - Research, MD Anderson Cancer Center, USA, 2Department of Pediatrics, Northwestern Feinberg School of Medicine, USA, 3Salarius Pharmaceuticals, JLABS @ TMC, USA, 4Department of Pediatrics, Nationwide Children's and the Ohio State Comprehensive Cancer Center, USA, 5Department of Neurology & Neurological Sciences, Stanford University, USA, 6Children's Cancer Hospital, Division of Pediatrics, MD Anderson Cancer Center, USA, 7The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Malignant primary brain and other central nervous system tumours diagnosed among the Canadian paediatric population from 2009 to 2013
Emily Walker1,2, Sana Amjad*1,2, Faith Davis1,2, The CBTR Surveillance and Reporting Working Group2
1School of Public Health, University of Alberta, Canada, 2Canadian Brain Tumour Registry (CBTR): Surveillance and Reporting Working Group, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Malignant rhabdoid tumors originating within and outside the central nervous system are clinically and molecularly heterogeneous
Emilia Pinto1, Dima Hamideh1, Armita Bahrami1, Brent Orr1, Tong Lin1, Stanley Pounds1, Gerard Zambetti1, Alberto Pappo1, Sameer Agnihotri2, Amar Gajjar1, Alberto Broniscer*1,2
1St. Jude Children’s Research Hospital, USA, 2Children's Hospital of Pittsburgh, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Malignant transformation of an optic nerve glioma: case report
Huseyin Erdemir*1, Gozde Erdemir2, Aimee Carlson1, Gary Hsich2, Tanya Tekautz1
1Department of Pediatric Hematology/Oncology and BMT; Cleveland Clinic Children’s Hospital, USA, 2Department of Pediatric Neurology; Cleveland Clinic Children’s Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Malignant transformation, second malignant neoplasms, and survival in 50 years of follow-up of childhood low-grade glioma: a single-institute experience
Sebastiaan Somers1, Cees Lucas2, Eleonora Aronica2, Antoinette Schouten-van Meeteren*1
1Emma Children's Hospital AMC, The Netherlands, 2Academic Medical Hospital, The Netherlands
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Management of CNS germ cell tumors: Experience from Sun Yat-sen University Cancer Center
Chengcheng Guo, Qun-ying Yang, Jian Wang, Xiao-fei Sun, Shao-xiong Wu, Zhong-ping Chen*
Sun Yat-sen University Cancer Center, China
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Mass spectrometry of common cerebellar tumours identifies differences in metabolism
Christopher Bennett*1,2, Sarah Kohe1,2, Simrandip Gill1,2, Nigel Davies2,3, Lisa Storer4, Timothy Ritzmann4, Warwick Dunn5,6, Daniel Tennant6, Richard Grundy4, Andrew Peet1,2
1Institute of Cancer and Genomic Sciences, University of Birmingham, UK, 2Birmingham Children's Hospital, UK, 3University Hospitals Birmingham NHS Foundation Trust, UK, 4Children's Brain Tumour Research Centre, University of Nottingham, UK, 5Phenome Centre Birmingham, School of Biosciences, University of Birmingham, UK, 6Institute of Metabolism and Systems Research, University of Birmingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Medulloblastoma in patients with Gorlin syndrome: results from the HIT study group
Barbara Meissner*1, Martin Mynarek1, B. Ole Juhnke1, Katja von Hoff1,2, Torsten Pietsch3, Rolf D. Kortmann4, Monika Warmuth-Metz5, Brigitte Bison5, Stefan Rutkowski1
1University Medical Center Hamburg Eppendorf, Germany, 2Charite - University Medical Center Berlin, Germany, 3University of Bonn, Germany, 4University of Leipzig, Germany, 5University of Würzburg, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Medulloblastoma: A dilemma in a tertiary cancer centre In Nepal
Surendra Gauchan*1, Shivaji Poudel1, Ranjan Bhakta Bhandari1, Subhas Pandit2
1B P Koirala Memorial Cancer Hospital, Nepal, 2Kathmandu Cancer Center, Nepal
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Medulloblastoma: application of genomic medicine for molecular classification in a Taiwanese Cohort
Shih-Hung Yang*1, Meng-Fai Kuo1, Yung-Li Yang1, Hsin-Yi Huang1, Shinn-Forng Peng1, Hsuan-Yu Chen2
1National Taiwan University Hospital, Taiwan, 2Academia Sinica, Taiwan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Medulloblastomas associated with APC germline mutation: a multicentric French and Belgian review
Aurore Surun1, Laurence Brugières2, Léa Guerrini-Rousseau2, Pascale Varlet3, Brigitte Lacour4, Cécile Faure-Conter5, Pierre Leblond6, Anne-Isabelle Bertozzi-Salomon7, Claire Berger8, Nicolas Andre9, Eric Sariban10, Fabienne Prieur8, Françoise Desseigne11, Hélène Zattara-Cannoni9, Marc Polivka12, Marie-Bernadette Delisle7, Alexandre Vasiljevic13, Chrystelle Colas1, François Doz1,15, Franck Bourdeaut*1,14
1Institut Curie, France, 2Gustave Roussy, France, 3Hôpital Sainte-Anne, France, 4French National Childhood Solid Cancer Registry, CHU Nancy, France, 5Institut d'Hémato-Oncologie Pédiatrique, France, 6Oscar Lambret, France, 7CHU Toulouse, France, 8CHU Hôpital Nord, France, 9La Timone, France, 10Université Libre de Bruxelles, Belgium, 11Centre Léon Bérard, France, 12Hôpital Lariboisière, France, 13Hospices Civils de Lyon, France, 14INSERM U830, Translational Research in Pediatric Oncology Team, France, 15Université Paris Descartes, Sorbonne Paris Cité, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
MEK-inhibitor monotherapy to treat concurrent optic glioma and metastatic neuroblastoma in a patient with Neurofibromatosis type 1 (NF1)
Jennifer Belsky, Richard Graham, Jeffery Leonard, Jonathan Finlay, Jeremy Jones, Daniel Boué, Mark Ranalli, Mohamed AbdelBaki*
Nationwide Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
MELK inhibition as a potential therapeutic strategy against all molecular subtypes of medulloblastoma
Jia-Min Ho1, Zhi-Han Lim1, Sekar Karthik1, Jack M Su2, Qi Lin2, YuChen Du2, Jianhe Shen2, Wing-Yuk Chow2, Ching C Lau2, Adesina Adekunle3, Angela Major4, M. Tarek Elghetany4, Xiaonan Li2, Kam-Man Hui1, Wan-Yee Teo*1,2
1Humphrey Oei Institute of Cancer Research, National Cancer Center Singapore: KK Women’s & Children’s Hospital; SingHealth-Duke-NUS Academic Medical Center; Cancer and Stem Cell Biology Program, Duke-N, Singapore, 2Department of Pediatrics, Division of Hematology-Oncology, Texas Children’s Cancer Center: Baylor College of Medicine, Dan L. Duncan Cancer Center, USA, 3Department of Molecular Pathology, Texas Children’s Hospital; Baylor College of Medicine, Dan L. Duncan Cancer Center, USA, 4Department of Pathology, Texas Children’s Hospital; Baylor College of Medicine, Dan L. Duncan Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Meta-analysis of the incidence and patterns of second neoplasms after photon craniospinal irradiation in children with medulloblastoma
Abhishek Bavle*1, Sayani Tewari1, Amy Sisson2, Murali Chintagumpala3, Michael Anderson4, Arnold Paulino5
1Jimmy Everest Section of Pediatric Hematology/Oncology, University of Oklahoma Health Sciences Center, USA, 2Texas Medical Center Library, USA, 3Section of Pediatric Hematology/Oncology, Baylor College of Medicine, USA, 4Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, USA, 5Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Meta-analysis of treatment modalities in metastatic atypical teratoid/rhabdoid tumors in children
Reena Underiner*1, Mostafa Eltobgy2, Joseph Stanek3, Jean Michaud4, Wafik Zaky5, Eric Bouffet6, Jonathan Finlay3, Mohamed AbdelBaki3
1The Ohio State University College of Medicine, USA, 2Ain Shams Faculty of Medicine, Egypt, 3Division of Hematology, Oncology, and Bone Marrow Transplant - Nationwide Children's Hospital, USA, 4Department of Pathology - Children's Hospital of Eastern Ontario, University of Ottawa, Canada, 5Division of Pediatric Hematology and Oncology, Department of Pediatrics - The University of Texas MD Anderson Cancer Center, USA, 6Pediatric Neuro-Oncology Program, Division of Hematology/Oncology - Hospital for Sick Children, University of Toronto, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Metabolic profiling in pediatric low grade glioma identifies glutathione depletion after mTORC1 inhibition and validates everolimus and carboplatin as a potential combination therapy
Brad Poore*1, Ming Yuan1, Antje Arnold1, Antionette Price1, Jesse Alt2,4, Jeffrey Rubens3, Barbara Slusher2,4, Charles Eberhart1,3, Eric Raabe1,3
1Johns Hopkins Pathology, USA, 2Johns Hopkins Drug Discovery, USA, 3Sidney Kimmel Comprehensive Cancer Center, USA, 4Johns Hopkins Department of Neurology, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Metastatic choroid plexus carcinoma without adjuvant treatment with good survival: a case report
Lacey Carter*, Naina Gross
University of Oklahoma Health Sciences Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Metastatic disease in the suprasellar area at diagnosis in medulloblastoma
Helen Toledano*1,2, Mika Rootman1, Shalom Michowiz1,2, Osnat Konen1,2
1Schneider Children's Medical Center, Israel, 2Sackler Faculty of Medicine, Tel Aviv University, Israel
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Metformin results in hippocampal remodeling and improved memory encoding in paediatric brain tumor survivors treated with cranial radiation: A pilot randomized controlled crossover study
Ramy Ayoub*1,2, Freda Miller1,2, Kiran Beera1, Cynthia de Medeiros1, Suzanne Laughlin1,2, Eric Bouffet1,2, Donald Mabbott1,2
1Hospital for Sick Children, Canada, 2University of Toronto, Canada
Sunday, July 1:  Quality of Life/Survival/Rehabilitation  -  1:30pm - 3:00pm
Methylation profile in a retrospective series of Spanish pediatric medulloblastoma
Idoia Martin-Guerrero1,2, Olaia Aurtenetxe1, Laura Zaldumbide3, Itziar Astigarraga1,4, Debbie Hicks5, Ed Schwalbe5, Steve Clifford5, Miguel Garcia-Ariza*1,4, Aurora Navajas1
1Biocruces Health Research Institute, Spain, 2Department of Genetics, Physic Anthropology and Animal Physiology. University of the Basque Country, UPV/EHU, Spain, 3Department of Pathological Anatomy, Cruces University Hospital, Spain, 4Department of Pediatric Hematology and Oncology. Cruces University Hospital, Spain, 5Northern Institute for Cancer Research, Newcastle University, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Methylphenidate improves health-related quality of life and attentional impairment in paediatric neuro-oncology survivors
Sarah Jane Watts1,2, Gail Halliday1, Jade Ryles1, Simon Bailey*1,2
1Newcastle Upon Tyne Hospitals NHS Foundation Trust, UK, 2Newcastle University, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Metronomic chemotherapy and the use of a novel app (CareZone) for facilitation of medication administration and compliance
Eileen Gillan, Jeanne Walczak*, Heather Rea
Connecticut Children's Medical Center, USA
Saturday, June 30:  Nursing Symposium  - 
Metronomic therapy for recurrent ependymoma; preliminary results
Eileen Gillan*, Markus Bookland
Connecticut Children's Medical Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
MGMT protein expression and MGMT gene promoter methylation as markers of drug sensitivity to epigenetic therapy in childhood medulloblastoma
Andrey Levashov*1, Dmitry Khochenkov3, Anna Stroganova2, Marina Ryzhova4, Sergey Gorelyshev5, Stepan Babelyan1, Natalya Subbotina1, Vidmante Daylidite1, Igor Dolgopolov1, Svetlana Zagidullina1, Georgy Seregin6, Georgy Mentkevich1
1Pediatric Hematology and Oncology Institution FSBI «N.N. Blokhin National Medical Research Center of Oncology», of the Ministry of Health of the Russian Federation, Russia, 2Department of pathology, FSBI «N.N. Blokhin National Medical Research Center of Oncology», of the Ministry of Health of the Russian Federation, Russia, 3Experimental Diagnostic and Treatment of Tumor Institution FSBI «N.N. Blokhin National Medical Research Center of Oncology», of the Ministry of Health of the Russian Federation, Russia, 4Department of Neuropathology, «N.N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian Federation, Russia, 5Department of Neurosurgery №1, «N.N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian Federation, Russia, 6FSBEI HE Moscow State University of Medicine and Dentistry, Russia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
MiR-1253, a candidate tumor suppressor microRNA in non-SHH/WNT medulloblastoma
Ranjana Kanchan*1, Naveen Kumar Perumal1, Wasim Naseer1, Deborah Perry2, Surinder Batra1, Sidharth Mahapatra1
1University of Nebraska Medical Center, USA, 2Children’s Hospital and Medical Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
miR-379-5p regulates proliferation, migration and invasion in BRAF mutant-glioblastoma
Rui-qi Zhang*1, Kay Ka-Wai Li1,2, Ho-Keung Ng1,2
1The Chinese University of Hong Kong, China, 2Shenzhen Research Institute, the Chinese University of Hong Kong, China
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Modelling medulloblastoma invasion and chemoresistance in a 3D hyaluronan hydrogel system
Franziska Linke*1, Catherine L. R. Merry2, Anna M. Grabowska2, Snow Stolnik-Trenkic3, Ian D. Kerr4, Beth Coyle1
1Children’s Brain Tumour Research Centre, School of Medicine; University of Nottingham, UK, 2Division of Cancer & Stem Cells, School of Medicine; University of Nottingham, UK, 3Division of Molecular Therapeutics and Formulation, School of Pharmacy; University of Nottingham, UK, 4Division of Cell Signalling & Pharmacology, School of Life Sciences; University of Nottingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Modelling the brain/CSF interface in medulloblastoma
Macha Aldighieri*1, Franziska Linke1, Anna M Grabowska2, Ian D Kerr3, Beth Coyle1
1Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, UK, 2Division of Cancer & Stem Cells, School of Medicine, University of Nottingham, UK, 3Division of Cell Signalling & Pharmacology, School of Life Sciences, University of Nottingham, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Modified carboplatin and vincristine chemotherapy in pediatric brain stem low-grade gliomas
Jingjing Ge, Cheng Li, Zhimeng Gao, Fengjun Xue, Junping Zhang*
Sanbo Brain Hospital, Capital Medical University, China
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecular alterations in pregnant adolescent and young adult women with glioma
Julie Bennett*1, Scott Ryall1, Michal Zapotocky1, Ana Guerreiro Stucklin1, Kohei Fukuoka1, Sunit Das2, Warren Mason3, James Perry4, Arjun Sahgal4, Kenneth Aldape3, Julia Keith4, David Munoz2, Uri Tabori1, Cynthia Hawkins1
1The Hospital for Sick Children, Canada, 2St. Michael's Hospital, Canada, 3University Health Network, Canada, 4Sunnybrook Health Sciences Centre, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Molecular and chromosomal characterization of a unique series of diffuse midline gliomas in children and young adults
Charlotte Dufour*1, Romain Vasseur1, Romain Perbet1,2, Pierre Leblond3, Matthieu Vinchon1,2, Nicolas Reyns1,2, Gustavo Touzet1, Claude-Alain Maurage1,2, Escande Fabienne1, Renaud Florence1,2
1Lille University Hospital, France, 2Lille University, France, 3Oscar Lambret Cancer Center, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecular and clinical heterogeneity in histologically-diagnosed CNS-PNET patients prospectively treated as a single entity: a report from the Children’s Oncology Group ACNS0332 trial
Eugene Hwang*5, Marcel Kool3, Peter Burger17, David Capper7, Lukas Chavez4, Sebastian Brabetz4, Chris Williams-Hughes16, Catherine Billups8, Linda Heier9, Alok Jaju10, Jeff Michalski12, Yimei Li8, Sarah Leary1, Tianni Zhou11, Andreas vonDiemling7, David TWJones4, Maryam Fouladi13, Ian Pollack14, Amar Gajjar15, Roger Packer5, Stefan Pfister4,3, James Olson1
1Seattle Children’s Hospital and Research Institute and the Fred Hutchinson Cancer Research Center, USA, 2Hopp-Children´s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 3Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Germany, 4Division of Pediatric Neuro-oncology, German Cancer Research Center, Germany, 5Brain Tumor Institute, Children’s National Medical Center, USA, 6Brain Tumor Institute, Children’s National Medical Center, USA, 7Department of Neuropathology, University Hospital Heidelberg, Germany, 8Department of Biostatistics, St. Jude Children’s Research Hospital, USA, 9Department of Radiology, USA, 10Department of Medical Imaging, Ann & Robert H. Lurie Children’s Hospital of Chicago, USA, 11Department of Mathematics and Statistics, California State University, USA, 12Department of Radiation Oncology, Washington University School of Medicine, USA, 13Brain Tumor Center, Cincinnati Children’s Hospital Medical Center, USA, 14Brain Tumor Center, Cincinnati Children’s Hospital Medical Center, USA, 15St. Jude Children’s Research Hospital, USA, 16Children's Oncology Group, USA, 17Johns Hopkins University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Molecular biology and phase I study of GM-CSF and intrathecal trastuzumab in children with recurrent posterior fossa ependymoma
Kathleen Dorris*1,2, Melissa Widener1, Vladimir Amani2, Andrew Donson2, Debra Schissel1, Brent O'Neill1,2, Todd Hankinson1,2, Michael Handler1,2, Margaret Macy1, Nicholas Foreman1,2
1Children's Hospital Colorado, USA, 2Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Monday, July 2:  Early Phase Trials  -  9:30am - 10:30am
Molecular characterization of nodular desmoplastic medulloblastomas in young children treated on ACNS1221. A report from the Children Oncology Group
Lucie Lafay-Cousin*1, Giles Robinson2, Vasilisa Rudneva2, Paul Northcott2, Catherine Billups2, Arzu Onar-Thomas2, Cynthia Hawkins3, Charles Eberhart4, Craig Horbinski5, Linda Heier6, Mark Souweidane6, Douglas Strother1, Maryam Fouladi7, Eric Bouffet3, Amar Gajjar2
1Alberta Children's Hospital, Canada, 2St Jude Research Hospital, USA, 3Hospital for Sick Children, Canada, 4John Hopkins Medicine, Canada, 5Northwestern Memorial Hospital, USA, 6Weill Cornell Medical college, USA, 7Cincinnati Children Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecular characterization of recurrent medulloblastoma reveals an unexpectedly high incidence of secondary malignancy
Rahul Kumar*1, Maximilian Deng2,10, Vasilisa A. Rudneva1, Giles W. Robinson3, Girish Dhall4, Laure J. Klesse5, Daniel C. Bowers5, Murali Chintagumpala6, Sarah Leary7, Brent A. Orr8, Stefan M. Pfister9,10, Amar Gajjar3, David T.W. Jones2,10, Paul A. Northcott1
1Department of Developmental Neurobiology, St. Jude Children's Research Hospital, USA, 2Pediatric Glioma Research (G702), German Cancer Research Center, Germany, 3Department of Oncology, St. Jude Children's Research Hospital, USA, 4Children's Hospital of Los Angeles, USA, 5University of Texas Southwestern Medical Center, USA, 6Texas Children's Hospital, USA, 7Seattle Children's Hospital, USA, 8Department of Pathology, St. Jude Children's Research Hospital, USA, 9Division of Pediatric Neurooncology, German Cancer Research Center, Germany, 10Hopp Children's Tumour Center at NCT Heidelberg (KiTZ), Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecular classification of medulloblastomas: Nanostring nCounter assay vs a combination of immunohistochemistry and fluorescence in-situ hybridisation
Kavneet Kaur*1, Pankaj Pathak1, Prerana Jha1, Ajay Garg2, Vaishali Suri1, Mehar C Sharma1, Ashish Suri3, Chitra Sarkar1
1Department of Pathology, All India Institute of Medical Sciences, India, 2Department of Neuroradiology, All India Institute of Medical Sciences, India, 3Department of Neurosurgery, All India Institute of Medical Sciences, India
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Molecular determinants of response to radiotherapy in DIPG: a clinical and in vitro study
Coralie Werbrouck1, Cláudia C.S. Evangeslista1, Emilie Barret1, Stéphanie Puget2, Jacques Grill1,3, Marie-Anne Debily1,4, David Castel*1,3
1UMR8203 Vectorologie and Thérapeutiques Anticancéreuses, CNRS, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, France, 2Département de Neurochirurgie Pédiatrique, Hôpital Necker-Enfants Malades, Université Paris V Descartes, France, 3Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, France, 4Département de Biologie, Université Evry Val-d'Essonne, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecular heterogeneity among pediatric posterior fossa ependymoma
Kristian W. Pajtler*1,2, Ji Wen3, Martin Sill1,2, Tong Lin3, Jens M. Hübner1,2, Vijay Ramaswamy4, Chandanamali Punchihewa3, David T. W. Jones1,2, Hendrik Witt1,2, Lukas Chavez1,2, Ruth G. Tatevossian3, Richard Grundy5, Thomas E. Merchant3, Arzu Onar-Thomas3, Michael D. Taylor4, Stefan M. Pfister1,2, Andrey Korshunov2, Marcel Kool1,2, David W. Ellison3
1Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2German Cancer Research Center, Germany, 3St. Jude Children's Research Hospital, USA, 4The Hospital for Sick Children, Canada, 5Children’s Brain Tumour Research Centre, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Molecular heterogeneity of subependymal giant cell astrocytomas in patients with mild-phenotype tuberous sclerosis complex
Cody Nesvick*, Amulya Nageswara Rao, Aditya Raghunathan, David Daniels
Mayo Clinic, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Molecular landscape and clinical correlations of CNS sarcomas
Adriana Fonseca*1, Ben Ho1, Jonathon Torchia1, Sarah Leary2, Mei Lu1, Gino Sommers1, Abha Gupta1, Ronald Grant1, Joe Norman1, Lucie Lafay-Cousin3, Cynthia Hawkins1, Ute Bartels1, Eric Bouffet1, Annie Huang1
1The Hospital for Sick Children, Canada, 2Seattle Children's Hospital, USA, 3Alberta Children's Hospital, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecular pathophysiology of histone G34R mutant childhood brain tumours; towards the development of novel targeted therapies
Farhana Haque*1, Anbarasu Lourdusamy1, Ruman Rahman1, Pascale Varlet2, Angel Carcaboso3, Chris Jones4, Robert Layfield1, Richard Grundy1
1University of Nottingham, UK, 2Sainte-Anne Hospital, France, 3Institut de Recerca Sant Joan de Deu, Spain, 4The Institute of Cancer Research, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecular profiling and identification of targeted therapies for children and young adults with primary central nervous system tumours in the United Kingdom
Ajla Wasti*1, Fernando Carceller1,2, Sally George2,1, Eleni Koutroumanidou2, Elisa Izquierdo2, Pilar Guerra6, Magdalena Zarowiecki2, James Campbell2, Bissan Al-Lazikani2, Lynley Marshall1,2, Chris Jones2, Matthew Clarke2, Karen Powell1, Tracey Crowe1, Tony Rogers1, Julia Chisholm1,2, Sucheta Vaidya1,2, Henry Mandeville1,2, Frank Saran1,2, Bassel Zebian3, Samantha Hettige4, Safa Al-Sarraj3, Leslie Bridges4, Tom Jacques5, Darren Hargrave5, Andy Pearson1,2, Brian Walker8, David Gonzalez de Castro7, Michael Hubank2, Louis Chesler2,1
1The Royal Marsden Hospital, UK, 2The Institute of Cancer Research, UK, 3King's College Hospital, UK, 4St George's Hospital, UK, 5Great Ormond Street Hospital, UK, 6Hospital 12 de Octubre, Spain, 7Queen's University Belfast, UK, 8University of Arkansas for Medical Sciences, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Molecular study in pediatric medulloblastoma. Validation of genetic markers in a national cohort of forty years.
Miguel Garcia-Ariza*1,2, Olaia Aurtenetxe2, Idoia Martin-Guerrero2, Laura Zaldumbide3, Itziar Astigarraga1,2, Anna Llort4, Carlota Calvo5, Tomas Acha6, Eduardo Quiroga7, Jose Miguel Couselo8, Alvaro Lassaletta9, Ofelia Cruz10, Aurora Navajas1,2
1Department of Pediatric Hematology and Oncology. Cruces University Hospital, Spain, 2Biocruces Health Institute, Spain, 3Department of Pathology. Cruces University Hospital, Spain, 4Department of Pediatric Hematology and Oncology. Vall d´Hebron University Hospital, Spain, 5Department of Pediatric Hematology and Oncology. Miguel Servet University Hospital, Spain, 6Pediatric oncology section. Carlos Haya University Hospital, Spain, 7Department of Pediatric Hematology and Oncology. Virgen del Rocio University Hospital, Spain, 8Department of Pediatric Hematology and Oncology. University Hospital Complex of Santiago, Spain, 9Department of Pediatric Oncology. Niño Jesus University Hospital, Spain, 10Department of Pediatric Oncology. Sant Joan de Deu University Hospital, Spain
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecular subgroups of atypical teratoid/rhabdoid tumor (ATRT): towards a consensus
Martin Hasselblatt*1, Pascal D. Johann2,3, Ben Ho4, Yura Grabovska5, Fupan Yao4,6, Franck Bourdeaut7, Michael C. Frühwald8, Dan Williamson5, Marcel Kool2, Annie Huang4
1Institute of Neuropathology, University Hospital Münster, Germany, 2Hopp-Children’s Cancer Center at the NCT Heidelberg, and Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Germany, 3Dept. of Pediatric Oncology and Hematology, University Hospital Heidelberg, Germany, 4Labatt's Brain Tumor Research Centre, Division of Hematology/Oncology, Hospital for Sick Children, Canada, 5Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, UK, 6Dept. of Medical Biophysics, University of Toronto, Canada, 7Pediatric Care and Research Center, Institute Curie, Paris Sciences et Lettres Research University, France, 8Swabian Children’s Cancer Center, Children’s Hospital Augsburg, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Molecular, pathological, radiological and immune profiling of non-brainstem paediatric high grade glioma from the HERBY phase II randomised trial
Alan Mackay1, Anna Burford1, Valeria Molinari1, David Jones2, Elisa Izquierdo1, Juriaan Brouwer-Visser3, Felice Giangaspero4, Christine Haberler5, Torsten Pietsch6, Thomas Jacques7, Dominique Figarella-Branger8, Daniel Rodriguez9, Paul Morgan9, Pichai Raman10, Angela Waanders10, Adam Resnick10, Maura Massimino11, Maria Luisa Garre12, Helen Smith13, David Capper14, Stefan Pfister2, Thomas Wurdinger15, Rachel Tam16, Josep Garcia13, Meghna Das Thakur16, Giles Vassal17, Jacques Grill17, Tim Jaspan9, Pascale Varlet18, Chris Jones*1
1Institute of Cancer Research, UK, 2DKFZ, Germany, 3Roche, USA, 4Sapienza University, Italy, 5Medical University Vienna, Austria, 6University of Bonn Medical Centre, Germany, 7GOSH, UK, 8Marseille University, France, 9University of Nottingham, UK, 10CHOP, USA, 11Istituto Nazionale Tumori, Italy, 12Istituto Giannina Gaslini, Italy, 13Roche, Switzerland, 14Charite, Germany, 15VUmc, The Netherlands, 16Genentech, USA, 17Institut Gustav Roussy, France, 18Sainte-Anne Hospital, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Molecularly-defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features
Maximilian Y. Deng*1,2, Felix Sahm3,4, Martin Sill1,2, Jason Chiang5, David Capper6, Till Milde1,7, Martin Ebinger8, Martin Schuhmann9, Jens Schittenhelm10, Camelia-Maria Monoranu11, Andrey Korshunov3,4, David Ellison5, Andreas von Deimling3,4, Stefan M. Pfister1,2, David Jones1,2
1Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 3Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Germany, 4Clinical Cooperation Unit Neuropathology, German Cancer Consortium, German Cancer Research Center (DKFZ), Germany, 5Department of Pathology, St. Jude Children’s Research Hospital, USA, 6Department of Neuropathology, Charité Universitaetsmedizin Berlin, Germany, 7Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Germany, 8Department of Pediatric Hematology/Oncology, Children's University Hospital Tuebingen, Germany, 9Department of Neurosurgery, Division of Pediatric Neurosurgery, University Hospital Tuebingen, Germany, 10Department of Neuropathology, Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tuebingen-Stuttgart, University Hospital of Tuebingen, Germany, 11Institute of Pathology, Department of Neuropathology, University of Wuerzburg, Comprehensive Cancer Center (CCC) Mainfranken, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Multi-institutional neuro-oncology nursing collaboration: The Pediatric Brain Tumor Consortium nursing committee experience
Lauren Hancock*1, Anna Evans2, Elizabeth Gilger3, Mary Petriccione4, Megan Urban5, Lindsay Chapman6
1Children's National Medical Center, USA, 2Children's Hospital Los Angeles, USA, 3Cincinnati Children's Hospital Medical Center, USA, 4Memorial Sloan Kettering Cancer Center, USA, 5Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 6St. Jude Children's Research Hospital, USA
Saturday, June 30:  Nursing Symposium  - 
Multimodal immunotherapy keeps long-term remission after second relapse of pineoblastoma in infant
Stefaan Van Gool*, Jennifer Makalowski, Wilfried Stuecker
IOZK, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Multiplexed immunofluorescence reveals potential PD-1/PD-L1 pathway vulnerabilities in craniopharyngioma
Shannon Coy*1,2, Rumana Rashid1, Jia-Ren Lin2,3, Ziming Du1, Andrew M. Donson4,5, Todd C. Hankinson5,6, Nicholas K. Foreman4,5, Peter E. Manley2,7, Mark W. Kieran2,7, David A. Reardon2,8, Peter K. Sorger2,3, Sandro Santagata1,9
1Department of Pathology, Brigham and Women's Hospital, USA, 2Harvard Medical School, USA, 3MS LINCS Center and Laboratory of Systems Pharmacology, USA, 4Department of Pediatrics, University of Colorado School of Medicine, USA, 5Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA, 6Department of Neurosurgery, Children's Hospital Colorado, USA, 7Pediatric Medical Neuro-Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, USA, 8Department of Medical Oncology, Dana-Farber Cancer Institute, USA, 9Ludwig Center at Harvard, USA, 10Department of Pathology, Boston Children's Hospital, USA, 11Department of Oncologic Pathology, Dana Farber Cancer Institute, USA
Sunday, July 1:  Craniopharyngioma/Rare Tumors  -  2:30pm - 3:30pm
Multi-state-analysis for pediatric patients with low-grade glioma
Anna-Maria Goebel1, Astrid K. Gnekow2,3, Daniela Kandels2,3, Olaf Witt4,5, Rene Schmidt6, Pablo Hernáiz Driever*1
1Department of Pediatric Oncology/Hematology, Charité University Hospital Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany, 2Swabian Children's Cancer Center, Augsburg University Hospital, Germany, 3SIOP-LGG central study registry, Augsburg University Hospital, Germany, 4Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Germany, 5German Cancer Research Center (DKFZ), and German Consortium for Translational Cancer Research (DKTK), Germany, 6Institute of Biostatistics and Clinical Research, University of Muenster, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Murine Sox2-positive early precursor cells give rise to rhabdoid tumors with features of the human ATRT-MYC group
Natalia Moreno Galarza1, Dörthe Holdhof2, Marta Interlandi1, Viktoria Melcher1, Monika Graf*1, Dennis Kastrati1, Michael Meisterernst3, Pascal Johann4, Marcel Kool4,5, Michael Frühwald6, Ulrich Schüller2, Kornelius Kerl1
1Department of Pediatric Hematology and Oncology, University Children’s Hospital, Westfalian-Wilhelms-University, Germany, 2Research Institute Children's Cancer Center Hamburg, Eppendorf University Hospital, University of Hamburg, Germany, 3Institute of Molecular Tumorbiology Muenster, University Hospital Muenster, Germany, 4Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 5Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 6Children’s Hospital Augsburg, Swabian Children’s Cancer Center, Germany
Monday, July 2:  ATRT  -  11:00am - 12:30pm
National UK guidelines for the investigation, treatment and long-term follow-up of paediatric craniopharyngioma
Hoong-Wei Gan1,3, Kristian Aquilina*3, Paul Morillon2, Assunta Albanese8, Konstantinos Barkas9, Chris Chandler9, Yen-Ching Chang10, Christina Daousi11, Evangelos Drimtzias12, Sarah Farndon13, Tom Jacques3, Marta Korbonits14, Adam Kuczynski3, Jennifer Limond15, Louise Robinson16, Ian Simmons12, Nick Thomas9, Sophie Thomas6, Nicola Thorpe17, Faraneh Vargha-Khadem1,3, Daniel Warren12, Bassel Zebian9, Conor Mallucci4, Ashley Gamble5, Sophie Wilne6, Barney Harrison7, Helen Spoudeas3
1University College London Great Ormond Street Institute of Child Health, UK, 2Kingston Hospital NHS Foundation Trust, UK, 3Great Ormond Street Hospital for Children NHS Foundation Trust, UK, 4Alder Hey Children's NHS Foundation Trust, UK, 5UK Children's Cancer and Leukaemia Group, UK, 6Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, UK, 7Sheffield Teaching Hospitals NHS Foundation Trust, UK, 8St. George's University Hospitals NHS Foundation Trust, UK, 9King's College Hospital NHS Foundation Trust, UK, 10University College London Hospitals NHS Foundation Trust, UK, 11Aintree University Hospital NHS Foundation Trust, UK, 12Leeds Teaching Hospitals NHS Trust, UK, 13East and North Hertfordshire NHS Trust, UK, 14Queen Mary University of London, UK, 15University of Glasgow, UK, 16Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, UK, 17The Clatterbridge Cancer Centre NHS Foundation Trust, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Natural Killer cell immunotherapy for diffuse intrinsic pontine glioma
Javiera Bravo-Alegria*1, Shinji Maegawa1, Keri Callegari1, Bridget Kennis1, Wencai Ma1, William Brugmann1, Arvind Rao1, Dean Anthony Lee2, Soumen Khatua1, Wafik Zaky1, David Sandberg1, Stewart Goldman3, Vidya Gopalakrishnan1
1University of Texas MD Anderson Cancer Center, USA, 2Nationwide Children’s Hospital and The Ohio State University Comprehensive Cancer Center, USA, 3Ann & Robert H. Lurie Children’s Hospital of Chicago, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Neurocognitive late effects of posterior fossa tumors. Psychological risk and protective factors
Justyna Korzeniewska*, Marta Perek-Polnik, Bozenna Dembowska-Bagińska
Childrens Memorial Health Institute, Poland
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Neurocognitive sequelae in pediatric low grade glioma patients under observation - neuropsychological results from the SIOP-LGG-2004 study & LGG-Register
Thomas Traunwieser*, Daniela Kandels, Astrid Gnekow
Swabian Children’s Cancer Center, Children’s Hospital Augsburg, Germany
Sunday, July 1:  Low Grade Gliomas  -  8:45am - 11:00am
Neurocognitive sequelae of children treated for CNS tumors: experience from the first systematic evaluation in Greece
Natalia Karra*1, Evangelia Saleptsi1, Chrysovalanto-Sofia Karatosidi1, Maria Filippidou2, Kleoniki Roka2, Antonis Kattamis2
1Brain Injury Day Treatment Unit, ELEPAP, Greece, 2Division of Pediatric Hematology-Oncology, First Department of Pediatrics, Athens Medical School, Greece
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Neurocognitive status in supratentorial PNET treated on COG ACNS0332 within the first 30 months from diagnosis: A report from the Children's Oncology Group
Karin Walsh*1, Eugene Hwang1, Kristina Hardy1, Leanne Embry2, Anthony Gioia1, Tess Kennedy1, Catherine Billups3, Yimei Li3, Roger Packer1, James Olson4
1Children's National Health System, USA, 2UT Health San Antonio, USA, 3St. Jude Children's Research Hospital, USA, 4University of Washington, USA
Sunday, July 1:  Quality of Life/Survival/Rehabilitation  -  1:30pm - 3:00pm
Neuroendoscopic biopsy of intracranial germ cell tumors: accuracy and complications
Tomonari Suzuki*1, Junichi Adachi1, Kazuhiko Mishima1, Takamitsu Fujimaki1,2, Takaaki Yanagisawa1,3, Ryo Nishikawa1
1Saitama Medical University International Medical Center, Japan, 2Saitama Medical University Hospital, Japan, 3Tokyo Jikei University Hospital, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Neurofibromatosis therapeutics: Pearls to treat the complex child
Molly Hemenway*, Melissa Waters
Children's Hospital Colorado, Univ of Colorado, USA
Saturday, June 30:  Nursing Symposium  - 
Neurologic compromise and outcome after proton beam therapy (PBT) for posterior fossa tumors (PFTs) of childhood
Aimee Sato*1, Jonathan Murnick1, Matthew Ladra2,1, Elizabeth Wells1, Lindsay Kilburn1, Eugene Hwang1, Roger Packer1
1Children's National Health System, USA, 2Johns Hopkins Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Neuropsychological assessment of 21 patients treated for a childhood brain frontal lobe tumour : aspects of social cognition and theory of mind
Audrey Longaud*, Mathilde Chevignard, Jacques Grill, Christelle Dufour, Stéphanie Puget, Christian Sainte-Rose, Dominique Valteau-Couanet, George Dellatolas
Gustave Roussy Cancer Campus, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
New approaches of oncology rehabilitation in children: Technotherapy – systematic literature review
Irem Kurt, Müberra Tanriverdi*
Bezmialem Vakif University, Turkey
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
New therapeutic approach for brainstem glioma: Intranasal delivery of nanoliposomal SN-38
Xingyao He*1, Nundia Louis1, Hiroaki Katagi1, Peng Zhang1, Irina Balyasnikova1, Craig Horbinski1,2, Stewart Goldman3,4, Rintaro Hashizume1,5
1Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, USA, 2Departments of Pathology and Neurosurgery, Northwestern University, USA, 3Division of Hematology, Oncology, Neuro­Oncology & Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 4Department of Pediatric­-Hematology, Oncology and Stem Cell Transplantation, Northwestern University Feinberg School of Medicine, USA, 5Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
NFκB and FOXM1 mediate anti-cancer activity of dual HDAC and PI3K inhibition in pediatric high grade glioma and DIPG
Sharmistha Pal*1, David Kozono1, Xiaodong Yang2, Whitney Fitts4, Jing Ni1, John Alberta1, Jean Zhao1, Kevin Liu1, Jie Bian1, Nathalene Truffaux2, William Weiss2, Adam Resnick3, Pratiti Bandopadhayay1, Keith Ligon1, Steven DuBois1, Sabine Mueller2, Dipanjan Chowdhury1, Daphne Haas-Kogan1,4
1Dana Farber Cancer Institute, USA, 2University of California San Francisco, USA, 3University of Pennsylvania, USA, 4Harvard Medical School, USA
Monday, July 2:  High Grade Glioma  -  3:30pm - 5:00pm
NF105: A phase II prospective study of Cabozantinib (XL184) for plexiform neurofibromas in subjects with neurofibromatosis type 1: a Neurofibromatosis Clinical Trial Consortium (NFCTC) study
Chie-Schin Shih*1, Jaishri Blakeley2, Wade Clapp1, Pam Wolters3, Eva Dombi3, Gary Cutter4, Nichole Ullrich5, Jeffrey Allen6, Roger Packer7, Stewart Goldman8, David Gutmann9, Scott Plotkin10, Tena Rosser11, Kent Robertson1, Brigitte Widemann3, Bruce Korf4, Michael Fisher12
1Indiana University, USA, 2Johns Hopkins University, USA, 3National Cancer Institute-Pediatric Oncology Branch, USA, 4University of Alabama-Birmingham, USA, 5Boston Children's Hospital, USA, 6New York University, USA, 7Children's National Medical Center, USA, 8Children's Hospital of Chicago, USA, 9Washington University, USA, 10Massachusetts General Hospital, USA, 11Children's Hospital of Los Angeles, USA, 12Children's Hospital of Philadelphia, USA
Tuesday, July 3:  Neurofibromatosis  -  8:00am - 9:00am
NF106: Phase 2 trial of the MEK inhibitor PD-0325901 in adolescents and adults with NF1-related plexiform neurofibromas: An NF Clinical Trials Consortium study
Brian Weiss1, Scott Plotkin2, Brigitte Widemann3, James Tonsgard4, Jaishri Blakeley5, Jeffrey Allen6, Elizabeth Schorry1, Bruce Korf7, Tena Rosser8, Stewart Goldman9, Alexander Vinks1, Gary Cutter7, Eva Dombi3, Nancy Ratner1, Roger Packer10, Michael Fisher*11
1Cincinnati Children’s Hospital Medical Center, USA, 2Massachusetts General Hospital, USA, 3National Cancer Institute, USA, 4University of Chicago, USA, 5Johns Hopkins Medical Center, USA, 6New York University, USA, 7University of Alabama-Birmingham, USA, 8Children’s Hospital Los Angeles, USA, 9Ann & Robert H. Children’s Lurie Hospital, USA, 10Children’s National Medical Center, USA, 11Children’s Hospital of Philadelphia, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Nivolumab in the treatment of recurrent or refractory pediatric brain tumors: A single institutional experience
Hamza Gorsi*1,2, Denise Malicki1,2, Paritosh Khanna1,2, Jennifer Elster1,2, Valentin Barsan1,2, Mark Tumblin1, Lanipua Yeh-Nayre1, Mehrzad Milburn1, John Crawford1,2
1Rady Children's Hospital, USA, 2UC San Diego, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Non-targeted mutation and fusion analyses can aid in classification and treatment of pediatric gliomas
Ahmed Gilani*1, Jean Mulcahy Levy,1,2, Bette Kleinschmidt-DeMasters1
1Children's Hospital Colorado, University of Colorado Denver, USA, 2Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Novel FGFR2 fusions drive oncogenesis via MAPK and PI3K/mTOR pathway activation in dysembryoplastic neuroepithelial tumors
Payal Jain*1,2, Lea Surrey1, Joshua Straka1, Minjie Luo1, Adam C. Resnick1,2, Phillip B. Storm1,2, Mariarita Santi1, Marilyn Li1, Angela J. Waanders1,2
1Children's Hospital of Philadelphia, USA, 2University of Pennsylvania, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Novel PTCH1-INPPL1 fusion in a patient with extraneural metastatic ependymoma - a case report
Gurcharanjeet Kaur*, Ira Dunkel, Neerav Shukla, Ahmet Zahir, Matthias Karajannis
Memorial Sloan Kettering Cancer Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Novel treatment approach for patients with central nervous system (CNS) pure embryonal carcinoma with intensive induction and consolidation marrow-ablative chemotherapy followed by an anti-CD30 antibody-drug conjugate, without irradiation
Mohammad H. Abu Arja*1, Suzanne E. Conley1, Mohamed S. AbdelBaki1, Diana S. Osorio1, Scott Coven1, Rolla T. Abu-Arja1, Daniel Boué2, Kevin Ginn3, Jeffrey Leonard4, Jonathan L. Finlay1
1The Division of Hematology, Oncology and BMT, the Department of Pediatrics, Nationwide Children's Hospital, USA, 2The Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, USA, 3The Division of Pediatric Hematology and Oncology, the Department of Pediatrics, Children’s Mercy Hospital, USA, 4The Division of Neurosurgery, the Department of Pediatric Surgery, Nationwide Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Novel tumor-derived models of CNS HGNET-BCOR provide insights into underlying molecular mechanisms and innovative therapeutic options
Johannes Gojo*1,2, Dominik Kirchhofer1,3, Daniela Lötsch2,3, Thomas Mohr3, Christine Pirker3, Kristian W. Pajtler4,6, Konstantin Okonechnikov4,5, Bernhard Englinger3, Bernd Boidol7, Charles-Hugues Lardeau7, Thomas Czech2,8, Stefan Kubicek7, Dominik Sturm4,6, Stefan M. Pfister4,5, Andreas Peyrl1,2, Christine Haberler2,9, Marcel Kool4,5, Walter Berger2,3, Irene Slavc1,2
1Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria, 2Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, Austria, 3Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Austria, 4Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 5Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 6Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Germany, 7CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria, 8Department of Neurosurgery, Medical University of Vienna, Austria, 9Institute of Neurology, Medical University of Vienna, Austria
Monday, July 2:  Preclinical Models/Drug Discovery  -  8:30am - 9:30am
Nursing impact on bone marrow transplant in the outpatient setting
Melissa Waters*, Erin Kissell, Stacy Silverman, Molly Hemenway, Jenny Raybin
Children's Hospital Colorado, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Nutrition risk classification and intervention decision tool for children with central nervous system tumors
Rachel Hill, Mandy Mansell, Danielle Johnson, Ashleigh Hines*
Cook Children's Healthcare System, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Oncogenic mechanisms of H3.3 K27M in a spontaneous DIPG mouse model
Jon Larson*, Lawryn Kasper, Barbara Paugh, Gang Wu, Hongjian Jin, Yiping Fan, Chang-Hyuk Kwon, David Finkelstein, Andre Silveira, Raymond Xu, Xiaoyan Zhu, Junyuan Zhang, Beisi Xu, Helen Russell, Peter McKinnon, David Ellison, Jinghui Zhang, Suzanne Baker
St. Jude Children's Research Hospital, USA
Monday, July 2:  DIPG/Diffuse Midline Glioma  -  1:30pm - 3:00pm
Oncolytic virus for pHGG and DIPGs: from the bench to the bedside
Sonia Tejada*1, Naiara Martinez-Velez1, Maider Varela1, Pablo Dominguez1, Juan Fueyo2, Candelaria Gomez-Manzano2, Javier Aristu1, Ricardo Diez1, Marta Alonso1
1Clinica Universidad de Navarra, Spain, 2MD Anderson Cancer Center, USA
Monday, July 2:  DIPG/Diffuse Midline Glioma  -  1:30pm - 3:00pm
Optic pathway glioma volume predicts visual acuity loss and axonal loss in children with Neurofibromatosis type 1
Robert Avery*1, Awais Mansoor2, Grant Liu1, Carmelina Trimboli-Heidler1, Gui-Shuang Ying3, Nadine Eltoukhy3, Roger Packer2, Michael Fisher1, Marius Linguraru2
1Children's Hospital of Philadelphia, USA, 2Children's National Health System, USA, 3University of Pennsylvania, USA
Tuesday, July 3:  Neurofibromatosis  -  8:00am - 9:00am
Oral vinorelbine in progressive unresectable low-grade glioma:  Experience of a single institution
Andrea Cappellano*, Cynthia M Silveira, Milena RS Oliveira, Sergio Cavalheiro, Patricia Dastoli, Maria Teresa S Alves, Gregorio Pereira, Frederico A Silva, Daniela Barbosa, Nasjla Saba da Silva
IOP/GRAACC/UNIFESP, Brazil
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Orthotopic transplantation of paediatric glioma stem cells in mice mirrors the clinical course of the patient
Anna Wenger*1, Susanna Larsson1, Sándor Dósa2, Magnus Sabel3,4, Teresia Kling1, Helena Carén1
1Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden, 2Department of Pathology, Sahlgrenska University Hospital, Sweden, 3Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden, 4The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Sweden
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Ototoxicity in medulloblastoma survivors following proton radiation
John Byun*2, Clayton B. Hess1, Benjamin V. M. Bajaj1, Elizabeth A. Weyman1, Miranda P. Lawell1, Sara L. Gallotto1, David H. Ebb, MD1, Shannon M. MacDonald, MD1, Nancy J. Tarbell, MD1, Torunn I. Yock, MD1
1Massachusetts General Hospital, USA, 2Rutgers Cancer Institute of New Jersey, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Outcome and toxicity of medulloblastoma in Alexandria, Egypt: 10 years experience
Zeyad Abdelaziz, Basmaa Elsabe, Ahmed Farhod, Amr Abdelkarim, Shady Fadel*
Alexandria University, School of medicine, Egypt
Sunday, July 1:  Neuro-Oncology in Developing Regions  -  11:30am - 12:30pm
Outcome of children with medulloblastoma at Tertiary Care Hospital in Pakistan
Syed Ahmer Hamid*, Maria Idrees Dawson, Rahil Khan, Muhammad Shamvil Ashraf, Ibrahim Qaddoumi
The Indus Hospital, Pakistan
Tuesday, July 3:  Medulloblastoma - Clinical  -  10:40am - 12:10pm
Outcome of children with medulloblastoma treated in a tertiary referral centre in Malaysia
Mukhtaar Shaalih Tsai Ei Chan, Siti Nuraihan Nordin, Sing Yee Hiew, Eni Juraida Abdul Rahman, Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Bina Sharine Menon, Yin Sear Lim, Kok Hoi Teh*
Hospital Kuala Lumpur, Malaysia
Sunday, July 1:  Neuro-Oncology in Developing Regions  -  11:30am - 12:30pm
Outcome of intracranial germ cell tumours: 20-year experience of a single tertiary center from a middle-income country
Revathi Rajagopal*, Sheng Hoay Leong, Dharmendra Ganesan, Anita Zarina Bustam Mainudin, Kein Seong Mun, Jen Chun Foo, Vida Jawin, Tsiao Yi Yap, Hany Ariffin
University Malaya Medical Centre, Malaysia
Sunday, July 1:  Neuro-Oncology in Developing Regions  -  11:30am - 12:30pm
Outcome of patients with recurrent diffuse intrinsic pontine glioma (DIPG) treated with pembrolizumab (anti-PD-1): a Pediatric Brain Tumor Consortium study (PBTC045)
Eugene Hwang*1, Arzu Onar2, Tina Young-Poussaint3, Duane Mitchell4, Lindsay Kilburn1, Ashley Margol5, Stephen Gilheeny6, Tong Lin2, Ira Dunkel6, Maryam Fouladi7
1Children's National Medical Center, USA, 2St. Jude Children’s Research Hospital, USA, 3Boston Children's Hospital, USA, 4University of Florida, USA, 5Children's Hospital of LA, USA, 6Memorial Sloan Kettering Cancer Center, USA, 7Cincinnati Children's Hospital, USA
Tuesday, July 3:  Immunotherapy  -  10:40am - 11:40am
Outcome of single-trajectory endoscopic third ventriculostomy and biopsy in the management algorithm of pineal region tumors: a case series and review of the literature
Mahmoud Abbassy*, Khaled Aref, Ahmed Farhood, Anwar Hekal
Alexandria University, Egypt
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Outcome of young children with supratentorial ependymoma treated with radical surgical resection and intensive chemotherapy: Final report of the Head Start I-III Trials, 1991-2009
Mohamed AbdelBaki*1, Rajkumar Venkatramini2, Stergios Zacharoulis3, Sharon Gardner4, Girish Dhall5, Jonathan Finlay1
1Division of Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, USA, 2Texas Children’s Hospital, Baylor College of Medicine, USA, 3The Harley Street Clinic Children’s Hospital, UK, 4New York University School of Medicine, USA, 5Children’s Hospital of Los Angeles, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Outcomes of malignant brain tumors in young children treated with chemotherapy and delayed radiotherapy in a resource limited setting
Ananda KC*, Hari Sankaran, Vasudev Bhat, Prakash Shetty, Jayanth Shastry, Ayushi Sahay, Epari Shridhar, Abhishek Mahajan, Maya Prasad, Tushar Vora, Sona Pungaonkar, Aliasgar Moiyadi, Tejpal Gupta, Rakesh Jalali, Girish Chinnaswamy
Tata Memorial Hospital, India
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Outcomes of re-irradiation in pediatric patients with recurrent CNS tumors
Andrew Chang*1, Jayne Vonbergen2, Markus Fitzek4, Allan Thornton3, Chie-Schin Shih2, Kamnesh Pradhan2
1California Protons, USA, 2Riley Children's Hospital, USA, 3Hampton Univeristy Proton Therapy Center, USA, 4Indiana University, USA
Tuesday, July 3:  Radiation Oncology  -  8:00am - 9:00am
Outcomes of stereotactic radiosurgery for pilocytic astrocytoma: an international multicenter study
Erin S. Murphy*1, Jason P. Sheehan2, Daniel M. Trifiletti2, David Mathieu3, Hideyuki Kano4, Fang Fang4, John Y.K Lee5, Brendan McShane5, Cheng-chia Lee6, Huai-che Yang6, Roberto Martinez Alvarez7, Nuria Martinez Moreno7, Gabriela Simonova8, Roman Liscak8, Douglas Kondziolka9, Mayur Sharma1, Gene H. Barnett1
1Cleveland Clinic, USA, 2University of Virginia, USA, 3Université de Sherbrooke, Centre de recherche du CHUS, Canada, 4University of Pittsburgh Medical Center, USA, 5University of Pennsylvania, USA, 6Neurological Institute, Taipei Veterans General Hospital, Taiwan, 7Hospital Ruber Internacional, Spain, 8Na Homolce Hospital, Czech Republic, 9New York University Langone Medical Center, USA
Tuesday, July 3:  Radiation Oncology  -  8:00am - 9:00am
Overexpression and mutations of CXorf67 in ‘infant-type’ posterior fossa type-A (PFA) ependymomas
Wilda Orisme*1, Ji Wen1, Bo Tang1, Jens-Martin Hübner2,3, Gang Wu4, Sujuan Jia1, John Easton4, Kelly Haupfear1, Brian D. Freibaum5, Hong Joo Kim5, Anthony High6, BaoHan Vo8, Ruth G. Tatevossian1, Junmin Peng6, Stefan M. Pfister2,7, Jinghui Zhang4, J. Paul Taylor5, Martine Roussel8, Kristian W. Pajtler2,7, Marcel Kool2,3, David W. Ellison1
1Department of Pathology, St. Jude Children’s Research Hospital, USA, 2Division of Pediatric Neurooncology, German Cancer Research Center, Germany, 3Hopp-Children´s Cancer Center at the NCT Heidelberg, Germany, 4Department of Computational Biology, St. Jude Children’s Research Hospital, USA, 5Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, USA, 6Proteomics Shared Resource, St. Jude Children’s Research Hospital, USA, 7Department of Pediatric Oncology, Hematology and Immunology, University Hospital, Germany, 8Department of Tumor Cell Biology, St. Jude Children’s Research Hospital, USA
Sunday, July 1:  Ependymoma  -  3:30pm - 5:00pm
Oxytocin in childhood-onset craniopharyngioma - First experiences with neuropsychological effects of oxytocin administration
Anika Hoffmann1, Jale Özyurt2, Christiane Thiel2, Hermann L. Müller*1
1Dep.of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg, Medical Campus University Oldenburg, Germany, 2Biological Psychology Lab, Department of Psychology, Faculty of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Paediatric extraventricular neurocytoma: a series and a rare complication
Alexandra Johnson*1,2, Annie Bye1,2, David Ziegler1,2, Andrew Gifford3, Erica Jacobsen1,2, Richard Cohn1,2
1Sydney Children's Hospital, Australia, 2School of Women's and Children's Health, University of New South Wales, Australia, 3South East Area Laboratory Service, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Palliative Care Bereavement Intervention: An educational and support program for neuro-oncology staff  
Melissa Mark*, Elizabeth Gilger, Aimee Thompson, Maryam Fouladi
Cincinnati Children's Hospital Medical Center, USA
Saturday, June 30:  Social Work Session  - 
Palliative treatment for DIPG (diffuse intrinsic pontine glioma) at Kobe Children’s Hospital in Japan
Atsufumi Kawamura*, Junji Koyama, Nobuyuki Akutsu, Mai Azumi
Hyogo Prefectural Kobe Children's Hospital, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Panacea: a novel blackBerry 10 based, support mobile app for brain tumor affected patients.
Abhishek Puri*1, Amit Garg1, P Mohandass1
1Fortis Cancer Institute, India, 2Hugsoft Inc., India
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Papillary craniopharyngioma with BRAF V600E mutation in a four year old child: a case report and review of clinical cases from literature
Roisin Borrill1, Anthony Penn1,2, Edmund Cheesman3, Stavros Stivaros4,5, Ian D Kamaly-Asl1,6, Kanna Gnanalingham7, John-Paul Kilday*1,2
1Children's Brain Tumour Research Network (CBTRN), Royal Manchester Children's Hospital, UK, 2The Centre for Paediatric, Teenage and Young Adult Cancer, Institute of Cancer Sciences, The University of Manchester, UK, 3Department of Paediatric Histopathology, Royal Manchester Children's Hospital, UK, 4Centre for Imaging Sciences, University of Manchester, UK, 5Academic Unit of Paediatric Radiology, Royal Manchester Children's Hospital, UK, 6Manchester Academic Health Sciences Centre , University of Manchester, UK, 7Department of Neurosurgery, Salford Royal NHS Foundation Trust Hospital, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Patient derived cell lines to study ATRX and ALT in pediatric brain tumors
Heba Ijaz1, Robert Dilley2, Mateusz Koptra3, Gonzalo Garcia1, Yuankun Zhu3, Bo Zhang3, Valerie Baubet3, Jennifer Mason3, Adam Resnick3, Krutika Gaonkar3, Angela Waanders1,3, Pichai Raman1,3, Roger Greenberg2, Kristina Cole*1,2
1The Children's Hospital of Philadelphia, Division of Oncology, USA, 2University of Pennsylvania, Perelman School of Medicine, USA, 3The Children's Hospital of Philadelphia, Center for Data Driven Discovery in Biomedicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Patient-derived PFA ependymoma xenograft model
Andrea Griesinger*1,2, Angela Pierce1,2, Davis Witt1,2, Patrick Flannery1,2, Andrew Donson1,2, Katherine Gowan2, Todd Hankinson1, Michael Handler1, Kenneth Jones2, Adam Green1,2, Rajeev Vibhakar1,2, Nicholas Foreman1,2
1Children's Hospital Colorado, USA, 2University of Colorado Denver Anschutz Medical Campus, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
PDL-1 expression on circulating CD68 (-) monocyte-like cells in NF2 meningioma as a biomarker for tumor progression
Shiyang Wang1, Benjamin Liechty2, An Hanna1, Seema Patel1, Matija Snuderl1, Matthias Karajannis3, Allen Jeffrey1, Sharon Gardner*1
1NYU Langone Health, USA, 2Columbia University Medical Center, USA, 3Memorial Sloan Kettering Cancer Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
PedcBioPortal, a cancer data visualization tool for integrative pediatric cancer analyses
Pichai Raman1, Komal Rathi1, Karthik Kalletla1, Yuankun Zhu1, Bo Zhang1, Nikolaus Schultz2, Ethan Cerami3, Alan Mackay6, Chris Jones6, Sabine Mueller4, Javad Nazarian5, John M Maris1, Phillip B Storm1, Angela J Waanders1, Adam C Resnick*1
1Children's Hospital of Philadelphia, USA, 2Memorial Sloan Kettering Cancer Center, USA, 3Dana-Farber Cancer Institute, USA, 4UCSF Benioff Children's Hospital, USA, 5Children’s National Health System, USA, 6The Institute of Cancer Research, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Pediatric craniopharyngioma in association with familial adenomatous polyposis
Nathan A. Dahl*1,2, Drew Pratt3, Chandan Kumar4, Sandra Camelo-Piragua3, Rajen J. Mody5, Seth Septer6, Todd Hankinson2,7, Carl Koschmann5, Lindsey Hoffman1
1Pediatric Neuro-Oncology Program, Children's Hospital Colorado, University of Colorado School of Medicine, USA, 2Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA, 3Neuropathology Division, Department of Pathology, University of Michigan, USA, 4Center for Translational Pathology, Department of Pathology, University of Michigan, USA, 5Pediatric Hematology-Oncology, Department of Pediatrics, University of Michigan, USA, 6Pediatric Gastroenterology, Children's Hospital Colorado, University of Colorado School of Medicine, USA, 7Department of Neurosurgery, Children's Hospital Colorado, University of Colorado School of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pediatric diffuse glioma WHO-grade II: Prognostic impact of molecular genetic variants
Astrid K Gnekow*1, Daniela Kandels1, Monika Warmuth-Metz2, Brigitte Bison2, René Schmidt3, Rolf-Dieter Kortmann4, Marco Gessi5, Torsten Pietsch5
1Swabian Children's Cancer Center, Children's Hospital, Klinikum Augsburg, Germany, 2Institute of Neuroradiology, University Hospital of Wuerzburg, Germany, 3Institute of Biostatistics and Clinical Research, University of Muenster, Germany, 4Department of Radio-Oncology, University of Leipzig, Germany, 5Institute of Neuropathology, University of Bonn, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pediatric gliosarcoma with and without neurofibromatosis type 1: a whole-exome comparison of two patients
Richard T. Graham1,2, Erica Hlavin Bell*2, Amy Webb2, Cynthia Timmers2, Nathan Robison3, Joshua Palmer2, Jonathan L. Finlay1,2, Arnab Chakravarti2
1Nationwide Children's Hospital, USA, 2The Ohio State University, USA, 3Children's Hospital Los Angeles, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pediatric intracranial ependymoma: correlation of symptoms and signs at recurrence with outcome in the second prospective AIEOP protocol follow-up
Maura Massimino*1, Francesco Barretta1, Felice Giangaspero17,19, Luisa Chiapparini2, Alessandra Erbetta2, Luna Boschetti1, Piergiorgio Modena18, Manila Antonelli17, Paolo Ferroli2, Daniele Bertin3, Emilia Pecori1, Veronica Biassoni1, Maria Luisa Garrè4, Elisabetta Schiavello1, Iacopo Sardi7, Elisabetta Viscardi10, Giovanni Scarzello11, Maurizio Mascarin9, Lucia Quaglietta8, Giuseppe Cinalli8, Lorenzo Genitori7, Paola Peretta3, Anna Mussano3, Salvina Barra22, Angela Mastronuzzi5, Carlo Giussani20, Carlo Efisio Marras5, Rita Balter15, Patrizia Bertolini16, Assunta Tornesello14, Milena La Spina13, Francesca Romana Buttarelli17, Antonio Ruggiero12, Massimo Caldarelli12, Geraldina Poggi21, Lorenza Gandola1
1Fondazione IRCCS Istituto Nazionale dei Tumori, Italy, 2Fondazione IRCCS Istituto Neurologico Carlo Besta, Italy, 3A.O.U. Città della Salute e della Scienza, Italy, 4Istituto Giannina Gaslini, Italy, 5Ospedale Pediatrico Bambino Gesù, Italy, 6Ospedale Microcitemico, Azienda Brotzu, Italy, 7Ospedale Pediatrico Meyer, Italy, 8Ospedale Santobono/Pausilipon, Italy, 9IRCCS Centro di Riferimento Oncologico, Aviano, Italy, Italy, 10Azienda Ospedaliera, Italy, 11Istituto Oncologico Veneto, Italy, 12Ospedale Gemelli, Italy, 13Policlinico Vittorio Emanuele, Italy, 14Ospedale Vito Fazzi, Italy, 15Ospedale della Donna e del Bambino, Italy, 16Azienda Ospedaliero-Universitaria, Italy, 17Università La Sapienza, Italy, 18Ospedale S. Anna, Italy, 19IRCCS Neuromed, Italy, 20Ospedale S. Gerardo, Italy, 21IRCCS Eugenio Medea, Italy, 22Policlinico San Martino, Italy
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Pediatric intra-medullary spinal cord tumors at children's cancer hospital Egypt; a single-center 10-year-experience
Moatasem El-Ayadi*1,2, Soha Abdel-Razek3,4, Ahmed Elhemaly1,2, Eslam Maher5, Ayda Yousef6,7, Mohamed El-Beltagy8,9, Hala Taha10,11
1Department of Pediatric Oncology, Children's Cancer Hospital Egypt (CCHE-57357), Egypt, 2Department of Pediatric Oncology, National Cancer Institute, Cairo University, Egypt, 3Department of Radiation Oncology, Children's Cancer Hospital Egypt (CCHE-57357), Egypt, 4Department of Clinical Oncology, Aswan University, Aswan, Egypt., Egypt, 5Department of Clinical Research, Children’s Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt, Egypt, 6Department of Radiology, Children's Cancer Hospital Egypt (CCHE-57357), Egypt, 7Department of Radiology, National Cancer Institute, Cairo University, Egypt, 8Department of Neurosurgery, Children’s Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt, Egypt, 9Department of Neurosurgery, Kasr El-Ainy School of medicine, Cairo University, Cairo, Egypt., Egypt, 10Department of Pathology, Children’s Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt, Egypt, 11Department of Pathology, National Cancer Institute, Cairo University, Egypt
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pediatric meningiomas are molecularly distinct from adult counterparts
Elmar Kirches1, Felix Sahm2, Christina Blücher1, Svenja Boekhoff3, Ulrich Schüller4, Jens Schittenhelm5, Matija Snuderl12, Matthias Karajannis13, Arie Perry14, Torsten Pietsch6, Hermann Müller3, Joshua Rubin15, David Capper7, Katja Beck8, Matthias Schlesner9, Siegfried Kropf10, Priscilla Brastianos16, Andrey Korshunov2, Stefan Pfister11, Christian Mawrin*1
1Department of Neuropathology, Germany, 2Department of Neuropathology, Germany, 3Department of Pediatrics and Pediatric Hematology/Oncology, Germany, 4Institute of Neuropathology and Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany, 5Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital, Germany, 6Department of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, Germany, 7Department of Neuropathology, Charité University Hospital, Germany, 8Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Germany, 9Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Germany, 10Institute for Biometrics and Medical Informatics, Otto-von-Guericke University, Germany, 11Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 12Division of Molecular Pathology, Department of Pathology, New York University School of Medicine, USA, 13Department of Pediatrics, Memorial Sloan Kettering Cancer Center, USA, 14Department of Neurological Surgery, University of California San Francisco, USA, 15Department of Pediatrics and Neuroscience, Washington University School of Medicine, USA, 16Divisions of Neuro-Oncology and Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Pediatric neurosurgeons as “Two-way players”
Akira Gomi*, Takashi Yamaguchi, Hirofumi Oguma, Satsuki Miyata
Jichi Medical University, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pediatric non-pontine diffuse midline glioma H3K27M mutant: a monoinstitutional experience
Elisabetta Schiavello*1, Veronica Biassoni1, Emilia Pecori1, Barbara Diletto1, Manila Antonelli2, Piergiorgio Modena3, Lorenza Gandola1, Maura Massimino1
1Fondazione IRCCS Istituto Nazionale dei Tumori, Italy, 2Università La Sapienza, Italy, 3Ospedale S. Anna, Italy
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Pediatric prolactinoma: 
initial presentation, treatment, and long-term prognosis
Anika Hoffmann1, Sarah Adelmann1, Alexander Claviez2, Hermann L. Müller*1
1Dep.of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg, Medical Campus University Oldenburg, Germany, 2Department of Pediatric Oncology, University Hospital, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Pediatric Targeted Therapy 2.0: development of personalized pediatric oncology
Jonas Ecker1,2, Florian Selt1,2, Felix Sahm3,4, David Capper3,5, Andrey Korshunov3,4, Kerstin Grund6,7, Nicola Dikow7, Christian Sutter7, Cornelis van Tilburg1,2, Hendrik Witt1,6, Andreas von Deimling3,4, David T. W. Jones1,6, Stefan M. Pfister1,6, Olaf Witt1,2, Till Milde*1,2
1Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Germany, 3Department of Neuropathology, Germany, 4Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Germany, 5Department of Neuropathology, Charité – Universitätsmedizin Berlin, Campus Charité Mitte, Germany, 6Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Germany, 7Department of Human Genetics, Institute of Human Genetics, Heidelberg University Hospital, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pembrolizumab as salvage treatment in children with recurrent diffuse midline glioma: Report of three cases
Yi-Yen Lee*1,2, Hsin-Hung Chen1,2, Yi-Wei Chen1,2, Feng-Chi Chang1,2, Shih-Chieh Lin1,2, Muh-Lii Liang1,2
1Taipei Veterans General Hospital, Taiwan, 2National Yang-Ming University, Taiwan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Peptide vaccine immunotherapy biomarkers and response patterns in pediatric gliomas
Soren Muller2, Sameer Agnihotri1, Karsen Shoger1, Max Myers1, Aaron Diaz2, Hideho Okada2, Ian Pollack1, Gary Kohanbash*1
1University of Pittsburgh, USA, 2University of California San Francisco, USA
Tuesday, July 3:  Immunotherapy  -  10:40am - 11:40am
perfusion imaging in presumed pediatric diffuse intrinsic pontine glioma: a uk regional analysis.
John-Paul Kilday*1,2, Catherine Pringle3, Ian D Kamaly-Asl1,4, Barry Pizer5, Conor Mallucci6, Dawn Hennigan6, Shivaram Avula7, Edmund Cheesman8, Daniel du Plessis9, Stavros Stivaros10,11
1Children's Brain Tumour Research Network (CBTRN), Royal Manchester Children's Hospital, UK, 2The Centre for Paediatric, Teenage and Young Adult Cancer, Institute of Cancer Sciences, The University of Manchester, UK, 3Department of Paediatric Neurosurgery, Royal Manchester Children’s Hospital, UK, 4Manchester Academic Health Sciences Centre , University of Manchester, UK, 5Department of Paediatric Oncology, Alder Hey Children’s NHS Foundation Trust Hospital, UK, 6Department of Paediatric Neurosurgery, Alder Hey Children’s NHS Foundation Trust Hospital, UK, 7Department of Paediatric Radiology, Alder Hey Children’s NHS Foundation Trust Hospital, UK, 8Department of Paediatric Histopathology, Royal Manchester Children's Hospital, UK, 9Department of Histopathology, Alder Hey Children’s NHS Foundation Trust Hospital, UK, 10Centre for Imaging Sciences, University of Manchester, UK, 11Academic Unit of Paediatric Radiology, Royal Manchester Children's Hospital,, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Pericyte-derived Periostin is crucial for neo-vessel formation in glioma
Changbin Zhu1,2, Ihsan Chrifi3, Yang Zhao1, Johan Kros2, Caroline Cheng3,4, Jie Ma*1
1Department of Pediatric Neurosurgery, Shanghai Xinhua Hospital affiliated to School of Medicine, Shanghai Jiao Tong University, China, 2Department of Pathology,Erasmus Medical Center, The Netherlands, 3Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus Medical Center, The Netherlands, 4Department of Nephrology and Hypertension, DIGD, University Medical Center Utrecht, The Netherlands
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Perioperative outcomes in pediatric ependymomas – a retrospective analysis of 47 patients
Vikas Singh*, Abhay Kattepur, Aditya Patil, Prakash Shetty, Tejpal Gupta, Girish Chinnaswamy, Sridhar Epari, Rakesh Jalali, Ali Asgar Moiyadi
Tata Memorial Centre, India
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Periostin concentrations in childhood-onset craniopharyngioma patients
Kerstin Heinks1, Caroline De Schutter-Nüsse1,4, Svenja Boekhoff1, Anika Hoffmann1, Jinzhou Zhu2, Junxiang Peng3,1, Hermann L. Müller*1
1Department of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg, Medical Campus University Oldenburg, Germany, 2Department of Gastroenterology. Zhejiang University, Hangzhou, China, 3Department of Neurosurgery, Nanfang Hospital, Southern Medical University, China, 4European Medical School Oldenburg - Groningen, Carl von Ossietzky University, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Peroxiredoxin1 is a therapeutic target in group-3 medulloblastoma
Babu Sajesh*1, Ngoc On2, Refaat Omar1, Holly Fediuk1, Lin Li1, Samaa Alrushaid2, W Wang3, J Pu3, HD Sun3, Teruna Siahaan4, Tamra Werbowetski-Ogilvie5, Matthias Wolfl6, Marc Remke7, Vijay Ramaswamy8, Michael Taylor9, Charles Eberhart10, Marc Symons11, Rosa Maria Ruggieri11, Donald Miller2, Magimairajan Issai Vanan1,12
1Research Institute in Oncology and Hematology, Canada, 2Department of Pharmacology, University of Manitoba, Canada, 3Kunming Institute of Botany, China, 4Department of Pharmaceutical chemistry, University of Kansas, USA, 5Regenerative medicine program, University of Manitoba, Canada, 6Department of Pediatrics, University of Wuerzburg, Germany, 7Department of Pediatric Oncology, Hematology, and Clinical Immunology, Heinrich Heine University Dusseldorf, Germany, 8Sick Kids, University of Toronto, Canada, 9The Arthur and Sonia Labatt Brain Tumour Research Centre, University of Toronto, Canada, 10John Hopkins University School of Medicine, USA, 11Feinstein Institute for Medical Research, USA, 12Departments of Biochemistry and Medical Genetics, Pediatrics and Child Health, University of Manitoba, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Personalized immunotherapy with translatable RNA nanoparticles targeting medulloblastoma
Elias Sayour*, Hector Mendez-Gomez, Adam Grippin, Gabriel De Leon, Brian Stover, Catherine Flores, Christina Pham, Duane Mitchell
Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, Department of Neurosurgery, University of Florida, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Phase 1b study Polio Vaccine Sabin-Rhinovirus Poliovirus (PVSRIPO) for recurrent malignant glioma in children
David M. Ashley*, Eric M. Thompson, Daniel Landi, Annick Desjardins, Allan H. Friedman, Stevie Threatt, James E. Herndon, II, Susan Boulton, Frances McSherry, Eric S. Lipp, John H. Sampson, Henry S. Friedman, Darell D. Bigner, Matthias Gromeier
Duke University Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Phase 2 nested cohort study of Depatuxizumab mafodotin in children with high grade glioma and diffuse intrinsic pontine glioma with EGFR amplification
Martin van den Bent1, Winand Dinjens1, Vassilis Golfinopoulos2, Peter Ansell3, Fiona Dungey3, Jan Peter de Geus3, Earle Bain3, Jim Looman3, Hao Xiong3, Darren Hargrave*4
1Erasmus MC Cancer Institute, The Netherlands, 2European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Belgium, 3AbbVie Inc., USA, 4Great Ormond Street Hospital for Children, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system  
Soumen Khatua*1, Vidya Gopalakrishnan1, David Sandberg1, Leena Ketonen1, Jason Johnson1, Laurence Cooper1, Judy Moyes1, Dean Lee2, Heather Meador1, Michael Rytting1, Diane Liu1, Wafik Zaky1
1MD Anderson Cancer Center, USA, 2Nationwide Children's Hospital, USA
Monday, July 2:  Early Phase Trials  -  9:30am - 10:30am
Phase I trial (NCT02457845) safety, tolerability and preliminary efficacy of immunovirotherapy with HSV G207 in children with progressive malignant supratentorial brain tumors
Gregory Friedman*1, Asim Bag1, Avi Madan-Swain1, Rong Li2, Kara Kachurak1, Diana Osorio3, Juliette Hukin4, Allison Martin5, Devang Pastakia6, Matthias Karajannis7, Joshua Bernstock1, John Fiveash1, Alyssa Reddy1, Richard Whitley1, Yancey Gillespie1, James Markert1, James Johnston1
1University of Alabama at Birmingham, USA, 2Children's of Alabama, USA, 3Nationwide Children's Hospital, USA, 4University of British Columbia, Canada, 5Johns Hopkins School of Medicine, USA, 6Vanderbilt University Medical Center, USA, 7Memorial Sloan Kettering Cancer Center, USA
Tuesday, July 3:  Immunotherapy  -  10:40am - 11:40am
Phase II study of Peginterferon alfa-2b (PEGIntron)/Sylatron for pediatric patients with progressive or recurrent craniopharyngioma following radiotherapy: A Pediatric Brain Tumor Consortium Study (PBTC-039)
Stewart Goldman*1, Ian Pollack2, Larry Kun3, Catherine Billups4, Alberto Broniscer2, Giles Robinson4, Girish Dhall5, Nathan Robison5, ashok Panigrahy2, Tina Young Poussaint6, Adekunle Adesina7, Arzu Onar-Thomas4, Reggie Jakacki8, Ira Dunkel9, Maryam Fouladi10
1Lurie Children's of Chicago Northwestern University, USA, 2Children's Hospital of Pittsburgh, USA, 3University of Texas Southwest, USA, 4St. Jude Children's Research Hospital, USA, 5Children's Hospital of Los Angeles, USA, 6Boston Children's Hospital, USA, 7Texas Children's Hospital Baylor University, USA, 8Janssen Pharma, USA, 9Memorial Sloan-Kettering Cancer Center, USA, 10Cincinnatti Children's Hospital, USA
Monday, July 2:  Early Phase Trials  -  9:30am - 10:30am
Pilocytic astrocytomas, exhibit differential age-based patterns of BRAFV600E and BRAF gene fusions across different locations
Mukesh Barange*1, Mamta Gurav2, Hetakshi Kurani2, Omshree Shetty2, Prakash Shetty3, Aliasgar Moiyadi3, Ayushi Sahay1, Jayant Sastri Goda4, Rahul Krishnatry4, Girish Chinaswamy5, Tejpal Gupta4, Rakesh Jalali4, Sridhar Epari1,2
1Department of Pathology, Tata Memorial Centre, India, 2Molecular Pathology Division, Department of Pathology, Tata Memorial Centre, India, 3Neurosurgery, Tata Memorial Centre, India, 4Radiation Oncology, Tata Memorial Centre, India, 5Pediatric Oncology, Tata Memorial Centre, India
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pilomyxoid astrocytoma in young patients: three case studies and a literature review
Linbo Cai*1, Weiping Hong1, Yanying Yang1, Junjie Zhen1, Xiao Xiao1, Changguo Shan1, Mingyao Lai1, Lichao Wang1
1Guangdong 999 Brain Hospital, China, 2Guangdong 999 Brain Hospital, China
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Pineoblastoma segregates into molecular subtypes with distinct clinicopathologic features: report from the Rare Brain Tumor Consortium
Bryan Li*1,2, Alexandre Vasiljevic3,4, Ben Ho1, Joseph Norman1, Mei Lu1, Eugene Hwang5, Jordan Hansford6, Anne Jouvet4,7, Annie Laquerriere8, Marie-Bernadette Delisle9, Sridharan Gururangan10, Jason Fangusaro11, Fabien Forest12, Nobusawa Sumihito13, Helen Toledano14, Diane Birks15, Xing Fan16, Maryam Fouladi17, Amar Gajjar18, Guillaume Gauchotte19, Lindsey Hoffman15, Chris Jones20, Delphine Loussouarn21, Karima Mokhtari22, Scott Pomeroy23, Audrey Rousseau24, Gino Somers25, Michael Taylor26, David Ziegler27, Cynthia Hawkins25, Eric Bouffet28, Richard Grundy29, Christelle Dufour30, Annie Huang1,2
1Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Hematology/Oncology, The Hospital for Sick Children, Canada, 2Laboratory Medicine and Pathobiology, University of Toronto, Canada, 3Faculté de Médecine, Université de Lyon, France, 4CHU de Lyon, France, 5Department of Oncology, Children’s National Medical Center, USA, 6Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, Australia, 7Pathology & Molecular Biology, SFCE, France, 8Department of Pathology, Rouen University Hospital, France, 9CHU de Toulouse, Hôpital Ranguei, France, 10Lillian S. Well Dept of Neurosurgery, University of Florida, USA, 11Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, USA, 12Department of Pathology, CHU St. Etienne, France, 13Department of Human Pathology, Gunma University, Japan, Japan, 14Department of Pediatric Hematology Oncology, Children’s Medical Center of Israel, Israel, 15Department of Pediatrics, University of Colorado Denver, USA, 16Department of Neurosurgery, University of Michigan, USA, 17Division of Oncology, Cincinnati Children's Hospital Medical Center, USA, 18Department of Oncology, Division of Neuro-Oncology, St. Jude Children's Research Hospital, USA, 19Department of Pathology, CHU Nancy, France, 20The Institute of Cancer Research, UK, 21Service d'Anatomie et de Cytologie pathologiques, CHU Nantes, France, 22Département de Neuropathologie, Hôpital Universitaire Pitie-Salpetriere, France, 23F.M. Kirby Neurobiology Center, Boston Children's Hospital, USA, 24Département de Pathologie cellulaire et tissulaire, CHU d'Angers, France, 25Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Pathology, The Hospital for Sick Children, Canada, 26Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Neurosurgery, The Hospital for Sick Children, Canada, 27Kids Cancer Centre, Sydney Children's Hospital, Australia, 28Division of Hematology/Oncology, The Hospital for Sick Children, Canada, 29Faculty of Medicine & Health Sciences, University of Nottingham, UK, 30Département de Cancérologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, France
Sunday, July 1:  Embryonal Tumors  -  11:30am - 12:30pm
Pituitary failures in CNS Germinoma. Experience generated in SIOP CNS GCT 96
Christian Asmus Kuhrt1, Claire Alapetite2, Rolf Dieter Kortmann3, James C. Nicholson4, Jans-Enno Müller1, Maria Luisa Garre5, Thomas Czech6, Umberto Ricardi7, Frank Saran8, Didier Frappaz9, Gabriele Calaminus*1
1University Children’s Hospital, Germany, 2Department for Paediatric Hematology/Oncology, Radiation Oncology Department, Paris & Proton Therapy Center, Orsay, Institut Curie, France, 3Department of Radiation Therapy and Radio-oncology, University of Leipzig, Germany, 4Department of Paediatric Oncology, Addenbrookes Hospital, UK, 5Neuro-Oncology Unit, Department of Pedeatric Hematology and Oncology, G. Gaslini Children’s Hospital, Italy, 6Department of Neurosurgery, University of Vienna Medical School, Austria, 7Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Turin, Italy, 8Department of Radiotherapy, Royal Marsden Hospital, Sutton, UK, 9Institute d’He´mato-Oncologie Pe´diatrique, Centre Leon Berard, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Pituitary failures in CNS Mixed Malignant Germ Cell Tumors (MMGCTs). Experience generated in SIOP CNS GCT 96
Christian Asmus Kuhrt1, Rolf Dieter Kortmann2, Didier Frappaz3, Frank Saran4, Maria Luisa Garre5, Jans-Enno Müller1, Umberto Ricardi6, Thomas Czech7, Claire Alapetite8, James C Nicholson9, Gabriele Calaminus*1
1University Children’s Hospital,, Germany, 2Department of Radiation Therapy and Radio-oncology, University of Leipzig, Germany, 3Institute d’He´mato-Oncologie Pe´diatrique, Centre Leon Berard, France, 4Department of Radiotherapy, Royal Marsden Hospital, Sutton, UK, 5Neuro-Oncology Unit, Department of Pedeatric Hematology, Italy, 6Department of Medical and Surgical Sciences, Radiation Oncology Unit,, Italy, 7Department of Neurosurgery, University of Vienna Medical School, Austria, 8Department for Paediatric Hematology/Oncology, Radiation Oncology Department, Paris & Proton Therapy Center, Orsay, Institut Curie, France, 9Department of Paediatric Oncology, Addenbrookes Hospital, UK
Sunday, July 1:  Germ Cell Tumors  -  1:30pm - 2:30pm
Plasma and cerebrospinal fluid pharmacokinetics of the DNA hypomethylating agent, Guadecitabine (SGI-110), following subcutaneous administration in a non-human primate model
Cynthia M. Lester McCully*1, Arman Odabs1, Rafael Cruz1,2, Cody Peer1, William D. Figg1, John W. Glod1, Katherine E. Warren1
1National Cancer Institute, USA, 2Leidos Biomedical Research, Inc, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Playful sensorimotor training to reduce the symptoms of chemotherapy-induced peripheral neuropathy in pediatric brain tumor patients- a randomized controlled trial (RESET)
Fiona Streckmann1, Vanessa Rustler3, Uta Tacke2, Patricia Hafner2, Oliver Faude1, Katrin Scheinemann*2
1Departement für Sport, Bewegung und Gesundheit, Universität Basel, Switzerland, 2University Children's Hospital Basel, Switzerland, 3Deutsche Sporthochschule Köln, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
PNOC-003: precision medicine trial for children with diffuses intrinsic pontine glioma: preliminary experience with multi-agent personalized therapy recommendations
Lindsay Kilburn*1, John Kuhn6, Kellie Nazemi4, Annette Molinaro2, Winnie Liang5, Anu Banerjee2, Eugene Hwang1, John Crawford7, Theodore Nicolaides2, Roger Packer1, Javad Nazarian1, Nalin Gupta2, Adam C Resnick3, Sara Byron5, Michael Berens5, Michael Prados2, Sabine Mueller2
1Children's National Health System, USA, 2University of California -San Francisco, USA, 3Children's Hospital of Philadelphia, USA, 4Oregon Health and Science University, USA, 5The Translational Genomics Research Institue, USA, 6University of Texas Health Sciences Center, USA, 7University of California San Diego, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Population-based analysis of demographic and socioeconomic disparities in pediatric CNS tumor survival in the United States
Shadi Zahedi*1,2, Robert Fineberg1,2, Megan Eguchi1,3, Myles Cockburn1,3, Adam Green1,2
1University of Colorado Denver, USA, 2Children's Hospital Colorado, USA, 3Department of Epidemiology, Colorado School of Public Health, USA
Monday, July 2:  Epidemiology  -  11:30am - 12:00pm
Postoperative paediatric cerebellar mutism syndrome- Identifying quantitative biomarkers on longitudinal follow-up MRI
Shivaram Avula*1, Michaela Spiteri2, Jean-Yves Guillemaut2, David Windridge2, Ram Kumar1, Barry Pizer1, Conor Mallucci1, Emma Lewis2
1Alder Hey Children's NHS Foundation Trust, UK, 2Centre for Vision, Speech and Signal Processing (CVSSP), University of Surrey, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Potent clinical and radiological response to larotrectinib in first case of TRK fusion high grade glioma
David Ziegler*1,2, Maria Tsoli2, Vanessa Tyrell2, Richard Cohn1, Loretta Lau1,2, Michael Cox3, Mark Cowley5, Paul Ekert4, Glenn Marshall1,2, Michelle Haber1,2
1Sydney Children's Hospital, Australia, 2Children's Cancer Institute, Australia, 3Loxo Oncology, USA, 4Murdoch Children's Research Institute, Australia, 5Garvan Institute, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
PPM1D mutation mediates tumorigenesis and is a therapeutic target in diffuse intrinsic pontine glioma (DIPG)
Mwangala Akamandisa1,2, Kai Nie1, Jing Wen1, Rita Nahta1,4, Dolores Hambardzumyan1,2, Robert Castellino*1,2
1Emory University, USA, 2Aflac Cancer & Blood Disorders Center, USA, 3Children's Healthcare of Atlanta, USA, 4Winship Cancer Institute, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Preclinical efficacy of combined ACVR1 and PI3K/mTOR inhibition in diffuse intrinsic pontine glioma (DIPG)
Diana Carvalho*1, Nagore Gene Olaciregui2, Ruth Ruddle1, Adam Donovan1, Akos Pal1, Florence Raynaud1, Peter J. Richardson3, Angel Montero Carcaboso2, Chris Jones1
1The Institute of Cancer Research, UK, 2Hospital Sant Joan de Deu, Spain, 3Benevolent AI, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Preclinical efficacy of combined inhibition of MEK and MELK in atypical teratoid/rhabdoid tumors
Michaël Meel*1, Miriam Guillén Navarro1, Mark de Gooijer2, Piotr Waranecki1, Naomi Petersen1, Dannis van Vuurden1,3, Gertjan Kaspers1,3, Esther Hulleman1,3
1VU University Medical Center, The Netherlands, 2The Netherlands Cancer Institute, The Netherlands, 3Princess Máxima Center for Pediatric Oncology, The Netherlands
Monday, July 2:  ATRT  -  11:00am - 12:30pm
Preclinical efficacy of MELK inhibition in diffuse intrinsic pontine glioma
Michaël Meel*1, Mark de Gooijer2, Miriam Guillén Navarro1, Piotr Waranecki1, Marjolein Breur1, Levi Buil2, Laurine Wedekind1, Jos Twisk1, Jan Koster3, Rintaro Hashizume4, Eric Raabe5, Ángel Montero Carcaboso6, Marianna Bugiani1, Olaf van Tellingen2, Dannis van Vuurden1,7, Gertjan Kaspers1,7, Esther Hulleman1,7
1VU University Medical Center, The Netherlands, 2The Netherlands Cancer Institute, The Netherlands, 3University of Amsterdam Academic Medical Center, The Netherlands, 4Northwestern University Feinberg School of Medicine, USA, 5Johns Hopkins University School of Medicine, USA, 6Hospital Sant Joan de Déu, Spain, 7Princess Máxima Center for Pediatric Oncology, The Netherlands
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Preclinical studies of dianhydrogalactitol (VAL-083) in DIPG, as single agent or as a combination with radiation or AZD1775
Anne Steino1, Jeffrey Bacha1, Dennis Brown*2, Sabine Mueller3,4
1DelMar Pharmaceuticals, Inc., Canada, 2DelMar Pharmaceuticals, Inc., USA, 3Department of Neurosurgery, University of California, San Francisco, USA, 4Department of Neurology and Pediatrics, University of California, San Francisco, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Predisposition of WNT-activated medulloblastoma for primary intratumoral hemorrhage
Dominik Reisinger*1, Johannes Gojo1, Andreas Peyrl1, Amedeo Azizi1, Lisa Mayr1, Marcel Kool2, Thomas Czech1, Gregor Kasprian3, Irene Slavc1
1Medical University of Vienna,Department of Pediatrics and Adolescent Medicine, Austria, 2German Cancer Research Center, German Cancer Consortium, Germany, 3Medical University of Vienna,Department of Radiology, Austria
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Preliminary experience of chronic intermittent convection enhanced delivery of carboplatin and valproic acid for the treatment of diffuse intrinsic pontine glioma following radiation therapy
Milo Hollingworth*1,4, Cornelia Hurter2, Max Wooley3,4, Owen Lewis3,4, Steven Gill2,3, Stergios Zacharoulis2
1Southmead Hospital, UK, 2Harley Street Clinic, UK, 3Renishaw Plc, UK, 4University of Bristol, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Preliminary report of a multicenter, phase 2 study of bevacizumab in children and adults with neurofibromatosis 2 and progressive vestibular schwannomas: an NF Clinical Trials Consortium study
James Tonsgard1, Nicole Ullrich2, Jaishri Blakeley3, Tena Rosser4, Roger Packer5, Bruce Korf6, Michael Fisher7, Gary Cutter6, Scott Plotkin*8, Matthias Karajannis9, Jeffrey Allen10, D. Wade Clapp11, Coretta Thomas6, Jian Campian12
1University of Chicago Medicine Comer Children's Hospital, USA, 2Boston Children's Hospital, USA, 3Johns Hopkins University School of Medicine, USA, 4Children's Hospital of Los Angeles, USA, 5Children's National Health System, USA, 6University of Alabama at Birmingham, USA, 7Children's Hospital of Philadelphia, USA, 8Massachusetts General Hospital, USA, 9Memorial Sloan Kettering Cancer Center, USA, 10NYU Langhone Health, USA, 11Indiana University School of Medicine, USA, 12Washington University School of Medicine in St. Louis, USA
Tuesday, July 3:  Neurofibromatosis  -  8:00am - 9:00am
Preliminary Results of a Brazilian Central Nervous System Germ Cell Tumor Consortium Protocol.
Andrea M Cappellano*1, Jonathan Finlay2, Bruna Mançano3, Daniela Barbosa1, Sergio Cavalheiro1, Patricia A Dastoli1, 1Frederico A Silva1, Simone S Aguiar4, Elvis Valera5, Nasjla Saba da Silva1
1IOP/GRAACC/UNIFESP, Brazil, 2Nationwide Children’s Hospital, USA, 3Hospital de Cancer de Barretos, Brazil, 4CIPED/UNICAMP, Brazil, 5Faculdade de Medicina de Ribeirão Preto, Brazil
Sunday, July 1:  Neuro-Oncology in Developing Regions  -  11:30am - 12:30pm
Preliminary results of response assessment with 18F-FET PET for intracranial germ cell tumors in adolescents
Lisbeth Marner1, Karsten Nysom*2, Astrid Sehested2, Lise Borgwardt1, René Mathiasen2, Peder Skov Wehner3, Otto Mølby Henriksen1, Michael Lundemann1, Carsten Thomsen4, Lars Bøgeskov5, Jane Skjøth-Rasmussen5, Helle Broholm6, David Scheie6, Marianne Juhler5, Liselotte Højgaard1, Ian Law1
1Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet, Denmark, 2Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Denmark, 3Hans Christian Andersen Children’s Hospital, Odense University Hospital, Denmark, 4Department of Diagnostic Radiology, Copenhagen University Hospital Rigshospitalet, Denmark, 5Department of Neurosurgery, Copenhagen University Hospital Rigshospitalet, Denmark, 6Department of Pathology, Copenhagen University Hospital Rigshospitalet, Denmark
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Preparation of genetic testing system of AT/RT for pediatric cancer predisposition program
Chikako Kiyotani*1, Ryota Shirai1, Yui Kimura1, Yoko Sioda1, Tomoo Osumi1, Motohiro Kato1, Daisuke Tomizawa1, Kenichi Usami2, Hideki Ogiwara2, Hidekazu Aoki3, Yoshiyuki Tsutsumi3, Hiroshi Fuji3, Rie Irie4, Takako Yoshioka4, Kimikazu Matsumoto1, Keita Terashima1
1Children's Cancer Center, National Center for Child Health and Development, Japan, 2Division of Neurosurgery, National Center for Child Health and Development, Japan, 3Department of Radiology, National Center for Child Health and Developmen, Japan, 4Department of Pathology, National Center for Child Health and Development, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pre-randomisation central review and real-time biomarkers screening in the multicentre BIOlogical Medicine for DIPG Eradication (BIOMEDE) trial: lessons learnt from the first 120 biopsies
Pascale Varlet*1, Marie-Anne Debily2,3, Gwenael Le Teuff4, Arnault Tauziede-Espariat1, Mélanie Pages1, Felipe Andreiuolo1, Emanuele Lechapt-Zalcman1, Emilie Barret2, Stephanie Picot2, Karsten Nysom5, Sophie Pravong2, Gilles Vassal7, David Castel3, Stephanie Puget8, Jacques Grill9
1Department of Neuropathology, France, 2Gustave Roussy, UMR 8203 CNRS, France, 3University of Evry-Val d’Essonne, France, 4Gustave Roussy, Department of Biostatistics, France, 5Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Denmark, 6Departement d’Oncologie Pédiatrique, Hôpital Universitaire des Enfants, Belgium, 7Clinical Research Direction, Gustave Roussy, France, 8Departement de Neurochirurgie, Hôpital Necker, France, 9Department of Pediatric and Adolescent Oncology, Gustave Roussy,, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Pre-treatment monocyte-to-lymphocyte ratio in pediatric gliomas with histone H3 K27M mutation
Seema Patel*, Shiyang Wang, Jonathan Serrano, Sharon Gardner, Matija Snuderl
New York University Langone Health, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Prevalence of biallelic mismatch repair deficiency in children with malignant glioma treated at King Fahad Medical City (KFMC)
Nahla Ali Mobark1, Othman Mosleh2, Amal Abd Al Samie Marie3, Latifa AlMubara2, Nada AlTassan4, Cynthia Howakins6, Faris Safaq Faris Safaq Alshammari1, Fatimah Ibrahim Al-Huzaimi,5, Roba Ibrahim Aboabat5, Fay Saad AlDossari5, Ghaida Ali AlGhamdi5, Ali Abdullah O. Balbaid3, Musa Al-Harbi Al-Harbi*1, Malak Abedalthagafi2
1Pediatric Haematology Oncology Department, Comprehensive Cancer Center, King Fahad Medical City, Saudi Arabia, 2Research Centre and Pathology Department, Saudi Human Genome Lab, King Fahad Medical City and King Abdulaziz city for science and technology, Saudi Arabia, 3Radiation Oncology Department, Cancer Centre, King Fahad Medical City, Saudi Arabia, 4Genetic Department king faisal specialist hospital and research center, Saudi Arabia, 5College of Medicine Princess Nourah bint Abdulrahman University (PNU), Saudi Arabia, 6Pathology department Sickkids hospital, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Primary bithalamic glioma with EGFR mutation: a rare case report
Reuben Antony*1, David Solomon2, Lee-Way Jin1, Arie Perry2, Sabine Mueller2, Marike Zwienenberg-Lee1, Arzu Ozturk1
1University of California at Davis Comprehensive Cancer Center, USA, 2University of California, San Francisco, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Primary central nervous system germ cell tumors in Down syndrome
Margaret Lamb, Mohamed AbdelBaki*, Joseph Stanek
Nationwide Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Primary glioblastoma in the pineal region of a pediatric patient: A case report and review of the literature
Lee Hwang*, Gabrielle Yeaney, Tanya Tekautz, Kaine Onwuzulike, Violette Recinos
The Cleveland Clinic, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Primary paediatric brain tumors in Singapore: a 17-year Southeast-Asian perspective on epidemiology and outcomes
Jiani Sherry Liu1, Sharon Yin Yee Low2,3, Wan Teow Seow2,3, David Low2,3, Leong May Lian1, Tseng Tsai Yeo1, Ning Chou1, Miriam Kimpo1, Vincent Nga1, Chun Peng Goh*1
1National University Hospital, Singapore, 2KK Women's and Children's Hospital, Singapore, 3National Neuroscience Institute, Singapore
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Profile of Low Grade Gliomas (LGGs) in Greek patients
Kleoniki Roka*1, Maria Filippidou1, Georgios Georgoulis4, Marios Themistokleous4, Natalia Karra3, Evangelia Saleptsi3, Chrysovalanto Sofia Karatosidi3, Kalliopi Stefanaki5, Roser Pons2, Antonis Kattamis1
1Division of Pediatric Hematology-Oncology, First Department of Pediatrics, Athens Medical School, Greece, 2First Department of Pediatrics, Athens Medical School, Greece, 3Brain Injury Day Treatment Unit, ELEPAP, Greece, 4Department of Neurosurgery, Aghia Sophia Children's Hospital, Greece, 5Pathology Department, Aghia Sophia Childrens Hospital, Greece
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Profiles of executive functions in survivors of pediatric brain tumor. A comprehensive approach
Jeanne Roche1,2, Mathilde Chevignard*5,6, Didier Le Gall1, Didier Frappaz3, Jean-Luc Roulin4, Arnaud Roy1,7
1Laboratory of Psychology Pays de la Loire, France, 2SMAEC Resource Centre for Children, adolescents, young adults with acquired neurological injury, France, 3Institut d'Hématologie et d'Oncologie Pédiatrique, France, 4Université de Savoie Mont-Blanc, France, 5Rehabilitation Department for children with acquired brain injury, France, 6Sorbonne Universités UMR 7371, France, 7Centre référent des troubles d'apprentissage, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Prognostic factors for overall survival after recurrence in childhood medulloblastoma
Sophie Huybrechts*1, Anaïs Chivet2, Christophe Leys3, Pascale Varlet4, Arnault Tauziede-Espariat4, Stéphanie Puget2, Léa Guerrini-Rousseau5, Jacques Grill5, Christelle Dufour5
1Hematology and Oncology, Hôpital Universitaire Des Enfants Reine Fabiola, Université Libre de Bruxelles, Belgium, 2Département de Neurochirurgie, Hôpital Necker, France, 3Centre de recherche de psychologie sociale et interculturelle, Université Libre de Bruxelles, Belgium, 4Service de Neuropathologie, Hôpital Sainte-Anne, Université Paris Descartes, France, 5Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Prognostic significance of molecular subgroups of medulloblastoma in children receiving irradiation-sparing regimens 
Kee Kiat Yeo*1, Ashley Margol1, Rebekah Kennedy2, Long Hung2, Nathan Robison1, Girish Dhall1, Shahab Asgharzadeh1,2
1Children's Center for Cancer and Blood Diseases, Division of Hematology, Oncology and Blood & Marrow Transplantation, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern C, USA, 2The Saban Research Institute, Children's Hospital Los Angeles, USA
Tuesday, July 3:  Medulloblastoma - Clinical  -  10:40am - 12:10pm
Programmable VP shunts: indications, safety and warnings
Maria Donzelli
Memorial Sloan Kettering Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Prolonged survival and eventual death by disseminated pulmonary metastasis in a pediatric patient with diffuse pontine H3.1K27M glioma: a case report
Christina Coleman*1, Tabitha Cooney1, Arie Perry2, Hua Guo1, David Solomon2, Joseph Torkildson1
1UCSF Benioff Children's Hospital Oakland, USA, 2UCSF, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Prospective symptom assessment in children with progressive brain tumors
Elizabeth Gilger*1, Molly Hemenway2, Jennifer Raybin2, Chelsea Balian3, Jessica Ward3, Kathleen Montgomery4
1Cincinnati Children's Hospital Medical Center, USA, 2Children's Hospital Colorado, USA, 3Children's Hospital Los Angeles, USA, 4American Family Children's Hospital, USA
Saturday, June 30:  Nursing Symposium  - 
Prospective, longitudinal study of neurocognitive change in pediatric brain tumor patients treated with proton beam radiotherapy versus surgery only
Lisa S. Kahalley*1,6, Anita Mahajan2, M. Fatih Okcu1,6, Murali Chintagumpala1,6, M. Douglas Ris1,6, Arnold C. Paulino3, Charles Minard1, William Whitehead1,6, Emily A. Warren4, Jessica Orobio1, Judy J. Xue5, David R. Grosshans3
1Baylor College of Medicine, USA, 2Mayo Clinic, USA, 3The University of Texas MD Anderson Cancer Center, USA, 4University of Houston, USA, 5Rice University, USA, 6Texas Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Proteogenomics reveals three distinct biological pilocytic astrocytoma subgroups
Daniel Picard1,2, Jörg Felsberg3, Maike Langini1,4, David Pauck1,2, Viktoria Marquardt1,6, Frauke Meyer1,2, Anja Stefanski4,5, Lucia Roque7, Kai Stühler4,5, Arndt Borkhardt1,2, Guido Reifenberger1,3, Cláudia Faria8,9, Marc Remke*1
1Department of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen / Düsseldorf, Germany, 2Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Germany, 3Department of Neuropathology, Heinrich Heine University Düsseldorf, Medical Faculty, Germany, 4Molecular Proteomics Laboratory, BMFZ, Heinrich-Heine-University Düsseldorf, Germany, 5Institute for Molecular Medicine, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany, 6Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Germany, 7Unidade de Investigação em Patobiologia Molecular (UIPM) – IPOFG, Portuguese Cancer Institute, Portugal, 8Instituto de Medicina Molecular, Faculdade de Medicina, da Universidade de Lisboa, Portugal, 9Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Portugal
Sunday, July 1:  Low Grade Gliomas  -  8:45am - 11:00am
Proteomic analysis identified CECR1 mediated response in macrophage and tumor associated macrophage
Changbin Zhu1,2, Yang Zhao1, Johan Kros2, Caroline Cheng3,4, Jie Ma*1
1Department of Pediatric Neurosurgery, Shanghai Xinhua Hospital affiliated to School of Medicine, Shanghai Jiao Tong University, China, 2Department of Pathology,Erasmus Medical Center, The Netherlands, 3Department of Experimental Cardiology,Erasmus Medical Center, The Netherlands, 4Department of Nephrology and Hypertension, DIGD, University Medical Center Utrecht, The Netherlands
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Psychological intervention applied to minimizing the use of sedatives in 3-14 years old central nervous system tumors undergoing radiotherapy
Xing Zhang, Yuliang Xiang, Mingyao Lai, Qiaomin Zhou, Qing Xiao, Rishun Luo, Xiuqiong Chen, Linbo Cai*, Jinfeng Wen
999 Brain Hospital, China
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Quality of life and growth after childhood craniopharyngioma: Results of the multinational trial KRANIOPHARYNGEOM 2007
Kerstin Heinks1, Svenja Boekhoff1, Monika Warmuth-Metz2, Maria Eveslage3, Junxiang Peng4, Gabriele Calaminus5, Hermann L. Müller*1
1Dep.of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg, Medical Campus University Oldenburg, Germany, 2Dep. of Neuroradiology, University Hospital Würzburg, Germany, 3Institute of of Biostatistics and Clinical Research, University Münster, Germany, 4Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, 5Department of Pediatric Oncology and Hematology, University Hospital, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Quality of life and sexual functioning in adulthood two decades after primary gross-total resection for childhood craniopharyngioma
Eveline Teresa Hidalgo, Svetlana Kvint, Cordelia Orillac, Michelle W. McQuinn, Jeffrey H. Wisoff*
NYU Langone Health, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Quality of life in survivors of childhood brain tumors
Jessica Channell*1, Jennifer Raybin1,2, Nicholas Foreman1,2, Christa Hutaff-Lee1,2
1Children's Hospital Colorado, USA, 2University of Colorado, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Quality of life (QoL) according to risk groups of medulloblastoma survivors
Marta Perek-Polnik*1, Justyna Korzeniewska1, Marta Grudzinska1, Monika Drogosiewicz1, Ewa Swieszkowska1, Iwona Filipek1, Pawel Kowalczyk2, Marzanna Chojnacka3, Danuta Perek1, Bozenna Dembowska-Baginska1
1The Children's Memorial Health Institute, Pediatric Oncology Department, Poland, 2The Children's Memorial Health Institute, Neurosurgical Department, Poland, 3The Maria Sklodowska-Curie Institute of Oncology, Poland
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Quality of survival in SIOPE brain tumour clinical trials for children aged less than 5 years: Development of a clinical trial protocol
Jenny Limond1, Sophie Thomas2, Kim Bull3, Jurgen Lemiere*4, Thomas Traunwieser5, Helen Spoudeas6, Hanneke M Van Santen7, Liesa Weiler-Wichtl8, Peggy Lüttich9, Gabriele Calaminus10, Mathilde Chevignard11
1University of Exeter, UK, 2University of Southampton, UK, 3Notthingham University Hospitals, UK, 4University Hospitals Leuven, Belgium, 5Klinikum Augsburg, Germany, 6Great Ormond Street Hospital, UK, 7University Medical Center, The Netherlands, 8Medizinischer Universitäts Campus Wien/AKH Wien, Austria, 9UniversitätsKlinikum Heidelberg, Germany, 10UniversitätsKlinikum Bonn, Germany, 11Hôpitaux de Saint Maurice, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Quantitative needs assessment differences in the management of children with central nervous system (CNS) cancer in a middle-income country and a high-income country
Allison Fischer*1,2, Roberto Roecker3, Jonathan Finlay1,2, Andrea Capellano3, Diana Osorio1,2
1The Ohio State University, USA, 2Nationwide Children's Hospital, USA, 3IOP/GRAACC/UNIFESP, Brazil
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Radiation DNA damage repair inhibition by GSK-J4 induced chromatin compaction in DIPG
Nundia Louis*1, Xingyao He1, Dustin Unruh1, Andrea Piunti2, Lihua Zou2, Patrick Ozark2, Xiao Tianc3, Vera Gorbunova3, Hiroaki Katagi1, Daniel Gryzlo1, Ali Zhang1, Amanda Saratsis1,4, Kathryn Laurie5,6, Rishi Lulla5,6, Jason Fangusaro5,6, Craig Horbinski1,7, Stewart Goldman4,5, C. David James1, Ali Shilatifard2, Rintaro Hashizume1,2
1Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, USA, 2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, USA, 3Department of Biology, University of Rochester, USA, 4Division of Pediatric Neurosurgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 5Division of Hematology, Oncology, Neuro­Oncology & Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 6Department of Pediatric­Hematology, Oncology and Stem Cell Transplantation, Northwestern University Feinberg School of Medicine, USA, 7Departments of Pathology, Northwestern University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Radiation dose effect on neuropsychological outcome of posterior fossa brain tumor survivors
Jeffrey Tanedo1,2, Sharon O'Neil1,2, Katrina Huft1,2, Aditi Tondulkar1,2, Kenneth Wong1,2, Arthur Olch1,2, Jemily Malvar2, Katherine Maina1,2, Sinchai Tsao2, Natasha Lepore1,2, Mary Baron Nelson*1,2
1University of Southern California, USA, 2Children's Hospital Los Angeles, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Radiation dose response of neurologic symptom improvement during radiotherapy for diffuse intrinsic pontine glioma
Christopher Tinkle*1, Kristen Campbell1, Brandon Bianski1, Yimei Li1, Yuanyuan Han1, Alberto Broniscer2, Zsila Sadghi1, Thomas Merchant1
1St. Jude Children's Research Hospital, USA, 2University of Pittsburgh Medical Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Radiation increases pre-clinical efficacy of OLIG2 inhibitor CT-179 in pediatric GBM
Holly Lindsay*1, Yuchen Du1, Lin Qi1, Huiyuan Zhang1, Sibo Zhao1, Frank Braun1, Mari Kogiso1, Sarah Injac1, Mary Sobieski2, Clifford Stephan2, Gordon Alton3, Gregory Stein3, Graham Beaton3, Xiao-Nan Li1
1Texas Children's Cancer Center, Baylor College of Medicine, USA, 2Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, USA, 3Curtana Pharmaceuticals, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Radiogenomic correlation of the newly proposed molecular characterisation of glioneuronal tumours of the brain
Kshitij Mankad*, Ai Peng Tan, Wajanat Jan, Thomas J Stone, Thomas S Jacques
Great Ormond Street Hospital for Children NHS Foundation Trust, UK
Sunday, July 1:  Imaging  -  4:00pm - 5:00pm
Radio-immunotherapy using the IDO pathway inhibitor indoximod for children with newly-diagnosed DIPG
Theodore S. Johnson*1, Dolly Aguilera3, Ahmad Al-Basheer1, Craig Castellino3, Bree R. Eaton4, Natia Esiashvili4, Nicholas Foreman5, Ian M. Heger1, Eugene P. Kennedy6, Charles J. Link6, William Martin2, Eric Ring1, Ramses F. Sadek1, Amy Smith7, Nicholas N. Vahanian6, Tobey J. MacDonald3, David H. Munn1
1Georgia Cancer Center, Augusta University, USA, 2Department of Radiation Oncology, Augusta University, USA, 3Aflac Cancer & Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, USA, 4Department of Radiation Oncology and Winship Cancer Institute of Emory University, USA, 5Department of Pediatrics, Children’s Hospital Colorado, USA, 6NewLink Genetics Corporation, USA, 7Department of Pediatrics, Arnold Palmer Hospital for Children, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
RANO criteria and volumetric tumor measurement produce significantly incongruous results in non-radiated low grade astrocytomas which may lead to misinterpretation of therapy response
Dianna Bardo, Jeffrey Miller, Patricia Cornejo, Marrit Thorkelson, Robyn Augystyn, Elizabeth Eden, Michael Etzl*
Phoenix Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Reclassification of central nervous system primitive neuroectodermal tumor (CNS-PNET) into entities reflects outcome: results from the prospective SJYC07 and SJMB03 trials
Anthony Liu*1, Brent Orr2, Tong Lin3, Tim Hassall4, Daniel C. Bowers5, Eric Bouffet6, Sridharan Gururangan7, Paul Fisher8, John Crawford9, Stewart J. Kellie10, Murali Chintagumpala11, Michael Fisher12, Anne Bendel13, David Ellison2, Giles Robinson1, Amar Gajjar1
1Department of Oncology, St Jude Children's Research Hospital, USA, 2Department of Pathology, St Jude Children's Research Hospital, USA, 3Department of Biostatistics, St Jude Children's Research Hospital, USA, 4Lady Cilento Children’s Hospital, Australia, 5Division of Pediatric Hematology and Oncology, University of Texas Southwestern Medical Center, USA, 6Paediatric Brain Tumour Program, The Hospital for Sick Children, Canada, 7Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, USA, 8Department of Neurology, Stanford University, USA, 9University of California San Diego and Rady Children's Hospital, USA, 10Children’s Cancer Centre, The Children’s Hospital at Westmead & University of Sydney, Australia, 11Department of Pediatrics, Texas Children‘s Hospital, Baylor College of Medicine, USA, 12Department of Pediatrics, Division of Oncology, Children‘s Hospital of Philadelphia, USA, 13Children’s Hospitals and Clinics of Minnesota, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Recurrent ependymoma: role of intraventricular targeted radioimmunotherapy
Kim Kramer*, Neeta Pandit Taskar, John Humm, Pat Zanzonico, Maria Donzelli, Sofia Haque, Yasmin Khakoo, Jason Lewis, Nai-Kong Cheung
Memorial Sloan Kettering Cancer Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP containing the ancestral DUF1220 domain in pineoblastoma
Matija Snuderl1, Kasthuri Kannan1, Elke Pfaff2, Shiyang Wang1, James Stafford1, Jonathan Serrano1, Adriana Heguy1, Karina Ray1, Arline Faustin1, Olga Aminova1, Igor Dolgalev1, Stacie Stapleton3, David Zagzag1, Luis Chiriboga1, Sharon Gardner1, Jeffrey Wisoff1, John Golfinos1, David Capper1, Volker Hovestadt1, Marc Rosenblum4, Dimitris Placantonakis1, Sarah LeBoeuf1, Thales Papagiannakopoulos1, Lukas Chavez2, Sama Ahsan5, Charles Eberhart5, Stefan Pfister2, David Jones2, Matthias Karajannis*4
1NYU Langone Health, USA, 2German Cancer Research Center (DKFZ), Germany, 3All Children's Hospital, USA, 4Memorial Sloan Kettering Cancer Center, USA, 5Johns Hopkins Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Recursive partitioning analysis of prognostic factors for pediatric low-grade gliomas treated with radiation therapy
Sahaja Acharya*, David Ellison, Ibrahim Qaddoumi, Amar Gajjar, Thomas Merchant
St. Jude Children's Research Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Reduced radiotherapy dose and volume following chemotherapy for intracranial germinoma with b-HCG level < 200 mIU/mL: preliminary results of SMC G-13 trial
Ji Won Lee*1, Do Hoon Lim2, Ki Woong Sung1, Hyung Jin Shin3
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea, 2Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea, 3Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea
Sunday, July 1:  Germ Cell Tumors  -  1:30pm - 2:30pm
Reducing time to diagnosis of paediatric brain tumours in the UK - HeadSmart awareness campaign (www.headsmart.org.uk)
Shaarna Shanmugavadivel1, Jo-fen Liu1, Sophie Wilne2, David Walker*1
1Children's Brain Tumour Research Centre, University of Nottingham, UK, 2Nottingham Children's Hospital, UK
Monday, July 2:  Epidemiology  -  11:30am - 12:00pm
Refining our neuro-oncology multidisciplinary clinic
Erin Kissell*1, Jenny Raybin1,2
1Children's Hospital Colorado, USA, 2University of Colorado Denver, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Regulation of medulloblastoma immunogenicity by TP53 and TNF alpha
Alexandra Garancher*1, Hiromichi Suzuki2, Vijay Ramaswamy3, Michael D. Taylor2, Robert J. Wechsler-Reya1
1Tumor Initiation & Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, USA, 2Division of Neurosurgery, Hospital for Sick Children, Canada, 3Division of Haematology/Oncology and Department of Paediatrics, Hospital for Sick Children, Canada
Tuesday, July 3:  Medulloblastoma - Basic/Translational Research  -  9:00am - 10:20am
Regulation of oncogene-induced senescence in pilocytic astrocytoma
Juliane L. Buhl*1, Florian Selt1,2, Thomas Hielscher3, Felix Sahm4,5, David Capper4,6, Kathrin Schramm7, Johannes Ridinger1, Diren Usta1, Jonas Ecker1,2, Ina Oehme1, Cornelis M. van Tilburg1,2, Marcel Kool8, Andreas von Deimling4,5, Martin U. Schuhmann9, Andrey Korshunov4,5, Stefan M. Pfister2,8, Tilman Brummer10, David T.W. Jones8, Olaf Witt1,2, Till Milde1,2
1Clinical Cooperation Unit Pediatric Oncology, Pre-Clinical Program, Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Germany, 2KiTZ Clinical Trial Unit (ZIPO), Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 3Division of Biostatistics, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Germany, 4Department of Neuropathology, Heidelberg University Hospital, Germany, 5Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Germany, 6Department of Neuropathology, Charité Center Neurology, Charité University Hospital Berlin, Germany, 7Division of Molecular Genetics, German Cancer Research Center (DKFZ), Germany, 8Division of Pediatric Neurooncology, Pre-Clinical Program, Hopp Children’s Cancer Center at the NCT (KiTZ), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Germany, 9Division of Pediatric Neurosurgery, Department of Neurosurgery, University Hospital Tübingen, Germany, 10Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University and University Medical Center, German Cancer Consortium (DKTK), Freiburg, German Cancer Research Center (DKFZ), Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Re-irradiation for recurrent diffuse intrinsic pontine glioma
Yui Kimura*1, Keita Terashima1, Chikako Kiyotani1, Tomoo Osumi1, Yoko Shioda1, Motohiro Kato1, Daisuke Tomizawa1, Hiroshi Fuji2, Kenichi Usami3, Hidekazu Aoki4, Rie Irie5, Hideki Ogiwara3, Yoshiyuki Tsutsumi4, Takako Yoshioka5, Kimikazu Matsumoto1
1Children's Cancer Center, National Center for Child Health and Development, Japan, 2Division of Radiation Oncology, National Center for Child Health and Development, Japan, 3Division of Neurosurgery, National Center for Child Health and Development, Japan, 4Department of Radiology, National Center for Child Health and Development, Japan, 5Department of Pathology, National Center for Child Health and Development, Japan
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Relapse pattern and treatment outcome of recurrent central nervous system germ cell tumors
Takaaki Yanagisawa*1,2, Tomonari Suzuki2, Kohei Fukuoka2, Junichi Adachi2, Kazuhiko Mishima2, Ryo Nishikawa2, Takamitsu Fujimaki2, Masao Matsutani2, Masayoshi Yamaoka3, Wataru Ohyama3, Kentaro Yokoi3, Masaharu Akiyama3, Ai Masumoto1, Yuichiro Nonaka1, Yasuharu Akasaki1, Yuichi Murayama1
1Dep of Paediatric Neuro-Oncology/Neurosurgery, Jikei University School of Medicine, Japan, 2Dep of Neuro-oncology/Neurosurgery, Saitama International Medical Centre, Saitama Medical University, Japan, 3Dep of Paediatrics, Jikei University School of Medicine, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
remarkable objective response and favorable survival for braf-v600e childhood low-grade gliomas to braf inhibitors compared conventional chemotherapy
Michal Zapotocky*1,2, Scott Ryall1, Kohei Fukuoka1, Ana Guerreiro Stucklin1, Julie Bennett1, David Sumerauer2, Zdenek Pavelka3, Ofelia Cruz4, Palma Solano5, Maria Luisa Garre7, Peter Hauser8, Didier Frappaz9, Jordan Hansford10, Nisreen Amayiri11, Helena Morse12, Magnus Sabel13, Anne Grete Bechensteen14, Jack Su15, Matthias Karajannis16, Jonathan Finlay17, David Eisenstat18, Adela Canete6, Helen Toledano19, Sonika Dahiya20, Sarah Leary21, Theodore Nicolaides22, Elisabeth Finch23, Sabine Mueller24, Jean Mulcahy Levy25, David Ellison26, Alvaro Lassaletta27, Valerie Larouche28, Vijay Ramaswamy1, Peter Dirks1, Tara McKeown1, Ute Bartels1, Eric Bouffet1, Cynthia Hawkins1, Uri Tabori1, On Behalf of PLGG Taskforce .1
1Hospital for Sick Children, Canada, 2University Hospital Motol, Czech Republic, 3University Hospital Brno, Czech Republic, 4Hospital Sant Joan de Déu, Spain, 5Hospital Infantil Virgen del Rocío, Spain, 6University of Valencia, Spain, 7G.Gaslini Children's Hospital, Italy, 8Semmelweis University, Hungary, 9Institute d'Hémato-Oncologie Pédiatrique, Centre Leon Berard, France, 10The Royal Children's Hospital, Australia, 11King Hussein Cancer Center, Jordan, 12Lund University, Sweden, 13Sahlgrenska University Hospital, Sweden, 14Oslo University Hospital, Norway, 15Texas Children's Hospital, USA, 16Memorial Sloan Kettering Cancer Center, USA, 17Nationwide Children's Hospital, USA, 18Stollery Children's Hospital, University of Alberta, Canada, 19Schneiders Children's Medical Center Of Israel, Israel, 20Washington University School of Medicine, USA, 21Seattle Children's Hospital, USA, 22New York University Langone Medical Center, USA, 23University of North Carolina, USA, 24University of California San Francisco, USA, 25Children's Hospital Colorado, USA, 26St. Jude Children's Research Hospital, USA, 27Hospital Infantil Universitario Niño Jesús, Spain, 28Universite Laval, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Re-MATCH protocol: Phase I study of autologous tumor specific lymphocyte transfer (ALT) + DC vaccine (DCV) during recovery from myeloablative  chemotherapy (MAC) and autologous stem cell rescue (HDC + ASCR) or non-myeloablative chemotherapy (NMAC) in patients with recurrent central PNETs (r-PNET)
Sridharan Gururangan*1,2, Gerald Grant3,4, Tim Driscoll5,9, Gerald Archer7,9, James Herndon8,9, Henry Friedman6,9, Joanne Kurtzberg5,9, Darell Bigner6,9, John Sampson7,9, Duane Mitchell1,2
1Preston A. Wells Center for Brain Tumor Therapy, USA, 2University of Florida, USA, 3Department of Neurosurgery, USA, 4Stanford University, USA, 5Pediatric Bone Marrow Transplant, USA, 6Preston Robert Tisch Brain Tumor Center, USA, 7Department of Neurosurgery, USA, 8Department of Biostatistics, USA, 9Duke University Medical Center, USA
Tuesday, July 3:  Immunotherapy  -  10:40am - 11:40am
Repeated progressions in pediatric chiasmatic-hypothalamic gliomas (CHG): Can we identify successful treatment strategies?
Daniela Kandels*1, René Schmidt2, Monika Warmuth-Metz3, Brigitte Bison3, Rolf-Dieter Kortmann4, Beate Timmermann5, Torsten Pietsch6, Astrid K. Gnekow1
1Swabian Children’s Cancer Center, Children’s Hospital, Klinikum Augsburg, Germany, 2Institute of Biostatistics and Clinical Research, University of Muenster, Germany, 3Institute of Neuroradiology, University Hospital of Wuerzburg, Germany, 4Department of Radio-Oncology, University of Leipzig, Germany, 5Clinic for Particle Therapy, Westdeutsches Protonentherapiezentrum, University of Essen, Germany, 6Institute of Neuropathology, University of Bonn, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Replicating clinical radiation therapy protocols in preclinical brain tumour models 
Raelene Endersby*1,2, Hilary Hii1, Brooke Strowger1, Mathew Ancliffe1,3, Tracy Seymour1,2, Nicholas Gottardo1,4
1Telethon Kids Institute, Australia, 2University of Western Australia, Australia, 3Murdoch University, Australia, 4Princess Margaret Hospital, Australia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Repressive chromatin remodelers in SHH-driven medulloblastoma
Rong-Hua Tao1, Tara Dobson*1, Shinji Maegawa1, Jyothismathi Swaminathan1, Shavali Shaik1, Pete Taylor1, Bridget Kennis1, Lin Qi2, Soumen Khatua1, Stewart Goldman3, Rishi Lulla3, Jason Fangusaro3, Tobey MacDonald4, Xiao-Nan Li2, Cynthia Hawkins5, Veena Rajaram6, Vidya Gopalakrishnan1
1UT MD Anderson Cancer Center, USA, 2Texas Children's Cancer Center, Baylor College of Medicine, USA, 3Northwestern University, USA, 4Emory University, USA, 5Hospital for Sick Children, Canada, 6UT Southwestern Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Requirement of adjuvant treatment in childhood low grade gliomas (LGG) of the spinal cord: experiences from the German LGG study group
Thomas Perwein1, Martin Benesch*1, Daniela Kandels2, Torsten Pietsch3, Beate Timmermann4, Brigitte Bison5, Monika Warmuth-Metz5, Astrid Katharina Gnekow2
1Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria, 2Swabian Children's Cancer Center, Children's Hospital, Klinikum Augsburg, Germany, 3Institute of Neuropathology, University of Bonn, Germany, 4West German Proton Therapy Center Essen/Clinic for Particle Therapy, Essen University Hospital, Germany, 5Department of Neuroradiology, University of Würzburg, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Residual tumour size as a predictor of progression for paediatric low-grade glioma
Neelakshi Ghosh1, Karen Manias2, Christopher D Bennett2, Adam Oates1, Martin English1, Andrew Peet1, Jenny Adamski*1
1Birmingham Children's Hospital, UK, 2University of Birmingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Resolving transcriptional profiles in BRAF-rearranged pilocytic astrocytoma using single cell RNA sequencing
Zachary Reitman*1,2, Brenton Paolella2, Guillaume Bergthold1, Kristine Pelton1, Sarah Becker1, Robert Jones1, Zach Herbert1,2, Leslie Grimmett1, John Daley1, Mariella Filbin1,3, Mario Suva5, Liliana Goumnerova3, Karen Wright3, Susan Chi3, Mark Kieran3, Aviv Regev3, Alex Shalek4, Keith L Ligon1, Rameen Beroukhim1, Pratiti Bandopadhayay1,3
1Dana Farber Cancer Institute, USA, 2Broad Institute, USA, 3Boston Children's Hospital, USA, 4Massachusetts Institute of Technology, USA, 5Massachusetts General Hospital, USA
Sunday, July 1:  Low Grade Gliomas  -  8:45am - 11:00am
Response of recurrent malignant childhood CNS tumors to a MEMMAT based metronomic antiangiogenic combination therapy varies dependent on tumor type: Experience in 71 patients
Irene Slavc*1, Andreas Peyrl1, Monika Chocholous1, Dominik Reisinger1, Lisa Mayr1, Amedeo Azizi1, Karin Dieckmann1, Christine Haberler1, Thomas Czech1
1Medical University of Vienna, Department of Pediatrics, Austria, 2Medical University of Vienna, Department of Radiotherapy., Austria, 3Medical University of Vienna, Institute of Neurology, Austria, 4Medical University of Vienna, Department of neurosurgery, Austria
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Response rates to different re-induction chemotherapy regimens in patients with recurrent central nervous system mixed malignant germ cell tumors
Mohammad H. Abu Arja*, Joseph R. Stanek, Jonathan L. Finlay, Mohamed S. AbdelBaki
Nationwide Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Response to the first-line chemotherapy in pediatric low-grade gliomas according to histopathology and BRAF alterations
Tasnime Akbaraly1, Volodia Dangouloff-Ros2, Arnault Tauziede-Espariat3, Ludovic Lacroix1, Stéphanie Puget2, Pascale Varlet3, Léa Guerrini-Rousseau1, Jacques Grill1, Christelle Dufour*1
1Gustave Roussy, France, 2Hopital Necker Enfants Malades, France, 3Centre hospitalier Sainte-Anne, France
Sunday, July 1:  Low Grade Gliomas  -  8:45am - 11:00am
Rest modulates neovasculature via regulation of gremlin expression in diffuse intrinsic pontine glioma
Shavali Shaik*1, Bridget Kennis1, Shinji Maegawa1, Keri Schadler1, Yang Yanwen1, Keri Callegari1, Rishi Lulla2, Stewart Goldman2, Javad Nazarian3, Veena Rajaram4, Jason Fangusaro2, Vidya Gopalakrishnan1
1M.D. Anderson Cancer Center, USA, 2Northwestern University, USA, 3George Washington University School of Medicine, USA, 4UT Southwestern Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Retinoids as potential chemotherapeutic options for posterior fossa ependymoma of childhood
Vladimir Amani*, Andrew Donson, Andrea Griesinger, Davis Witt, Jean Mulcahy Levy, Lindsey Hoffman, Todd Hankinson, Michael Handler, Rajeev Vibhakar, Kathleen Dorris, Nicholas Foreman
Children’s Hospital Colorado, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Retrospective analysis of atypical teratoid rhabdoid tumor in the era of multimodal treatment in Japan
Kai Yamasaki*1, Yuko Watanabe2, Kiyotaka Isobe3, Yuhki Koga4, Chikako Kiyotani5, Keita Terashima5, Yoshiki Arakawa7, Daiichiro Hasegawa6, Yoshiyuki Kosaka6, Hiroaki Goto8, Katsuyoshi Koh3, Junichi Hara1
1Department of Pediatric Hematology and Oncology, Osaka City General Hospital, Japan, 2Department of Pediatrics, Tohoku University School of Medicine, Japan, 3Department of Hematology/OncologySaitama Children’s Medical Center, Japan, 4Department of PediatricsKyushu University, Japan, 5Division of Pediatric Oncology, National Center for Child Health and Development, Japan, 6Department of Hematology and Oncology, Kobe Children's Hospital, Japan, 7Department of Neurosurgery, Kyoto University Graduate School of Medicine, Japan, 8Kanagawa Children's Medical Center, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Retrospective analysis of Victorian patients diagnosed with medulloblastoma between 1990-2017
S Khan*1,2, C White1,3, PA Downie1,3, J Hansford4,5, CR Cochrane1,2, A Szczepny1,2, P Siswara3, A Sexton-Oates5, D McGregor4,5, TB Phung3, E Algar1,2, JE Cain1,2
1Centre for Cancer Research, Hudson Institute of Medical Research, Australia, 2Department of Molecular and Translational Sciences, Monash University, Australia, 3Monash Medical Centre, Monash Children's Hospital, Australia, 4The Royal Children's Hospital, Australia, 5Murdoch Children's Research Institute, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Review of clinical presentation and diagnosis interval in pediatric patients with primary brain tumours in Western Ukraine
Roman Kizyma*1, Zoryana Kizyma1, Bogdan Kotsay3, Oleksandra Dvornyak1, Iryna Shchurovska1, Taras Mykytyn2, Konstyantin Biganych2
1Western Ukrainian Specialized Childrens Medical Centre, Ukraine, 2Lviv City Children Hospital, Ukraine, 3Lviv National Medical University, Ukraine
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Risk of development of sinusoidal obstruction syndrome on head start regimens in young children with medulloblastoma
Ossama Maher*1, Jorge Galvez1, Kamar Godder1, Toba Niazi1, Matthew Hall1,2, Ziad Khatib1
1Nicklaus Children's Hospital, USA, 2Baptist Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Risk of premature radionecrosis in paediatric patients with high risk medulloblastoma treated with protons on the cranium spinal axis
Giovanna Stefania Colafati1, Chiara Carducci1, Barbara Rombi2, Stefano Lorentini2, Andrea Carai3, I.Paul Voicu4, Antonella Cacchione4, Angela Mastronuzzi4, Maurizio Amichetti2, Sabina Vennarini*2
1Department of Neuroradiology – IRCCS Bambino Gesù Children's Hospital, Italy, 2Proton Therapy Center; APSS, Italy, 3Department of Neuroscience and Neurorehabilitation, Neurosurgery Unit- IRCCS Bambino Gesù Children's Hospital, Italy, 4Department of Pediatric Hematology and Oncology – IRCCS Bambino Gesù Children's Hospital, Italy
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Risk of progression/relapse in pediatric intracranial ependymoma: Single-center experience from a developing country
Anirban Das*, Suman Paul Chowdhury, Rimpa Basu Achari, Lateef Zameer, Saugata Sen, Gopal Achari, Arpita Bhattacharya
Tata Medical Center, India
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Risk stratification of medulloblastoma on the basis of molecular subgrouping; an experience from a single tertiary care center from a developing country
Naureen Mushtaq*1, Quratulain Riaz1, Cynthia Hawkins2, Vijay Ramaswamy2, Khurram Minhas1, Eric Bouffet2
1Aga Khan University Hospital, Pakistan, 2The Hospital Of Sick Children, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
RNA-seq analysis of recurrent paediatric ependymomas reveals immunological changes specific to molecular subgroups
Timothy A Ritzmann*1, Hazel A Rogers1, Andrew M Donson4, Alex Virasami3, Thomas S Jacques3, Simon ML Paine1,2, Nicholas Foreman4, Richard G Grundy1,2
1The University of Nottingham, UK, 2Nottingham University Hospitals NHS Trust, UK, 3UCL GOS Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital for Children NHS Trust, UK, 4Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, USA
Sunday, July 1:  Ependymoma  -  3:30pm - 5:00pm
RNA-sequencing of medulloblastoma patient-derived orthotopic xenograft (PDOX) models enables identification of both tumor and microenvironment specific biomarkers
Natalie Jäger*1,2, Sebastian Brabetz1,2, Stefan Pfister1,3, Marcel Kool1
1Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Germany, 3Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Role of DNA methylation analysis in recurrent paediatric ependymoma
Hazel A Rogers*1, Timothy A Ritzmann1, Simon ML Paine6, Lisa D Storer1, Kristian W Pajtler2,3, Martin Sill2,3, Andrew M Donson5, Nicholas K Foreman5, Marcel Kool2,3, Stefan M Pfister2,3, Richard G Grundy1
1University of Nottingham, UK, 2Hopp Children's Cancer Center at the NCT (KiTZ), Germany, 3German Cancer Research Center DKFZ, Germany, 4Heidelberg University Hospital, Germany, 5Department of Pediatrics, University of Colorado, USA, 6Nottingham University Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Role of irradiation in relapsed medulloblastoma: a report of the German medulloblastoma relapse studies
Stephan Tippelt*1, Julia Küter1, Ruth Mikasch1, Nele Siegler1, Monika Warmuth-Metz2, Stefan Rutkowski3, Martin Mynarek3, Katja von Hoff4, Torsten Pietsch5, Stefan M. Pfister6, Olaf Witt6, Rolf-Dieter Kortmann7, Stefan Dietzsch7, Robert Kwiecien8, Andreas Faldum8, Udo Bode9, Gudrun Fleischhack1
1University Hospital of Essen, Pediatrics III, Pediatric Hematology and Oncology, Germany, 2University of Wuerzburg, Neuroradiology, Germany, 3University Medical Center Hamburg-Eppendorf, Dept. of Pediatric Hematology and Oncology, Germany, 4Charité-Universitätsmedizin, Department of Pediatric Oncology/Hematology, Germany, 5University of Bonn, Medical Center, Institute of Neuropathology, Germany, 6University of Heidelberg, Pediatric Hematology and Oncology, Germany, 7University of Leipzig, Radiooncology, Leipzig, Germany, 8University of Muenster, Institute of Biostatistics and Clinical Research, Muenster, Germany, 9University of Bonn, Children’s Hospital, Pediatric Hematology and Oncology, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Safety and efficacy of chemotherapy intensification with autologous hematopoietic stem cell rescue, without radiation, for children with CNS embryonal tumors
Abhishek Bavle*1, Naina Gross2, Theresa Gavula1, Michael Confer3, Jo Elle Peterson4, Kar-Ming Fung4, Laura Rooms1, David Crawford1, Rene McNall-Knapp1
1Jimmy Everest Section of Pediatric Hematology/Oncology, University of Oklahoma Health Sciences Center, USA, 2Department of Neurosurgery, University of Oklahoma Health Sciences Center, USA, 3ProCure Proton Therapy Center, USA, 4Department of Pathology, University of Oklahoma Health Sciences Center, USA
Tuesday, July 3:  Medulloblastoma - Basic/Translational Research  -  9:00am - 10:20am
Safety and efficacy of concurrent carboplatin during craniospinal irradiation for high-risk/ medulloblastoma in a resource-limited setting
Tejpal Gupta*, Girish Chinnaswamy, Hari Sankaran, Tushar Vora, Maya Prasad, Sridhar Epari, Ayushi Sahay, Aliasgar Moiyadi, Prakash Shetty, Neelam Shirsat, Rahul Krishnatry, GodaJayant Sastri, Rakesh Jalali
Tata Memorial Centre, India
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Safety and efficacy of gamma knife radiosurgery for pediatric brain tumors
Ashley S. Plant1, Jody Pathare1, Darcy Engelhart*2, Venita Williams1, Ivan Kirov1, William G. Loudon1
1Children's Hospital Orange County, USA, 2University of California, San Diego, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Safety and efficacy of intraventricular 131I-labeled monoclonal antibody 8H9 targeting the surface glycoprotein B7-H3
Kim Kramer*, Brian Kushner, Shakeel Modak, Neeta Pandit Taskar, Ursula Tomlinson, Maria Donzelli, Suzanne Wolden, Pat Zanzonico, John Humm, Sofia Haque, Mark Souweidane, Jeffrey Greenfield, Ellen Basu, Stephen Roberts, Jorge Carrasquillo, Jason Lewis, Serge Lyashchenko, Steven Larson, Nai-Kong Cheung
Memorial Sloan Kettering Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Safety and efficacy of trametinib in the management of children with RASopathies
Abhishek Bavle*1, Farooq Choudhry2, Theresa Gavula1, Rikin Shah3, Alejandro Ruiz-Elizalde4, Ashley Taylor5, Naina Gross6, Jo Elle Peterson7, Kar-Ming Fung7, Rene McNall-Knapp1
1Jimmy Everest Section of Pediatric Hematology/Oncology, University of Oklahoma Health Sciences Center, USA, 2Department of Radiology, University of Oklahoma Health Sciences Center, USA, 3Department of Pediatrics, Baylor College of Medicine, USA, 4Department of Surgery, University of Oklahoma Health Sciences Center, USA, 5Section of Pediatric Genetics, University of Oklahoma Health Sciences Center, USA, 6Department of Neurosurgery, University of Oklahoma Health Sciences Center, USA, 7Department of Pathology, University of Oklahoma Health Sciences Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Safety and tolerability of concomitant multi-agent intra-ventricular chemotherapy for the treatment of recurrent central nervous system (CNS) tumors
Scott Coven*1,2, Mohammad Abu Arja1, Diana Osorio1,2, Jonathan Finlay1,2
1Nationwide Children's Hospital, USA, 2The Ohio State University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Safety of ultrasound-induced blood-brain barrier opening in pediatric patients with refractory sus-tentorial malignant brain tumors before chemotherapy administration – The SONOKID clinical trial
K Beccaria*1,2, M Canney3, G Bouchoux3, S Zohar4, N Boddaert5, F Bourdeaut6, F Doz6, C Dufour7, J Grill7,8, A Carpentier9,10, S Puget1,2
1APHP,Department of Pediatric Neurosurgery, Necker-Enfants Malades Hospital, France, 2Université Rene Descartes, PRES Sorbonne Paris Cité, France, 3CarThera Research Team, Brain and Spine Institute, France, 4INSERM, UMRS 1138, Team 22, CRC, University Paris 5, University Paris 6, France, 5APHP, Department of Pediatric Radiology, Necker-Enfants Malades Hospital, France, 6Department of Pediatric, Adolescents and Young Adults Oncology, Institut Curie, France, 7Department of Pediatric Oncology Gustave Roussy Institute, France, 8UMR8203, « Vectorologie & Thérapeutiques Anticancéreuses », CNRS, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, France, 9APHP, Department of Neurosurgery, Pitie-Salpetriere Hospital, France, 10School of Medicine, Sorbonne University, France
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
Salvage therapy for childhood medulloblastoma: A single center experience
Michelle Kameda-Smith*, Alick Wang, Noora Abdulhadi, Ashley Adile, Olufemi Ajani, Blake Yarascavitch, Forough Farrokhyar, Petrelli Tina, Constantine Samaan, Cheryl Alyman, Sheila Singh, Adam Fleming
McMaster University, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Second generation molecular subgrouping of medulloblastoma: towards a working consensus of Group 3/4 subtypes
Tanvi Sharma1,7, Edward C. Schwalbe2,3, Daniel Williamson2, Volker Hovestadt4, Lukas Chavez5, Marcel Kool1, Paul A. Northcott6, Stefan M. Pfister*1, Steven C. Clifford2
1Hopp Children´s Cancer Center at the NCT Heidelberg (KiTZ); German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Germany, 2Northern Institute for Cancer Research, Newcastle University, UK, 3Dept. of Applied Sciences, Northumbria University, UK, 4Broad Institute, USA, 5Dept. of Medicine, University of California, San Diego, USA, 6Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, USA, 7Faculty of Biosciences, Heidelberg University, Germany
Tuesday, July 3:  Medulloblastoma - Clinical  -  10:40am - 12:10pm
Secondary primary tumor and survival outcome in medulloblastoma: a surveillance, epidemiology, and end results (SEER) analysis
Chonnipa Nantavithya*1,2, Debra Yeboa1, Kaiping Liao1, Susan McGovern1, David Grosshans1, Mary McAleer1, Kristina Woodhouse1, Soumen Khatua1, Murali Chintagumpala3, Arnold Paulino1
1University of Texas, MD Anderson Cancer Center, USA, 2King Chulalongkorn Memorial Hospital, Chulalongkorn University, Thailand, 3Texas Children's hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Seizure in pediatric patients with brain tumors
Viviane Robert-Boire, Béatrice Desnous, Alexander Weil, Sébastien Perreault*
CHU Sainte-Justine, Canada
Sunday, July 1:  Quality of Life/Survival/Rehabilitation  -  1:30pm - 3:00pm
Seizures in low-grade gliomas: clinical and histopathological characteristics
Victor Toro*, Clarissa Aguilar
Hospital Escuela Universitario, Honduras
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Sensitivity of DIPG cells to BMI-1 modulator PTC596 is independent of EZH2 activity
Shiva Senthil Kumar1, Satarupa Sengupta*1, Kyungwoo Lee1, Rachid Drissi1,2
1Cincinnati Children's Hospital Medical Center, USA, 2University of Cincinnati College of Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Significant rates of ACTH suppression misdiagnosed as ACTH deficiency after perioperative dexamethasone in craniopharyngioma
Kyriaki Pieri, Maria Michaelidou, Antonia Dastamani, Helen A Spoudeas*
London Centre for Paediatric Endocrinology, Great Ormond Street (GOSH) and University College Hospitals (UCLH), UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Single cell RNAseq identifies a putative cancer stem cell population in posterior fossa EPN
Andrew Donson*1,2, Austin Gillen1, Kent Riemondy1, Jay Hesselberth1, Vladimir Amani1,2, Andrea Griesinger1,2, Davis Witt1,2, Todd Hankinson1,2, Michael Handler1,2, Rajeev Vibhakar1,2, Nicholas Foreman1,2
1University of Colorado Anschutz Medical Campus, USA, 2Children's Hospital Colorado, USA
Sunday, July 1:  Ependymoma  -  3:30pm - 5:00pm
Single cell transcriptomic analysis defines discrete subpopulations in SHH-driven medulloblastomas that are differentially affected by vismodegib.
Jennifer Ocasio*1, Benjamin Babcock1, Alejandro Colaneri1, Michael Taylor2, Kirk Wilhelmsen1, Timothy Gershon1
1University of North Carolina at Chapel Hill, USA, 2The Hospital for Sick Children, Canada
Tuesday, July 3:  Medulloblastoma - Basic/Translational Research  -  9:00am - 10:20am
Single-cell transcriptome analysis of medulloblastoma
Volker Hovestadt*1,2, Mariella G. Filbin1,3, Laure Bihannic4, McKenzie L. Shaw1,2, John M. DeWitt1,2, Andrew Groves1,2, Kyle S. Smith4, Jennifer Hadley4, Amar Gajjar5, Giles W. Robinson5, Lisa Mayr6, Irene Slavc6, Liliana Goumnerova3, Keith L. Ligon2,3, Mario L. Suva1,2, Paul A. Northcott4, Bradley E. Bernstein1,2
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, USA, 2Broad Institute of Harvard and MIT, USA, 3Dana-Farber Boston Children’s Cancer and Blood Disorders Center, USA, 4Department of Developmental Neurobiology, St Jude Children’s Research Hospital, USA, 5Department of Oncology, St Jude Children’s Research Hospital, USA, 6Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria
Tuesday, July 3:  Medulloblastoma - Basic/Translational Research  -  9:00am - 10:20am
Smarcb1-deficient tumors activate both innate and adaptive immune responses and are susceptible to checkpoint blockade and TLR3 activation.
Amaury Leruste*1, Pamela Caudana2, Arnault Tauziede-Espariat4, Zhi-Yan Han1, Rodrigo N Ramos2, Jovan Nikolic2, Jimena Tosello2, Solene Brohard1, Mamy Andrianteranagna1, Céline Chauvin1, Julien Masliah-Planchon1, Christine Sedlick1, Aurore Coulomb6, Louise Galmiche-Rolland5, Dominique Ranchere7, Philippe Benaroch2, Joshua J Waterfall1, Olivier Delattre1, Eliane Piaggio2, Franck Bourdeaut1
1Paris-Sciences-Lettres, Institut Curie Research Center, INSERM U830, France, 2Paris-Sciences-Lettres, Institut Curie Research Center, INSERM U932, France, 3Paris-Sciences-Lettres, Institut Curie Hospital, Department of Pediatric Oncology, Adolescents and Young Adults, France, 4Sainte Anne Hospital, Department of Neuropathology, France, 5Necker Enfants Malades Hospital, AP-HP, Department of Pathology, France, 6Armand Trousseau Hospital, AP-HP, Department of Pathology, France, 7Centre Leon Berard, Department of Pathology, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
SMARCB1-dependencies in atypical teratoid/rhabdoid tumours: a strategy for pre-clinical therapeutic target identification in the absence of actionable mutations
Martina Anna Finetti*1, Matthew p Selby1, Alicia del-Carpio Pons1, Sarah Batting1, James A Wood1, James M Barker1, Amanda Smith1, Stephen Crosier1, Matthew Bashton1, Jessica C Pickles2,3, Amy R Fairchild2,3, Aimee Avery3, Patricia O'Hare4, Barry Pizer5, Bernadette Brennan6, Stephen Lowis7, Darren Hargrave2, Thomas S Jacques2,3, Simon Bailey1, Steven C Clifford1, Daniel Williamson1
1Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, UK, 2Developmental Biology and Cancer Programme, University College London Great Ormond Street Institute of Child Health, UK, 3Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, UK, 4Department of Paediatric oncology, Great Ormond Street Hospital NHS trust, UK, 5Institute of Translational Medicine, University of Liverpool, UK, 6Royal Manchester Children’s Hospital and University of Manchester, UK, 7Royal Hospital for Children and Bristol Medical School, University of Bristol, UK
Monday, July 2:  ATRT  -  11:00am - 12:30pm
Spatio-temporal deletion of Smarcb1 determines mouse AT/RT subtypes
Zhi-Yan HAN1,2, Mamy Andrianteranagna1,2, Arnault Tauziède-Espariat3, Paul Fréneaux4, Julien Masliah-Planchon5, Christine Bourneix5, Gaelle Pierron5, Amaury Leruste1,2, Céline Chauvin1,2, Pascale Varlet3, Didier Surdez1, Olivier Delattre1,5, Franck Bourdeaut*2,6
1SIREDO InsermU830, Institut Curie, Laboratoire de Genetique et Biologie des Cancers, France, 2SiRIC- Institut Curie, Laboratoire de Recherche Translationnelle en Oncologie Pédiatrique, France, 3Sainte-Anne Hospital, Department of Neuropathology, France, 4Service d’anatomie pathologique, Département de Biologie des Tumeurs, Institut Curie, France, 5Unité de génétique somatique, Département de Biologie des Tumeurs, Institut Curie, France, 6Département d’oncologie pédiatrique, Institut Curie, France
Monday, July 2:  ATRT  -  11:00am - 12:30pm
Spectrum of intracranial imaging findings post proton beam therapy in a pediatric patient cohort: the Gosh experience
Debarata Bhattacharya*, Kshitij Mankad, Darren Harvrave, Jenny Gains, Rahul Lakshmana
Great Ormond Street Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Spinal cord atypical teratoid/rhabdoid tumors (AT/RT) in children: results of a European retrospective analysis under the auspices of the EU-RHAB study group
Martin Benesch*1, Petra Neumayer2, Karolina Nemes2, Torsten Pietsch3, Beate Timmermann4, Brigitte Bison5, Monika Warmuth-Metz5, Pablo Hernáiz Driever6, Georg Ebetsberger-Dachs7, Franck Bourdeaut8, Christelle Dufour9, Fanny Fouyssac10, Martin Hasselblatt11, Veronica Biassoni12, Andrés Morales La Madrid13, Natacha Entz-Werle14, Véronique Laithier15, Franz Quehenberger16, Michael C. Frühwald2
1Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria, 2Swabian Children's Cancer Center, Children's Hospital, Klinikum Augsburg, Germany, 3Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, Germany, 4West German Proton Therapy Center Essen/Clinic for Particle Therapy, Essen University Hospital, Germany, 5Department of Neuroradiology, University of Würzburg, Germany, 6Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Germany, 7Department of Pediatrics, Kepler Universitätsklinikum Linz, Austria, 8PSL Research University, Institute Curie, Pediatric Care and Research Center, France, 9Gustave Roussy - Grand Paris Cancer Campus, Department of Childhood and Adolescent Oncology, France, 10Pediatric Hematology and Oncology, University Hospital of Nancy, France, 11Institute of Neuropathology, University Hospital Münster, Germany, 12S.C. Pediatria, Fondazione IRCCS Istituto Nazionale Tumori, Italy, 13Oncology Department at Hospital Sant Joan de Deu - Barcelona Children's Hospital, Spain, 14Pediatric Oncology Unit, University Hospital, France, 15Department of Pediatric Oncology, University Hospital, France, 16Institute for Medical Statistics, Medical University of Graz, Austria
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Sporadic meningiomas of the pediatric population: A review of neuroradiological, neuropathological, and neuro-oncological attributes
Paraag Bhatt*1, Kathleen Dorris2,3, Jean Mulcahy Levy2,3, Kami Wolfe Schneider2, Alexandra Suttman2, Andrew Donson2,3, Nicholas Foreman2,3, Bette K. Kleinschmidt-DeMasters2, Nicholas Spence2, Ilana Neuberger2, David Mirsky2
1University of Colorado Denver - Anschutz Medical Campus, USA, 2Children’s Hospital Colorado, USA, 3Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Sports for all – motivating neuro-oncology patients to engage in sporting activity
Sharon Beardsmore*, Jane Guest, Alison Cooper, Sian Phillips, Jenny Adamski
Birmingham Children's Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
SPRINT: Phase II Study of the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886) in children with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PN)
Andrea Gross1, Pamela Wolters1, Andrea Baldwin1, Eva Dombi1, Michael J. Fisher2, Brian Weiss3, AeRang Kim4, Jaishri Blakeley5, Patricia Whitcomb,1, Marielle Holmblad6, Staci Maritin1, Marie Claire Roderick1, Scott M. Paul1, Janet Therrien1, Kara Heisey6, Austin Doyle1, Malcolm Smith1, John Glod1, Seth Steinberg1, Brigitte C. Widemann*1
1National Institutes of Health, USA, 2Children's Hospital of Philadelphia, USA, 3Cincinnati Children's Hospital Medical Center, USA, 4Children's National Medical Center, USA, 5Johns Hopkins University, USA, 6Leidos Biomedical Research, Inc, USA
Tuesday, July 3:  Neurofibromatosis  -  8:00am - 9:00am
St. Jude Global Academy Neuro-Oncology Seminar: The creation of a targeted curriculum for global neuro-oncology
Daniel Moreira, Carlos Rodriguez-Galindo, Ibrahim Qaddoumi*
St. Jude Children's Research Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
STAT3 as a therapeutic target in DIPG
Nagore G Olaciregui1,2, Diana Carvalho4,5, Alan Mackay4,5, Guillem Pascual-Pasto1,2, Matthew Clarke4,5, Valeria Molinari4,5, Elisa Izquierdo4,5, Jordan Goncalves6, Yann Courbebaisse6, Andres Morales La Madrid1,2, Mariona Suñol1,3, Ofelia Cruz1,2, Jaume Mora1,2, Chris Jones4,5, Angel M Carcaboso*1,2
1Institut de Recerca Sant Joan de Deu, Spain, 2Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Spain, 3Pathology, Hospital Sant Joan de Deu, Spain, 4Division of Molecular Pathology, The Institute of Cancer Research, UK, 5Division Cancer Therapeutics, The Institute of Cancer Research, UK, 6PK/PDesign, a subsidiary of Oncodesign, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Stereotactic radiosurgery provides effective local control for radioresistant brain metastases in pediatric patients
Tommy Sheu, Acsa M. Zavala, Tina M. Briere, Andrew J. Bishop, Mary Frances McAleer*
The University of Texas MD Anderson Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Stimulation of medulloblastoma stem cells differentiation by a peptidomimetic targeting Neuropilin-1
Caifeng Gong1, Julie Valduga1,2, Alicia Chateau1, Mylène Richard1, Nadia Pellegrini-Moise1, Muriel Barberi-Heyob1, Pascal Chastagner*1,2, Cédric Boura1
1CRAN UMR 7039, CNRS, Université de Lorraine, France, 2Service d’Onco-Hématologie Pédiatrique, CHU Nancy, France, 3SRSMC, UMR 7565, Université de Lorraine, Campus Science, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Stressed to death: EGFRvIII expression renders glioblastoma cells more sensitive to ER stress inducing chemotherapeutics
Regina Graham*, Katrina Kostenko, Ingrid Torrens, Nicolas De Cordoba, Melanie Freire, Fedeline Camile, Steven Vanni
University of Miami, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Structural connectivity abnormality in children treated for Medulloblastoma
Adeoye Oyefiade*, Kiran Beera, Jovanka Skocic, Cynthia De Medeiros, Donald Mabbott
The Hospital for Sick Children, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Study of anti-HER2 CAR T cells in the immunosuppressive ependymoma tumor microenvironment
Anandani Nellan*, Andrea Griesinger, Davis Witt, Andrew Donson, Vladimir Amani, Nicholas K. Foreman
University of Colorado, USA
Sunday, July 1:  Ependymoma  -  3:30pm - 5:00pm
Subependymal giant cell astrocytoma (SEGA) - a clinical, histopathological and molecular study
Wieslawa Grajkowska*1, Joanna Trubicka1, Katarzyna Kotulska-Jozwiak2, Marcin Roszkowski3, Bozenna Dembowska-Baginska4
1The Children's Memorial Healths Institute, Department of Pathology, Poland, 2The Children's Memorial Healths Institute, Department of Neurology, Poland, 3The Children's Memorial Healths Institute, Department of Neurosurgery, Poland, 4The Children's Memorial Healths Institute, Department of Oncology, Poland
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Subgroup specific long-term survival and neurocognitive outcomes in posterior fossa ependymoma (PFE)
Michal Zapotocky*, Kiran Beera, Jenny Adamski, Sharon Guger, Laura Janzen, Normand Laperierre, Ute Bartels, Cynthia Hawkins, Michael Taylor, Eric Bouffet, Donald Mabbott, Vijay Ramaswamy
Hospital for Sick Children, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Subgroup-directed clinical and molecular stratification of disease risk in infant medulloblastoma
Debbie Hicks*1, Gholamreza Rafiee1, Edward C Schwalbe2,1, Janet C Lindsey1, Rebecca M Hill1, Amanda Smith1, Stephen Crosier1, Abhijit Joshi3, Keith Robson4, Stephen Wharton5, Thomas Jacques6,7, Daniel Williamson1, Simon Bailey1, Steven C Clifford1
1Northern Institute for Cancer Research, Newcastle University, UK, 2Northumbria University, UK, 3Department of Neuropathology, Royal Victoria Infirmary (RVI), UK, 4Nottingham University Hospitals NHS Trust, UK, 5Sheffield University, UK, 6UCL Institute of Child Health, UK, 7Great Ormond Street Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Subgroup-specific therapy options for childhood supratentorial ependymoma
Vladimir Amani*, Andrew Donson, Andrea Griesinger, Davis Witt, Jean Mulcahy Levy, Lindsey Hoffman, Todd Hankinson, Michael Handler, Rajeev Vibhakar, Kathleen Dorris, Nicholas Foreman
Children’s Hospital Colorado, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Subtype-specific overexpression of Wilms' Tumor Protein in pediatric midline high grade gliomas
Sulgi Lee*1,2, Madhuri Kambhampati1, Sridevi Yadavilli1, Mariarita Santi3, Roger J Packer1, Conrad R Cruz1,2, Isabel Almira1, Eugene Hwang1, Javad Nazarian1,2
1Children's National Health System, USA, 2The George Washington University, USA, 3Children's Hospital of Philadelphia, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Success of high dose chemotherapy in infants presenting with Atypical Teratoid Rhabdoid Tumours (ATRT) 
Patricia O'Hare*1, Mette Jorgensen1, Anthony Michalski1, Olga Slater1, Kim Phipps2, Kristian Aquilina2, Owaase Jeelani2, Yen-Ch'ing Chang3, Jenny Gains3, Amy Fairchild4, Jess Pickles4, Thomas Jacques4, Darren Hargrave1,4
1Department of Paediatric Oncology, Great Ormond Street Hospital NHS Trust, UK, 2Department of Neurosurgery, Great Ormond Street Hospital NHS Trust,, UK, 3Department of Radiotherapy, University College London Hospitals NHS Foundation Trust, UK, 4Developmental Biology and Cancer Programme, University College London Great Ormond Street Institute of Child Health, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Successful salvage of desmoplastic nodular medulloblastoma patients treated on ACNS1221
Richard T. Graham, Suzanne Conley, Jonathan L. Finlay, Mohamed S. AbdelBaki*
Nationwide Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Successful treatment of a secondary pediatric high grade glioma with a novel BEND4-NTRK2 fusion with entrectinib, a TRK inhibitor
James Felker1,2, Bryan Philbrook1,2, Matthew Schneiderjan3, Joshua Chern4, Claire Mazewski1,2, Bree Eaton5, Edna Chow-Maneval6, Tobey MacDonald1,2, Dolly Aguilera*1,2
1Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, USA, 2Department of Pediatrics, Emory University School of Medicine, USA, 3Department of Pathology, Emory University, USA, 4Department of Pediatric Neurosurgery,, USA, 5Department of Radiation Oncology, Emory University, USA, 6Ignyta, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Supporting ongoing school education for children with a central nervous system tumour diagnosis
Kate Fernandez
Women's and Children's Hospital, Australia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Supra- and infratentorial tractogram changes in childhood posterior fossa tumor survivors
Charlotte Sleurs*1,2, Sabine Deprez3, Anne Uyttebroeck1,2, Jurgen Lemiere2, Sandra Jacobs2
1Development & Regeneration, KU Leuven, Belgium, 2Pediatric Hemato-Oncology UZ Leuven, Belgium, 3Radiology, UZ Leuven, Belgium
Sunday, July 1:  Imaging  -  4:00pm - 5:00pm
Supratentorial ependymomas - L1CAM expression and RELA fusion, their correlation with clinicopathological features
Gouri Anvekar*1, Mamta Gurav2, Omshree Shetty2, Vinayak Kadam2, Ayushi Sahay1, Girish Chinnaswamy3, Prakash Shetty4, Aliasgar Moiyadi4, Tejpal Gupta5, Rakesh Jalali5, Sridhar Epari1,2
1Department of Pathology, Tata Memorial Centre, India, 2Division of Molecular Pathology, Department of Pathology, Tata Memorial Centre, India, 3Pediatric Oncology, Tata Memorial Centre, India, 4Neurosurgery, Tata Memorial Centre, India, 5Radiation Oncology, Tata Memorial Centre, India
Sunday, July 1:  Ependymoma  -  3:30pm - 5:00pm
Surgical management of symptomatic paediatric vertebral haemangiomas presenting with myelopathy with long term follow up
Pankaj Singh, P Sarat Chandra, Shashank Kale, Satish Verma, Dattaraj Sawarkar*, Amandeep Kumar
All India institute of medical sciences, India
Monday, July 2:  Neurosurgery  -  8:30am - 10:30am
Surprising role for WNT signaling in Sonic Hedgehog driven medulloblastoma
Jezabel Rodriguez-Blanco*1, Lina Pednekar1, Clara Penas1, Bin Li1, Vanesa Martin4, Jun Long1, Ethan Lee2, William Weiss3, Carmen Rodriguez4, Nadji Mehrdad4, Dao Nguyen1, Nagi Ayad1, Priyamvada Rai1, Anthony Capobianco1, David Robbins1
1University of Miami, USA, 2Vanderbilt University, USA, 3University of California, San Francisco, USA, 4Oviedo University, Spain
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Survival of infants and young children with malignant brain tumors treated with intensive induction and myeloablative chemotherapy and autologous hematopoietic progenitor cell rescue (AuHCR) with or without irradiation (XRT) post-AuHCR
Eesha Chakravartty, Jemily Malvar, Nathan Robison, Hung Ngoc Tran, Ashley Margol, Laura Vasquez, Kenneth Wong, Girish Dhall*
Children's Hospital Los Angeles, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Survival outcomes of children and adolescents with bi-thalamic gliomas: The South Thames Neuro-Oncology Unit experience
Ajla Wasti1, Tineke Boesten1, Karen Powell1, Lynley Marshall1,2, Sucheta Vaidya1,2, Paola Angelini1,2, Henry Mandeville1,2, Frank Saran1,2, Julia Chisholm1,2, Chris Jones2, Chris Chandler3, Simon Stapleton4, Leslie Bridges4, Safa Al-Sarraj3, Fernando Carceller*1,2
1The Royal Marsden Hospital, UK, 2The Institute of Cancer Research, UK, 3King's College Hospital, UK, 4St George's Hospital, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Sustained objective response to dabrafenib therapy across different brain histologies harbouring BRAF V600E activating mutation
David Sumerauer*1, Lenka Krskova2, Martin Kyncl3, Michal Zapotocky1,4, Adela Kuklova1, Josef Zamecnik2, Barbora Ondrova5, Jan Stary1
1Department of Pediatric Hematology and Oncology, Czech Republic, 2Department of Pathology and Molecular Medicine, Czech Republic, 3Department of Imaging Methods, Czech Republic, 4Division of Hematology and Oncology, Canada, 5Proton Therapy Center, Czech Republic
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Sustained response of three pediatric BRAFV600E mutated high-grade gliomas with BRAF and MEK inhibitor therapy
Stephanie Toll*1, Jennifer Cotter1,2, Alexander Judkins1,2, Benita Tamrazi1,2, Jaclyn Biegel1,2, Palak Patel2, Hung N. Tran3, Robert Cooper3, Ashley S. Margol1,2
1Children's Hospital Los Angeles, USA, 2University of Southern California Keck School of Medicine, USA, 3Kaiser Permanente, USA
Monday, July 2:  High Grade Glioma  -  3:30pm - 5:00pm
Sustained response to erlotinib and rapamycin in a patient with pediatric anaplastic oligodendroglioma
Adam Esbenshade*, Bret Mobely, Devang Pastakia, Asa Brockman, Aashim Bhatia, Rob Naftel, Rebecca Ihrie
Vanderbilt University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
­­­­SWI/SNF complex ­­heterogeneity relates with polyphenotypic differentiation and the immune micro environment in rhabdoid tumors
Sriram Venneti*1, Pooja Panwalkar1, Chan Chung1, Drew Pratt1, Daniel Martinez2, Jill Bayliss1, Christopher Paran1, Debra Hawes3, Bruce Pawel1, Alexander Judkins3
1University of Michigan, USA, 2Childrens Hospital of Philadelphia, USA, 3Childrens Hospital of Los Angeles, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Symptom burden experienced by children with brain tumors and its influential factors
Jin-Shei Lai*1,2, Jennifer Beaumont3, Peter Manley4, Stewart Goldman2,1
1Northwestern University Feinberg School of Medicine, USA, 2Ann & Robert H. Lurie Children’s Hospital of Chicago, USA, 3Terasaki Research Institute, USA, 4Boston Children's Hospital, USA
Sunday, July 1:  Quality of Life/Survival/Rehabilitation  -  1:30pm - 3:00pm
Synchronous central nervous system (CNS) atypical teratoid/ rhabdoid tumor (AT/RT) and malignant rhabdoid tumor of the kidney - Review of the Literature
Mohammad H. Abu Arja*1, Priyal Patel1, Summit Shah2, Jeffery Auletta1, Erin Meyer3, Suzanne E. Conley1, Jennifer Aldrink4, Jonathan Pindrik5, Mohamed S. AbdelBaki1
1The Division of Hematology, Oncology, Blood and Marrow Transplant, the Department of Pediatrics, Nationwide Children's Hospital, USA, 2The Department of Radiology, Nationwide Children's Hospital, USA, 3The Department of Pathology and Lab Medicine, Nationwide Children's Hospital, USA, 4The Division of General Pediatric Surgery, the Department of Pediatric Surgery, Nationwide Children's Hospital, USA, 5The Division of Pediatric Neurosurgery, Department of Pediatric Surgery, Nationwide Children's Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Systematic drug repurposing identifies Digoxin as a drug that prolongs survival in PDOX models of groups 3 and 4 medulloblastoma at clinically relevant doses
Sarah Injac*1, Lei Huang2, Hong Zhao2, Qi Lin1, Mari Kogiso1, Chris Man1, Xiao-nan Li1, Stephen Wong2, Ching Lau3,1
1Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, USA, 2Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, USA, 3Connecticut Children's Medical Center, University of Connecticut School of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Systematic review on treatment-related haematological adverse events after temozolomide for a CNS tumour
Daniel Bos1, Anja Gijtenbeek2, Annemarie Muller3, Antoinette Schouten-van Meeteren*1
1Emma Children's Hospital, Academic Medical Center, The Netherlands, 2Radboudumc, The Netherlands, 3Bijwerkingencentrum Lareb, The Netherlands
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
TAK228 combines with navitoclax to enhance platinum-induced cytotoxicity in AT/RT
Jeffrey Rubens*1, Sabrina Wang1, Shreya Sharma1, Smit Shah1, Kathy Warren2, Charles Eberhart1, Eric Raabe1
1Johns Hopkins University, USA, 2National Cancer institute, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Tandem high-dose chemotherapy with autologous hematopoietic stem cell transplantation for infants with embryonal brain tumors
Asmik Gevorgian*1, Polina Tolkunova1, Tatiana Iukhta1, Elena Morozova1, Ilya Kazantsev1, Tatiana Andreeva1, Andrew Kozlov1, Svetlana Safonova1, Yury Punanov1, Ludmila Zubarovskaya1, Olga Zheludkova2, Boris Afanasyev1
1Raisa Gorbacheva Memorial Institute of Pediatric Oncology, Hematology and Transplantation, Russia, 2Russian Scientific Center of Roentgenoradiology, Russia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Targeted inhibition of JMJD3 and BET bromodomain proteins for the treatment of diffuse intrinsic pontine gliomas
Hiroaki Katagi*1, Nundia Louis1, Xingyao He1, Kathryn Loughlin1,2, Ali Zhang1, Patrick Ozark3, Craig Horbinski1,4, Rishi Lulla2,5, Amanda Saratsis1,2, Stewart Goldman2, C. David James1,3, Ali Shilatifard3, Rintaro Hashizume1,3
1Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, USA, 2Department of Hematology, Oncology, Neuro-Oncology & Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, USA, 3Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, USA, 4Department of Pathology, Northwestern University Feinberg School of Medicine, USA, 5Department of Pediatrics, Northwestern University Feinberg School of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Targeting 6-thio-dG-induced G2/M arrest to eradicate brain tumor cell survivors
Satarupa Sengupta*1, Shiva Senthil Kumar1, Kyungwoo Lee1, Rachid Drissi1,2
1Cincinnati Children's Hospital Medical Center, USA, 2University of Cincinnati College of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Targeting atypical teratoid/rhabdoid tumor using mature let-7 leads to increased apoptosis
Shubin Shahab*1, Jeffrey Rubens1, Charles Eberhart2, Eric Raabe1
1Division of Oncology, Johns Hopkins University, USA, 2Department of Pathology, Johns Hopkins University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Targeting EGFR in hypomutated pediatric brain tumors using the D2C7 immunotoxin
Daniel Landi*2, Eric Thompson1, Roger McLendon1, Annick Desjardins1, Vidya Chandramohan1, David Ashley1, Darell Bigner1
1Preston Robert Tisch Brain Tumor Center, Duke University, USA, 2Preston Robert Tisch Brain Tumor Center, Department of Pediatrics, Duke University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Targeting multiple pathways as a treatment strategy in diffuse midline glioma
Michael Salacz1, Donna Murray*2, Richard Kast3
1University of Kansas, USA, 2Nativis, Inc, USA, 3IIAIGC Study Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Targeting NuRD and KAT7 for epigenome modification in neurofibromatosis1 associated malignant peripheral nerve sheath tumors
CHANDRA MAYANIL*1,5, MARIAM KHAN1,5, VINEET MOHANTY1,5, RAJ KUMAR2, GUIFA XI1,5, SHUNSUKE ICHI3, BAL RAM SINGH2, BARBARA MANIA-FARNELL4, TADANORI TOMITA1,5
1Ann and Lurie Children's Hospital of Chicago, USA, 2Institute of Advanced Sciences, USA, 3Japanese Red Cross Medical Center, Japan, 4Purdue University at Calumet, USA, 5Northwestern University Feinberg School of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Targeting primary ciliogenesis in atypical teratoid/rhabdoid tumors
Lena Blümel*1,2, Kornelius Kerl3, Nan Qin1,2, Johannes Berlandi4, Katharina Thiel4, Isabel Tegeder4, Astrid Jeibmann4, Daniel Picard1,2, Maike Langini1,5, Kai Stühler5,6, Frauke-Dorothee Meyer1,2, Bastian Malzkorn7, Max C. Liebau8, Pascal D. Johann9, Serap Erkek9, Marcel Kool9, Stefan M. Pfister9, Michael C. Frühwald10, Arndt Borkhardt2, Guido Reifenberger7, Martin Hasselblatt4, Marc Remke1,2
1Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site University Hospital Düsseldorf, Germany, 2Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany, 3Department of Pediatric Hematology and Oncology, University Hospital Münster, Germany, 4Institute of Neuropathology, University Hospital Münster, Germany, 5Molecular Proteomics Laboratory, BMFZ, Heinrich Heine University Düsseldorf, Germany, 6Institute of Molecular Medicine, University Hospital Düsseldorf, Düsseldorf, Germany, 7Institute of Neuropathology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany, 8Department of Pediatrics and Center for Molecular Medicine, University Hospital Cologne, Germany, 9Hopp Children´s Cancer Center at the NCT Heidelberg (KiTZ), Division of Pediatric Neurooncology, DKFZ and DKTK, and Heidelberg University Hospital, Germany, 10Swabian Childrens´ Cancer Center, Children´s Hospital Augsburg, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Targeting PRUNE-1 in a GEMM of metastatic medulloblastoma: a potential route of inhibition for new future therapies
Veronica Ferrucci*3,1, Pasqualino de Antonellis2,1, Francesco Paolo Pennino1,2, Fatemeh Asadzadeh2, Roberto Siciliano2, Antonella Virgilio4, Aldo Galeone4, Lucia De Martino6, Lucia Quaglietta6, Maria Elena Errico5, Vittoria Donofrio5, Daniel Picard7, Marc Remke7, Louis Chesler8, Fredrik Swartling9, William Weiss10, Michael Taylor11,12, Giuseppe Cinalli6, Massimo Zollo1,2
1Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Italy, 2CEINGE Biotecnologie Avanzate, Naples, Italy., Italy, 3European School of Molecular Medicine (SEMM), Italy, 4Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Italy, 5Surgical Pathology, Ospedale Santobono-Pausilipon, Italy, 6Paediatric Neurosurgery, Ospedale Santobono-Pausilipon, Italy, 7German Cancer Consortium (DKTK), Department of Paediatric Oncology, Haematology, and Clinical Immunology, University Hospital Düsseldorf, Germany, 8Division of Clinical Studies, The Institute of Cancer Research, UK, 9Science for Life Laboratory, Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Sweden, 10Department of Neurology, University of California, San Francisco, USA, 11Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada, 12Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Canada
Tuesday, July 3:  Medulloblastoma - Basic/Translational Research  -  9:00am - 10:20am
Targeting senescent cells with ABT-263 enhances cell death induced by BMI1 inhibition and ionizing radiation in DIPG
Ilango Balakrishnan1, Krishna Madhavan1,3, Angela Pierce1, Nathan Dahl2,3, Rakeb Lemma1, Susan Fosmire1, Dong Wang1, Eric Prince1, Irina Alimova1, Rintaro Hashizume4, Esther Huellman5, Cynthia Hawkins6, Angel Montero Carcaboso7, Nalin Gupta8, Michelle Monje9, Keneth Jones1, Adam Green2,3, Nicholas Foreman2,3, Rajeev Vibhakar2,3, Sujatha Venkataraman*1,3
1University of Colorado, USA, 2Childrens Hospital of Colorado, USA, 3Morgan Adams Foundation, USA, 4Feinberg School of Medicine Northwestern University, USA, 5VU University Medical Center, The Netherlands, 6Hospital for Sick Children, Canada, 7Institut de Recerca Sant Joan de Deu, Spain, 8UCSF, USA, 9Stanford, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Targeting SIRT2 in SMARCB1 deficient ATRT
Irina Alimova*1, Sujatha Venkataraman1, Angela M Pierce1, Diane Birks1, Rajeev Vibhakar1, Nicholas K Foreman1, Min Yang2, Hinning Ling2
1University of Colorado, USA, 2Cornell University, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Targeting the lethal pediatric tumors ATRT and DIPG with the DNA minor-groove binding agent quinacrine
Harpreet Kaur*, Huizi Guo, Smit Shah, Sepehr Akhtarkhavari, Charles Eberhart, Eric Raabe
Johns Hopkins University, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Targeting the polyamine pathway as a novel therapeutic treatment against diffuse intrinsic pontine glioma
Aaminah Khan*1, Laura Gamble1, Denise Yu1, Swapna Joshi1, Laura Franshaw1, Mark Burns2, Murray Norris1, Michelle Haber1, Maria Tsoli1, David Ziegler1,3
1Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Australia, 2Aminex Therapeutics Inc., USA, 3Kid’s Cancer Centre, Sydney Children’s Hospital, Randwick, NSW, Australia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Targeting transcriptional addiction for GBM therapy through CDK7 inhibition
Wei Meng1, Jiajia Wang1, Qifeng Li1, Fang Liu2, Meng Li2, Wenyan Jiang2, Li Lin3, Xiaomin Dai3,4, Hongxiang Wang5, Chenran Zhang1, Baocheng Wang1, Juxiang Chen5, Liye Zhang3, Yujie Tang1,2, Jie Ma*1
1Department of Pediatric Neurosurgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China, 2Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, China, 3School of Life Science and Technology, Shanghai Tech University, China, 4University of Chinese Academy of Sciences, China, 5Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, China
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
T-cell therapies demonstrate efficacy without toxicity in immunocompetent models of brainstem tumors
Matt Schuelke*1, Laura Evgin2, Phonphimon Wongthida2, Jill Thompson2, Tim Kottke2, Luis Sanchez-Perez3, John Sampson3, Richard Vile2
1Mayo Clinic Medical Scientist Training Program, USA, 2Mayo Clinic Department of Molecular Medicine, USA, 3Duke University Department of Neurosurgery, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Temporal genomic heterogeneity in pediatric low-grade gliomas
Christine Fuller*1, Austin Schafer1, Daniel Boue2, Diana Osorio2, Jonathan Finlay2, Sarah Rush3, Erin Wright3, Lindsey Hoffman4, Nancy Yanez-Escorza1, Jamie Reuss1, Trent Hummel1, Ralph Salloum1, Lionel M.L. Chow1, Mariko DeWire1, Peter de Blank1, Charles Stevenson1, Rachid Drissi1, Maryam Fouladi1
1Cincinnati Children's Hospital Medical Center, USA, 2Nationwide Children's Hospital, USA, 3Akron Children's Hospital, USA, 4Children's Hospital Colorado, USA
Sunday, July 1:  Low Grade Gliomas  -  8:45am - 11:00am
The aurora kinase A (AURKA) inhibitor alisertib acts synergistically with a polo-like kinase 4 (PLK4) inhibitor to target atypical teratoid / rhabdoid tumor (AT/RT) cells
Anders Bailey1,3, Amreena Suri1,3, Connor Dyer3, Clara Horn3, Tadanori Tomita1,2, Simone Sredni*1,2
1Ann and Robert H. Lurie Children's Hospital of Chicago, USA, 2Northwestern University, Feinberg School of Medicine, USA, 3Stanley Manne Children's Research Institute, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The current landscape of therapeutic clinical trials in pediatric brain tumors: a review of clinicaltrials.gov
Eugene Hwang*1, Sandeep Kuril3, Joanne Salcido2
1Children's National Medical Center, USA, 2Pediatric Brain Tumor Foundation, USA, 3Medical University of South Carolina, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The development of a school ‘Brain Aid Kit’ box
Jade Ryles*, Faye Fraser, Simon Bailey, Gail Halliday
Newcastle upon Tyne, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The diversity of molecular characteristics in pediatric high-grade gliomas
Akihide Kondo*, Junya Fujimura, Osamu Akiyama, Mario Suzuki, Hiroyuki Tamaichi, Hajime Arai
Juntendo University, Japan
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The effect of virtual reality exercises on balance in children with brain tumors
Müberra Tanriverdi*1, Fatma Karantay Mutluay2, Fatma Betül Çakir3
1Bezmialem Vakif University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Turkey, 2Istanbul Medipol University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Turkey, 3Bezmialem Vakif University, Faculty of Medicine, Department of Child Neurology, Turkey
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The effects of fatigue on daily living activities and quality of life in children with brain tumor
Muberra Tanriverdi*1, Fatma Karantay Mutluay2, Fatma Betul Cakir3
1Bezmialem Vakif University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Turkey, 2Istanbul Medipol University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Turkey, 3Bezmialem Vakıf University, Faculty of Medicine, Department of Child Oncology, Turkey
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The effects of radiation on cognitive scores in pediatric patients with medulloblastoma
Subha Mazzone, Sara McElroy, Sunnye Mayes, Jim Scott, Michael Anderson, Rene McNall-Knapp*
University of Oklahoma Health Sciences Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The epigenetic regulator, SETD8, facilitates self-renewal and invasion in Myc-driven medulloblastoma.
Bethany Veo*1, Sujatha Venkataraman1,3, Angela Pierce1,2, Ismail Sola1, Nicholas Foreman1,2, Rajeev Vibhakar1,2
1University of Colorado Anschutz Medical Campus, USA, 2Children's Hospital Colorado, USA, 3Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The genetic landscape of pediatric low-grade gliomas: incidence, prognosis and response to therapy
Scott Ryall1, Michal Zapotocky*1, Kohei Fukuoka1, Ana Guerreiro-Stucklin1, Julie Bennet1, Anthony Arnoldo1, Paul Kowalski1, Monique Johnson1, Alvaro Lassaletta1,2, Ute Bartels1, Annie Huang1, Vijay Ramaswamy1, David Ellison3, Uri Tabori1, Cynthia Hawkins1, On behalf of PLGG taskforce .1
1Hospital for Sick Children, Canada, 2Hospital Infantil Universitario Nino Jesus, Spain, 3St. Jude Children's Research Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The H3K27M mutation causes wide-ranging changes mediating DIPG tumorigenesis
Rakeb Lemma*, John DeSisto, Patrick Flannery, Bridget Sanford, Ilango Balakrishnan, Krishna Madhavan, Bethany Veo, Jean Mulcahy Levy, Nicholas Foreman, Rajeev Vibhakar, Kenneth Jones, Sujatha Venkataraman, Adam Green
University of Colorado Anschutz Medical Campus, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The Latin-American Brain Tumor Board (LATB) teleconference: results of a web-based survey to evaluate participant experience and the program
Mohammad H. Abu Arja*1, Scott Coven1, Joseph R. Stanek1, Andrés E. Morales La Madrid2, Alvaro Lassaletta3, Ute Bartels4, Ibrahim Qaddoumi5, Jonathan L. Finlay1, Diana S. Osorio1
1Department of Hematology/Oncology/Blood and Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, USA, 2Department of Hematology/Oncology/Blood and Marrow Transplant, Hospital St Joan de Déu, Spain, 3Pediatric Oncology, Hematology and Stem Cell Transplant Department, Hospital Infantil Universitario Niño Jesús, Spain, 4Department of Hematology Oncology, Hospital for Sick Children, Canada, 5Global Pediatric Medicine Department, St. Jude Children's Research Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The molecular and clinical landscape of infant medulloblastoma (iMB): results and molecular analysis from a prospective, multicenter phase II trial (SJYC07)
Giles W. Robinson*1, Vasilisa A. Rudneva2, Ivo Buchhalter3, Catherine A. Billups4, Sebastian M. Waszak5, Kyle Smith2, Daniel C. Bowers6, Anne Bendel7, Paul Fisher8, Sonia Partap8, John Crawford9, Tim Hassall10, Daniel J. Indelicato11, Frederick Boop12, Paul Klimo12, Noah D. Sabin13, Zoltan Patay13, Thomas E. Merchant14, Clinton F. Stewart15, Brent A. Orr16, Jan O. Korbel5, David T. W. Jones17,18, Tanvi Sharma17,18, Peter Lichter19, Marcel Kool17,18, Andrey Korshunov20, Stefan M. Pfister17,18, Richard J. Gilbertson21, Robert P. Sanders22, Arzu Onar-Thomas4, David W. Ellison16, Amar Gajjar1, Paul A. Northcott2
1Department of Oncology, St Jude Children's Research Hospital, USA, 2Department of Developmental Neurobiology, St Jude Children's Research Hospital, USA, 3Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Germany, 4Department of Biostatistics, St Jude Children's Research Hospital, USA, 5European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Germany, 6Department of Pediatric Hematology and Oncology, University of Southwestern Medical Center at Dallas, USA, 7Department of Pediatric Hematology and Oncology, Children’s Hospitals and Clinics of Minnesota, USA, 8Division of Child Neurology, Stanford University, USA, 9Department of Pediatric Hematology and Oncology, Rady Children’s Hospital, USA, 10Department of Paediatric Oncology, Lady Cilento Children’s Hospital, Australia, 11Department of Radiation-Oncology, University of Florida, USA, 12Department of Neurosurgery, University of Tennessee Health Science Center and Semmes-Murphy Neurologic & Spine Institute, USA, 13Department of Radiology, St Jude Children's Research Hospital, USA, 14Department of Radiation-Oncology, St Jude Children’s Research Hospital, USA, 15Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, USA, 16Department of Pathology, St Jude Children's Research Hospital, USA, 17Hopp Children’s Cancer Center at the NCT (KiTZ), Germany, 18Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Germany, 19Division of Molecular Genetics, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Germany, 20CCU Neuropathology, German Cancer Research Center (DKFZ), and Department of Neuropathology, University of Heidelberg, Germany, 21Department of Oncology, Cancer Research UK Cambridge Institute, UK, 22Department of Pediatrics, Methodist Children’s Hospital of South Texas, USA
Tuesday, July 3:  Medulloblastoma - Clinical  -  10:40am - 12:10pm
The most influential papers in the neurosurgical management of paediatric central nervous system tumours
Charlotte Burford*1, Yasmine Cherfi1, Cristina Bleil2, Bassel Zebian1
1King's College London, UK, 2King's College Hospital, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The oncogenic role of the super elongation complex in H3K27M-mutant diffuse midline gliomas
Nathan A. Dahl*1,2, Sujatha Venkataraman1,2, Ilango Balakrishnan1, Krishna Madhavan1,2, Susan Fosmire1, Rajeev Vibhakar1,2
1Pediatric Neuro-Oncology Program, Department of Pediatrics, University of Colorado School of Medicine, USA, 2Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The pediatric brain and spine tumor center at the University Children's Hospital in Basel, Switzerland
Uta Tacke1, Raphael Guzman1,2, Friederike Prüfer1, Alexandros Papachristofilou2, Gabor Szinnai1, Christine Wondrusch1, Janine Gutzwiller1, Marianne Heinzelmann1, Katja Möschlin1, Tamara Diesch1, Katrin Scheinemann*1
1University Children's Hospital Basel, Switzerland, 2University Hospital Basel, Switzerland
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The PI3K/mTOR pathway contributes to sex differences in glioblastoma
Jasmin Sponagel*1, Kwanha Yu2, Joseph Ippolito1, Benjamin Deneen2, Josh Rubin1
1Washington University School of Medicine, USA, 2Baylor College of Medicine, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The PROMOTE Study: Patient Reported Outcome Measures Online To Enhance communication and quality of life after childhood brain tumour
Kim Bull*1, Anne-Sophie Darlington1, Martha Grootenhuis2, Darren Hargrave3, Christina Liossi1, Christopher Morris4, David Walker5, Colin Kennedy1
1University of Southampton, UK, 2University of Utrecht, The Netherlands, 3Great Ormond Street Hospital, UK, 4University of Exeter, UK, 5Queen's Medical Centre, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The relationship between mathematics and working memory in paediatric brain tumour survivors treated with radiation
Carmelinda Longo*1, Lovetta Monteiro1, Alanah Throop2, Donald Mabbott1,3
1Sickkids, Canada, 2Adler School of Professional Psychology, Canada, 3University of Toronto, Canada
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The relationship between ventricular size and whole brain irradiation dose in central nervous system germ cell tumors
Stephanie Toll*1, Marjorie Jones1, Emi J. Yoshida3, Arthur Olch1,2, Girish Dhall1,2, Kenneth Wong1,2
1Children's Hospital Los Angeles, USA, 2University of Southern California Keck School of Medicine, USA, 3Cedars-Sinai Medical Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The results of treatment of children with ependymomas within the framework of the cooperated multicenter study in Russia
Ella Kumirova*1, Sergey Oserov1, Artur Merishavian1, Ekaterina Salnikova1, Victoria Emzova1, Yulia Vayzova1, Alexey Nechesnyk1, Margarita Belogurova3, Julia Denikina2, Marina Ryzhova4, Galina Tereschenko1, Andey Karmanov1, Alexandr Shapochnik1, Inna Gerbek1, Andrey Sysoev1, Alexandr Rumyanzev1
1Rogachev National Medical Research Centre for Pediatric Hematology, Oncology and Immunology, Russia, 2Almazov National Medical Research Centre, Russia, 3St. Petersburg Clinical Scientific and Practical Center of Specialized Medical Assistance (Oncological), Russia, 44National Medical Research Center of Neurosurgery named Burdenko, Russia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The role of a 'research extender' in a pediatric neuro-oncology program
Emily Owens Pickle*, Ana Aguilar-Bonilla, Amy Smith
Arnold Palmer Medical Center, USA
Saturday, June 30:  Nursing Symposium  - 
The role of COMBAT (Combined Oral Metronomic Biodifferentiating Antiangiogenic Treatment) in high-risk and relapsed medulloblastoma: A single institution experience
Girish Chinnaswamy*, Hari Sankaran, Vasudev Bhat, Anand KC, Megha Saroha, Maya Prasad, Tushar Vora, Ayushi Sahay, Rahul Krishnatry, Sona Pungavkar, Amit Janu, Tejpal Gupta, Rakesh Jalali, Shripad Banavali
Tata Memorial Centre, India
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The role of G-CSF receptor surface expression in medulloblastoma pathogenesis.
Megan Paul*, Peter Zage
University of California San Diego, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
The role of the G-Protein-coupled receptor, GPR17 in paediatric diffuse midline glioma
Katie Loveson*1, Eva Lepinay1,2, Samuel Robson1, Helen Fillmore1
1University of Portsmouth, UK, 2University of Rouen, France
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The tale of 100 DIPGs and radiotherapy
Rahul Krishnatry*1,2, Jayant Sastri Goda2,3, Amita Kadam1, Tejpal Gupta2,3, Girish Chinnaswamy1,2, Rakesh Jalali1,2, Vijay Patil1,2, Amit Janu1,2
1Tata Memorial Center, India, 2HBNI University, India, 3ACTREC, India
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion
Anna Burford*1, Alan Mackay1, Sergey Popov2, Maria Vinci1,3, Diana Carvalho1, Matthew Clarke1, Elisa Izquierdo1, Aimee Avery4, Thomas S Jacques4, Wendy J Ingram5, Andrew S Moore5,6, Kieran Frawley6, Timothy E Hassall6, Thomas Robertson5
1The Institute for Cancer Research, UK, 2Cardiff University School of Medicine, UK, 3Bambino Gesù Children’s Hospital, Italy, 4Great Ormond Street Hospital for Children NHS Foundation Trust, UK, 5The University of Queensland, Australia, 6Children’s Health Queensland Hospital, Australia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Therapy Assessment Tool for Long Term Survivors of Paediatric CNS malignancies
Louise Graham*, Ailie Hodgson, Elizabeth Rowen, Sara Thompson, Fiona Court, Karen Heale, Jade Ryles, Sandra Barlow, Gail Halliday, Sarah Watts, Simon Bailey
Great North Childrens Hospital, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Three cases of clinically suspected cavernomas found to have very different pathologies
Nicholas Pytel*1, Nicholas Harn2, Shahriar M. Salamat3, Kristin Bradley4, Raheel Ahmed5, Bermans Iskandar5, Diane Puccetti1
1University of Wisconsin - Dept of Pediatrics, USA, 2University of Wisconsin - Dept of Radiology, USA, 3University of Wisconsin - Dept of Pathology, USA, 4University of Wisconsin - Dept of Human Oncology, USA, 5University of Wisconsin - Dept of Neurological Surgery, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Timing of central line removal in pediatric neuro-oncology patients after completion of therapy
Zachary Prudowsky1, Joseph Stanek1, Mostafa Eltobgy2, Mohamed AbdelBaki*1
1Nationwide Children's Hospital, USA, 2Ohio State University Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
To study the demographic characteristics of pediatric ependymoma patients and evaluate the efficacy of different treatment modalities at King Fahad Medical City (KFMC), Riyadh
Syed Nizam Hussain, Sadeq W Al Dandan, Muhammad Shuja, Ali Balbaid, Mohammad Salman, Musa Al Harbi*
King Fahad Medical City (KFMC), Saudi Arabia
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
TORC1/2 inhibition sensitizes MYC-driven medulloblastoma cells to carboplatin chemotherapy
Rachael Maynard*, Allison Hanaford, Bradley Poore, Jeffrey Rubens, Tenley Archer, Pablo Tamayo, Scott Pomeroy, Charles Eberhart, Eric Raabe
Johns Hopkins University School of Medicine, Divisions of Pediatric Oncology and Neuropathology, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Toxicity profile and response to high dose methotrexate, bevacizumab, and temozolomide chemotherapy regimen in children with recurrent malignant pediatric brain tumors: single institution experience
Margaret Page*1, Sumit Singh2, Sasha Ramini2, Kara Kachurak1, Jessica Edmondson2, Rong Li2, Emily Waite2, Joshua Bernstock1, Elizabeth Alva1, Alyssa Reddy1, Gregory Friedman1
1University of Alabama at Birmingham, USA, 2Children's of Alabama, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Trametinib therapy in pediatric patients with low-grade gliomas (LGG) with BRAF gene fusion; a disease-specific cohort in the first pediatric testing of trametinib
Eric Bouffet*1, Mark Kieran2, Darren Hargrave3, Stephen Roberts4, Isabelle Aerts5, Alberto Broniscer6, Birgit Geoerger7, Kohinoor Dasgupta8, Lillian Tseng9, Mark Russo9, Bijoyesh Mookerjee9, Christopher Moertel10
1University of Toronto Hospital for Sick Children, Canada, 2Dana-Farber Boston Children's Hospital, USA, 3Great Ormond Street Hospital for Children, UK, 4Memorial Sloan Kettering Cancer Center, USA, 5Institut Curie, SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), PSL Research University, France, 6St. Jude Children's Research Hospital, USA, 7Institut Gustave Roussy, France, 8Novartis Healthcare Pvt. Ltd., India, 9Novartis Pharmaceuticals Corporation, USA, 10University of Minnesota, USA
Sunday, July 1:  Low Grade Gliomas  -  8:45am - 11:00am
Transcriptional analysis of ATRT samples from long-term survivors and matched primary/recurrent pairs
Patrick Flannery*, John DeSisto, Andrew Donson, Rakeb Lemma, Rajeev Vibhakar, Kenneth Jones, Adam Green
University of Colorado, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Transcriptional regulation of neural progenitor cell fate by DLX homeobox genes - relevance to diffuse intrinsic pontine glioma (DIPG)
David Eisenstat*1, Jamie Zagozewski2, Sara Japoni1, Xiaohua Song1, Roseline Godbout1, Alan Underhill1, Oren Becher3
1University of Alberta, Canada, 2University of Manitoba, Canada, 3Northwestern University, USA
Monday, July 2:  DIPG/Diffuse Midline Glioma  -  1:30pm - 3:00pm
Transcriptomic and proteomic comparison of pediatric and adult adamantinomatous craniopharyngioma
Eric Prince1,2, Ros Whelan*1,2, Andrew Donson1,2, Susan Staulcup1,2, Kevin Lillehei1, Nicholas Foreman1,2, Luca Massimi4, Michael Handler1,2, Todd Hankinson1,2
1University of Colorado Denver, USA, 2Children's Hospital Colorado, USA, 3Children's Hospital of Alabama, USA, 4Catholic University Rome, Italy
Sunday, July 1:  Craniopharyngioma/Rare Tumors  -  2:30pm - 3:30pm
Transcriptomics sequencing reveals aberrant alternative splicing in recurrent posterior fossa ependymomas
Anbarasu Lourdusamy*1, Timothy Ritzmann1, Hazel Rogers1, Andrew Donson2, Rebecca Chapman1, Lisa Storer1, Thomas Jacques3, Simon Paine1,4, Nicholas Foreman2, Richard Grundy1
1The Children’s Brain Tumour Research Centre, University of Nottingham, UK, 2Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, USA, 3UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, UK, 4Nottingham University Hospitals NHS Trust, UK
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Treatment and outcomes of central nervous system non-germinomatous germ cell tumors with early relapse during induction chemotherapy
Hung Tran*2, Ashley Margol1, Nathan Robison1, Kenneth Wong1, Jonathan Finlay3, Girish Dhall1
1Children's Hospital Los Angeles, USA, 2Southern California Permanente Group, USA, 3Nationwide Children’s Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Treatment failure patterns across medulloblastoma subgroups within a prospective phase II clinical trial of risk-adapted, volume-reduced radiation therapy and dose-intense chemotherapy with stem cell support
Christopher Tinkle*, John Lucas, Sudharsan Srinivasan, Parker Tumlin, Arzu Onar-Thomas, Jie Huang, Zoltan Patay, David Ellison, Brent Orr, Paul Northcott, Giles Robinson, Amar Gajjar, Thomas Merchant
St. Jude Children's Research Hospital, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Treatment of a pediatric patient with an H3.3 K27M mutant DIPG with ONC201, a selective DRD2 antagonist.
Fernando Suarez*1, James M. Stafford1, Rohinton Tarapore2, Wolfgang Oster2, Joshua E. Allen2, Andrew S. Chi1, Sharon Gardner1
1NYU Langone Health, USA, 2Oncoceutics, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Treatment of central nervous system atypical teratoid/rhabdoid tumor with VDC/ICE protocol, surgery and craniospinal irradiation
Piti Techavichit*1, Shanop Shuangshote2, Kanhatai Chiangthong1, Darintr Sosothikul1, Panya Seksarn1
1Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Thailand, 2Department of Pathology, Faculty of Medicine, Chulalongkorn University, Thailand
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Treatment of embryonal tumor with multilayered rosettes (ETMR) with targeted radioimmunotherapy
Kayleen Bailey, Neeta Pandit-Taskar, John Humm, Pat Zanzonico, Stephen W. Gilheeney, Kim Kramer*
Memorial Sloan Kettering Cancer Center, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Treatment outcome and long-term health deficits of patients with low-grade glioma diagnosed during the first year of life
Anthony Liu*1, Camden Hastings2, Shengjie Wu3, Johnnie K. Bass4, Andrew Heitzer5, Jason Ashford5, Robert Vestal7, Mary Hoehn1,7, Jason Chiang8, Yahya Ghazwani1, Sahaja Acharya9, Heather Conklin5, Frederick Boop6,10, Amar Gajjar1, Ibrahim Qaddoumi1
1Department of Oncology, St. Jude Children's Research Hospital, USA, 2Pediatric Oncology Education Program, St. Jude Children's Research Hospital, USA, 3Department of Biostatistics, St Jude Children's Research Hospital, USA, 4Rehabilitation Services, St. Jude Children's Research Hospital, USA, 5Department of Psychology, St. Jude Children's Research Hospital, USA, 6Department of Surgery, St. Jude Children's Research Hospital, USA, 7Department of Ophthalmology, University of Tennessee Health Science Center, USA, 8Department of Pathology, St. Jude Children's Research Hospital, USA, 9Department of Radiation Oncology, St. Jude Children's Research Hospital, USA, 10Department of Neurosurgery, University of Tennessee Health Science Center, USA, 11Le Bonheur Neuroscience Institute, Le Bonheur Children's Hospital, USA, 12Semmes Murphey Clinic, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Treatment outcomes and complication rates of single versus tandem autologous transplant for regimens for medulloblastoma
Ashley S. Plant*2, Clement Ma1,3, Derek Shyr1,4, Michelle A. Lee1,3, Susan N. Chi1
1Dana-Farber Cancer Institute, USA, 2Children's Hospital Orange County, USA, 3Harvard Medical School, USA, 4Harvard T.H. Can School of Public Health, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Treatment strategy for the expanding cyst of pediatric pilocytic astrocytomas
Tomoru Miwa*, Ryota Tamura, Hikaru Sasaki, Kazunari Yoshida
Keio University, Japan
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Treatment with vemurafenib in pediatric patients with low-grade gliomas with BRAF V600E mutation. Report of 4 cases
María Cores*1, Mariana Nana1, Paula Robledo2, Blanca Diez2, Mercedes García Lombardi1
1Hospital de Niños Ricardo Gutierrez, Argentina, 2FLENI, Argentina
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Tumor mutational burden analysis of pediatric tumors provides a diagnostic tool for germline replication repair deficiency and predict response to immune checkpoint inhibition
Brittany B Campbell*1, Nicholas Light1, David Fabrizio2, Eric Bouffet1, Valerie Larouche3, David Samuel4, Duncan Stearns5, Kristina A. Cole6, Enrico Opocher7, Gregory Thomas8, Magnus Sabel9, Peter Dirks1, Michael Taylor1, David Malkin1, Steffen Albrecht1, Roy Dudley1, Nada Jabado10, Cynthia Hawkins1, Adam Shlien1, Uri Tabori1
1The Hospital for Sick Children, Canada, 2Foundation Medicine Inc, USA, 3Centre Mère-enfant Soleil du CHU de Québec, Canada, 4Valley Children's Hospital, USA, 5UH Rainbow Babies and Children's Hospital, USA, 6Children's Hospital of Philadelphia, USA, 7Azienda Ospedaliera-Università degli Studi di Padova, Italy, 8, Oregon Health & Science University, USA, 9Sahlgrenska Academy, University of Gothenburg, Sweden, 10Montreal Children's Hospital, Canada
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Tumor mutational burden and driver mutations: further insight into the genomic landscape of pediatric brain tumors
Roshal Patel*1, Katharine Halligan2, Shakti Ramkissoon3, Jeffrey Ross3, Lauren Weintraub4
1Albany Medical College, USA, 2Pediatrics, Albany Medical Center, USA, 3Foundation Medicine, Inc., USA, 4Pediatric Hematology/Oncology, Albany Medical Center, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Tumor surveillance using liquid biome in pediatric high grade gliomas
Erin Bonner*1,2, Eshini Panditharatna1,2, Madhuri Kambhampati1, Stefaan Van Gool3, Wilfried Stuecker3, Roger Packer1, Javad Nazarian1,2
1Children's National Health System, USA, 2The George Washington University, USA, 3Immun-Okologisches Zentrum Koln, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Tumors of the pineal region can be classified into distinct subgroups based on molecular characteristics correlating with clinical parameters and genetic alterations
Elke Pfaff*1,2, Matija Snuderl3,4, Matthias A. Karajannis5, Christian Aichmüller6, Martin Sill7, Brent A. Orr8, David W. Ellison9, Stefan M. Pfister1,2, David T.W. Jones1
1Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ) and Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Germany, 2Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Germany, 3Division of Neuropathology and Department of Neurology, NYU Langone Medical Center, USA, 4Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, USA, 5Department of Pediatrics, Memorial Sloan Kettering Cancer Center, USA, 6Division of Molecular Genetics, German Cancer Research Center (DKFZ), Germany, 7Division of Biostatistics, German Cancer Research Center (DKFZ), Germany, 8Department of Pathology, St. Jude Children's Research Hospital, USA, 9Department of Oncology, St. Jude Children's Research Hospital, USA
Sunday, July 1:  Embryonal Tumors  -  11:30am - 12:30pm
Tumour compartment transcriptomics demonstrate the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identify novel therapeutic targets
John Apps*1,2, Romaine Guiho1, Ying Hong1, Darren Hargrave1,2, Paul Brogan1,2, Thomas Jacques1,2, Juan Pedro Martinez-Barbera1
1UCL GOS Institute of Child Health, UK, 2Great Ormond Street Hospital for Children NHS Foundation Trust, UK
Sunday, July 1:  Craniopharyngioma/Rare Tumors  -  2:30pm - 3:30pm
Turcot Syndrome: A synchronous clinical presentation of medulloblastoma and lower rectal tumor
Mehdi Borni*, Fatma Kolsi, Anis Abdelhedi, Firas Jarraya, Mohammed Zaher Boudawara
Neurosurgery department UHC Habib Bourguiba, Tunisia
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
TWIST1 plays a regulatory role in medulloblastoma metastasis
Alice Cardall*1, Aishah Nasir2, Franziska Linke1, Anna M Grabowska2, Ian D Kerr3, Beth Coyle1
1Children’s Brain Tumour Research Centre, School of Medicine, University of Nottingham, UK, 2Division of Cancer & Stem Cells, School of Medicine, University of Nottingham, UK, 3Division of Cell Signalling & Pharmacology, School of Life Sciences, University of Nottingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Type II BRAF inhibitor TAK-580 shows promise for upcoming clinal trial as evidenced by single patient IND study
Karen D. Wright*1,2, Mary Ann Zimmerman1,2, Elizabeth Fine1, Tristan Aspri1, Mark W. Kieran1,2, Susan Chi1,2
1Dana-Farber Cancer Institute, USA, 2Boston Children's Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Uncoupling CAR T cell recognition from tumor killing for DIPG therapy 
Karen D. Wright*, Alberto Nobili, Steven C. Neier, Pratiti Bandopadhayay, Colby P. Ledoux, Susanna Baumeister, Hye-Jung Kim, Carl D. Novina, Mark W. Kieran
Dana-Farber Cancer Institute, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Unfavorable clinical course of a WNT-activated medulloblastoma
Christine Haberler*1, Andreas Peyrl2, Thomas Czech3, Marcel Kool4,5, Irene Slavc2
1Institute of Neurology, Medical University of Vienna, Austria, 2Department of Pediatrics, Medical University of Vienna, Austria, 3Department of Neurosurgery, Medical University of Vienna, Austria, 4Hopp Children’s Cancer Center at the NCT (KiTZ)Heidelberg, Germany, 5German Cancer Research Center (DKFZ), Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Uniform volumetric measures of cross-platform MRI acquisitions in NF1 optic pathway gliomas: application of deep learning techniques to multi-center clinical trials
Awais Mansoor1, Robert Avery*2, Nicholas Stence3, Michael Fisher2, Emily McCourt3, Roger Packer1, Nicholas Foreman3, Marius Linguraru1
1Children's National Health System, USA, 2Children's Hospital of Philadelphia, USA, 3Children's Hospital Colorado, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Unusual disseminated dysembryoplastic neuroepithelial tumor indicating rosette-forming glioneural tumor
Taku Uchiyama*1, Rie Nagayama1, Junji Shibahara4, Noriyoshi Fukushima3, Daisuke Matsubara3, Kensuke Kawai1, Akira Gomi1
1Department of Neurosurgery, Jichi Medical University, Japan, 2Department of Pediatric Neurosurgery, Jichi Children's Medical Center Tochigi, Jichi Medical University, Japan, 3Department of Pathology, Jichi Medical University, Japan, 4Department of Pathology, Kyorin University School of Medicine, Japan
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Use of cannabinoids in the pediatric central nervous system tumor population
Kathleen Dorris*1,2, Jessica Channell1,2, Molly Hemenway1,2, Angelina Baroffio1, Michael Ellison1, Natalie Brionse1, Andrea Griesinger1,2, Andrew Donson1,2, Jennifer Madden1,2, Colleen Van Essen1, Jean Mulcahy Levy1,2, Daniel Ambruso1, Nicholas Foreman1,2
1Children's Hospital Colorado, USA, 2Morgan Adams Foundation Pediatric Brain Tumor Research Program, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Using Drosophila to explore the functional relevance of genes affected by epigenetic alterations in atypical teratoid/rhabdoid tumors (AT/RT)
Isabel Tegeder1, Katharina Thiel1, Johannes Berlandi1, Pascal Johann2,3, Serap Erkek2,4, Marcel Kool2,4, Astrid Jeibmann1, Martin Hasselblatt*1
1Institute of Neuropathology, University Hospital Münster, Germany, 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Germany, 3Dept. of Pediatric Oncology and Hematology, University Hospital Heidelberg, Germany, 4Hopp-Children’s Cancer Center, Germany
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Using sensitive magnetic resonance imaging techniques to improve the risk stratification of patients with metastatic medulloblastoma
Christine Mitoko*1,2, Franziska Linke1, Donald Macarthur1, Henryk Faas2, Beth Coyle1
1Children’s Brain Tumour Research Centre, School of Medicine, University of Nottingham, UK, 2Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Utilizing a histology-specific sequencing algorithm for precision neuro-oncology
Prajwal Rajappa*, Uday Maachani, Rohan Bareja, Kenneth Wang, Andrea Sboner, Caitlin Hoffman, Mark Souweidane, Olivier Elemento, David Pisapia, Jeffrey Greenfield
Weill Cornell Medicine, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Validation of proteasome inhibition as a therapeutic target in atypical teratoid/rhabdoid tumors
Andrew Morin*1, Caroline Soane1, Angela Pierce1, Irina Alimova1, Michele Desmarais1, Shadi Zahedi1, Rajeev Vibhakar1,2, Andrea Griesinger1, Adam Green1,2, Lindsey Hoffman1,2, Jean Mulcahy Levy1,2
1University of Colorado - Denver, USA, 2Children's Hospital of Colorado, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Vertebral body growth retardation following proton craniospinal radiation
Myrsini Ioakeim-Ioannidou*, Drosoula Giantsoudi, Andrzej Niemierko, Roshan V. Sethi, Torunn I. Yock, Nancy J. Tarbell, F. Joseph Simeone, Shannon M. MacDonald
Massachusetts General Hospital, USA
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Vincristine neurotoxicity unmasking Charcot-Marie-Tooth disease
Trisha Kissoon*, Sridharan Gururangan
University of Florida, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Vismodegib nanoparticle enhances tumor targeting in an in vivo medulloblastoma model
Hiroto Kiguchi*1, Yosef Shamay1, Janki Shah1, Jake Vaynshteyn2, Daniel Heller1,2, Praveen Raju1,2
1Memorial Sloan Kettering Cancer Center, USA, 2Weill Cornell Medical College, USA
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Visual impairment and auditory compensation in children treated for optic pathway glioma
Chiara Papini*1, Nicola Pitchford1, Rob Dineen2, David Walker3
1School of Psychology, University of Nottingham, UK, 2Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK, 3Children's Brain Tumour Research Centre, University of Nottingham, UK
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Visual rehabilitation: Integral for affected brain tumor patients
Himika Gupta*1,2, Yash Gala1, Varun Sarvodaya1, Purna Kurkure3, Rakesh Jalali4,7, Tejpal Gupta5,7, Aliasgar Moiyadi4,7, Aadil Chagla6, Rahul Krishnatry4,7
1MGM Medical College, India, 2Spectra Eye Care Low vision Service, India, 3SRCC Children's Hospital managed by Narayana Health, India, 4Tata Memorial Hospital, India, 5Advanced Centre for Treatment, Research and Education in Cancer, India, 6Seth G S Medical College and KEM Hospital, India, 7Homi Bhabha National Institute (HBNI University), India
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
What the FOX say? A molecular analysis of FOXR2 in pediatric brain tumors
Sjoerd van Rijn*1,2, Mikaella Vouri1,2, Stefan M. Pfister1,2, Daisuke Kawauchi1,2, Marcel Kool1,2
1Hopp Children's Cancer Center at the NCT Heidelberg, Germany, 2DKFZ, Germany
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Who are the high risk medulloblastoma subgroups in Jordan?
Nisreen Amayiri*1, Maisa Swaidan1, Ahmad Ibrahimi1, Nader Hirmas1, Awni Musharbash1, Eric Bouffet2, Maysa Al-Hussaini1, Vijay Ramaswamy2
1King Hussein Cancer Center, Jordan, 2The Hospital for Sick Children, Canada
Sunday, July 1:  Neuro-Oncology in Developing Regions  -  11:30am - 12:30pm
Whole exome sequencing of circulating tumor DNA extracted from the cerebrospinal fluid allows a pangenomic characteristisation of the primary tumor
Mathieu Chicard1,2, Valérie Combaret3,4, Adrien Danzon1,2, Nathalie Clément1,2, Julien Masliah-Planchon1,5, Mylène Bohec6, Sylvain Baulande6, Célio Pouponnot7, Didier Frappaz8, François Doz1,9, Olivier Delattre1,5, Gudrun Schleiermacher1,2, Franck Bourdeaut*1,2
1SIREDO center (Care innovation, research in pediatric, adolescents and young adult oncology), Institut Curie, France, 2SiRIC RTOP « Recherche Translationelle en Oncologie Pédiatrique », Translational Research Department, Research Center, PSL Research University, Institut Curie, France, 3Plateforme de Génomique des Cancers, Centre Léon Bérard, France, 4Laboratoire de Recherche Translationnelle, Centre Léon Bérard, France, 5Unité de Génétique Somatique, Service de Génétique, Hospital Group, Institut Curie, France, 6Institut Curie Genomics of Excellence (ICGex) Platform, Research Center, Institut Curie, France, 7CNRS UMR 3347, INSERM U1021, Paris Sud University, Institut Curie, France, 8Department of Pediatric Clinical Trials and Department of Pediatric Neuro-Oncology, Institut Hématologique et d'Oncologie Pédiatrique, France, 9Université Paris Descartes, France
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
Whole genome and epigenome characterization links ATRT-MYC to a subgroup of renal rhabdoid tumors
Pascal Johann*1,2, Elizabeth Chun3, Serap Erkek1, Murat Iskar4, Elizabeth Perlman5, Martin Hasselblatt6, Stefan M. Pfister1,2, Marco Marra3, Marcel Kool1,2
1Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ),, Germany, 2Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, Germany, 3Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Canada, 4Division of Genome Research, German Cancer Research Center, Germany, 5Department of Pathology and Laboratory Medicine,Lurie Children’s Hospital, Northwestern University’s Feinberg School of Medicine and Robert H. Lurie Cancer Center, USA, 6Institute of Neuropathology, University Hospital Münster, Germany
Monday, July 2:  ATRT  -  11:00am - 12:30pm
Whole person care in pediatric oncology: insight for chaplain-physician collaboration
Alex Lion*1, Jodi Skiles1, Beth Watson1,2, Daniel Young1, Alexia Torke1,2
1Indiana University School of Medicine, USA, 2Evans Center for Spirituality and Religion in Healthcare, Indiana University Health, USA
Saturday, June 30:  Social Work Session  - 
Whole ventricular irradiation for intracranial germ cell tumors: dosimetric comparison of pencil beam scanned protons vs. IMRT
Dora Correia*1,2, Alessia Pica1, Dario Terribilini3, Stefan Zepter1, Nicola Bizzocchi1, Sonja Stieb2, Frank Ahlhelm4, Evelyn Herrmann2, Michael K. Fix3, Peter Manser3, Daniel M. Aebersold2, Damien C. Weber1,2
1Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, Switzerland, 2Department of Radiation Oncology, Inselspital, Bern University Hospital, Switzerland, 3Division of Medical Radiation Physics, Inselspital, Bern University Hospital, Switzerland, 4Department of Radiology, Cantonal Hospital Baden, Switzerland
Sunday, July 1:  POSTER SESSION 1  -  5:00pm - 6:30pm
Will electronic integrated text, visual and audio questionnaire be a better tool to evaluate the health status of paediatric hydrocephalus patients?
Alf Nicholson1,2, John Caird1,2, Joy Tan*1,2
1RCSI, Ireland, 2Temple Street Children University Hospital, Ireland
Monday, July 2:  POSTER SESSION 2  -  5:00pm - 6:30pm
YAP1 fusion proteins mediate oncogenic activity in ependymoma via interaction with TEAD transcription factors
Kristian W. Pajtler*1,2, Konstantin Okonechnikov1,2, Mikaella Vouri1,2, Sebastian Brabetz1,2, David T. W. Jones1,2, Andrey Korshunov2, David Capper3, Lukas Chavez1,2, Stefan M. Pfister1,2, Marcel Kool1,2, Daisuke Kawauchi1,2
1Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2German Cancer Research Center, Germany, 3Charité – Universitätsmedizin Berlin, Germany
Sunday, July 1:  Ependymoma  -  3:30pm - 5:00pm