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Low Grade Gliomas
Sunday, July 1, 8:45am - 11:00am

 

SESSION CHAIRS: Jason Fangusaro, Jean Mulcahy-Levy, Alvaro Lassaletta

INVITED SPEAKER: Darren Hargrave

LATE BREAKING ABSTRACT: Updates on the Phase II and Re-Treatment Study of AZD6244 for Children with Recurrent or Refractory Pediatric Low Grade Glioma: A Pediatric Brain Tumor Consortium (PBTC) Study

 

 

 


LGG-38 Proteogenomics reveals three distinct biological pilocytic astrocytoma subgroups
Daniel Picard1,2, Jörg Felsberg3, Maike Langini1,4, David Pauck1,2, Viktoria Marquardt1,6, Frauke Meyer1,2, Anja Stefanski4,5, Lucia Roque7, Kai Stühler4,5, Arndt Borkhardt1,2, Guido Reifenberger1,3, Cláudia Faria8,9, Marc Remke*1
1Department of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen / Düsseldorf, Germany, 2Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Germany, 3Department of Neuropathology, Heinrich Heine University Düsseldorf, Medical Faculty, Germany, 4Molecular Proteomics Laboratory, BMFZ, Heinrich-Heine-University Düsseldorf, Germany, 5Institute for Molecular Medicine, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany, 6Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Germany, 7Unidade de Investigação em Patobiologia Molecular (UIPM) – IPOFG, Portuguese Cancer Institute, Portugal, 8Instituto de Medicina Molecular, Faculdade de Medicina, da Universidade de Lisboa, Portugal, 9Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Portugal
LGG-24 Temporal genomic heterogeneity in pediatric low-grade gliomas
Christine Fuller*1, Austin Schafer1, Daniel Boue2, Diana Osorio2, Jonathan Finlay2, Sarah Rush3, Erin Wright3, Lindsey Hoffman4, Nancy Yanez-Escorza1, Jamie Reuss1, Trent Hummel1, Ralph Salloum1, Lionel M.L. Chow1, Mariko DeWire1, Peter de Blank1, Charles Stevenson1, Rachid Drissi1, Maryam Fouladi1
1Cincinnati Children's Hospital Medical Center, USA, 2Nationwide Children's Hospital, USA, 3Akron Children's Hospital, USA, 4Children's Hospital Colorado, USA
LGG-13 Resolving transcriptional profiles in BRAF-rearranged pilocytic astrocytoma using single cell RNA sequencing
Zachary Reitman*1,2, Brenton Paolella2, Guillaume Bergthold1, Kristine Pelton1, Sarah Becker1, Robert Jones1, Zach Herbert1,2, Leslie Grimmett1, John Daley1, Mariella Filbin1,3, Mario Suva5, Liliana Goumnerova3, Karen Wright3, Susan Chi3, Mark Kieran3, Aviv Regev3, Alex Shalek4, Keith L Ligon1, Rameen Beroukhim1, Pratiti Bandopadhayay1,3
1Dana Farber Cancer Institute, USA, 2Broad Institute, USA, 3Boston Children's Hospital, USA, 4Massachusetts Institute of Technology, USA, 5Massachusetts General Hospital, USA
TBIO-21 Analysis of paired BRAFV600E mutant glioma patient samples identifies novel resistance mechanisms to targeted BRAF inhibition
Jean Mulcahy Levy*1,2, Bridget Sanford1, Andrew Morin1,2, Adam Green1,2, Patrick Flannery1,2, Kenneth Jones1, Anurhada Banerjee3, Kellie Nazemi4, David Samuel5, Lindsay Kilburn6, David Solomon3, Theodore Nicolaides3
1University of Colorado Denver, USA, 2Morgan Adams Pediatric Brain Tumor Reserach Program, USA, 3University of San Francisco, USA, 4Oregon Health Sciences University, USA, 5Valley Chidren's Healthcare, USA, 6Children's National Health System, USA
LGG-46 Trametinib therapy in pediatric patients with low-grade gliomas (LGG) with BRAF gene fusion; a disease-specific cohort in the first pediatric testing of trametinib
Eric Bouffet*1, Mark Kieran2, Darren Hargrave3, Stephen Roberts4, Isabelle Aerts5, Alberto Broniscer6, Birgit Geoerger7, Kohinoor Dasgupta8, Lillian Tseng9, Mark Russo9, Bijoyesh Mookerjee9, Christopher Moertel10
1University of Toronto Hospital for Sick Children, Canada, 2Dana-Farber Boston Children's Hospital, USA, 3Great Ormond Street Hospital for Children, UK, 4Memorial Sloan Kettering Cancer Center, USA, 5Institut Curie, SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), PSL Research University, France, 6St. Jude Children's Research Hospital, USA, 7Institut Gustave Roussy, France, 8Novartis Healthcare Pvt. Ltd., India, 9Novartis Pharmaceuticals Corporation, USA, 10University of Minnesota, USA
LGG-44 A phase I dose escalation trial of the MEK1/2 inhibitor MEK162 (binimetinib) in children with low-grade gliomas and other Ras/Raf pathway-activated tumors
Nathan Robison*1,2, Jasmine Pauly1, Jemily Malvar1, Mariella Gruber-Filbin11,3, Rebecca Loret de Mola4, Kathleen Dorris5, Anne Bendel6, Daniel Bowers7, Miriam Bornhorst8, Karen Gauvain9, Sarah Leary10, Patricia Diaz1, Yi Juin Tan1, Ashley Margol1,2, Girish Dhall1,2, Tena Rosser1,2, Pratiti Bandopadhayay11,3, Tom Davidson13, Nicole Ullrich12,11, Mark Borchert1,2, Marvin Nelson1,2, Claire Sinai11, Keith Ligon11,3, Richard Sposto1,2, Mark Kieran11,12
1Children's Hospital Los Angeles, USA, 2University of Southern California Keck School of Medicine, USA, 3The Broad Institute, USA, 4Oregon Health and Science University, USA, 5Children's Hospital Colorado, USA, 6Children's Hospitals and Clinics of Minnesota, USA, 7University of Texas Southwestern Medical Center at Dallas, USA, 8Children's National Health System, USA, 9Washington University, USA, 10Fred Hutchinson Cancer Research Center, USA, 11Dana-Farber Cancer Institute, USA, 12Boston Children's Hospital, USA, 13University of California Los Angeles, USA
LGG-28 Neurocognitive sequelae in pediatric low grade glioma patients under observation - neuropsychological results from the SIOP-LGG-2004 study & LGG-Register
Thomas Traunwieser*, Daniela Kandels, Astrid Gnekow
Swabian Children’s Cancer Center, Children’s Hospital Augsburg, Germany
LGG-45 Response to the first-line chemotherapy in pediatric low-grade gliomas according to histopathology and BRAF alterations
Tasnime Akbaraly*1, Volodia Dangouloff-Ros2, Arnault Tauziede-Espariat3, Ludovic Lacroix1, Stéphanie Puget2, Pascale Varlet3, Léa Guerrini-Rousseau1, Jacques Grill1, Christelle Dufour1
1Gustave Roussy, France, 2Hopital Necker Enfants Malades, France, 3Centre hospitalier Sainte-Anne, France