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Ependymoma
Sunday, July 1, 3:30pm - 5:00pm

 

SESSION CHAIRS: Richard Grundy, Amy Smith, Vijay Ramaswamy

 


EPEN-28 Heterogeneity within the PFB Ependymoma Subgroup
Florence Cavalli1, Jens-Martin Hübner2, Tanvi Sharma2, Martin Sill2, Betty Luu1, Michal Zapotocky1, Andrey Korshunov2, Stefan Pfister2, Kristian Pajtler2, Michael Taylor1, Kenneth Aldape3, Marcel Kool2, Vijay Ramaswamy*1
1Hospital for Sick Children, Canada, 2German Cancer Research Center, Germany, 3Princess Margaret Cancer Centre, Canada
EPEN-07 Overexpression and mutations of CXorf67 in ‘infant-type’ posterior fossa type-A (PFA) ependymomas
Wilda Orisme*1, Ji Wen1, Bo Tang1, Jens-Martin Hübner2,3, Gang Wu4, Sujuan Jia1, John Easton4, Kelly Haupfear1, Brian D. Freibaum5, Hong Joo Kim5, Anthony High6, BaoHan Vo8, Ruth G. Tatevossian1, Junmin Peng6, Stefan M. Pfister2,7, Jinghui Zhang4, J. Paul Taylor5, Martine Roussel8, Kristian W. Pajtler2,7, Marcel Kool2,3, David W. Ellison1
1Department of Pathology, St. Jude Children’s Research Hospital, USA, 2Division of Pediatric Neurooncology, German Cancer Research Center, Germany, 3Hopp-Children´s Cancer Center at the NCT Heidelberg, Germany, 4Department of Computational Biology, St. Jude Children’s Research Hospital, USA, 5Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, USA, 6Proteomics Shared Resource, St. Jude Children’s Research Hospital, USA, 7Department of Pediatric Oncology, Hematology and Immunology, University Hospital, Germany, 8Department of Tumor Cell Biology, St. Jude Children’s Research Hospital, USA
EPEN-21 Single cell RNAseq identifies a putative cancer stem cell population in posterior fossa EPN
Andrew Donson*1,2, Austin Gillen1, Kent Riemondy1, Jay Hesselberth1, Vladimir Amani1,2, Andrea Griesinger1,2, Davis Witt1,2, Todd Hankinson1,2, Michael Handler1,2, Rajeev Vibhakar1,2, Nicholas Foreman1,2
1University of Colorado Anschutz Medical Campus, USA, 2Children's Hospital Colorado, USA
EPEN-09 RNA-seq analysis of recurrent paediatric ependymomas reveals immunological changes specific to molecular subgroups
Timothy A Ritzmann*1, Hazel A Rogers1, Andrew M Donson4, Alex Virasami3, Thomas S Jacques3, Simon ML Paine1,2, Nicholas Foreman4, Richard G Grundy1,2
1The University of Nottingham, UK, 2Nottingham University Hospitals NHS Trust, UK, 3UCL GOS Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital for Children NHS Trust, UK, 4Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, USA
EPEN-24 YAP1 fusion proteins mediate oncogenic activity in ependymoma via interaction with TEAD transcription factors
Kristian W. Pajtler*1,2, Konstantin Okonechnikov1,2, Mikaella Vouri1,2, Sebastian Brabetz1,2, David T. W. Jones1,2, Andrey Korshunov2, David Capper3, Lukas Chavez1,2, Stefan M. Pfister1,2, Marcel Kool1,2, Daisuke Kawauchi1,2
1Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Germany, 2German Cancer Research Center, Germany, 3Charité – Universitätsmedizin Berlin, Germany
EPEN-34 High-throughput drug screening of primary cultures reveals irreversible ERBB2 inhibition as novel therapeutic vulnerability of ependymomas
David Pauck*1,2, Sevgi Sarikaya-Seiwert4,5, Viktoria Marquardt1,6, Daniel Picard1,2, Jasmin Bartl1,2, Lena Blümel1,2, Mara Maue1,2, Christian Dimitriadis1,2, Michaela Kuhlen2, Ute Fischer2, Hans-Jakob Steiger5, Guido Reifenberger3, Arndt Borkhardt2, Thomas Beez5, Marc Remke1,2
1Division of Pediatric Neuro-Oncogenomics, German Cancer Consortium and German Cancer Research Center, partner site Essen/Düsseldorf, Germany, 2Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany, 3Institute of Neuropathology, Heinrich Heine University Düsseldorf, Germany, 4Department of Neurosurgery, University of Bonn Medical Center, Germany, 5Department of Neurosurgery, Heinrich Heine University Düsseldorf, Germany, 6Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Germany
EPEN-33 Study of anti-HER2 CAR T cells in the immunosuppressive ependymoma tumor microenvironment
Anandani Nellan*, Andrea Griesinger, Davis Witt, Andrew Donson, Vladimir Amani, Nicholas K. Foreman
University of Colorado, USA
EPEN-19 Supratentorial ependymomas - L1CAM expression and RELA fusion, their correlation with clinicopathological features
Gouri Anvekar*1, Mamta Gurav2, Omshree Shetty2, Vinayak Kadam2, Ayushi Sahay1, Girish Chinnaswamy3, Prakash Shetty4, Aliasgar Moiyadi4, Tejpal Gupta5, Rakesh Jalali5, Sridhar Epari1,2
1Department of Pathology, Tata Memorial Centre, India, 2Division of Molecular Pathology, Department of Pathology, Tata Memorial Centre, India, 3Pediatric Oncology, Tata Memorial Centre, India, 4Neurosurgery, Tata Memorial Centre, India, 5Radiation Oncology, Tata Memorial Centre, India